1-Octacosanol(1-Octa)is recognized worldwide as a functional anti-fatigue agent with additional antiinflammatory and energy-boosting benefits.However,it has low bioavailability owing to the poor water solubility and i...1-Octacosanol(1-Octa)is recognized worldwide as a functional anti-fatigue agent with additional antiinflammatory and energy-boosting benefits.However,it has low bioavailability owing to the poor water solubility and instability in the gastrointestinal tract;this limits its use in food,medical,and health care products.To address this,we aimed to prepare a water-soluble octenyl succinate anhydride debranched starch(OSD)-Octa complex and investigate the effects of degree of substitution of OSD and reaction temperature on the drug loading,structure,and water solubility of the complex.The contact angle of free 1-Octa was 110.3°,which decreased to<55°in the complex,and the solubility of 1-Octa in the complex ranged from 0.329±0.008 to 1.532±0.023 mg/mL,which indicated a notable increase in the aqueous solubility of 1-Octa.Furthermore,1-Octa was found to penetrate the amylose helical cavity of OSD and form exohydrophilic and endohydrophobic nanoparticles with OSD through hydrophobic interaction.Finally,OSD-Octa effectively mitigated the degradation of 1-Octa under extreme pH conditions and in the presence of digestive enzymes compared to that of free 1-Octa.These findings suggest that the OSD system is an effective approach to enhancing the solubility and stability of hydrophobic functional factors.展开更多
A series of carbon nanotubes/TiO2 nanotubes （CNTs/TNTs） composite photocatalysts were successfully prepared by incorporation of CNTs in HNO3 washing process. These photocatalysts were characterized by XRD, N2 physic...A series of carbon nanotubes/TiO2 nanotubes （CNTs/TNTs） composite photocatalysts were successfully prepared by incorporation of CNTs in HNO3 washing process. These photocatalysts were characterized by XRD, N2 physical adsorption, UV-vis diffuse reflectance spectroscopy, TEM and Raman spectroscopy, respectively, and their photocatalytic activities were tested by using methyl orange （MO） as a model compound. Also, the effects of amount of CNTs incorporated, calcination temperature and amount of catalyst on the photocatalytic activity of the composite photocatalyst were systematically investigated. The results show that the CNTs/TNTs composite exhibits much higher photocatalytic activity than that of the TNTs or CNTs alone.展开更多
基金supported by National Natural Science Foundation of China(22276078,32302066)Research Program of State Key Labora-tory of Food Science and Resources,Jiangnan University(No.SKLF-ZZB-202406)+1 种基金China Postdoctoral Science Foundation(2023M731337)Postdoctoral Fellowship Program of CPSF(GZC20230986).
文摘1-Octacosanol(1-Octa)is recognized worldwide as a functional anti-fatigue agent with additional antiinflammatory and energy-boosting benefits.However,it has low bioavailability owing to the poor water solubility and instability in the gastrointestinal tract;this limits its use in food,medical,and health care products.To address this,we aimed to prepare a water-soluble octenyl succinate anhydride debranched starch(OSD)-Octa complex and investigate the effects of degree of substitution of OSD and reaction temperature on the drug loading,structure,and water solubility of the complex.The contact angle of free 1-Octa was 110.3°,which decreased to<55°in the complex,and the solubility of 1-Octa in the complex ranged from 0.329±0.008 to 1.532±0.023 mg/mL,which indicated a notable increase in the aqueous solubility of 1-Octa.Furthermore,1-Octa was found to penetrate the amylose helical cavity of OSD and form exohydrophilic and endohydrophobic nanoparticles with OSD through hydrophobic interaction.Finally,OSD-Octa effectively mitigated the degradation of 1-Octa under extreme pH conditions and in the presence of digestive enzymes compared to that of free 1-Octa.These findings suggest that the OSD system is an effective approach to enhancing the solubility and stability of hydrophobic functional factors.
基金Financial supports from the Project Supported by the Natural Science Foundation of the Jiangsu Province Higher Education Institutions of China(09KJD150002)Project Supported by the Graduate Innovation Program Foundation of the Jiangsu Province Higher Education Institutions of China(CXLX_0570)
文摘A series of carbon nanotubes/TiO2 nanotubes （CNTs/TNTs） composite photocatalysts were successfully prepared by incorporation of CNTs in HNO3 washing process. These photocatalysts were characterized by XRD, N2 physical adsorption, UV-vis diffuse reflectance spectroscopy, TEM and Raman spectroscopy, respectively, and their photocatalytic activities were tested by using methyl orange （MO） as a model compound. Also, the effects of amount of CNTs incorporated, calcination temperature and amount of catalyst on the photocatalytic activity of the composite photocatalyst were systematically investigated. The results show that the CNTs/TNTs composite exhibits much higher photocatalytic activity than that of the TNTs or CNTs alone.
