Commercial paper is of great potential as a ready-made substrate to make battery separator due to superior electrolyte affinity of cellulose.Nevertheless,the direct utilization of commercial paper as a separator is im...Commercial paper is of great potential as a ready-made substrate to make battery separator due to superior electrolyte affinity of cellulose.Nevertheless,the direct utilization of commercial paper as a separator is impracticable because of its micro-sized holes between coarse cellulose fibers,which might induce short circuits.Herein,a novel reinforced composite separator is proposed by modifying commercial paper(CP)with highdielectric polymer poly(vinylidene fluoride)(PVDF)via a vacuum filtration method.The paper substrate enables excellent electrolyte wettability and high ionic conductivity of the CP-PVDF composite separator due to the superior electrolyte affinity of cellulose molecule.Meanwhile,the strong hydrogen bonds between F atoms in PVDF and H atoms in the-OH groups of cellulose endow the separator with high thermal stability and mechanical strength.Moreover,the CP-PVDF exhibits outstanding interfacial compatibility toward Li metal anode and guarantees the prominent cycle durability of symmetric Li/Li cells up to 600 h.As a result,the LiFePO_(4)/Li cells assembled with CP-PVDF separator show dramatic rate performance with high discharge capacity of 113.7 m Ah g^(-1),and prolonged cycle life at 5 C.This work indicates that the paper-based composite membranes possess great potential for high-safety and electrochemical performance batteries.展开更多
Snow cover is one of the important components of land cover,and it is necessary to accurately monitor the depth and coverage of snow cover.Using the GPS signal receiver data and the basic principle of snow depth detec...Snow cover is one of the important components of land cover,and it is necessary to accurately monitor the depth and coverage of snow cover.Using the GPS signal receiver data and the basic principle of snow depth detection based on GPS-MR technology,the snow depth of the three sites on the Greenland PBO network GLS1,GLS2,and GLS3 from 2012 to 2018 was obtained.The inversion snow depth is affected by site drift,which is a quite difference from the measured snow depth.Combined with the stable reference point,the velocity field distribution of Greenland Island and the U-direction component change value of the station can be obtained through GAMIT calculation.By analyzing the glacial flow and U-direction component,the influence of the site drift on the snow depth was deducted,and finally compared the corrected inversion snow depth and measured snow depth found that the two were better than before the correction,the results were significantly improved,and the consistency was good.The analysis of the experimental results showed that in extremely cold areas such as Greenland Island,affected by glaciers,the continuous,real-time,high-time resolution snow depth around the measured station obtained by ground-based GPS tracking stations has a large gap with the measured snow depth value,and the gap will gradually increase with time.By deducting the impact of glacier drift,the trend of the two is the same and the consistency is good.The correctness and feasibility of the application of ground-based GPS snow cover theory in the polar area further expand the application scope and practical value of ground-based GPS in snow monitoring.展开更多
Query translation mining is a key technique in cross-language information retrieval and machine translation knowl-edge acquisition. For better performance, the queries are classified into transliterated words and non-...Query translation mining is a key technique in cross-language information retrieval and machine translation knowl-edge acquisition. For better performance, the queries are classified into transliterated words and non-transliterated words based on transliterated word identification model, and are further channeled to different mining processes. This paper is a pilot study on query classification for better translation mining performance, which is based on supervised classification and linguistic heuristics. The person name identification gets a precision of over 97%. Transliterated word translation mining shows satisfactory performance.展开更多
Background:Rhodiola rosea L.(R.rosea),a traditional Chinese medicinal herb,has gained global attention for its diverse pharmacological activities,especially its anti-tumor effect.While studies have confirmed that R.ro...Background:Rhodiola rosea L.(R.rosea),a traditional Chinese medicinal herb,has gained global attention for its diverse pharmacological activities,especially its anti-tumor effect.While studies have confirmed that R.rosea can hinder the growth of multiple cancer cells,the underlying mechanisms of R.rosea in breast cancer remain elusive.Objective:To investigate the anti-breast cancer efficacy and potential mechanism of R.rosea.Methods:UPLC-Q/TOF MS was utilized to examine the components of R.rosea.Eight-week-old MMTV-PyMT mice were used to assess the potential impact of R.rosea in breast cancer development.Flow cytometry was performed to evaluate the effectiveness of immune cells in mediating the anti-tumor effects of R.rosea.Additionally,the xCELLigence system aided in examining the proliferation of breast cancer cells after treatment with R.rosea.Furthermore,RNA-seq,RT-qPCR and Western blot were employed to elucidate the underlying mechanism of R.rosea in breast cancer.Lastly,network pharmacology was applied to delve deeper into the primary chemically active components responsible for the pharmacological effects of R.rosea.Results:R.rosea exhibits a substantial effect in curtailing the progression of breast cancer,accomplished by repressing the proliferation of tumor cells and reconfiguring the tumor microenvironment(TME).Mechanistically,R.rosea exerts its anti-tumor effects by downregulating the expression of HIF-1α,TGF-β,and Smad3 in tumor cells,thereby alleviating the hypoxic TME and enhancing immune surveillance.Conclusion:Our study revealed that R.rosea suppressed the development of breast cancer by inhibiting the hy-poxic immune microenvironment mediated by the activation of HIF-1α/TGF-β/Smad signaling pathway in tumor cells.These findings,which underscore R.rosea potential as a potent antineoplastic agent,offer a compelling basis for its use as an adjuvant therapy in the treatment of breast cancer.展开更多
Background:Since RNA sequencing has shown that induced pluripotent stem cells(iPSCs)share a common antigen profile with tumor cells,cancer vaccines that focus on iPSCs have made promising progress in recent years.Prev...Background:Since RNA sequencing has shown that induced pluripotent stem cells(iPSCs)share a common antigen profile with tumor cells,cancer vaccines that focus on iPSCs have made promising progress in recent years.Previously,we showed that iPSCs derived from leukemic cells of patients with primary T cell acute lymphoblastic leukemia(T-ALL)have a gene expression profile similar to that of T-ALL cell lines.Methods:Mice with T-ALL were treated with dendritic and T(DC-T)cells loaded with intact and complete antigens from T-ALL-derived iPSCs(T-ALL-iPSCs).We evaluated the safety and antitumor efficiency of autologous tumor-derived iPSC antigens by flow cytometry,cytokine release assay,acute toxicity experiments,long-term toxicity experiments,and other methods.Results:Our results indicate that complete tumor antigens from T-ALL-iPSCs could inhibit the growth of inoculated tumors in immunocompromised mice without causing acute and long-term toxicity.Conclusion:T-ALL-iPSC-based treatment is safe and can be used as a potential strategy for leukemia immunotherapy.展开更多
This study investigated the efficiency of natural killer(NK)cell immunotherapy on non-small cell lung cancer with and without EGFRmutations in order to evaluate the response rate(RR)and progression-free survival(PFS)....This study investigated the efficiency of natural killer(NK)cell immunotherapy on non-small cell lung cancer with and without EGFRmutations in order to evaluate the response rate(RR)and progression-free survival(PFS).Among the 48 patients recruited,24 were clinically confirmed to be EGFR mutation positive.The study group was treated with autologous NK cell immunotherapy.Comparisons of the lymphocyte number,serum tumourrelated biomarkers,circulating tumour cells(CTC),Karnofsky Performance Status(KPS)and survival curves were carried out before and after NK cell immunotherapy.The safety and short-term effects were evaluated,followed by median PFS and RR assessments.The serum CEA and CA125 values were found lower in the NK cell therapy group than that of the non-NK treatment group(p<0.05).Theχ2 test showed a 75%RR of the study group A,significantly higher than that of the control group B(16.7%;p<0.01).The RR of groups C(58.3%)and D(41.7%)were not statistically significant.The p values of the 4 groups were 0.012,0.012,0.166 and 1 from group A to group D,respectively.The median PFS was 9 months in EGFR mutation positive group undergoing NK cell infusion interference.By evaluating the changes in immune function,tumour biomarkers,CTC,KPS and PFS,we demonstrated that NK cell therapy had better clinical therapeutic effects on EGFR mutation-positive lung adenocarcinoma.展开更多
As the cathode with the highest electron emission capability in the thermionic cathode,the scandate cathode has attracted more and more attention in recent years,especially the scandia doped tungsten matrix scandate c...As the cathode with the highest electron emission capability in the thermionic cathode,the scandate cathode has attracted more and more attention in recent years,especially the scandia doped tungsten matrix scandate cathode.Experimental studies show that scandia doped tungsten matrix scandate cathodes with submicron microstructures exhibit excellent emission capacity,and the pulse emission current density in the space-charge region can be over 35 A cm^(−2) at 850°Cb.In the direct current(DC)condition with temperature compensation,the emission current density could reach 25 A cm^(−2) at 850°Cb.The device lifetime is over 3700 h after operating at 950°C_(b) with the DC loading of 40 A cm^(−2).The emission mechanism of the scandate cathode including the effect of the surface structure and composition on the work function of the cathode are systematically reviewed.展开更多
基金financially supported by the National Natural Science Foundation of China(21863006,51662029)Key Laboratory of Jiangxi Province for Environment and Energy Catalysis(20181BCD40004)
文摘Commercial paper is of great potential as a ready-made substrate to make battery separator due to superior electrolyte affinity of cellulose.Nevertheless,the direct utilization of commercial paper as a separator is impracticable because of its micro-sized holes between coarse cellulose fibers,which might induce short circuits.Herein,a novel reinforced composite separator is proposed by modifying commercial paper(CP)with highdielectric polymer poly(vinylidene fluoride)(PVDF)via a vacuum filtration method.The paper substrate enables excellent electrolyte wettability and high ionic conductivity of the CP-PVDF composite separator due to the superior electrolyte affinity of cellulose molecule.Meanwhile,the strong hydrogen bonds between F atoms in PVDF and H atoms in the-OH groups of cellulose endow the separator with high thermal stability and mechanical strength.Moreover,the CP-PVDF exhibits outstanding interfacial compatibility toward Li metal anode and guarantees the prominent cycle durability of symmetric Li/Li cells up to 600 h.As a result,the LiFePO_(4)/Li cells assembled with CP-PVDF separator show dramatic rate performance with high discharge capacity of 113.7 m Ah g^(-1),and prolonged cycle life at 5 C.This work indicates that the paper-based composite membranes possess great potential for high-safety and electrochemical performance batteries.
文摘Snow cover is one of the important components of land cover,and it is necessary to accurately monitor the depth and coverage of snow cover.Using the GPS signal receiver data and the basic principle of snow depth detection based on GPS-MR technology,the snow depth of the three sites on the Greenland PBO network GLS1,GLS2,and GLS3 from 2012 to 2018 was obtained.The inversion snow depth is affected by site drift,which is a quite difference from the measured snow depth.Combined with the stable reference point,the velocity field distribution of Greenland Island and the U-direction component change value of the station can be obtained through GAMIT calculation.By analyzing the glacial flow and U-direction component,the influence of the site drift on the snow depth was deducted,and finally compared the corrected inversion snow depth and measured snow depth found that the two were better than before the correction,the results were significantly improved,and the consistency was good.The analysis of the experimental results showed that in extremely cold areas such as Greenland Island,affected by glaciers,the continuous,real-time,high-time resolution snow depth around the measured station obtained by ground-based GPS tracking stations has a large gap with the measured snow depth value,and the gap will gradually increase with time.By deducting the impact of glacier drift,the trend of the two is the same and the consistency is good.The correctness and feasibility of the application of ground-based GPS snow cover theory in the polar area further expand the application scope and practical value of ground-based GPS in snow monitoring.
文摘Query translation mining is a key technique in cross-language information retrieval and machine translation knowl-edge acquisition. For better performance, the queries are classified into transliterated words and non-transliterated words based on transliterated word identification model, and are further channeled to different mining processes. This paper is a pilot study on query classification for better translation mining performance, which is based on supervised classification and linguistic heuristics. The person name identification gets a precision of over 97%. Transliterated word translation mining shows satisfactory performance.
基金sponsored by the National Natural Science Foun-dation of China(Grant 82274175 and 82474168 to Q.Y.S.,Grant 82174026 to H.Y.F.,Grant 82404915 to L.J.)the Natural Science Foun-dation of Zhejiang Province(Grant LY22H280012 to H.Y.F..,Grant Y23H280029 to X.L.)+1 种基金Zhejiang Provincial Administration of Traditional Chinese Medicine Co-construction Key Project(Grant GZY-ZJ-KJ-23069 to Q.Y.S.)Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents.
文摘Background:Rhodiola rosea L.(R.rosea),a traditional Chinese medicinal herb,has gained global attention for its diverse pharmacological activities,especially its anti-tumor effect.While studies have confirmed that R.rosea can hinder the growth of multiple cancer cells,the underlying mechanisms of R.rosea in breast cancer remain elusive.Objective:To investigate the anti-breast cancer efficacy and potential mechanism of R.rosea.Methods:UPLC-Q/TOF MS was utilized to examine the components of R.rosea.Eight-week-old MMTV-PyMT mice were used to assess the potential impact of R.rosea in breast cancer development.Flow cytometry was performed to evaluate the effectiveness of immune cells in mediating the anti-tumor effects of R.rosea.Additionally,the xCELLigence system aided in examining the proliferation of breast cancer cells after treatment with R.rosea.Furthermore,RNA-seq,RT-qPCR and Western blot were employed to elucidate the underlying mechanism of R.rosea in breast cancer.Lastly,network pharmacology was applied to delve deeper into the primary chemically active components responsible for the pharmacological effects of R.rosea.Results:R.rosea exhibits a substantial effect in curtailing the progression of breast cancer,accomplished by repressing the proliferation of tumor cells and reconfiguring the tumor microenvironment(TME).Mechanistically,R.rosea exerts its anti-tumor effects by downregulating the expression of HIF-1α,TGF-β,and Smad3 in tumor cells,thereby alleviating the hypoxic TME and enhancing immune surveillance.Conclusion:Our study revealed that R.rosea suppressed the development of breast cancer by inhibiting the hy-poxic immune microenvironment mediated by the activation of HIF-1α/TGF-β/Smad signaling pathway in tumor cells.These findings,which underscore R.rosea potential as a potent antineoplastic agent,offer a compelling basis for its use as an adjuvant therapy in the treatment of breast cancer.
基金Science,Technology and Innovation Commission of Shenzhen Municipality,Grant/Award Number:CYJ20170412155231633Health Commission of Shenzhen Municipality,Grant/Award Number:SZXK062。
文摘Background:Since RNA sequencing has shown that induced pluripotent stem cells(iPSCs)share a common antigen profile with tumor cells,cancer vaccines that focus on iPSCs have made promising progress in recent years.Previously,we showed that iPSCs derived from leukemic cells of patients with primary T cell acute lymphoblastic leukemia(T-ALL)have a gene expression profile similar to that of T-ALL cell lines.Methods:Mice with T-ALL were treated with dendritic and T(DC-T)cells loaded with intact and complete antigens from T-ALL-derived iPSCs(T-ALL-iPSCs).We evaluated the safety and antitumor efficiency of autologous tumor-derived iPSC antigens by flow cytometry,cytokine release assay,acute toxicity experiments,long-term toxicity experiments,and other methods.Results:Our results indicate that complete tumor antigens from T-ALL-iPSCs could inhibit the growth of inoculated tumors in immunocompromised mice without causing acute and long-term toxicity.Conclusion:T-ALL-iPSC-based treatment is safe and can be used as a potential strategy for leukemia immunotherapy.
基金The authors thank all 48 participants.This study was funded by the Innovation of Science and Technology Commission of Shenzhen(Grant No:KQJSCX2017033116-0008397,JCYJ20170412155231633,JCYJ20170307171034705 and JCYJ20170816105345191).
文摘This study investigated the efficiency of natural killer(NK)cell immunotherapy on non-small cell lung cancer with and without EGFRmutations in order to evaluate the response rate(RR)and progression-free survival(PFS).Among the 48 patients recruited,24 were clinically confirmed to be EGFR mutation positive.The study group was treated with autologous NK cell immunotherapy.Comparisons of the lymphocyte number,serum tumourrelated biomarkers,circulating tumour cells(CTC),Karnofsky Performance Status(KPS)and survival curves were carried out before and after NK cell immunotherapy.The safety and short-term effects were evaluated,followed by median PFS and RR assessments.The serum CEA and CA125 values were found lower in the NK cell therapy group than that of the non-NK treatment group(p<0.05).Theχ2 test showed a 75%RR of the study group A,significantly higher than that of the control group B(16.7%;p<0.01).The RR of groups C(58.3%)and D(41.7%)were not statistically significant.The p values of the 4 groups were 0.012,0.012,0.166 and 1 from group A to group D,respectively.The median PFS was 9 months in EGFR mutation positive group undergoing NK cell infusion interference.By evaluating the changes in immune function,tumour biomarkers,CTC,KPS and PFS,we demonstrated that NK cell therapy had better clinical therapeutic effects on EGFR mutation-positive lung adenocarcinoma.
基金the National Key Research and Development Program of China(Grant 2017YFB0305600)National Science Foundation of China(Grant 51534009,51621003)Beijing Municipal High Level Innovative Team Building Program(Grant IDHT 20170502).
文摘As the cathode with the highest electron emission capability in the thermionic cathode,the scandate cathode has attracted more and more attention in recent years,especially the scandia doped tungsten matrix scandate cathode.Experimental studies show that scandia doped tungsten matrix scandate cathodes with submicron microstructures exhibit excellent emission capacity,and the pulse emission current density in the space-charge region can be over 35 A cm^(−2) at 850°Cb.In the direct current(DC)condition with temperature compensation,the emission current density could reach 25 A cm^(−2) at 850°Cb.The device lifetime is over 3700 h after operating at 950°C_(b) with the DC loading of 40 A cm^(−2).The emission mechanism of the scandate cathode including the effect of the surface structure and composition on the work function of the cathode are systematically reviewed.
