Potentilla discolor Bunge, a traditional Chinese medicinal herb, has been extensively utilized for treating diverse ailments including diabetes, bacterial infections, viral diseases, and inflammatory disorders. Modern...Potentilla discolor Bunge, a traditional Chinese medicinal herb, has been extensively utilized for treating diverse ailments including diabetes, bacterial infections, viral diseases, and inflammatory disorders. Modern phytochemical investigations have identified over 200 bioactive compounds, predominantly flavonoids, tannins, triterpenoids, and phenolic acids. Pharmacological studies demonstrate that P. discolor exerts multi-target therapeutic effects through antioxidant, anti-inflammatory, antimicrobial, antiviral, antidiabetic, and anticancer activities. Its mechanisms involve modulation of key signaling pathways including PI3K/Akt, MAPK, NF-κB, and Nrf2/HO-1, alongside regulation of glucose-lipid metabolism and gut microbiota. This review systematically summarizes the phytochemistry, traditional applications, and contemporary pharmacological advances of P. discolor, emphasizing its multi-target characteristics and molecular mechanisms. Furthermore, current research limitations and future perspectives are discussed to provide scientific evidence for its clinical development and therapeutic applications.展开更多
Objective:To investigate the effectiveness of Quality Control Circle(QCC)activities in reducing the loss rate during storage of Traditional Chinese Medicine(TCM)decoction pieces in our hospital pharmacy department.Met...Objective:To investigate the effectiveness of Quality Control Circle(QCC)activities in reducing the loss rate during storage of Traditional Chinese Medicine(TCM)decoction pieces in our hospital pharmacy department.Methods:A QCC team was established to systematically analyze the causes of TCM decoction piece losses.Using quality improvement tools including Pareto charts,the 80/20 rule,and fishbone diagrams,we identified key areas for improvement and developed targeted intervention strategies.The study period spanned from January to December 2023,with pre-intervention data collected from January to December 2022.Loss rates were calculated and compared before and after QCC implementation.Results:According to the“80/20 rule”analysis,the primary improvement targets were identified as inadequate maintenance of decoction pieces and dispensing losses.Following QCC implementation,the loss rate of TCM decoction pieces decreased significantly from 1.27%(pre-intervention)to 0.65%(post-intervention),achieving an improvement rate of 47.40%.The total monetary loss decreased from 9,592.62 RMB to 4,546.97 RMB.Conclusion:QCC activities can effectively reduce the loss rate of TCM decoction pieces in hospital pharmacy departments,improve the quality of herbal medicines,ensure patient medication safety,and enhance pharmaceutical service quality.This systematic approach provides a valuable framework for continuous quality improvement in TCM pharmacy management.展开更多
文摘Potentilla discolor Bunge, a traditional Chinese medicinal herb, has been extensively utilized for treating diverse ailments including diabetes, bacterial infections, viral diseases, and inflammatory disorders. Modern phytochemical investigations have identified over 200 bioactive compounds, predominantly flavonoids, tannins, triterpenoids, and phenolic acids. Pharmacological studies demonstrate that P. discolor exerts multi-target therapeutic effects through antioxidant, anti-inflammatory, antimicrobial, antiviral, antidiabetic, and anticancer activities. Its mechanisms involve modulation of key signaling pathways including PI3K/Akt, MAPK, NF-κB, and Nrf2/HO-1, alongside regulation of glucose-lipid metabolism and gut microbiota. This review systematically summarizes the phytochemistry, traditional applications, and contemporary pharmacological advances of P. discolor, emphasizing its multi-target characteristics and molecular mechanisms. Furthermore, current research limitations and future perspectives are discussed to provide scientific evidence for its clinical development and therapeutic applications.
文摘Objective:To investigate the effectiveness of Quality Control Circle(QCC)activities in reducing the loss rate during storage of Traditional Chinese Medicine(TCM)decoction pieces in our hospital pharmacy department.Methods:A QCC team was established to systematically analyze the causes of TCM decoction piece losses.Using quality improvement tools including Pareto charts,the 80/20 rule,and fishbone diagrams,we identified key areas for improvement and developed targeted intervention strategies.The study period spanned from January to December 2023,with pre-intervention data collected from January to December 2022.Loss rates were calculated and compared before and after QCC implementation.Results:According to the“80/20 rule”analysis,the primary improvement targets were identified as inadequate maintenance of decoction pieces and dispensing losses.Following QCC implementation,the loss rate of TCM decoction pieces decreased significantly from 1.27%(pre-intervention)to 0.65%(post-intervention),achieving an improvement rate of 47.40%.The total monetary loss decreased from 9,592.62 RMB to 4,546.97 RMB.Conclusion:QCC activities can effectively reduce the loss rate of TCM decoction pieces in hospital pharmacy departments,improve the quality of herbal medicines,ensure patient medication safety,and enhance pharmaceutical service quality.This systematic approach provides a valuable framework for continuous quality improvement in TCM pharmacy management.
