This study examines how generative artificial intelligence(AI)reshapes creative identity in design education.Drawing on post-humanist and network-based theories,it frames AI as a cognitive collaborator in ideation and...This study examines how generative artificial intelligence(AI)reshapes creative identity in design education.Drawing on post-humanist and network-based theories,it frames AI as a cognitive collaborator in ideation and authorship.Mixed-methods data reveal student anxiety and stylistic confusion,contrasted with designers’adaptive strategies.The AI–Cognition–Identity framework supports curricula that promote reflective,ethical,and epistemically informed AI-integrated pedagogy.展开更多
Weathered crust elution-deposited rare earth ores(WREOs)are rich in medium and heavy rare earth.In order to improve the in-situ leaching process,which is prone to landslides and poor permeability,cationic hydroxyethyl...Weathered crust elution-deposited rare earth ores(WREOs)are rich in medium and heavy rare earth.In order to improve the in-situ leaching process,which is prone to landslides and poor permeability,cationic hydroxyethyl cellulose(PQ-10)was used as a novel green swelling inhibitor and percolation promoter and was mixed with conventional leaching agent ammonium sulfate((NH_(4))_(2)SO_(4))to form a composite leaching agent to study the performance and mechanism of swelling inhibition and percolation promotion.Adding PQ-10 can inhibit the hydration swelling of WREOs,promote the percolation effect of the leaching agent,improve the rare earth(RE)leaching efficiency,and reduce the im purity aluminum(Al)leaching efficiency.Compared with the conventional leaching agent 2 wt%(NH_(4))_(2)SO_(4),the percolation time is reduced by 50%by using the composite leaching agent(0.02 wt%PQ-10+2 wt%(NH_(4))_(2)SO_(4)).PQ-10 has positively charged quaternary ammonium groups and hydrophilic group hydroxyl groups,which makes it easy to adsorb on WREOs multiple sites through electrostatic interaction and hydrogen bonding,weakening the electrostatic repulsion between mineral particles,reducing the WREOs interlayer spacing,compressing the double electric layer thickness at the solid-liquid interface,weakening the mineral hydration swelling and increasing the percolation rate.The long carbon chains of the polymer entangle and link the fine mineral particles to agglomerate them,increasing their particle size and reduc ing their hydration dispersion,and preventing blockage of the pe rcolation pores caused by migration of the fine particles through the ore body with the solution.PQ-10 molecules also insert the mine ral interlayer and expulsion of the internal water,further inhibiting the swelling of WREOs.Adding PQ-10 reduces the surface tension of(NH_(4))_(2)SO_(4)solution,improving the spreading and spreading ability of the solution,reducing the adhesion work between molecules in the solid-liquid phase and the adhesion work reduction factor.It proves that PQ-10 promotes the percolation effect of the leaching process of WREOs.In addition,PQ-10 expands the leaching pore size and seepage channels,further improving the percolation rate.展开更多
Skeletal muscle dysfunction is a common extrapulmonary comorbidity of chronic obstructive pulmonary disease(COPD) and is associated with decreased quality-of-life and survival in patients. The autophagy lysosome pathw...Skeletal muscle dysfunction is a common extrapulmonary comorbidity of chronic obstructive pulmonary disease(COPD) and is associated with decreased quality-of-life and survival in patients. The autophagy lysosome pathway is one of the proteolytic systems that significantly affect skeletal muscle structure and function. Intriguingly, both promoting and inhibiting autophagy have been observed to improve COPD skeletal muscle dysfunction, yet the mechanism is unclear. This paper first reviewed the effects of macroautophagy and mitophagy on the structure and function of skeletal muscle in COPD, and then explored the mechanism of autophagy mediating the dysfunction of skeletal muscle in COPD. The results showed that macroautophagy-and mitophagy-related proteins were significantly increased in COPD skeletal muscle. Promoting macroautophagy in COPD improves myogenesis and replication capacity of muscle satellite cells, while inhibiting macroautophagy in COPD myotubes increases their diameters. Mitophagy helps to maintain mitochondrial homeostasis by removing impaired mitochondria in COPD. Autophagy is a promising target for improving COPD skeletal muscle dysfunction, and further research should be conducted to elucidate the specific mechanisms by which autophagy mediates COPD skeletal muscle dysfunction, with the aim of enhancing our understanding in this field.展开更多
Cathodoluminescence （CL） as a radiative light produced by an electron beam exciting a luminescent material, has beenwidely used in imaging and spectroscopic detection of semiconductor, mineral and biological samples...Cathodoluminescence （CL） as a radiative light produced by an electron beam exciting a luminescent material, has beenwidely used in imaging and spectroscopic detection of semiconductor, mineral and biological samples with an ultrahigh spatial resolution. Conventional CL spectroscopy shows an excellent performance in characterization of traditional mate-rial luminescence, such as spatial composition variations and fluorescent displays. With the development of nanotech-nology, advances of modern microscopy enable CL technique to obtain deep valuable insight of the testing sample, and further extend its applications in the material science, especially for opto-electronic investigations at nanoscale. In this article, we review the study of CL microscopy applied in semiconductor nanostructures for the dislocation, carrier diffu-sion, band structure, doping level and exciton recombination. Then advantages of CL in revealing and manipulating sur-face plasmon resonances of metallic nanoantennas are discussed. Finally, the challenge of CL technology is summa-rized, and potential CL applications for the future opto-electronic study are proposed.展开更多
Photonic topological insulators with robust boundary states can enable great applications for optical communication and quantum emission,such as unidirectional waveguide and single-mode laser.However,because of the di...Photonic topological insulators with robust boundary states can enable great applications for optical communication and quantum emission,such as unidirectional waveguide and single-mode laser.However,because of the diffraction limit of light,the physical insight of topological resonance remains unexplored in detail,like the dark line that exists with the crys-talline symmetry-protected topological edge state.Here,we experimentally observe the dark line of the Z_(2)photonic topo-logical insulator in the visible range by photoluminescence and specify its location by cathodoluminescence characteriza-tion,and elucidate its mechanism with the p-d orbital electromagnetic field distribution which calculated by numerical sim-ulation.Our investigation provides a deeper understanding of Z_(2)topological edge states and may have great signific-ance to the design of future on-chip topological devices.展开更多
Achieving an axial superresolved focus with a single lens by simply inserting a modulation mask in the pupil plane is preferred due to its compact configuration and general applicability. However, lack of a universal ...Achieving an axial superresolved focus with a single lens by simply inserting a modulation mask in the pupil plane is preferred due to its compact configuration and general applicability. However, lack of a universal theoretical model to manifest the superresolved focusing mechanism vastly complicates the mask design and hinders optimal resolution. Here we establish an interference model and find out that the axial resolution closely relates to the Gouy phase gradient(GPG) at the focal point. Using a GPG tuning-based optimization approach, the axial resolution of a ring-mask-modulated beam is readily improved to attain superresolved focal depth for multiple types of pupil function and polarization. In experiment, a focus with an axial resolution of 27% improved from the diffraction limit and 11% finer than the previously reported record is demonstrated for the radially polarized beam. In simulations, a spherical focus with 3D isotropic resolution and a superoscillation-like axial modulation behavior toward extremely high axial resolution is also presented. This approach can be applied for varied types of pupil function, wavelength, and polarization, and can be easily transferred to other traditional or superresolution microscopes to upgrade their axial resolution.展开更多
文摘This study examines how generative artificial intelligence(AI)reshapes creative identity in design education.Drawing on post-humanist and network-based theories,it frames AI as a cognitive collaborator in ideation and authorship.Mixed-methods data reveal student anxiety and stylistic confusion,contrasted with designers’adaptive strategies.The AI–Cognition–Identity framework supports curricula that promote reflective,ethical,and epistemically informed AI-integrated pedagogy.
基金Project supported by the National Natural Science Foundation of China(U2002215)。
文摘Weathered crust elution-deposited rare earth ores(WREOs)are rich in medium and heavy rare earth.In order to improve the in-situ leaching process,which is prone to landslides and poor permeability,cationic hydroxyethyl cellulose(PQ-10)was used as a novel green swelling inhibitor and percolation promoter and was mixed with conventional leaching agent ammonium sulfate((NH_(4))_(2)SO_(4))to form a composite leaching agent to study the performance and mechanism of swelling inhibition and percolation promotion.Adding PQ-10 can inhibit the hydration swelling of WREOs,promote the percolation effect of the leaching agent,improve the rare earth(RE)leaching efficiency,and reduce the im purity aluminum(Al)leaching efficiency.Compared with the conventional leaching agent 2 wt%(NH_(4))_(2)SO_(4),the percolation time is reduced by 50%by using the composite leaching agent(0.02 wt%PQ-10+2 wt%(NH_(4))_(2)SO_(4)).PQ-10 has positively charged quaternary ammonium groups and hydrophilic group hydroxyl groups,which makes it easy to adsorb on WREOs multiple sites through electrostatic interaction and hydrogen bonding,weakening the electrostatic repulsion between mineral particles,reducing the WREOs interlayer spacing,compressing the double electric layer thickness at the solid-liquid interface,weakening the mineral hydration swelling and increasing the percolation rate.The long carbon chains of the polymer entangle and link the fine mineral particles to agglomerate them,increasing their particle size and reduc ing their hydration dispersion,and preventing blockage of the pe rcolation pores caused by migration of the fine particles through the ore body with the solution.PQ-10 molecules also insert the mine ral interlayer and expulsion of the internal water,further inhibiting the swelling of WREOs.Adding PQ-10 reduces the surface tension of(NH_(4))_(2)SO_(4)solution,improving the spreading and spreading ability of the solution,reducing the adhesion work between molecules in the solid-liquid phase and the adhesion work reduction factor.It proves that PQ-10 promotes the percolation effect of the leaching process of WREOs.In addition,PQ-10 expands the leaching pore size and seepage channels,further improving the percolation rate.
基金supported by the National Natural Science Foundation of China(No.82172551)the Health Discipline Leader Project of Shanghai Municipal Health Commission(No.2022XD044),China.
文摘Skeletal muscle dysfunction is a common extrapulmonary comorbidity of chronic obstructive pulmonary disease(COPD) and is associated with decreased quality-of-life and survival in patients. The autophagy lysosome pathway is one of the proteolytic systems that significantly affect skeletal muscle structure and function. Intriguingly, both promoting and inhibiting autophagy have been observed to improve COPD skeletal muscle dysfunction, yet the mechanism is unclear. This paper first reviewed the effects of macroautophagy and mitophagy on the structure and function of skeletal muscle in COPD, and then explored the mechanism of autophagy mediating the dysfunction of skeletal muscle in COPD. The results showed that macroautophagy-and mitophagy-related proteins were significantly increased in COPD skeletal muscle. Promoting macroautophagy in COPD improves myogenesis and replication capacity of muscle satellite cells, while inhibiting macroautophagy in COPD myotubes increases their diameters. Mitophagy helps to maintain mitochondrial homeostasis by removing impaired mitochondria in COPD. Autophagy is a promising target for improving COPD skeletal muscle dysfunction, and further research should be conducted to elucidate the specific mechanisms by which autophagy mediates COPD skeletal muscle dysfunction, with the aim of enhancing our understanding in this field.
文摘Cathodoluminescence （CL） as a radiative light produced by an electron beam exciting a luminescent material, has beenwidely used in imaging and spectroscopic detection of semiconductor, mineral and biological samples with an ultrahigh spatial resolution. Conventional CL spectroscopy shows an excellent performance in characterization of traditional mate-rial luminescence, such as spatial composition variations and fluorescent displays. With the development of nanotech-nology, advances of modern microscopy enable CL technique to obtain deep valuable insight of the testing sample, and further extend its applications in the material science, especially for opto-electronic investigations at nanoscale. In this article, we review the study of CL microscopy applied in semiconductor nanostructures for the dislocation, carrier diffu-sion, band structure, doping level and exciton recombination. Then advantages of CL in revealing and manipulating sur-face plasmon resonances of metallic nanoantennas are discussed. Finally, the challenge of CL technology is summa-rized, and potential CL applications for the future opto-electronic study are proposed.
基金supported by the National Key Research and Development Program of China (grant no.2017YFA0206000)Beijing Natural Science Foundation (grant nos. Z180011)+3 种基金the National Key Research and Development Program of China (grant nos. 2020YFA0211300, 2017YFA0205700, 2019YFA0210203,2018YFA0306200)National Science Foundation of China (grant nos. 12027807, 61521004, 21790364 and 11625418)PKUBaidu Fund Project (grant no.2020BD023)High-performance Computing Platform of Peking University
文摘Photonic topological insulators with robust boundary states can enable great applications for optical communication and quantum emission,such as unidirectional waveguide and single-mode laser.However,because of the diffraction limit of light,the physical insight of topological resonance remains unexplored in detail,like the dark line that exists with the crys-talline symmetry-protected topological edge state.Here,we experimentally observe the dark line of the Z_(2)photonic topo-logical insulator in the visible range by photoluminescence and specify its location by cathodoluminescence characteriza-tion,and elucidate its mechanism with the p-d orbital electromagnetic field distribution which calculated by numerical sim-ulation.Our investigation provides a deeper understanding of Z_(2)topological edge states and may have great signific-ance to the design of future on-chip topological devices.
基金National Natural Science Foundation of China(61875073,61905097)National Key Research and Development Program of China(2021YFB2802000)+1 种基金Guangdong Provincial Innovation and Entrepreneurship Project(2016ZT06D081)Zhejiang Lab(2020MC0AE01)。
文摘Achieving an axial superresolved focus with a single lens by simply inserting a modulation mask in the pupil plane is preferred due to its compact configuration and general applicability. However, lack of a universal theoretical model to manifest the superresolved focusing mechanism vastly complicates the mask design and hinders optimal resolution. Here we establish an interference model and find out that the axial resolution closely relates to the Gouy phase gradient(GPG) at the focal point. Using a GPG tuning-based optimization approach, the axial resolution of a ring-mask-modulated beam is readily improved to attain superresolved focal depth for multiple types of pupil function and polarization. In experiment, a focus with an axial resolution of 27% improved from the diffraction limit and 11% finer than the previously reported record is demonstrated for the radially polarized beam. In simulations, a spherical focus with 3D isotropic resolution and a superoscillation-like axial modulation behavior toward extremely high axial resolution is also presented. This approach can be applied for varied types of pupil function, wavelength, and polarization, and can be easily transferred to other traditional or superresolution microscopes to upgrade their axial resolution.
