Objective Seminal vesiculitis is a prevalent infectious disease in the genitourinary system,but its intrinsic pathogenesis and molecular features remain unclear.Methods In this study,we utilized a next-generation sequ...Objective Seminal vesiculitis is a prevalent infectious disease in the genitourinary system,but its intrinsic pathogenesis and molecular features remain unclear.Methods In this study,we utilized a next-generation sequencing technology to demonstrate transcriptomic landscapes of clinical specimens from seminal vesiculitis patients.We identified enriched Go Ontology terms,pathway maps,processes,toxicity,and metabolic networks of seminal vesiculitis.Results Glutathione S-transferase activity is highly enriched,indicating its essential role in the disease's development.Furthermore,we established inflammation models of the seminal vesicle and verified the crucial function of glutathione S-transferase activity in these models.Conclusion Glutathione S-transferase serves an essential role in seminal vesiculitis patients.Our results shall provide a robust platform for further intensive studies of seminal vesiculitis.展开更多
This report details the CT and MR imaging findings of a primary orbital Ewing＇s sarcoma case involving the middle cranial fossa in a 13-year old boy. CT showed an ill-circumscribed homogeneous soft-tissue density mas...This report details the CT and MR imaging findings of a primary orbital Ewing＇s sarcoma case involving the middle cranial fossa in a 13-year old boy. CT showed an ill-circumscribed homogeneous soft-tissue density mass with needle-like bone reaction. On MRI, the mass showed homogeneous iso-intensity on T1WI, heterogeneous hyper- intensity on T2WI, and marked homogeneous enhancement. Meanwhile, the mass was hyper-intense on DWI, and ADC alue was 575x10-6 mm2/s. The mass showed as high rCBV and rCBF, prolonged MTT based on DCS- PWI, and wash-out pattern of TIC derived from the DCE-MRI. Our case suggests that functional MRI modalities, including DWI, DSC-PWI or DCE-MR, could provide additional information for differential diagnoses. Both CT and MRI should be performed and comprehensively analyzed for limiting differential diagnoses, determining lesion extension and facilitating operative approach.展开更多
基金supported by the Six Talent Peak Project of High-level Talents in Jiangsu Province (No. WSW-017 to Liu B)Medical research key project of Jiangsu Provincial Health Commission (No. K2023030 to Liu B)+1 种基金National Natural Science Foundation of China (No. 82203115 to Miao C), Natural Science Foundation of Jiangsu Province (No. BK20220726 to Miao C)Jiangsu Province Capability Improvement Project through Science, Technology and Education (No. ZDXK202219 to Wang Z).
文摘Objective Seminal vesiculitis is a prevalent infectious disease in the genitourinary system,but its intrinsic pathogenesis and molecular features remain unclear.Methods In this study,we utilized a next-generation sequencing technology to demonstrate transcriptomic landscapes of clinical specimens from seminal vesiculitis patients.We identified enriched Go Ontology terms,pathway maps,processes,toxicity,and metabolic networks of seminal vesiculitis.Results Glutathione S-transferase activity is highly enriched,indicating its essential role in the disease's development.Furthermore,we established inflammation models of the seminal vesicle and verified the crucial function of glutathione S-transferase activity in these models.Conclusion Glutathione S-transferase serves an essential role in seminal vesiculitis patients.Our results shall provide a robust platform for further intensive studies of seminal vesiculitis.
文摘This report details the CT and MR imaging findings of a primary orbital Ewing＇s sarcoma case involving the middle cranial fossa in a 13-year old boy. CT showed an ill-circumscribed homogeneous soft-tissue density mass with needle-like bone reaction. On MRI, the mass showed homogeneous iso-intensity on T1WI, heterogeneous hyper- intensity on T2WI, and marked homogeneous enhancement. Meanwhile, the mass was hyper-intense on DWI, and ADC alue was 575x10-6 mm2/s. The mass showed as high rCBV and rCBF, prolonged MTT based on DCS- PWI, and wash-out pattern of TIC derived from the DCE-MRI. Our case suggests that functional MRI modalities, including DWI, DSC-PWI or DCE-MR, could provide additional information for differential diagnoses. Both CT and MRI should be performed and comprehensively analyzed for limiting differential diagnoses, determining lesion extension and facilitating operative approach.
