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奥希替尼联合贝伐珠单抗治疗14例EGFR突变型肺腺癌脑转移的疗效观察 被引量:16
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作者 黄智昊 叶美凤 岑文昌 《中国肿瘤临床》 CAS CSCD 北大核心 2021年第6期297-300,共4页
目的:观察和评估奥希替尼联合贝伐珠单抗治疗14例EGFR突变型肺腺癌脑转移患者的疗效及安全性。方法:回顾性分析2017年1月至2019年12月广州市胸科医院收治的伴有EGFR突变的肺腺癌脑转移患者共14例,所有患者均给予奥希替尼及贝伐珠单抗联... 目的:观察和评估奥希替尼联合贝伐珠单抗治疗14例EGFR突变型肺腺癌脑转移患者的疗效及安全性。方法:回顾性分析2017年1月至2019年12月广州市胸科医院收治的伴有EGFR突变的肺腺癌脑转移患者共14例,所有患者均给予奥希替尼及贝伐珠单抗联合治疗,每3周为1个周期,观察其脑转移病灶疗效并评估不良反应。结果:14例患者中11例(78.6%)脑转移病灶为部分缓解,2例疾病稳定(14.3%),1例疾病进展(7.1%),客观缓解率为78.6%(11/14),疾病控制率为92.9%(13/14)。颅内中位无进展生存期(median progression-free survival,mPFS)为12.5个月(95%CI:8.53~15.87)。最常出现的不良反应为贫血(57.1%)、高血压(50.5%)以及蛋白尿(28.6%),未出现因不良反应停药事件发生。结论:奥希替尼联合贝伐珠单抗治疗EGFR突变型肺腺癌脑转移疗效较好,不良反应可控,但仍需大样本临床试验进一步验证。 展开更多
关键词 奥希替尼 贝伐珠单抗 肺腺癌 脑转移
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All-fiber-based ultrastable laser with long-term frequency stability of 1.1×10^(-14) 被引量:4
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作者 黄亚峰 胡笛 +8 位作者 叶美凤 王亚婷 李彦黎 李明 陈胤男 屈求智 汪凌珂 刘亮 李唐 《Chinese Optics Letters》 SCIE EI CAS CSCD 2023年第3期84-89,共6页
We demonstrate an ultrastable miniaturized transportable laser system at 1550 nm by locking it to an optical fiber delay line[FDL].To achieve optimized long-term frequency stability,the FDL was placed into a vacuum ch... We demonstrate an ultrastable miniaturized transportable laser system at 1550 nm by locking it to an optical fiber delay line[FDL].To achieve optimized long-term frequency stability,the FDL was placed into a vacuum chamber with a five-layer thermal shield,and a delicate two-stage active temperature stabilization,an optical power stabilization,and an RF power stabilization were applied in the system.A fractional frequency stability of better than 3.2×10^[-15]at 1 s averaging time and1.1×10^[-14]at 1000 s averaging time was achieved,which is the best long-term frequency stability of an all-fiber-based ultrastable laser observed to date. 展开更多
关键词 fiber delay line frequency stability ultrastable laser
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All-fiber-based laser with 200 mHz linewidth 被引量:2
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作者 Junchao Huang Lingke Wang +4 位作者 Yifei Duan Yafeng Huang meifeng ye Liang Liu Tang Li 《Chinese Optics Letters》 SCIE EI CAS CSCD 2019年第7期71-74,共4页
We demonstrate the frequency stabilization of a 1.55 μm erbium-doped fiber laser by locking it to a 5-km-long optical fiber delay line(FDL).The stabilized laser is characterized via comparison with a second identical... We demonstrate the frequency stabilization of a 1.55 μm erbium-doped fiber laser by locking it to a 5-km-long optical fiber delay line(FDL).The stabilized laser is characterized via comparison with a second identical laser system.We obtain a fractional frequency stability of better than 3 × 10^-15 over time scales of 1–10 s and a laser linewidth of 0.2 Hz, which is the narrowest linewidth of an FDL-stabilized laser observed to date. 展开更多
关键词 All-fiber-based LASER 200mHz LINEWIDTH delay line
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All-fiber-based photonic microwave generation with 10^(-15) frequency instability 被引量:2
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作者 Yifei Duan Yafeng Huang +8 位作者 Yanli Li Yating Wang meifeng ye Ming Li Yinnan Chen Jiaqi Zhou Lingke Wang Liang Liu Tang Li 《Chinese Optics Letters》 SCIE EI CAS CSCD 2022年第2期96-99,共4页
We demonstrate an all-fiber-based photonic microwave generation with 10^(-15) frequency instability.The system consists of an ultra-stable laser by optical fiber delay line,an all-fiber-based"figure-of-nine"... We demonstrate an all-fiber-based photonic microwave generation with 10^(-15) frequency instability.The system consists of an ultra-stable laser by optical fiber delay line,an all-fiber-based"figure-of-nine"optical frequency comb,a high signal-tonoise ratio photonic detection unit,and a microwave frequency synthesizer.The whole optical links are made from optical fiber and optical fiber components,which renders the whole system compactness,reliability,and robustness with respect to environmental influences.Frequency instabilities of 3.5×10^(-15) at 100 s for 6.834 GHz signal and 4.3×10^(-15) at 100 s for9.192 GHz signal were achieved. 展开更多
关键词 ultra-stable laser optical frequency comb photonic microwave generation
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Optimization of temperature characteristics of a transportable 87Rb atomic fountain clock 被引量:2
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作者 Xinwen Wang Kangkang Liu +13 位作者 Henan Cheng Wei Ren Jingfeng Xiang Jingwei Ji Xiangkai Peng Zhen Zhang Jianbo Zhao meifeng ye Lin Li Tang Li Bin Wang Qiuzhi Qu Liang Liu Desheng Lü 《Chinese Optics Letters》 SCIE EI CAS CSCD 2019年第8期1-5,共5页
A high-performance transportable fountain clockis attractive for use in laboratories with high-precisiontime-frequency measurement requirements. This Letterreports the improvement of the stability of atransportable ru... A high-performance transportable fountain clockis attractive for use in laboratories with high-precisiontime-frequency measurement requirements. This Letterreports the improvement of the stability of atransportable rubidium-87 fountain clock because of anoptimization of temperature characteristics. This clockintegrates its physical packaging, optical benches,microwave frequency synthesizers, and electronic controlsonto an easily movable wheeled plate. Two optical bencheswith a high-vibration resistance are realized in thiswork. No additional adjustment is required after movingthem several times. The Allan deviation of the fountainclock frequency was measured by comparing it with that ofthe hydrogen maser. The fountain clock got a short-termstability of 2.3×10^-13 at 1 s and long-term stabilityon the order of 10-16 at 100,000 s. 展开更多
关键词 transportable clockis anoptimization
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Vibration-insensitive fiber spool for laser stabilization
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作者 Junchao Huang Lingke Wang +5 位作者 Yifei Duan Yafeng Huang meifeng ye Lin Li Liang Liu Tang Li 《Chinese Optics Letters》 SCIE EI CAS CSCD 2019年第8期47-51,共5页
Excess frequency noise induced by mechanical vibration is the dominant noise source at low Fourier frequencies in fiber-delay-line stabilized lasers. To resolve this problem, a double-winding fiber spool is designed a... Excess frequency noise induced by mechanical vibration is the dominant noise source at low Fourier frequencies in fiber-delay-line stabilized lasers. To resolve this problem, a double-winding fiber spool is designed and implemented that has ultralow acceleration sensitivity in all spatial directions. By carefully choosing the optimal geometry parameters of the fiber spool, we achieve acceleration sensitivity of 8 × 10^-11/g and 3 × 10^-11/g(g denotes the gravitational acceleration) in axial and radial directions, respectively. 展开更多
关键词 noise VIBRATION DIRECTIONS
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