目的:探讨进入IV期危重型手足口病(Hand-mouth and foot disease, HFMD)死亡的临床特点、诊治经过及死亡分析,总结经验及教训。方法:采用回顾性分析方法对2009年1月至2014年12月昆明周边及地州转入我院救治19例危重型HFMD患儿的临床资...目的:探讨进入IV期危重型手足口病(Hand-mouth and foot disease, HFMD)死亡的临床特点、诊治经过及死亡分析,总结经验及教训。方法:采用回顾性分析方法对2009年1月至2014年12月昆明周边及地州转入我院救治19例危重型HFMD患儿的临床资料进行分析。结果:19例患儿来自农村,其中男性13例(68.42%),女性6例(31.58%),3岁以下16例,占84.21%,3岁以上3例,占15.79%。所有病例均有发热、惊跳、肢体抖动的表现。16例患儿入院时出现肺出血、呼吸循环衰竭的表现。17例患儿均出现白细胞总数及中性粒细胞、超敏C-反应蛋白升高,12例血糖升高。4例合并消化道出血,1例同时合并肾功能衰竭。病原学:18例EV71阳性,1例为其它未定型肠道病毒感染。结论:早期识别并及时治疗第2期HFMD病例,及时进行干预,避免进展为危重型HFMD,危重型HFMD主要由EV71病毒感染引起,致死率高,进入IV期危重型HFMD出现神经源性肺水肿、肺出血、呼吸循环衰竭、严重脑功能障碍等严重并发症,死亡率高。展开更多
Controlling mass transportation using intrinsic mechanisms is a challenging topic in nanotechnology.Herein,we employ molecular dynamics simulations to investigate the mass transport inside carbon nanotubes(CNT)with te...Controlling mass transportation using intrinsic mechanisms is a challenging topic in nanotechnology.Herein,we employ molecular dynamics simulations to investigate the mass transport inside carbon nanotubes(CNT)with temperature gradients,specifically the effects of adding a static carbon hoop to the outside of a CNT on the transport of a nanomotor inside the CNT.We reveal that the underlying mechanism is the uneven potential energy created by the hoops,i.e.,the hoop outside the CNT forms potential energy barriers or wells that affect mass transport inside the CNT.This fundamental control of directional mass transportation may lead to promising routes for nanoscale actuation and energy conversion.展开更多
JUNO is a multi-purpose neutrino observatory under construction in the south of China.This publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)...JUNO is a multi-purpose neutrino observatory under construction in the south of China.This publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the experiment.The sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite detector.It is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data collection.In the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering hypothesis.The new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.展开更多
The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental physics.In this study,the potential of searching for proton decay in the p→νK...The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental physics.In this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification.Moreover,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals.Based on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data collection.The estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.展开更多
The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neut...The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.展开更多
Purpose A capture superconducting solenoid is designed for the Experimental Muon Source(EMuS)which is proposed at China Spallation Neutron Source(CSNS)in Dongguan for muon science and neutrino physics research.The cap...Purpose A capture superconducting solenoid is designed for the Experimental Muon Source(EMuS)which is proposed at China Spallation Neutron Source(CSNS)in Dongguan for muon science and neutrino physics research.The capture superconducting solenoid of the EMuS consists of four coils with different radius generating a peak central field of 5 T at 3944 A of nominal current.Methods The aluminum-stabilized NbTi Rutherford cable is used to wind the solenoid coils.Iron yokes are arranged for flux returning and field shielding.Ti alloy Ti-6Al-4V rods are adopted to support the cold mass.The vacuum vessel of the solenoid is manufactured by 304 stainless steel.The coils are pre-stressed by interference fits assembly,the outer support cylinder or binding the coils with aluminum alloy wire in order to reduce the peak stress of the coils.The parameters of the coils such as the thickness and the tensile stress of the binding wire and the thickness of the outer support cylinder have been optimized in order to minimize the cold mass by using FEA software.Results The maximum stress in the winding is allowable with two layers of 40 mm thickness outer support cylinder through interference fits assembly.But the maximum stress in the winding is allowable with 40 mm thickness of binding wire and 30 mm thickness of outer support cylinder.Conclusion The method of binding the windings with aluminum alloy wire is suggested to be used to manufacture the solenoid.This paper presents the mechanical design and analysis of the capture superconducting solenoid for EMuS.展开更多
文摘目的:探讨进入IV期危重型手足口病(Hand-mouth and foot disease, HFMD)死亡的临床特点、诊治经过及死亡分析,总结经验及教训。方法:采用回顾性分析方法对2009年1月至2014年12月昆明周边及地州转入我院救治19例危重型HFMD患儿的临床资料进行分析。结果:19例患儿来自农村,其中男性13例(68.42%),女性6例(31.58%),3岁以下16例,占84.21%,3岁以上3例,占15.79%。所有病例均有发热、惊跳、肢体抖动的表现。16例患儿入院时出现肺出血、呼吸循环衰竭的表现。17例患儿均出现白细胞总数及中性粒细胞、超敏C-反应蛋白升高,12例血糖升高。4例合并消化道出血,1例同时合并肾功能衰竭。病原学:18例EV71阳性,1例为其它未定型肠道病毒感染。结论:早期识别并及时治疗第2期HFMD病例,及时进行干预,避免进展为危重型HFMD,危重型HFMD主要由EV71病毒感染引起,致死率高,进入IV期危重型HFMD出现神经源性肺水肿、肺出血、呼吸循环衰竭、严重脑功能障碍等严重并发症,死亡率高。
基金Project supported by the Doctoral Fund of Yanshan University (Grant No.B919)the Program of Independent Research for Young Teachers of Yanshan University (Grant No.020000534)the S&T Program of Hebei Province of China (Grant No.QN2016123)。
文摘Controlling mass transportation using intrinsic mechanisms is a challenging topic in nanotechnology.Herein,we employ molecular dynamics simulations to investigate the mass transport inside carbon nanotubes(CNT)with temperature gradients,specifically the effects of adding a static carbon hoop to the outside of a CNT on the transport of a nanomotor inside the CNT.We reveal that the underlying mechanism is the uneven potential energy created by the hoops,i.e.,the hoop outside the CNT forms potential energy barriers or wells that affect mass transport inside the CNT.This fundamental control of directional mass transportation may lead to promising routes for nanoscale actuation and energy conversion.
基金Supported by the Chinese Academy of Sciencesthe National Key R&D Program of China+18 种基金the CAS Center for Excellence in Particle Physics,Wuyi Universitythe Tsung-Dao Lee Institute of Shanghai Jiao Tong University in Chinathe Institut National de Physique Nucléaire et de Physique de Particules(IN2P3)in Francethe Istituto Nazionale di Fisica Nucleare(INFN)in Italythe Italian-Chinese collaborative research program MAECI-NSFCthe Fond de la Recherche Scientifique(F.R.S-FNRS)FWO under the“Excellence of Science-EOS in Belgium”the Conselho Nacional de Desenvolvimento Científico e Tecnològico in Brazilthe Agencia Nacional de Investigacion y Desarrollo and ANID-Millennium Science Initiative Program-ICN2019_044 in Chilethe Charles University Research Centre and the Ministry of Education,Youth,and Sports in Czech Republicthe Deutsche Forschungsgemeinschaft(DFG)the Helmholtz Associationthe Cluster of Excellence PRISMA+in Germanythe Joint Institute of Nuclear Research(JINR)and Lomonosov Moscow State University in Russiathe joint Russian Science Foundation(RSF)National Natural Science Foundation of China(NSFC)research programthe MOST and MOE in Taiwanthe Chulalongkorn University and Suranaree University of Technology in Thailand,University of California at Irvinethe National Science Foundation in USA。
文摘JUNO is a multi-purpose neutrino observatory under construction in the south of China.This publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the experiment.The sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite detector.It is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data collection.In the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering hypothesis.The new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.
基金supported by the Chinese Academy of Sciencesthe National Key R&D Program of China+22 种基金the CAS Center for Excellence in Particle PhysicsWuyi Universitythe Tsung-Dao Lee Institute of Shanghai Jiao Tong University in Chinathe Institut National de Physique Nucléaire et de Physique de Particules (IN2P3) in Francethe Istituto Nazionale di Fisica Nucleare (INFN) in Italythe Italian-Chinese collaborative research program MAECI-NSFCthe Fond de la Recherche Scientifique (F.R.S-FNRS)FWO under the "Excellence of Science-EOS" in Belgiumthe Conselho Nacional de Desenvolvimento Científico e Tecnològico in Brazilthe Agencia Nacional de Investigacion y Desarrollo in Chilethe Charles University Research Centrethe Ministry of Education,Youth,and Sports in Czech Republicthe Deutsche Forschungsgemeinschaft (DFG)the Helmholtz Associationthe Cluster of Excellence PRISMA+ in Germanythe Joint Institute of Nuclear Research (JINR)Lomonosov Moscow State University in Russiathe joint Russian Science Foundation (RSF)National Natural Science Foundation of China (NSFC) research programthe MOST and MOE in Taiwan,Chinathe Chulalongkorn UniversitySuranaree University of Technology in Thailandthe University of California at Irvine in USA
文摘The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental physics.In this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification.Moreover,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals.Based on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data collection.The estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.
基金This work was supported by the Chinese Academy of Sciences,the National Key R&D Program of China,the CAS Center for Excellence in Particle Physics,the Joint Large Scale Scientific Facility Funds of the NSFC and CAS,Wuyi University,and the Tsung-Dao Lee Instiute of Shanghai Jiao Tong University in China,the In stiut National de Physique Nucleaire et de Physique de Particules(IN2P3)in France,the Istituto Nazionale di Fisica Nucleare(INFN)in Italy,the Fond de la Recherche Scintifique(F.R.S-FNRS)and FWO under the"Excellence of Science-EOS"in Belgium,the Conselho Nacional de Desenvolvimento Cientificoce Tecnologico in Brazil,the Agencia Nacional de Investigacion y Desrrollo in Chile,the Charles University Research Centre and the Ministry of Education,Youth,and Sports in Czech Republic,the Deutsche Forschungsgemeinschaft(DFG),the Helmholtz Association,and the Cluster of Exellence PRISMA+in Germany,the Joint Institute of Nuclear Research(JINR),Lomonosov Moscow State University,and Russian Foundation for Basic Research(RFBR)in Russia,the MOST and MOE in Taiwan,the Chu-lalongkorm University and Suranaree University of Technology in Thailand,and the University of aliformia at Irvine in USA.
文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.
基金National Natural Science Foundation of China(Project:11527811).
文摘Purpose A capture superconducting solenoid is designed for the Experimental Muon Source(EMuS)which is proposed at China Spallation Neutron Source(CSNS)in Dongguan for muon science and neutrino physics research.The capture superconducting solenoid of the EMuS consists of four coils with different radius generating a peak central field of 5 T at 3944 A of nominal current.Methods The aluminum-stabilized NbTi Rutherford cable is used to wind the solenoid coils.Iron yokes are arranged for flux returning and field shielding.Ti alloy Ti-6Al-4V rods are adopted to support the cold mass.The vacuum vessel of the solenoid is manufactured by 304 stainless steel.The coils are pre-stressed by interference fits assembly,the outer support cylinder or binding the coils with aluminum alloy wire in order to reduce the peak stress of the coils.The parameters of the coils such as the thickness and the tensile stress of the binding wire and the thickness of the outer support cylinder have been optimized in order to minimize the cold mass by using FEA software.Results The maximum stress in the winding is allowable with two layers of 40 mm thickness outer support cylinder through interference fits assembly.But the maximum stress in the winding is allowable with 40 mm thickness of binding wire and 30 mm thickness of outer support cylinder.Conclusion The method of binding the windings with aluminum alloy wire is suggested to be used to manufacture the solenoid.This paper presents the mechanical design and analysis of the capture superconducting solenoid for EMuS.
