Nutrition plays a vital role in human health,particularly through the type and quality of dietary fats.While excessive saturated fatty acid(SFA)intake is associated with negative cardiovascular outcomes,unsaturated fa...Nutrition plays a vital role in human health,particularly through the type and quality of dietary fats.While excessive saturated fatty acid(SFA)intake is associated with negative cardiovascular outcomes,unsaturated fats especially monounsaturated(MUFA)and polyunsaturated fatty acids(PUFA)offer protective benefits.Among the bioactive lipids derived from unsaturated fats are nitrated fatty acids(NO2-FAs),electrophilic signaling molecules formed naturally during inflammation or via dietary interactions between nitrite-rich vegetables and unsaturated lipids.NO2-FAs have been shown to exert anti-inflammatory,antioxidant,and antiplatelet effects,influencing metabolic pathways involved in cardiometabolic health.This review explores the formation,meta-bolism,and biological actions of NO2-FAs from dietary sources,emphasizing their role within dietary patterns like the Mediterranean diet.By bridging lipid biochemistry and nutritional science,we underscore the therapeutic potential of NO2-FAs as diet-derived agents for disease prevention and treatment in metabolic and cardiovascular disorders.展开更多
Cardiovascular diseases rank first in mortality worldwide.Platelets have been considered the main cardiovascular risk factor since they play an important role,in atherosclerosis and the development of acute thrombotic...Cardiovascular diseases rank first in mortality worldwide.Platelets have been considered the main cardiovascular risk factor since they play an important role,in atherosclerosis and the development of acute thrombotic events.The hyperactivation of platelets leads to platelet aggregation and the formation of clogs,blocking the passage of blood to the different organs and tissues.Blood obstruction contributes to blood vessel stenosis,ischemia,and heart attack.At present,it is vital to find new targets for the development of safer and more effective antiplatelet agents.A diet rich in bioactive compounds can help in the prevention of cardiovascular events since it has been shown that some of these metabolites can reduce the risk of atherosclerosis and atherothrombotic disease by inhibiting platelet aggregation.This review aims to collect and discuss the largest amount of information reported updated on the cardioprotective and antiplatelet activities of the different bioactive compounds extracted from natural products.The compounds were divided into different groups(phenolic acids,flavonoids,carotenoids(lycopene and B-carotenes),and sulfides.展开更多
基金the support of ANID-FONDECYT POSDOCTORAL 3220099,ANID-FONDECYT REGULAR No 1220339,FOVI240019 and FOVI240035,ANID/FONDEQUIP N°EQM200049ANID/DOCTORATE No.21221883CSIC-Uruguay,INIA-Fpta-Uruguay,and Programa de Desarrollo de las Ciencias B´asicas(PEDECIBA,Uruguay).
文摘Nutrition plays a vital role in human health,particularly through the type and quality of dietary fats.While excessive saturated fatty acid(SFA)intake is associated with negative cardiovascular outcomes,unsaturated fats especially monounsaturated(MUFA)and polyunsaturated fatty acids(PUFA)offer protective benefits.Among the bioactive lipids derived from unsaturated fats are nitrated fatty acids(NO2-FAs),electrophilic signaling molecules formed naturally during inflammation or via dietary interactions between nitrite-rich vegetables and unsaturated lipids.NO2-FAs have been shown to exert anti-inflammatory,antioxidant,and antiplatelet effects,influencing metabolic pathways involved in cardiometabolic health.This review explores the formation,meta-bolism,and biological actions of NO2-FAs from dietary sources,emphasizing their role within dietary patterns like the Mediterranean diet.By bridging lipid biochemistry and nutritional science,we underscore the therapeutic potential of NO2-FAs as diet-derived agents for disease prevention and treatment in metabolic and cardiovascular disorders.
基金ANID/FONDECYT grant N◦1220339(Eduardo Fuentes).Also thanks to the ANID/FONDECYT grant N◦3220099(Lyanne Rodríguez).
文摘Cardiovascular diseases rank first in mortality worldwide.Platelets have been considered the main cardiovascular risk factor since they play an important role,in atherosclerosis and the development of acute thrombotic events.The hyperactivation of platelets leads to platelet aggregation and the formation of clogs,blocking the passage of blood to the different organs and tissues.Blood obstruction contributes to blood vessel stenosis,ischemia,and heart attack.At present,it is vital to find new targets for the development of safer and more effective antiplatelet agents.A diet rich in bioactive compounds can help in the prevention of cardiovascular events since it has been shown that some of these metabolites can reduce the risk of atherosclerosis and atherothrombotic disease by inhibiting platelet aggregation.This review aims to collect and discuss the largest amount of information reported updated on the cardioprotective and antiplatelet activities of the different bioactive compounds extracted from natural products.The compounds were divided into different groups(phenolic acids,flavonoids,carotenoids(lycopene and B-carotenes),and sulfides.
