Nucleic acids-based functional nanomaterials in biological imaging have drawn more and more attention in recent years.The rapid development of various nanomaterials provides nucleic acids more possibility to achieve t...Nucleic acids-based functional nanomaterials in biological imaging have drawn more and more attention in recent years.The rapid development of various nanomaterials provides nucleic acids more possibility to achieve the recognition and bioimaging of different small moleculars in living cells.Coupling of nucleic acids and various nanomaterials obviously enhances the cell uptake efficiency of nucleic acids and the signal amplification strategies of nucleic acids have successfully expanded the applications of nucleic acids-based functional nanomaterials for the detection of trace small molecules in living cells,like microRNAs,proteins,and so on.This review summarizes the recent progresses of nucleic acids-based functional nanomaterials in the application of bioimaging with different amplification mechanism and the recent rapid development of stimulate-response nucleic acids-based nanomaterial for time-spatial controlled imaging of intracellular targets.The advantages of these nucleic acids-based functional nanomaterials and possibility of future development of bioimaging are discussed from the perspective of biological imaging.展开更多
Over the past 2 years,many DNA motors have been synthesized and run in living cells,but there are still challenges in designing integrated DNA motors self-powered to enable autonomous intracellular walking without aux...Over the past 2 years,many DNA motors have been synthesized and run in living cells,but there are still challenges in designing integrated DNA motors self-powered to enable autonomous intracellular walking without auxiliary additives.Herein,we report a smart strategy based on a DNA motor–MnO2 nanocomposite,which successfully meets these requirements of intracellular analysis and enables sensitive imaging of specific microRNAs(miRNAs)in living cells.展开更多
基金supported by the National Natural Science Foundation of China(21922408 and 61771253)the Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars(BK20190038)the Scientific Research Foundation of Nanjing University of Posts and Telecommunications(NY220155)
文摘Nucleic acids-based functional nanomaterials in biological imaging have drawn more and more attention in recent years.The rapid development of various nanomaterials provides nucleic acids more possibility to achieve the recognition and bioimaging of different small moleculars in living cells.Coupling of nucleic acids and various nanomaterials obviously enhances the cell uptake efficiency of nucleic acids and the signal amplification strategies of nucleic acids have successfully expanded the applications of nucleic acids-based functional nanomaterials for the detection of trace small molecules in living cells,like microRNAs,proteins,and so on.This review summarizes the recent progresses of nucleic acids-based functional nanomaterials in the application of bioimaging with different amplification mechanism and the recent rapid development of stimulate-response nucleic acids-based nanomaterial for time-spatial controlled imaging of intracellular targets.The advantages of these nucleic acids-based functional nanomaterials and possibility of future development of bioimaging are discussed from the perspective of biological imaging.
基金support from the National Key R&D Program of China(grant no.2016YFA0201200)the National Natural Science Foundation of China(grant no.21991080)the Excellent Research Program of Nanjing University(ZYJH004).
文摘Over the past 2 years,many DNA motors have been synthesized and run in living cells,but there are still challenges in designing integrated DNA motors self-powered to enable autonomous intracellular walking without auxiliary additives.Herein,we report a smart strategy based on a DNA motor–MnO2 nanocomposite,which successfully meets these requirements of intracellular analysis and enables sensitive imaging of specific microRNAs(miRNAs)in living cells.
