α,α-Difluoro-β-aminophosphonates can be looked as structural analogies withα-amino acids,which have attracted great attention in biological and medicinal chemistry during the past decades.Furthermore,these compoun...α,α-Difluoro-β-aminophosphonates can be looked as structural analogies withα-amino acids,which have attracted great attention in biological and medicinal chemistry during the past decades.Furthermore,these compounds also belong to an important type of organic building blocks for the rapid synthesis of difluoromethylenephosphonate-containing molecules.Thus,the preparation and application ofα,α-difluoro-β-aminophosphonates are hot research topics in organic phosphine chemistry.A comprehensive summary of the literature reports related toα,α-difluoro-β-aminophosphonates in recent years is presented.And aspects of synthesis and applications ofα,α-difluoro-β-aminophosphonates are discussed,in order to provide critical guidance for the further development of reactions and applications for the synthesis of difluoromethylenephosphonate derivatives.展开更多
文摘α,α-Difluoro-β-aminophosphonates can be looked as structural analogies withα-amino acids,which have attracted great attention in biological and medicinal chemistry during the past decades.Furthermore,these compounds also belong to an important type of organic building blocks for the rapid synthesis of difluoromethylenephosphonate-containing molecules.Thus,the preparation and application ofα,α-difluoro-β-aminophosphonates are hot research topics in organic phosphine chemistry.A comprehensive summary of the literature reports related toα,α-difluoro-β-aminophosphonates in recent years is presented.And aspects of synthesis and applications ofα,α-difluoro-β-aminophosphonates are discussed,in order to provide critical guidance for the further development of reactions and applications for the synthesis of difluoromethylenephosphonate derivatives.
