Objective:To examine the analgesic and anti-inflammatory activities ofXanthosoma sagittifolium L. (X. sagittifolium) leaves. <br> Methods: The fresh leaves ofX. sagittifolium were extracted with methanol followe...Objective:To examine the analgesic and anti-inflammatory activities ofXanthosoma sagittifolium L. (X. sagittifolium) leaves. <br> Methods: The fresh leaves ofX. sagittifolium were extracted with methanol followed by fractionation using ethyl acetate fraction (EAF),n-hexane fraction, chloroform fraction and aqueous fraction. The analgesic activity was determined by acetic acid-induced writhing test and tail immersion test using Swiss albino male mice. Carrageenan-induced paw edema test was used to resolve the anti-inflammatory activity using Wistar albino male rats. <br> Results: The results displayed that among these four samples,EAF had maximum analgesic efficacy (P < 0.001) measured by acetic acid-induced writhing test (71.37%). In case of tail immersion test,EAF also exerted maximum activity (5.03 s,P < 0.001) at 180 min compared ton-hexane fraction, chloroform fraction and aqueous fraction at maximum concentration. In case of anti-inflammatory test,EAF remained ascendancy in its activity (P < 0.001) and it inhibited 72.92% of paw edema at maximum concentration at 180 min with respect to remaining fractions. <br> Conclusions:The above evidences suggest thatEAF ofX. sagittifolium leaves is a potential source of natural compounds having analgesic and anti-inflammatory activities.展开更多
文摘Objective:To examine the analgesic and anti-inflammatory activities ofXanthosoma sagittifolium L. (X. sagittifolium) leaves. <br> Methods: The fresh leaves ofX. sagittifolium were extracted with methanol followed by fractionation using ethyl acetate fraction (EAF),n-hexane fraction, chloroform fraction and aqueous fraction. The analgesic activity was determined by acetic acid-induced writhing test and tail immersion test using Swiss albino male mice. Carrageenan-induced paw edema test was used to resolve the anti-inflammatory activity using Wistar albino male rats. <br> Results: The results displayed that among these four samples,EAF had maximum analgesic efficacy (P < 0.001) measured by acetic acid-induced writhing test (71.37%). In case of tail immersion test,EAF also exerted maximum activity (5.03 s,P < 0.001) at 180 min compared ton-hexane fraction, chloroform fraction and aqueous fraction at maximum concentration. In case of anti-inflammatory test,EAF remained ascendancy in its activity (P < 0.001) and it inhibited 72.92% of paw edema at maximum concentration at 180 min with respect to remaining fractions. <br> Conclusions:The above evidences suggest thatEAF ofX. sagittifolium leaves is a potential source of natural compounds having analgesic and anti-inflammatory activities.
