Trained immunity is a phenomenon in which brief exposure to an infectious agent or a vaccine can induce long-lasting changes in the host’s immune system,enhancing protection against subsequent infections.The concept ...Trained immunity is a phenomenon in which brief exposure to an infectious agent or a vaccine can induce long-lasting changes in the host’s immune system,enhancing protection against subsequent infections.The concept of trained immunity has a significant impact on the field of immunology and has the potential to revolutionize how we approach vaccination and infectious disease control.Investigations into trained immunity are rapidly advanc-ing and have led to the development of new vaccines and immunotherapeutic strategies that harness the power of this phenomenon.While more investigations are needed to fully understand the mechanisms of trained immunity and its potential limitations,the prospects for its future application in clinical practice are promising.Here,we describe trained immunity as a biological process and explore the innate cues,epigenetic changes,and metabolic reprogram-ming activities that affect how trained immunity is induced.展开更多
A study on infectious bursal disease virus(IBDV)on chickens of Cobb-500 strain broiler breed at Thakurgaon district of Bangladesh was performed.The protective antibody was measured on one day old chicks(DOC)and post-v...A study on infectious bursal disease virus(IBDV)on chickens of Cobb-500 strain broiler breed at Thakurgaon district of Bangladesh was performed.The protective antibody was measured on one day old chicks(DOC)and post-vaccinated(PV)flocks up to 75 weeks by indirect enzyme linked-immunosorbent assay(I-ELISA).The assays have included five flocks with vaccination historic against IBDV contained 45,000 birds with age ranging from DOC to 75 weeks,just before culling.Maternally derived antibody(MDA)mean titer(MT)ranged from 3,395 to 5,184.The antibody from serum samples(N=92 per flock)were titer tested by I-ELISA at age 14 d,5,8,23,50 and 75 weeks of each vaccinated flock.Antibody titer level gradually decreased before vaccination.Vaccination done by intermediate plus vaccine resulting titers level was increased and stayed at the same level.The antibody MT at the 14th day was 500,which supported Deventer method.The protective antibody MT was declined at growing,laying,mid laying and last stage of laying groups.So MDA titer was enough in offspring that could protect birds easily.展开更多
文摘Trained immunity is a phenomenon in which brief exposure to an infectious agent or a vaccine can induce long-lasting changes in the host’s immune system,enhancing protection against subsequent infections.The concept of trained immunity has a significant impact on the field of immunology and has the potential to revolutionize how we approach vaccination and infectious disease control.Investigations into trained immunity are rapidly advanc-ing and have led to the development of new vaccines and immunotherapeutic strategies that harness the power of this phenomenon.While more investigations are needed to fully understand the mechanisms of trained immunity and its potential limitations,the prospects for its future application in clinical practice are promising.Here,we describe trained immunity as a biological process and explore the innate cues,epigenetic changes,and metabolic reprogram-ming activities that affect how trained immunity is induced.
文摘A study on infectious bursal disease virus(IBDV)on chickens of Cobb-500 strain broiler breed at Thakurgaon district of Bangladesh was performed.The protective antibody was measured on one day old chicks(DOC)and post-vaccinated(PV)flocks up to 75 weeks by indirect enzyme linked-immunosorbent assay(I-ELISA).The assays have included five flocks with vaccination historic against IBDV contained 45,000 birds with age ranging from DOC to 75 weeks,just before culling.Maternally derived antibody(MDA)mean titer(MT)ranged from 3,395 to 5,184.The antibody from serum samples(N=92 per flock)were titer tested by I-ELISA at age 14 d,5,8,23,50 and 75 weeks of each vaccinated flock.Antibody titer level gradually decreased before vaccination.Vaccination done by intermediate plus vaccine resulting titers level was increased and stayed at the same level.The antibody MT at the 14th day was 500,which supported Deventer method.The protective antibody MT was declined at growing,laying,mid laying and last stage of laying groups.So MDA titer was enough in offspring that could protect birds easily.
