In Bangladesh, Enteric fever is a persistent health issue throughout the year, occasionally reaching epidemic levels. The growing antibiotic resistance makes treatment increasingly challenging. Therefore, studying the...In Bangladesh, Enteric fever is a persistent health issue throughout the year, occasionally reaching epidemic levels. The growing antibiotic resistance makes treatment increasingly challenging. Therefore, studying the antibiotic resistance patterns within the population is crucial to ensure a more effective treatment strategy. This study was designed to determine the prevalence, antimicrobial susceptibility profile, and factors associated with Salmonella spp. infections among clinically suspected Enteric fever patients in Bangladesh. This study also aimed to investigate whether there has been a re-emergence in the susceptibility of bacterial strains to conventional drugs. Data were collected from February 2024 to July 2024, from patients suspected Enteric fever (fever less than seven days duration) in a Private Diagnostic Center of Bangladesh. A total of 195 blood samples were cultured, where 53.85% came out positive, among which 79.05% Salmonella typhi and 20.95% Salmonella paratyphi A were found. Prevalence of Typhoid fever was observed high among the school-going age group (0 - 15 years) patients. Both these organisms were susceptible to ceftazidime, cefixime, ceftriaxone and cefepime but resistant to nalidixic acid, ciprofloxacin and levofloxacin. Nalidixic Acid is resistant to all S. paratyphi A and sensitive to few S. typhi. Ciprofloxacin and levofloxacin showed delayed response (36.14% and 22.72% sensitive to S. typhi and S. paratyphi A, respectively) and resistance (63.85% and 77.27% resistant to S. typhi and S. paratyphi A, respectively). In case of S. typhi, the resistance was found against ampicillin (32.53%), chloramphenicol (27.71%), cotrimoxazole (24.09%) and the resistance of S. paratyphi A found against ampicillin (4.54%), chloramphenicol (0%) and cotrimoxazole (0%). This study will provide clinicians with alternative drug options and facilitate the effective treatment of Enteric fever.展开更多
Worldwide prevalence of diabetes mellitus has become an issue of great concern in current decades. This life threatening disease is associated with worsening of glycemic control and progressive metabolic dysfunctions....Worldwide prevalence of diabetes mellitus has become an issue of great concern in current decades. This life threatening disease is associated with worsening of glycemic control and progressive metabolic dysfunctions. Objective: Current study aimed to investigate the effect of hydroxychloroquine (HCQ) as an adjunct to glibenclamide or metformin on glycemic control in alloxan induced diabetic rats. Methods: HCQ was combined separately with two conventional anti-diabetic drugs;glibenclamide and metformin. At first, alloxan (120 mg/kg) induced diabetic rats were treated with single dose of metformin (850 mg/70 kg BW), glibenclamide (10 mg/70 kg BW) and HCQ (300 mg/70 kg BW) intraperitoneally once daily for two weeks. Then non fixed dose combinations of glibenclamide (5 mg/70 kg BW) with HCQ (150 mg/70 kg BW) and metformin (425 mg/70 kg BW) with HCQ (150 mg/70 kg BW) were injected along with those of the three drugs alone once daily for four weeks. Results: In alloxan induced diabetic rats, glibenclamide, metformin and their combination therapies reduced blood glucose level significantly but combination therapies are the most effective. Glibenclamide or metformin in combination with HCQ also significantly (P < 0.05) reduced the elevated levels of total cholesterol, triglycerides, and low density lipoprotein cholesterol (LDL-C) level and increased high density lipoprotein cholesterol (HDL-C) level. Moreover, HCQ potentiates the liver glycogen synthesis of metformin or glibenclamide. Conclusion: Outcomes of this investigation indicate that combination of glibenclamide or metformin with HCQ improves glycemic control and provides additional metabolic benefits, not achieved with either glibenclamide or metformin alone.展开更多
Pabna is one the most densely populated town with poor transport infrastructure in Bangladesh. Here huge pedestriangathers in roads and intersections in CBD （Central Business District） area mainly for commercial and...Pabna is one the most densely populated town with poor transport infrastructure in Bangladesh. Here huge pedestriangathers in roads and intersections in CBD （Central Business District） area mainly for commercial and business purposes. At present,pedestrian facilities are one of the greatest challenges in terms of traffic and safety for the urban dwellers. The footpath, zebra rossing,road intersection, walkways, parking and other facilities are the major part of road transportation system as well as pedestrianfacilities and people have to pass walking distance to reach their destinations, before and after use of transport mode. For instance,this paper tries to emphasize the problems of pedestrian facilities and to explore the qualitative level of comfort for the pedestrians ofthree selected intersections namely Traffic More, Indra More and Nimtola More in CBD area of Pabna Municipality through primaryand secondary data. However, about 60% trips are making on foot every day, but the pedestrians are facing many problems whileusing the walkways. Pedestrian crossing behaviors were also observed by using pedestrian volume survey and the survey exploresthat pedestrian crossing rate at these intersections is about 5,000 to 7,000 per hour at a peak period and average 15% to 25% illegalcrossing occurs at those intersections. The physical observation and data from the questionnaire survey also indicate that informalbusiness on the footpath, illegal parking, illegal vendor on walkways, physical obstacle, poor lighting facilities and geometricproblem of the road intersection makes uncomfortable situations for the pedestrian day by day.展开更多
The major objectives of the study were to determine farmers’ knowledge on climate change effects in agriculture and to identify the factors that influenced farmers’ knowledge on climate change effects in agriculture...The major objectives of the study were to determine farmers’ knowledge on climate change effects in agriculture and to identify the factors that influenced farmers’ knowledge on climate change effects in agriculture. The study was conducted in four villages under Kazipur upazila of Sirajgonj district. Data were collected by using interview schedule from randomly selected 113 respondents during 1st January to 30th January, 2018. The findings revealed that an overwhelming majority (78.8%) of the respondents had medium to high knowledge on climate change effects in agriculture. Among eight selected characteristics, extension media contact, training received, organizational participation, and cosmopoliteness had significant positive contribution to the farmers’ knowledge on climate change effects in agriculture. It is recommended that to increase farmers’ knowledge on climate change effects initiative should be taken to improve farmers’ knowledge through more involving with organization, extension media and program.展开更多
In recent years, global warming, drought and little rain, forest fires, forest destruction and other human disturbances have had an important impact on the habitat environment of birds, affecting the number and qualit...In recent years, global warming, drought and little rain, forest fires, forest destruction and other human disturbances have had an important impact on the habitat environment of birds, affecting the number and quality of bird habitats, directly threatening the survival and reproduction of birds, leading to a sharp decline in the diversity of bird species. In this study, the PKK National Park (18䓎' - 18䓠'N;102䓦' - 102䓻'E), Laos was used as a research site. The birds and their habitats in the park were used as research objects. The species, quantity and distribution of birds were investigated. In addition, the distribution of vegetation and the relationship between bird’s community and habitat types in PKK National Park were studied. Species diversity and Abundance of birds at PKK National Park, was monthly assessed by point count method between January and December 2018. A total of 117 species of birds belonging to 43 families and 18 orders were found in the inspection areas. Among them, Passerine birds (60 species) and Non-Finches (57 species) were almost equal to each other, accounting for 51.3% and 48.7% of total birds species respectively. Again, Anseriformes birds account for the largest number amongst Non-Passeriformes, reaching 15 species, followed by Falconiformes, accounting for 20.5% of total. On the other hand, based on migratory habits, resident birds were found to be highest in our research site which account for 35.04% of total birds and followed by Summer Migratory birds (32.28%), Passage Migrant (23.93%) and Winter Migratory birds (6.83%). Through the quantitative measurement and analysis of various parameters, the focus is on the diversity of birds and species in the park. Further, the factors that can affect species diversity, especially the bird’s survival factors such as vegetation change pattern, transformation rate of green areas, recruitment and restoration pattern of wild animals, especially birds, and other beneficial animal populations were also emphasized in our study. Over and above, exploring the scientific basis for the construction of the green space system of the PKK National Park in Laos with reasonable structure, complete functions and ornamental values was in the heart of this research.展开更多
文摘In Bangladesh, Enteric fever is a persistent health issue throughout the year, occasionally reaching epidemic levels. The growing antibiotic resistance makes treatment increasingly challenging. Therefore, studying the antibiotic resistance patterns within the population is crucial to ensure a more effective treatment strategy. This study was designed to determine the prevalence, antimicrobial susceptibility profile, and factors associated with Salmonella spp. infections among clinically suspected Enteric fever patients in Bangladesh. This study also aimed to investigate whether there has been a re-emergence in the susceptibility of bacterial strains to conventional drugs. Data were collected from February 2024 to July 2024, from patients suspected Enteric fever (fever less than seven days duration) in a Private Diagnostic Center of Bangladesh. A total of 195 blood samples were cultured, where 53.85% came out positive, among which 79.05% Salmonella typhi and 20.95% Salmonella paratyphi A were found. Prevalence of Typhoid fever was observed high among the school-going age group (0 - 15 years) patients. Both these organisms were susceptible to ceftazidime, cefixime, ceftriaxone and cefepime but resistant to nalidixic acid, ciprofloxacin and levofloxacin. Nalidixic Acid is resistant to all S. paratyphi A and sensitive to few S. typhi. Ciprofloxacin and levofloxacin showed delayed response (36.14% and 22.72% sensitive to S. typhi and S. paratyphi A, respectively) and resistance (63.85% and 77.27% resistant to S. typhi and S. paratyphi A, respectively). In case of S. typhi, the resistance was found against ampicillin (32.53%), chloramphenicol (27.71%), cotrimoxazole (24.09%) and the resistance of S. paratyphi A found against ampicillin (4.54%), chloramphenicol (0%) and cotrimoxazole (0%). This study will provide clinicians with alternative drug options and facilitate the effective treatment of Enteric fever.
文摘Worldwide prevalence of diabetes mellitus has become an issue of great concern in current decades. This life threatening disease is associated with worsening of glycemic control and progressive metabolic dysfunctions. Objective: Current study aimed to investigate the effect of hydroxychloroquine (HCQ) as an adjunct to glibenclamide or metformin on glycemic control in alloxan induced diabetic rats. Methods: HCQ was combined separately with two conventional anti-diabetic drugs;glibenclamide and metformin. At first, alloxan (120 mg/kg) induced diabetic rats were treated with single dose of metformin (850 mg/70 kg BW), glibenclamide (10 mg/70 kg BW) and HCQ (300 mg/70 kg BW) intraperitoneally once daily for two weeks. Then non fixed dose combinations of glibenclamide (5 mg/70 kg BW) with HCQ (150 mg/70 kg BW) and metformin (425 mg/70 kg BW) with HCQ (150 mg/70 kg BW) were injected along with those of the three drugs alone once daily for four weeks. Results: In alloxan induced diabetic rats, glibenclamide, metformin and their combination therapies reduced blood glucose level significantly but combination therapies are the most effective. Glibenclamide or metformin in combination with HCQ also significantly (P < 0.05) reduced the elevated levels of total cholesterol, triglycerides, and low density lipoprotein cholesterol (LDL-C) level and increased high density lipoprotein cholesterol (HDL-C) level. Moreover, HCQ potentiates the liver glycogen synthesis of metformin or glibenclamide. Conclusion: Outcomes of this investigation indicate that combination of glibenclamide or metformin with HCQ improves glycemic control and provides additional metabolic benefits, not achieved with either glibenclamide or metformin alone.
文摘Pabna is one the most densely populated town with poor transport infrastructure in Bangladesh. Here huge pedestriangathers in roads and intersections in CBD （Central Business District） area mainly for commercial and business purposes. At present,pedestrian facilities are one of the greatest challenges in terms of traffic and safety for the urban dwellers. The footpath, zebra rossing,road intersection, walkways, parking and other facilities are the major part of road transportation system as well as pedestrianfacilities and people have to pass walking distance to reach their destinations, before and after use of transport mode. For instance,this paper tries to emphasize the problems of pedestrian facilities and to explore the qualitative level of comfort for the pedestrians ofthree selected intersections namely Traffic More, Indra More and Nimtola More in CBD area of Pabna Municipality through primaryand secondary data. However, about 60% trips are making on foot every day, but the pedestrians are facing many problems whileusing the walkways. Pedestrian crossing behaviors were also observed by using pedestrian volume survey and the survey exploresthat pedestrian crossing rate at these intersections is about 5,000 to 7,000 per hour at a peak period and average 15% to 25% illegalcrossing occurs at those intersections. The physical observation and data from the questionnaire survey also indicate that informalbusiness on the footpath, illegal parking, illegal vendor on walkways, physical obstacle, poor lighting facilities and geometricproblem of the road intersection makes uncomfortable situations for the pedestrian day by day.
文摘The major objectives of the study were to determine farmers’ knowledge on climate change effects in agriculture and to identify the factors that influenced farmers’ knowledge on climate change effects in agriculture. The study was conducted in four villages under Kazipur upazila of Sirajgonj district. Data were collected by using interview schedule from randomly selected 113 respondents during 1st January to 30th January, 2018. The findings revealed that an overwhelming majority (78.8%) of the respondents had medium to high knowledge on climate change effects in agriculture. Among eight selected characteristics, extension media contact, training received, organizational participation, and cosmopoliteness had significant positive contribution to the farmers’ knowledge on climate change effects in agriculture. It is recommended that to increase farmers’ knowledge on climate change effects initiative should be taken to improve farmers’ knowledge through more involving with organization, extension media and program.
文摘In recent years, global warming, drought and little rain, forest fires, forest destruction and other human disturbances have had an important impact on the habitat environment of birds, affecting the number and quality of bird habitats, directly threatening the survival and reproduction of birds, leading to a sharp decline in the diversity of bird species. In this study, the PKK National Park (18䓎' - 18䓠'N;102䓦' - 102䓻'E), Laos was used as a research site. The birds and their habitats in the park were used as research objects. The species, quantity and distribution of birds were investigated. In addition, the distribution of vegetation and the relationship between bird’s community and habitat types in PKK National Park were studied. Species diversity and Abundance of birds at PKK National Park, was monthly assessed by point count method between January and December 2018. A total of 117 species of birds belonging to 43 families and 18 orders were found in the inspection areas. Among them, Passerine birds (60 species) and Non-Finches (57 species) were almost equal to each other, accounting for 51.3% and 48.7% of total birds species respectively. Again, Anseriformes birds account for the largest number amongst Non-Passeriformes, reaching 15 species, followed by Falconiformes, accounting for 20.5% of total. On the other hand, based on migratory habits, resident birds were found to be highest in our research site which account for 35.04% of total birds and followed by Summer Migratory birds (32.28%), Passage Migrant (23.93%) and Winter Migratory birds (6.83%). Through the quantitative measurement and analysis of various parameters, the focus is on the diversity of birds and species in the park. Further, the factors that can affect species diversity, especially the bird’s survival factors such as vegetation change pattern, transformation rate of green areas, recruitment and restoration pattern of wild animals, especially birds, and other beneficial animal populations were also emphasized in our study. Over and above, exploring the scientific basis for the construction of the green space system of the PKK National Park in Laos with reasonable structure, complete functions and ornamental values was in the heart of this research.
