<div style="text-align:justify;"> <span style="font-family:Verdana;">Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the...<div style="text-align:justify;"> <span style="font-family:Verdana;">Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the literature. This study is aimed to determine the association of visceral adiposity index (VAI) with insulin resistance in adults with prediabetes. This cross-sectional study was done among 117 adults with newly detected prediabetes [m/f;23/94;mean ± SD: Age 36.30 ± 9.99 years, BMI 28.89 ± 4.35 kg/m<sup>2</sup>] based on American Diabetes Association 2018 criteria and 141 matched healthy controls [m/f: 28/113;mean ± SD: 35.30 ± 6.88 years, BMI 25.03 ± 4.58]. Waist circumference, body mass index, fasting triglyceride, HDL cholesterol, fasting blood glucose and insulin were measured in each group to calculate VAI and homeostatic model assessment of insulin resistance (HOMA-IR). People with prediabetes had significantly higher median value of VAI {3.08 (2.26) vs. 1.86 (2.31);p < 0.001} with higher frequency of high VAI (>1) (98.3% vs. 85.8%;p < 0.001) than the control population. HOMA-IR level was significantly higher in prediabetes with high VAI (cut-off of 2.64) than control with normal VAI [2.78 (2.22, 4.15) vs. 2.20 (1.53, 3.36);p = 0.002]. VAI was positively correlated with HOMA-IR in females with prediabetes (r = 0.299, p = 0.003). VAI had predictive association with prediabetes [OR (95% CI: 9.504 (2.173, 41.576);p = 0.03] and high insulin resistance (HOMA-IR ≥ 2.6) in females with prediabetes [OR (95% CI) = 3.50 (1.476, 8.297);p = 0.004] only. It could satisfactorily discriminate prediabetes in both sexes (male: AUC = 0.767, p = 0.001;female: AUC = 0.641, p < 0.001) and high insulin resistance in females with prediabetes (AUC = 0.641;p = 0.019) only. So, VAI was associated with prediabetes and insulin resistance only in females with prediabetes.</span> </div>展开更多
<div style="text-align:justify;"> <span style="font-family:Verdana;"><strong><em>Background:</em></strong> Very limited data are available regarding the associat...<div style="text-align:justify;"> <span style="font-family:Verdana;"><strong><em>Background:</em></strong> Very limited data are available regarding the association of vitamin D with glycemic status among adults with newly detected type 2 diabetes mellitus (T2DM) in Bangladesh. <strong><em>Objectives:</em></strong> To determine vitamin D status and its association with glycemic status in Bangladeshi adults with newly detected T2DM. <strong><em>Materials and Methods:</em></strong> This cross-sectional study was carried out in 102 newly detected T2DM diagnosed on the basis of the American Diabetes Association 2017 criteria (age: 42.95 ± 10.68 yrs.;m/f: 44/58) and equal number of age and sex matched controls (age: 40.43 ± 11.04 years) recruited consecutively from the Department of Endocrinology, B中央人民政府 to measure serum vitamin D by high performance liquid chromatography method. <strong><em>Results:</em></strong> Both vitamin D deficiency (<20 ng/ml) (87.3% vs. 74.5%, <em>p </em>< 0.03) and severe vitamin D deficiency (<10 ng/ml) (56.2% vs. 26.3%, <em>p</em> < 0.001) were significantly higher in people with T2DM than control population. The mean level of 25(OH)D was significantly lower in adults with T2DM than control population (12.41 ± 6.85 ng/ml vs. 15.74 ± 6.25 ng/ml, <em>p</em> < 0.001). A significant inverse correlation was observed between vitamin D & HbA<span style="white-space:nowrap;"><sub>1</sub></span>c (r = <span style="white-space:nowrap;">-</span>0.249, <em>p</em> = 0.011) in patients with T2DM. HbA<span style="white-space:nowrap;"><sub>1</sub></span>c was linearly associated with vitamin D (<em>β </em>= <span style="white-space:nowrap;">-</span>0.26, <em>p</em> = 0.009) and severe vitamin D deficiency by binary (OR = 1.37, <em>p</em> = 0.003) and multinomial logistic regression (HbA<span style="white-space:nowrap;"><sub>1</sub></span>c ≥ 10%: OR = 4.25, <em>p </em>= 0.04) in people with T2DM after adjustment for age and BMI. <strong>Conclusions:</strong> Severe vitamin D deficiency was positively associated with T2DM and inversely associated with HbA<span style="white-space:nowrap;"><sub>1</sub></span>c in patients with newly detected T2DM.</span> </div>展开更多
文摘<div style="text-align:justify;"> <span style="font-family:Verdana;">Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the literature. This study is aimed to determine the association of visceral adiposity index (VAI) with insulin resistance in adults with prediabetes. This cross-sectional study was done among 117 adults with newly detected prediabetes [m/f;23/94;mean ± SD: Age 36.30 ± 9.99 years, BMI 28.89 ± 4.35 kg/m<sup>2</sup>] based on American Diabetes Association 2018 criteria and 141 matched healthy controls [m/f: 28/113;mean ± SD: 35.30 ± 6.88 years, BMI 25.03 ± 4.58]. Waist circumference, body mass index, fasting triglyceride, HDL cholesterol, fasting blood glucose and insulin were measured in each group to calculate VAI and homeostatic model assessment of insulin resistance (HOMA-IR). People with prediabetes had significantly higher median value of VAI {3.08 (2.26) vs. 1.86 (2.31);p < 0.001} with higher frequency of high VAI (>1) (98.3% vs. 85.8%;p < 0.001) than the control population. HOMA-IR level was significantly higher in prediabetes with high VAI (cut-off of 2.64) than control with normal VAI [2.78 (2.22, 4.15) vs. 2.20 (1.53, 3.36);p = 0.002]. VAI was positively correlated with HOMA-IR in females with prediabetes (r = 0.299, p = 0.003). VAI had predictive association with prediabetes [OR (95% CI: 9.504 (2.173, 41.576);p = 0.03] and high insulin resistance (HOMA-IR ≥ 2.6) in females with prediabetes [OR (95% CI) = 3.50 (1.476, 8.297);p = 0.004] only. It could satisfactorily discriminate prediabetes in both sexes (male: AUC = 0.767, p = 0.001;female: AUC = 0.641, p < 0.001) and high insulin resistance in females with prediabetes (AUC = 0.641;p = 0.019) only. So, VAI was associated with prediabetes and insulin resistance only in females with prediabetes.</span> </div>
文摘<div style="text-align:justify;"> <span style="font-family:Verdana;"><strong><em>Background:</em></strong> Very limited data are available regarding the association of vitamin D with glycemic status among adults with newly detected type 2 diabetes mellitus (T2DM) in Bangladesh. <strong><em>Objectives:</em></strong> To determine vitamin D status and its association with glycemic status in Bangladeshi adults with newly detected T2DM. <strong><em>Materials and Methods:</em></strong> This cross-sectional study was carried out in 102 newly detected T2DM diagnosed on the basis of the American Diabetes Association 2017 criteria (age: 42.95 ± 10.68 yrs.;m/f: 44/58) and equal number of age and sex matched controls (age: 40.43 ± 11.04 years) recruited consecutively from the Department of Endocrinology, B中央人民政府 to measure serum vitamin D by high performance liquid chromatography method. <strong><em>Results:</em></strong> Both vitamin D deficiency (<20 ng/ml) (87.3% vs. 74.5%, <em>p </em>< 0.03) and severe vitamin D deficiency (<10 ng/ml) (56.2% vs. 26.3%, <em>p</em> < 0.001) were significantly higher in people with T2DM than control population. The mean level of 25(OH)D was significantly lower in adults with T2DM than control population (12.41 ± 6.85 ng/ml vs. 15.74 ± 6.25 ng/ml, <em>p</em> < 0.001). A significant inverse correlation was observed between vitamin D & HbA<span style="white-space:nowrap;"><sub>1</sub></span>c (r = <span style="white-space:nowrap;">-</span>0.249, <em>p</em> = 0.011) in patients with T2DM. HbA<span style="white-space:nowrap;"><sub>1</sub></span>c was linearly associated with vitamin D (<em>β </em>= <span style="white-space:nowrap;">-</span>0.26, <em>p</em> = 0.009) and severe vitamin D deficiency by binary (OR = 1.37, <em>p</em> = 0.003) and multinomial logistic regression (HbA<span style="white-space:nowrap;"><sub>1</sub></span>c ≥ 10%: OR = 4.25, <em>p </em>= 0.04) in people with T2DM after adjustment for age and BMI. <strong>Conclusions:</strong> Severe vitamin D deficiency was positively associated with T2DM and inversely associated with HbA<span style="white-space:nowrap;"><sub>1</sub></span>c in patients with newly detected T2DM.</span> </div>
