The heat generation effects on magnetohydrodynamic(MHD) natural convection flow along a vertical wavy surface with variable thermal conductivity have been investigated. The governing boundary layer equations are first...The heat generation effects on magnetohydrodynamic(MHD) natural convection flow along a vertical wavy surface with variable thermal conductivity have been investigated. The governing boundary layer equations are first transformed into a non-dimensional form using suitable set of dimensionless variables. The resulting nonlinear system of partial differential equations are mapped into the domain of a vertical flat plate and then solved numerically employing the implicit finite difference method, known as Keller-box scheme. The numerical results of the surface shear stress in terms of skin friction coefficient and the rate of heat transfer in terms of local Nusselt number, the stream lines as well as the isotherms are shown graphically for a selection of parameters set consisting of thermal conductivity variation parameter, heat generation parameter Q, magnetic parameter M and Prandtl number Pr. Comparison of numerical results of present work with other published data has been shown in table.展开更多
The conjugate effects of radiation and joule heating on magnetohydrodynamic (MHD) free convection flow along a sphere with heat generation have been investigated in this paper. The governing equations are transformed ...The conjugate effects of radiation and joule heating on magnetohydrodynamic (MHD) free convection flow along a sphere with heat generation have been investigated in this paper. The governing equations are transformed into dimensionless non-similar equations by using set of suitable transformations and solved numerically by the finite difference method along with Newton’s linearization approximation. Attention has been focused on the evaluation of shear stress in terms of local skin friction and rate of heat transfer in terms of local Nusselt number, velocity as well as temperature profiles. Numerical results have been shown graphically for some selected values of parameters set consisting of heat generation parameter Q, radiation parameter Rd, magnetic parameter M, joule heating parameter J and the Prandtl number Pr.展开更多
Mast cells are emerging as players in the communication between peripheral nerve endings and cells of the immune system.However,it is not clear the mechanism by which mast cells communicate with peripheral nerves.We p...Mast cells are emerging as players in the communication between peripheral nerve endings and cells of the immune system.However,it is not clear the mechanism by which mast cells communicate with peripheral nerves.We previously found that mast cells located within healing tendons can express glutamate receptors,raising the possibility that mast cells may be sensitive to glutamate signaling.To evaluate this hypothesis,we stimulated primary mast cells with glutamate and showed that glutamate induced the profound upregulation of a panel of glutamate receptors of both the ionotropic type(NMDAR1,NMDAR2A,and NMDAR2B)and the metabotropic type(mGluR2 and mGluR7)at both the mRNA and protein levels.The binding of glutamate to glutamate receptors on the mast cell surface was confirmed.Further,glutamate had extensive effects on gene expression in the mast cells,including the upregulation of proinflammatory components such as IL-6 and CCL2.Glutamate also induced the upregulation of transcription factors,including Egr2,Egr3 and,in particular,FosB.The extensive induction of FosB was confirmed by immunofluorescence assessment.Glutamate receptor antagonists abrogated the responses of the mast cells to glutamate,supporting the supposition of a functional glutamate–glutamate receptor axis in mast cells.Finally,we provide in vivo evidence supporting a functional glutamate–glutamate receptor axis in the mast cells of injured tendons.Together,these findings establish glutamate as an effector of mast cell function,thereby introducing a novel principle for how cells in the immune system can communicate with nerve cells.展开更多
Correction to:Cellular and Molecular Immunology https://doi.org/10.1038/s41423-020-0421-z,published online 20 April 2020 The authors have agreed to add Parmis Blomgran(Linköping University,Department of Orthopedi...Correction to:Cellular and Molecular Immunology https://doi.org/10.1038/s41423-020-0421-z,published online 20 April 2020 The authors have agreed to add Parmis Blomgran(Linköping University,Department of Orthopedics and Sports Medicine,Linkoping,Sweden)as co-author of this study.The updated order of authors will be:Md Abdul Alim,Mirjana Grujic,Paul W Ackerman,Per Kristiansson,Parmis Blomgran,Pernilla Eliasson,Magnus Peterson,Gunnar Pejler.展开更多
文摘The heat generation effects on magnetohydrodynamic(MHD) natural convection flow along a vertical wavy surface with variable thermal conductivity have been investigated. The governing boundary layer equations are first transformed into a non-dimensional form using suitable set of dimensionless variables. The resulting nonlinear system of partial differential equations are mapped into the domain of a vertical flat plate and then solved numerically employing the implicit finite difference method, known as Keller-box scheme. The numerical results of the surface shear stress in terms of skin friction coefficient and the rate of heat transfer in terms of local Nusselt number, the stream lines as well as the isotherms are shown graphically for a selection of parameters set consisting of thermal conductivity variation parameter, heat generation parameter Q, magnetic parameter M and Prandtl number Pr. Comparison of numerical results of present work with other published data has been shown in table.
文摘The conjugate effects of radiation and joule heating on magnetohydrodynamic (MHD) free convection flow along a sphere with heat generation have been investigated in this paper. The governing equations are transformed into dimensionless non-similar equations by using set of suitable transformations and solved numerically by the finite difference method along with Newton’s linearization approximation. Attention has been focused on the evaluation of shear stress in terms of local skin friction and rate of heat transfer in terms of local Nusselt number, velocity as well as temperature profiles. Numerical results have been shown graphically for some selected values of parameters set consisting of heat generation parameter Q, radiation parameter Rd, magnetic parameter M, joule heating parameter J and the Prandtl number Pr.
基金This study was funded by grants from AFA Forsakring(M.P.).
文摘Mast cells are emerging as players in the communication between peripheral nerve endings and cells of the immune system.However,it is not clear the mechanism by which mast cells communicate with peripheral nerves.We previously found that mast cells located within healing tendons can express glutamate receptors,raising the possibility that mast cells may be sensitive to glutamate signaling.To evaluate this hypothesis,we stimulated primary mast cells with glutamate and showed that glutamate induced the profound upregulation of a panel of glutamate receptors of both the ionotropic type(NMDAR1,NMDAR2A,and NMDAR2B)and the metabotropic type(mGluR2 and mGluR7)at both the mRNA and protein levels.The binding of glutamate to glutamate receptors on the mast cell surface was confirmed.Further,glutamate had extensive effects on gene expression in the mast cells,including the upregulation of proinflammatory components such as IL-6 and CCL2.Glutamate also induced the upregulation of transcription factors,including Egr2,Egr3 and,in particular,FosB.The extensive induction of FosB was confirmed by immunofluorescence assessment.Glutamate receptor antagonists abrogated the responses of the mast cells to glutamate,supporting the supposition of a functional glutamate–glutamate receptor axis in mast cells.Finally,we provide in vivo evidence supporting a functional glutamate–glutamate receptor axis in the mast cells of injured tendons.Together,these findings establish glutamate as an effector of mast cell function,thereby introducing a novel principle for how cells in the immune system can communicate with nerve cells.
文摘Correction to:Cellular and Molecular Immunology https://doi.org/10.1038/s41423-020-0421-z,published online 20 April 2020 The authors have agreed to add Parmis Blomgran(Linköping University,Department of Orthopedics and Sports Medicine,Linkoping,Sweden)as co-author of this study.The updated order of authors will be:Md Abdul Alim,Mirjana Grujic,Paul W Ackerman,Per Kristiansson,Parmis Blomgran,Pernilla Eliasson,Magnus Peterson,Gunnar Pejler.
