Antioxidant-the word itself is magic.Using the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called"free-radical"reactions,the rush is on to mine claims for the latest and most...Antioxidant-the word itself is magic.Using the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called"free-radical"reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging compounds.We must acknowledge that such"radicals"have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and folate.Defense strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and carotenoids.This paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall health.It is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell sites.Further evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally展开更多
Beneficial effects of dietary energy restriction (DER), including extension of life-span, reduction in cancer risk, anti-cancer effects and decrease in age related neurodegenerative diseases have been well established...Beneficial effects of dietary energy restriction (DER), including extension of life-span, reduction in cancer risk, anti-cancer effects and decrease in age related neurodegenerative diseases have been well established. Given that DER is difficult to implement in humans due to practical constraints, development of energy restriction mimetics (ERMs) is considered as a suitable alternative. Our recent studies have established the anti-tumor effects of the dietary administration of the glycolytic inhibitor 2-deoxy-D-glucose, a potential ERM, an alternative to DER;without any adverse effects on general physiology. Since functioning of the brain is critically dependent on glucose, we investigated the effects of chronic dietary 2-DG administration on the behavioural outcome in mice. Our findings based on a battery of neuro-behavioural tests clearly suggest that the chronic dietary administration of 2-DG that appreciably impairs the process of tumorigenesis has no adverse effect on the cognitive, affective and sensory-motor functions. Together with the maintenance of normal physiology reported by us earlier, these observations strengthen the potential of dietary 2-DG as a safe cancer preventive strategy.展开更多
In this manuscript we present a current mode biquad using one dual output-voltage differencing buffered amplifier (DO-VDBA) and four passive components (2 grounded capacitors and 2 resistors). The proposed circuit off...In this manuscript we present a current mode biquad using one dual output-voltage differencing buffered amplifier (DO-VDBA) and four passive components (2 grounded capacitors and 2 resistors). The proposed circuit offers very low active and passive sensitivity. The filter presented here is electronically tunable, frequency of oscillation (FO) can be tuned by controlling transconductance (gm) by varying the bias current (IB) of the circuit. The workability of proposed circuit is tested using PSPICE with 180 nm TSMC CMOS process parameters.展开更多
Databases for two-dimensional materials host numerous ferromagnetic materials without the vital information of Curie temperature since its calculation involves a manually intensive complex process.In this work,we deve...Databases for two-dimensional materials host numerous ferromagnetic materials without the vital information of Curie temperature since its calculation involves a manually intensive complex process.In this work,we develop a fully automated,hardwareaccelerated,dynamic-translation based computer code,which performs first principles-based computations followed by Heisenberg model-based Monte Carlo simulations to estimate the Curie temperature from the crystal structure.We employ this code to conduct a high-throughput scan of 786 materials from a database to discover 26 materials with a Curie point beyond 400 K.For rapid data mining,we further use these results to develop an end-to-end machine learning model with generalized chemical features through an exhaustive search of the model space as well as the hyperparameters.We discover a few more high Curie point materials from different sources using this data-driven model.Such material informatics,which agrees well with recent experiments,is expected to foster practical applications of two-dimensional magnetism.展开更多
Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules.Coccinia indica belongs to the ...Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules.Coccinia indica belongs to the family Cucurbitaceae.It is a rapidly growing,perennial climber or trailing vine.Traditionally different parts of this plant namely the roots,leaves and fruits are used in folklore medicine for several purposes like jaundice,diabetes,wound healing,ulcers,stomach ache,skin disease,fever,asthma,cough.The leaf and its constituents have been reported to possess hypoglycaemic,hypolipidemic and antioxidant properties.This review provides adequate information to develop suitable therapeutics out of these plant parts.展开更多
基金Supported by Institute of Pharmacy,Bandelkhand University.Jhansi U.Pa,India(Grant number.BU/PHARM/02-13)
文摘Antioxidant-the word itself is magic.Using the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called"free-radical"reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging compounds.We must acknowledge that such"radicals"have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and folate.Defense strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and carotenoids.This paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall health.It is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell sites.Further evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally
文摘Beneficial effects of dietary energy restriction (DER), including extension of life-span, reduction in cancer risk, anti-cancer effects and decrease in age related neurodegenerative diseases have been well established. Given that DER is difficult to implement in humans due to practical constraints, development of energy restriction mimetics (ERMs) is considered as a suitable alternative. Our recent studies have established the anti-tumor effects of the dietary administration of the glycolytic inhibitor 2-deoxy-D-glucose, a potential ERM, an alternative to DER;without any adverse effects on general physiology. Since functioning of the brain is critically dependent on glucose, we investigated the effects of chronic dietary 2-DG administration on the behavioural outcome in mice. Our findings based on a battery of neuro-behavioural tests clearly suggest that the chronic dietary administration of 2-DG that appreciably impairs the process of tumorigenesis has no adverse effect on the cognitive, affective and sensory-motor functions. Together with the maintenance of normal physiology reported by us earlier, these observations strengthen the potential of dietary 2-DG as a safe cancer preventive strategy.
文摘In this manuscript we present a current mode biquad using one dual output-voltage differencing buffered amplifier (DO-VDBA) and four passive components (2 grounded capacitors and 2 resistors). The proposed circuit offers very low active and passive sensitivity. The filter presented here is electronically tunable, frequency of oscillation (FO) can be tuned by controlling transconductance (gm) by varying the bias current (IB) of the circuit. The workability of proposed circuit is tested using PSPICE with 180 nm TSMC CMOS process parameters.
基金The GPU computing nodes used in this study were procured through the research funding from the Department of Science and Technology(DST),Government of India,under grant number DST/TMD/MES/2K18/28.
文摘Databases for two-dimensional materials host numerous ferromagnetic materials without the vital information of Curie temperature since its calculation involves a manually intensive complex process.In this work,we develop a fully automated,hardwareaccelerated,dynamic-translation based computer code,which performs first principles-based computations followed by Heisenberg model-based Monte Carlo simulations to estimate the Curie temperature from the crystal structure.We employ this code to conduct a high-throughput scan of 786 materials from a database to discover 26 materials with a Curie point beyond 400 K.For rapid data mining,we further use these results to develop an end-to-end machine learning model with generalized chemical features through an exhaustive search of the model space as well as the hyperparameters.We discover a few more high Curie point materials from different sources using this data-driven model.Such material informatics,which agrees well with recent experiments,is expected to foster practical applications of two-dimensional magnetism.
文摘Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules.Coccinia indica belongs to the family Cucurbitaceae.It is a rapidly growing,perennial climber or trailing vine.Traditionally different parts of this plant namely the roots,leaves and fruits are used in folklore medicine for several purposes like jaundice,diabetes,wound healing,ulcers,stomach ache,skin disease,fever,asthma,cough.The leaf and its constituents have been reported to possess hypoglycaemic,hypolipidemic and antioxidant properties.This review provides adequate information to develop suitable therapeutics out of these plant parts.
