Tissue and organ differentiation is tightly controlled to ensure proper development and function of the growing embryo as well as cells such as lymphocytes that differentiate throughout the adult stage.Therefore it is...Tissue and organ differentiation is tightly controlled to ensure proper development and function of the growing embryo as well as cells such as lymphocytes that differentiate throughout the adult stage.Therefore it is vital that the genes and the protein they encode that are involved in these processes function accurately.Hence,any mutation or error that occurs along the way can result in extensive damage,which is expressed in various ways in the embryo and can result in immune pathogenesis,including immunodeficiency and autoimmune diseases,when lymphocyte development is altered.展开更多
Systemic lupus erythematosus(SLE)is a debilitating multi-factorial autoimmune disease(Shlomchik et al.,2001;La Cava,2009;Perry et al.,2011).It involves multiple organ systems with tissue damage driven by the activatio...Systemic lupus erythematosus(SLE)is a debilitating multi-factorial autoimmune disease(Shlomchik et al.,2001;La Cava,2009;Perry et al.,2011).It involves multiple organ systems with tissue damage driven by the activation of auto-reactive Tand B cells(Bruns et al.,2000;Langer et al.,2007).It can exist for years before being diagnosed and is known to be more common in women than in men.Intense research efforts have uncovered a complex lupus pathogenesis,many aspects of which are not very clear(Perry et al.,2011).展开更多
文摘Tissue and organ differentiation is tightly controlled to ensure proper development and function of the growing embryo as well as cells such as lymphocytes that differentiate throughout the adult stage.Therefore it is vital that the genes and the protein they encode that are involved in these processes function accurately.Hence,any mutation or error that occurs along the way can result in extensive damage,which is expressed in various ways in the embryo and can result in immune pathogenesis,including immunodeficiency and autoimmune diseases,when lymphocyte development is altered.
文摘Systemic lupus erythematosus(SLE)is a debilitating multi-factorial autoimmune disease(Shlomchik et al.,2001;La Cava,2009;Perry et al.,2011).It involves multiple organ systems with tissue damage driven by the activation of auto-reactive Tand B cells(Bruns et al.,2000;Langer et al.,2007).It can exist for years before being diagnosed and is known to be more common in women than in men.Intense research efforts have uncovered a complex lupus pathogenesis,many aspects of which are not very clear(Perry et al.,2011).
