In a recent study published in Nature,Zhang,Rubio Rodríguez Kirby and colleagues accurately recorded temporal,dynamic changes during brain development revealing the program underlying chromatin accessibility of g...In a recent study published in Nature,Zhang,Rubio Rodríguez Kirby and colleagues accurately recorded temporal,dynamic changes during brain development revealing the program underlying chromatin accessibility of genes involved in myelination and axonogenesis.1 By developing an in situ spatial tri-omics platform-spatial ARP-seq and spatial CTRP-seq-at a near singlecell resolution that simultaneously profiles the genome-wide chromatin state,the whole-transcriptome RNA and the proteome,the study unravels the spatiotemporal dynamics of brain development and neuroinflammatory responses,with an atlas of the mouse postnatal brain benchmarked to corresponding regions of the developing human visual cortex.展开更多
基金supported by the Systems Biology Grant of the University of Surrey to Matteo BarberisJinkun Xie was supported by a studentship of the Faculty of Health and Medical Sciences(FHMS)of the University of Surrey to Matteo Barberis.
文摘In a recent study published in Nature,Zhang,Rubio Rodríguez Kirby and colleagues accurately recorded temporal,dynamic changes during brain development revealing the program underlying chromatin accessibility of genes involved in myelination and axonogenesis.1 By developing an in situ spatial tri-omics platform-spatial ARP-seq and spatial CTRP-seq-at a near singlecell resolution that simultaneously profiles the genome-wide chromatin state,the whole-transcriptome RNA and the proteome,the study unravels the spatiotemporal dynamics of brain development and neuroinflammatory responses,with an atlas of the mouse postnatal brain benchmarked to corresponding regions of the developing human visual cortex.
