In a recently published study in The New England Journal of Medicine,Liu and colleagues were able to demonstrate that-apart from the antileukemic effects previously reported for hypomethylating agents(HMAs)-treatment ...In a recently published study in The New England Journal of Medicine,Liu and colleagues were able to demonstrate that-apart from the antileukemic effects previously reported for hypomethylating agents(HMAs)-treatment with these drugs can also lead to demethylation and subsequent upregulation of oncogenes resulting in shorter survival in patients with myelo-dysplastic syndrome(MDS).展开更多
The applicability of immune-competent mice to model metastatic tumor progression is limited by the immunogenicity of exogenous proteins like GFP and firefly(ff)luciferase commonly used to track metastatic cells.A rece...The applicability of immune-competent mice to model metastatic tumor progression is limited by the immunogenicity of exogenous proteins like GFP and firefly(ff)luciferase commonly used to track metastatic cells.A recent work published in Cancer Cell by Grzelak and colleagues now shows that development of mouse models that have been centrally tolerized to GFP can overcome this obstacle in transplantation models of metastasis.展开更多
文摘In a recently published study in The New England Journal of Medicine,Liu and colleagues were able to demonstrate that-apart from the antileukemic effects previously reported for hypomethylating agents(HMAs)-treatment with these drugs can also lead to demethylation and subsequent upregulation of oncogenes resulting in shorter survival in patients with myelo-dysplastic syndrome(MDS).
文摘The applicability of immune-competent mice to model metastatic tumor progression is limited by the immunogenicity of exogenous proteins like GFP and firefly(ff)luciferase commonly used to track metastatic cells.A recent work published in Cancer Cell by Grzelak and colleagues now shows that development of mouse models that have been centrally tolerized to GFP can overcome this obstacle in transplantation models of metastasis.
