An efficient synthesis of hexahydropyrido[2,3-d]pyrimidinetrione derivatives is achieved via tandem Knoevenagel-Michael addition of aromatic aldehydes,methylcyanoacetate and 4（6）-aminouracil in solvent-free conditio...An efficient synthesis of hexahydropyrido[2,3-d]pyrimidinetrione derivatives is achieved via tandem Knoevenagel-Michael addition of aromatic aldehydes,methylcyanoacetate and 4（6）-aminouracil in solvent-free conditions in the presence of 10 mol%of ZrO_2 nanoparticles（ZrO_2 NPs） as a heterogenous catalyst.The procedure is formed in high yields,short reaction time and an environmentally friendly specificity.展开更多
文摘An efficient synthesis of hexahydropyrido[2,3-d]pyrimidinetrione derivatives is achieved via tandem Knoevenagel-Michael addition of aromatic aldehydes,methylcyanoacetate and 4（6）-aminouracil in solvent-free conditions in the presence of 10 mol%of ZrO_2 nanoparticles（ZrO_2 NPs） as a heterogenous catalyst.The procedure is formed in high yields,short reaction time and an environmentally friendly specificity.
