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CD44v对大鼠多形胶质瘤细胞系RG2的转移促进作用 被引量:11
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作者 李宏 martin hofmann +4 位作者 刘佳 江岩 郭丽 罗阳 鲁海欧 《中华肿瘤杂志》 CAS CSCD 北大核心 1996年第5期343-346,共4页
研究颅外生长的胶质母细胞瘤能否转移以及CD44v对它们转移能力的影响。利用基因转染技术,将自发表达CD44v(meta-1)的载体导入转移力较低的大鼠胶质瘤RG2细胞内,并对有或无CD44v表达的RG2细胞做系统的实... 研究颅外生长的胶质母细胞瘤能否转移以及CD44v对它们转移能力的影响。利用基因转染技术,将自发表达CD44v(meta-1)的载体导入转移力较低的大鼠胶质瘤RG2细胞内,并对有或无CD44v表达的RG2细胞做系统的实验性转移观察。结果发现,与无CD44v表达的母系RG2细胞(RG2-m)相比,CD44v的转染子RG2-a的生长指标和形态学特点并无明显改变;但RG2-a在荷瘤大鼠体内转移出现的时间明显提前,在单位时间内,受累器官的数量增加和破坏程度更为严重。研究结果证实:颅外生长的胶质母细胞具有自发转移能力,CD44v可明显提高RG2细胞的转移效率。 展开更多
关键词 胶质母细胞瘤 CD基因 肿瘤转移
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智能汽车的发展愿景——从人工智能与数据分析的角度分析
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作者 胡志强 martin hofmann +1 位作者 Florian Neukart Thomas B?ck 《中国工业和信息化》 2018年第2期40-45,共6页
大体来说,从眼前的现实,来想象未来的图景可能并不困难.但落实到具体的制造行业,需要解决的问题“成如容易却艰辛”.就智能汽车的发展愿景,从人工智能与数据分析的角度,能看到什么呢?
关键词 人工智能 智能汽车 制造行业
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Tip-and Laser-based 3D Nanofabrication in Extended Macroscopic Working Areas
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作者 Ingo Ortlepp Thomas Frohlich +26 位作者 Roland FuBl Johann Reger Christoph Schaffel Stefan Sinzinger Steffen Strehle ReneTheska Lena Zentner Jens-Peter Zollner Ivo WRangelow Carsten Reinhardt Tino Hausotte Xinrui Cao Oliver Dannberg Florian Fern David Fischer Stephan Gorges martin hofmann Johannes Kirchner Andreas Meister Taras Sasiuk Ralf Schienbein Shraddha Supreeti Laura Mohr-Weidenfeller Christoph Weise Christoph Reuter Jaqueline Stauffenberg Eberhard Manske 《Nanomanufacturing and Metrology》 2021年第3期132-148,共17页
The field of optical lithography is subject to intense research and has gained enormous improvement.However,the effort necessary for creating structures at the size of 20 nm and below is considerable using conventiona... The field of optical lithography is subject to intense research and has gained enormous improvement.However,the effort necessary for creating structures at the size of 20 nm and below is considerable using conventional technologies.This effort and the resulting financial requirements can only be tackled by few global companies and thus a paradigm change for the semiconductor industry is conceivable:custom design and solutions for specific applications will dominate future development(Fritze in:Panning EM,Liddle JA(eds)Novel patterning technologies.International society for optics and photonics.SPIE,Bellingham,2021.https://doi.org/10.1117/12.2593229).For this reason,new aspects arise for future lithography,which is why enormous effort has been directed to the development of alternative fabrication technologies.Yet,the technologies emerging from this process,which are promising for coping with the current resolution and accuracy challenges,are only demonstrated as a proof-of-concept on a lab scale of several square micrometers.Such scale is not adequate for the requirements of modern lithography;therefore,there is the need for new and alternative cross-scale solutions to further advance the possibilities of unconventional nanotechnologies.Similar challenges arise because of the technical progress in various other fields,realizing new and unique functionalities based on nanoscale effects,e.g.,in nanophotonics,quantum computing,energy harvesting,and life sciences.Experimental platforms for basic research in the field of scale-spanning nanomeasuring and nanofabrication are necessary for these tasks,which are available at the Technische Universitiit Ilmenau in the form of nanopositioning and nanomeasuring(NPM)machines.With this equipment,the limits of technical structurability are explored for high-performance tip-based and laser-based processes for enabling real 3D nanofabrication with the highest precision in an adequate working range of several thousand cubic millimeters. 展开更多
关键词 Nanomeasuring NANOPOSITIONING NANOMANUFACTURING Scale-spanning Tip-based Laser-based Nanofabrication
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