Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes tha...Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.展开更多
Antimicrobial resistance poses a major challenge to modern medicine and jeopardizes the ability to maintain a robust global public health response against persistent infectious disease threats.A 2024 Lancet series on ...Antimicrobial resistance poses a major challenge to modern medicine and jeopardizes the ability to maintain a robust global public health response against persistent infectious disease threats.A 2024 Lancet series on antimicrobial resistance estimated that bacterial antimicrobial resistance was associated with 4.71 million deaths globally in 2021,including 1.14 million deaths directly attributable to resistant infections.If not actively addressed,antimicrobial resistance might result in an annual reduction of the global gross domestic product by$3.4 trillion and push an additional 24 million individuals into extreme poverty within the next decade.Antibiotic resistance genes(ARGs)are the key culprits behind antimicrobial resistance,widely disseminating among bacterial populations,particularly in medical,agricultural,and veterinary sectors.Furthermore,anthropogenic activities,such as wastewater discharge,trade,tourism,and chemical contamination,have reshaped microbial biogeography,creating an unforeseen global platform for ARG mobilization.This exacerbates the existing antimicrobial resistance crisis and enhances risks to global public health and environmental stability.展开更多
Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health.Despite global efforts to mitigate legacy pollutants,the continuous introduction of new su...Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health.Despite global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the planet.In response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution Prevention.This review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health approach.Strategies for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international levels.Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.展开更多
The emergence and rapid spread of antimicrobial resistance is of global public health concern.The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and ve...The emergence and rapid spread of antimicrobial resistance is of global public health concern.The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes(ARGs).In this review,we describe the reservoirs of gut ARGs and their dynamics in both animals and humans,use the One Health perspective to track the transmission of ARG-containing bacteria between humans,animals,and the environment,and assess the impact of antimicrobial resistance on human health and socioeconomic development.The gut resistome can evolve in an environment subject to various selective pressures,including antibiotic administration and environmental and lifestyle factors(e.g.,diet,age,gender,and living conditions),and interventions through probiotics.Strategies to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance.With the help of effective measures taken at the national,local,personal,and intestinal management,it will also result in preventing or minimizing the spread of infectious diseases.This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.展开更多
基金funded by the National Natural Science Foundation of China (No. 21677149)the Outstanding Youth Fund of the Natural Science Foundation of Jiangsu Province, China (No. BK20150050)+6 种基金the Innovative Project of Chinese Academy of Sciences (No. ISSASIP1616)funded by the Center for Health Impacts of Agriculture (CHIA) of Michigan State University, USAfunded by Agriculture and AgriFood Canada, the Canadian Genomics Research Development Initiative (GRDI-AMR)the Canadian Institute for Health Research (CIHR) through the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)the National Funds from FCT—Fundacao para a Ciência e a Tecnologia, Portugal (No. UID/Multi/ 50016/2013)funded by Academy of Finland and the Joint Programming Initiative “Water Challenges for a Changing World” (Water JPI)funded by the Collaborative Research Fund of Hong Kong (CRF), China (No. C6033-14G)
文摘Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.
基金supported by the Institute of Soil Science,Chinese Academy of Sciences(ISSAS2419)National Natural Science Foundation of China(42307048)+4 种基金Natural Science Foundation of Jiangsu,China(BK20231099)International Atomic Energy Agency Coordinated Research Project(D15022)Center for Health Impacts of Agriculture of Michigan State University and Research Group Linkage project from Alexander von Humboldt Foundationthe German Science Foundation(FOR 5095)Chinese Academy of Sciences,President’s International Fellowship Initiative(2024DC0009).
文摘Antimicrobial resistance poses a major challenge to modern medicine and jeopardizes the ability to maintain a robust global public health response against persistent infectious disease threats.A 2024 Lancet series on antimicrobial resistance estimated that bacterial antimicrobial resistance was associated with 4.71 million deaths globally in 2021,including 1.14 million deaths directly attributable to resistant infections.If not actively addressed,antimicrobial resistance might result in an annual reduction of the global gross domestic product by$3.4 trillion and push an additional 24 million individuals into extreme poverty within the next decade.Antibiotic resistance genes(ARGs)are the key culprits behind antimicrobial resistance,widely disseminating among bacterial populations,particularly in medical,agricultural,and veterinary sectors.Furthermore,anthropogenic activities,such as wastewater discharge,trade,tourism,and chemical contamination,have reshaped microbial biogeography,creating an unforeseen global platform for ARG mobilization.This exacerbates the existing antimicrobial resistance crisis and enhances risks to global public health and environmental stability.
基金funded by the National Key Research and Development Program of China(2020YFC1807000)the Strategic Priority Research Program of the Chinese Academy of Sciences(no.XDA28030501)+9 种基金the National Natural Science Foundation of China(41991333,41977137,42090060)the International Atomic Energy Agency Research Project(D15022)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2011225[Fang Wang],Y201859[H.Wang],2013201[J.Su],2021309[Y.Song],Y2022084[M.Ye])Chinese Academy of Sciences President’s International Fellowship Initiative(2020DC0005,2022DC0001,2024DC0009)the Institute of Soil Science,Chinese Academy of Sciences(ISSAS2419)the Research Group Linkage project from Alexander von Humboldt foundation,the Center for Health Impacts of Agriculture(CHIA)of Michigan State University,and the URI STEEP Superfund Center(grant#P42ES027706)Fang Wang was partly supported by the fellowship of Alexander von Humboldt for experienced researchers,and Shennong Young Talents of the Ministry of Agriculture and Rural Affairs,China(SNYCQN006-2022)J.P.and T.R.S.were supported by the Canada Research Chair program.B.W.B.was supported by a Royal Society of New Zealand Catalyst International Leaders fellowship.K.K.B.was supported by Innovation Fund Denmark and the European Commission Horizon 2020 financed under the ERA-NET Aquatic Pollutants Joint Transnational Call(REWA,GA no.869178)S.A.H.was partly supported by a grant from the National Institute of Environmental Health Sciences,National Institutes of Health grant number P42ES04911-29(Project 4)T.R.S.thanks CESAM by FCT/MCTES(UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020)。
文摘Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health.Despite global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the planet.In response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution Prevention.This review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health approach.Strategies for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international levels.Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.
基金supported by the National Natural Science Foundation of China(41977137 and 42307048)the International Atomic Energy Agency Research Project(D15022)+5 种基金Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB460)the China Postdoctoral Science Foundation(2023M733593)Chinese Academy of Sciences President's International Fellowship Initiative(2020DC0005)Academy of Finland,Innovation Fund Denmark and the European Commission Horizon 2020 financed under the ERA-NET Aquatic Pollutants Joint Transnational Call(REWA,GA No 869178)the Center for Health Impacts of Agriculture(CHIA)of Michigan State Universitysupported by the fellowship of Alexander von Humboldt for experienced researchers,and Shennong Young Talents of the Ministry of Agriculture and Rural Affairs,China(SNYCQN006-2022).
文摘The emergence and rapid spread of antimicrobial resistance is of global public health concern.The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes(ARGs).In this review,we describe the reservoirs of gut ARGs and their dynamics in both animals and humans,use the One Health perspective to track the transmission of ARG-containing bacteria between humans,animals,and the environment,and assess the impact of antimicrobial resistance on human health and socioeconomic development.The gut resistome can evolve in an environment subject to various selective pressures,including antibiotic administration and environmental and lifestyle factors(e.g.,diet,age,gender,and living conditions),and interventions through probiotics.Strategies to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance.With the help of effective measures taken at the national,local,personal,and intestinal management,it will also result in preventing or minimizing the spread of infectious diseases.This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.
