You know that a rooster goes cock-a-doodle-doo in most English-speaking countries. But do you know that roosters in other countries make all sorts of different "sounds"? In Russia, a rooster goes Kukuriki. I...You know that a rooster goes cock-a-doodle-doo in most English-speaking countries. But do you know that roosters in other countries make all sorts of different "sounds"? In Russia, a rooster goes Kukuriki. In Japan, it goes Kokekock-kom; in France, it goes Cocorico and in Germany, it goes Kikeriki. In Singapore, we say a cat goes Meow. In Ja-展开更多
Do you know that…1.A lobstar’s teeth are in its stomach.2.A snail can sleep for three years.3.A seagull can drink seawater because it has special glands that filter out the salt.4.Fleas can accelerate 50 times faste...Do you know that…1.A lobstar’s teeth are in its stomach.2.A snail can sleep for three years.3.A seagull can drink seawater because it has special glands that filter out the salt.4.Fleas can accelerate 50 times faster than the space shuttle.展开更多
AIM: To determine if hyperpolarisation-activated nucleotide-gated(HCN) channels exist in human colon, and to investigate the expression of HCN channels in Hirschsprung's disease.METHODS:We investigated HCN1,HCN2,H...AIM: To determine if hyperpolarisation-activated nucleotide-gated(HCN) channels exist in human colon, and to investigate the expression of HCN channels in Hirschsprung's disease.METHODS:We investigated HCN1,HCN2,HCN3 and HCN4 protein expression in pull-through specimens from patients with Hirschsprung’s disease(HSCR,n=10)using the proximal-most ganglionic segment and distalmost aganglionic segment,as well as in healthy control specimens obtained at the time of sigmoid colostomy closure in children who had undergone anorectoplasty for imperforate anus(n=10).Fluorescent immunohistochemistry was performed to assess protein distribution,which was then visualized using confocal microscopy.RESULTS:No HCN1 channel expression was observed in any of the tissues studied.Both HCN2 and HCN4proteins were found to be equally expressed in the aganglionic and ganglionic bowel in HSCR and controls.HCN3 channel expression was found to be markedly decreased in the aganglionic colon vs ganglionic colon and controls.HCN2-4 channels were seen to be expressed within neurons of the myenteric and submucosal plexus of the ganglionic bowel and normal controls,and also co-localised to interstitial cells of Cajal in all tissues studied.CONCLUSION:We demonstrate HCN channel expression in human colon for the first time.Reduced HCN3expression in aganglionic bowel suggests its potential role in HSCR pathophysiology.展开更多
1.The largest of the biga)Lioneats 15 the:c)LeoPard2. Alltige鲜s吻叭arethea)True:气介-a)Uungoe户tles尸c)nogs哗一__-b)Tigerd)Cou吕arSallle:b)Falseb)ImPalasd)川1 oftheabove4·The strongestgfthela)He硕ngand滋沙tfive ...1.The largest of the biga)Lioneats 15 the:c)LeoPard2. Alltige鲜s吻叭arethea)True:气介-a)Uungoe户tles尸c)nogs哗一__-b)Tigerd)Cou吕arSallle:b)Falseb)ImPalasd)川1 oftheabove4·The strongestgfthela)He硕ngand滋沙tfive senses.弓and tollellal,ec)Smell and sigllt5 .How doAsianld)Hearing and smelllions din七r ftom Af行eanlions?.中伪瓣脚a)They珊bi鲜犷娜厂今c)Haveb)Livein larger怪黔珍{d)Havelargerears一1一‘一一‘6 .snow leopards roarl疏au other bigoa比:李_缘氛抵__少,False1.最大的大猫留种是:a)狮子c)一的-1一老虎美洲狮b)d)所有老虎身上的花纹都是一样的:对b)错豹吃坑螂的足 「泽丫高角羚2. a)3司c)狗4.豹的五种的听觉和视以上的一切一...展开更多
Amazing Uoggie Facts:·Hairless dogs don't pant to cool off. They sweat!·A dog's mouth has fewer bacteria than a human's mouth.·Dogs should not be bathed too frequently as its skin and coat m...Amazing Uoggie Facts:·Hairless dogs don't pant to cool off. They sweat!·A dog's mouth has fewer bacteria than a human's mouth.·Dogs should not be bathed too frequently as its skin and coat may become too dry.·A dog's sense of smell is more than 100 times greater than that展开更多
文摘You know that a rooster goes cock-a-doodle-doo in most English-speaking countries. But do you know that roosters in other countries make all sorts of different "sounds"? In Russia, a rooster goes Kukuriki. In Japan, it goes Kokekock-kom; in France, it goes Cocorico and in Germany, it goes Kikeriki. In Singapore, we say a cat goes Meow. In Ja-
文摘Do you know that…1.A lobstar’s teeth are in its stomach.2.A snail can sleep for three years.3.A seagull can drink seawater because it has special glands that filter out the salt.4.Fleas can accelerate 50 times faster than the space shuttle.
基金Supported by National Children’s Research Centre/Children’s Medical Research Foundation,Ireland
文摘AIM: To determine if hyperpolarisation-activated nucleotide-gated(HCN) channels exist in human colon, and to investigate the expression of HCN channels in Hirschsprung's disease.METHODS:We investigated HCN1,HCN2,HCN3 and HCN4 protein expression in pull-through specimens from patients with Hirschsprung’s disease(HSCR,n=10)using the proximal-most ganglionic segment and distalmost aganglionic segment,as well as in healthy control specimens obtained at the time of sigmoid colostomy closure in children who had undergone anorectoplasty for imperforate anus(n=10).Fluorescent immunohistochemistry was performed to assess protein distribution,which was then visualized using confocal microscopy.RESULTS:No HCN1 channel expression was observed in any of the tissues studied.Both HCN2 and HCN4proteins were found to be equally expressed in the aganglionic and ganglionic bowel in HSCR and controls.HCN3 channel expression was found to be markedly decreased in the aganglionic colon vs ganglionic colon and controls.HCN2-4 channels were seen to be expressed within neurons of the myenteric and submucosal plexus of the ganglionic bowel and normal controls,and also co-localised to interstitial cells of Cajal in all tissues studied.CONCLUSION:We demonstrate HCN channel expression in human colon for the first time.Reduced HCN3expression in aganglionic bowel suggests its potential role in HSCR pathophysiology.
文摘1.The largest of the biga)Lioneats 15 the:c)LeoPard2. Alltige鲜s吻叭arethea)True:气介-a)Uungoe户tles尸c)nogs哗一__-b)Tigerd)Cou吕arSallle:b)Falseb)ImPalasd)川1 oftheabove4·The strongestgfthela)He硕ngand滋沙tfive senses.弓and tollellal,ec)Smell and sigllt5 .How doAsianld)Hearing and smelllions din七r ftom Af行eanlions?.中伪瓣脚a)They珊bi鲜犷娜厂今c)Haveb)Livein larger怪黔珍{d)Havelargerears一1一‘一一‘6 .snow leopards roarl疏au other bigoa比:李_缘氛抵__少,False1.最大的大猫留种是:a)狮子c)一的-1一老虎美洲狮b)d)所有老虎身上的花纹都是一样的:对b)错豹吃坑螂的足 「泽丫高角羚2. a)3司c)狗4.豹的五种的听觉和视以上的一切一...
文摘Amazing Uoggie Facts:·Hairless dogs don't pant to cool off. They sweat!·A dog's mouth has fewer bacteria than a human's mouth.·Dogs should not be bathed too frequently as its skin and coat may become too dry.·A dog's sense of smell is more than 100 times greater than that
