Porous metal–organic frameworks(MOFs) have been recently discovered to be efficient catalysts for energy applications and green technologies. Here, we report on a scalable catalytic platform using Cu–based MOFs for ...Porous metal–organic frameworks(MOFs) have been recently discovered to be efficient catalysts for energy applications and green technologies. Here, we report on a scalable catalytic platform using Cu–based MOFs for electrocatalytic alkaline hydrogen evolution reaction. First, the solvothermal synthesis of Cu–BTC MOFs(BTC = 1,3,5–benzenetricarboxylate) at 85 ℃ and a 1:60 ligand–to–solvent ratio allowed for minimizing the chemical consumption. Second, the obtained platform demonstrated enhanced electrochemical performance compared with commercially available Cu–based MOFs, with a potential of –230 versus –232 eV, logarithm of the current density of –3.6 versus –4.2 cm2, and electrochemical surface area of 75 versus 25 cm2per cm2of geometric area, respectively. Morphological and Raman analyses also revealed that the high concentration of defects in the obtained submicron Cu–BTC MOFs can contribute to their improved catalytic performance. Thus, our findings pave the way to the low–cost synthesis of energy–efficient MOF–based catalysts for hydrogen production.展开更多
Melanoma,a highly malignant and complex form of cancer,has increased in global incidence,with a growing number of new cases annually.Active targeting strategies,such as leveraging theα-melanocyte-stimulating hormone(...Melanoma,a highly malignant and complex form of cancer,has increased in global incidence,with a growing number of new cases annually.Active targeting strategies,such as leveraging theα-melanocyte-stimulating hormone(αMSH)and its interaction with the melanocortin 1 receptor(MC1R)overexpressed in melanoma cells,enhance the concentration of therapeutic agents at tumor sites.For instance,targeted delivery of plasmonic light-sensitive agents and precise hyperthermia management provide an effective,minimally invasive treatment for tumors.In this work,we present a comparative study on targeted photothermal therapy(PTT)using plasmonic gold nanorods(Au NRs)as a robust and safe nanotool to reveal how key treatment parameters affect therapy outcomes.Using an animal model(B16-F10)of melanoma tumors,we compare the targeting abilities of Au NRs modified with two different MC1R agonists,either closely mimicking theαMSH sequence or providing a superior functionalization extent of Au NRs(4.5%(w/w)versus 1.8%(w/w)),revealing 1.6 times better intratumoral localization.Following theoretical and experimental assessments of the heating capabilities of the developed Au NRs under laser irradiation in either the femtosecond(FS)-or nanosecond(NS)-pulsed regime,we perform targeted PTT employing two types of peptide-modified Au NRs and compare therapeutic outcomes revealing the most appropriate PTT conditions.Our investigation reveals greater heat release from Au NRs under irradiation with FS laser,due to the relaxation rates of the electron and phonon temperatures dissipating in the surrounding,which correlates with a more pronounced 17.6 times inhibition of tumor growth when using FS-pulsed regime.展开更多
基金This work was supported by Russian Science Foundation(22-73-10069“Design and application of fl exible Metal organic frameworks for photonics devices,”the chemical part and structural analysis of developed MOFs)The of stability MOFs was conducted under the fi nancial support of the Ministry of Science and Higher Education of the Russian Federation as part of the World-Class Research Center program:Advanced Digital Technologies(contract No.075-15-2022-311 dated 20.04.2022)The authors thank the Engineering Centre of Saint Petersburg State Institute of Technology for PXRD analysis.
文摘Porous metal–organic frameworks(MOFs) have been recently discovered to be efficient catalysts for energy applications and green technologies. Here, we report on a scalable catalytic platform using Cu–based MOFs for electrocatalytic alkaline hydrogen evolution reaction. First, the solvothermal synthesis of Cu–BTC MOFs(BTC = 1,3,5–benzenetricarboxylate) at 85 ℃ and a 1:60 ligand–to–solvent ratio allowed for minimizing the chemical consumption. Second, the obtained platform demonstrated enhanced electrochemical performance compared with commercially available Cu–based MOFs, with a potential of –230 versus –232 eV, logarithm of the current density of –3.6 versus –4.2 cm2, and electrochemical surface area of 75 versus 25 cm2per cm2of geometric area, respectively. Morphological and Raman analyses also revealed that the high concentration of defects in the obtained submicron Cu–BTC MOFs can contribute to their improved catalytic performance. Thus, our findings pave the way to the low–cost synthesis of energy–efficient MOF–based catalysts for hydrogen production.
基金Part of this work related to the synthesis of nanomaterials by the Russian Science Foundation(project no.24-75-10006)Part of this work related to the biological experiments was supported by the Russian Science Foundation(project no.21-75-30020)+4 种基金Part of this work related to the characterization of nanomaterials was supported by the Ministry of Science and Higher Education of Russia(grant number 075-15-2021-1349)The authors acknowledge the Clover Program and the Priority 2030 Federal Academic Leadership ProgramThe authors acknowledge Lidia Pogorelskaya for the proof-reading of the manuscriptThe authors acknowledge the Nanotechnology Centre of SPbSU for electron microscopy studiesThe work was partially performed at the ITMO Core Facility Center“Nanotechnologies”.
文摘Melanoma,a highly malignant and complex form of cancer,has increased in global incidence,with a growing number of new cases annually.Active targeting strategies,such as leveraging theα-melanocyte-stimulating hormone(αMSH)and its interaction with the melanocortin 1 receptor(MC1R)overexpressed in melanoma cells,enhance the concentration of therapeutic agents at tumor sites.For instance,targeted delivery of plasmonic light-sensitive agents and precise hyperthermia management provide an effective,minimally invasive treatment for tumors.In this work,we present a comparative study on targeted photothermal therapy(PTT)using plasmonic gold nanorods(Au NRs)as a robust and safe nanotool to reveal how key treatment parameters affect therapy outcomes.Using an animal model(B16-F10)of melanoma tumors,we compare the targeting abilities of Au NRs modified with two different MC1R agonists,either closely mimicking theαMSH sequence or providing a superior functionalization extent of Au NRs(4.5%(w/w)versus 1.8%(w/w)),revealing 1.6 times better intratumoral localization.Following theoretical and experimental assessments of the heating capabilities of the developed Au NRs under laser irradiation in either the femtosecond(FS)-or nanosecond(NS)-pulsed regime,we perform targeted PTT employing two types of peptide-modified Au NRs and compare therapeutic outcomes revealing the most appropriate PTT conditions.Our investigation reveals greater heat release from Au NRs under irradiation with FS laser,due to the relaxation rates of the electron and phonon temperatures dissipating in the surrounding,which correlates with a more pronounced 17.6 times inhibition of tumor growth when using FS-pulsed regime.
