Three mesoporous silica excipients （Syloid~ silicas AL-1 FR XDP 3050 and XDP 3150） were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent ...Three mesoporous silica excipients （Syloid~ silicas AL-1 FR XDP 3050 and XDP 3150） were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although other forms of mesoporous silica have been investigated in previous studies, the effect of inclusion with these specific Syloid silica based excipients and more interestingly, with phenylbutazone, is unknown. This work reports a significant enhancement for both the extent and rate of drug release for all three forms of Syloid silica at a 1：1 drug：silica ratio over a period of 30 min. An explanation for this increase was determined to be conversion to the amorphous form and an enhanced drug loading ability within the pores. Differences between the release profiles of the three silicas were concluded to be a consequence of the physicochemical differences between the three forms. Overall, this study confirms that Syloid silica based excipients can be used to enhance dissolution, and potentially therefore bioavailability, for compounds with poor aqueous solubility such as phenylbutazone. In addition, it has been confirmed that drug release can be carefully tailored based on the choice of Syloid~ silica and desired release profile.展开更多
This research aims to explore the intricate nature of the association between green attitudes and well-being in theworkplace. Based on the basic human value theory, this study attempted to unearth the moderating effec...This research aims to explore the intricate nature of the association between green attitudes and well-being in theworkplace. Based on the basic human value theory, this study attempted to unearth the moderating effects of itstwo main bipolar segments, namely self-transcendence-self-enhancement and openness to change-conservation.A quantitative approach with a sample of 1,532 hospitality employees from 35 European countries was used. Wefound that a green attitude contributes to deriving employee well-being. Further, we found empirical support forthe influence of human values, in the sense that this relationship is reinforced among the workers who are morealtruistic and receptive to changes. Moreover, this research suggests strategies oriented to reduce environmentaldegradation and achieve sustainable development in the hospitality sector. This article provides ideas to cope withthe challenges posed by COVID-19, particularly in the hospitality industry seriously damaged by the pandemicwhere the future of many jobs is in jeopardy.展开更多
Hybrid cotton production through exploitation of heterosis is the only way for having vertical improvement and betterment in seed cotton yield which has been stagnated in the recent years. The current study was conduc...Hybrid cotton production through exploitation of heterosis is the only way for having vertical improvement and betterment in seed cotton yield which has been stagnated in the recent years. The current study was conducted to evaluate the performance of F2 population for studying mean performance, heterotic effects and inbreeding depression in upland cotton for polygenic traits. Parental genotypes and their F2s were sown at Khyber Pakhtunkhwa Agricultural University, Peshawar during 2010, manually. All the traits revealed highly significant (p ≤ 0.01) variations for both parents and their F2 hybrids. Mean performance for parents and their F2 hybrids is: (5.26 to 7.12 & 4.43 to 6.60) seeds locule-1, (21.10 to 28.03 & 20.40 to 28.50) seed boll-1, (32.20 to 34.80 & 32.22 to 35.05) lint% and (62.87 to 85.47 & 45.94 to 92.04) seed cotton yield plant-1, respectively. Heterotic effects found over mid parent and better parent were: 66.66% & 46.66% (seeds locule-1), 60% & 30% (seed boll-1), 43.33% & 30% (lint %) and 36.66% & 16.66% (seed cotton yield plant-1), respectively. For the parameters: seeds locule-1 (11 & 10), seeds boll-1 (2 & 1) and seed cotton yield plant-1 (3 & 1) showed positive highly significant heterosis for both mid and better parent, respectively while lint% did not reveal any positive significant heterosis. F2 populations i.e. CIM-499 × CIM-554 and CIM-554 × CIM-499 revealed highly significant heterotic effects over mid and better parent for all the traits except lint % while CIM-554 × CIM-707 showed highly significant heterotic effects for seeds locule-1 and seed cotton yield palnt-1. Positive economic heterotic effects were also exhibited by more than 50% of the F2 population i.e., 76.66% for seed locule-1, 50% for seeds boll-1, 3.33% for lint% and 20% for seed cotton yield plant-1, respectively. By comparing F2 mean values with F1s, only lint % showed (0.00% to 15.55%) maximum inbreeding depression while negligible amount of inbreeding depression was observed for the remaining traits. However, negative inbreeding depression was revealed by majority of the F2 population like 96.66% (seeds locule-1 & seeds boll-1), 60% (lint%) and 90% (seed cotton yield-1), respectively meant F2 population has shown more stability even after segregation and have exceeded the check cultivars and better parents in performance.展开更多
Crimean-Congo hemorrhagic fever is a deadly and life-threatening viral sickness spreading throughout the world with high mortality rate of 10%–40%.The causative agents are ticks which show diversity in their strains ...Crimean-Congo hemorrhagic fever is a deadly and life-threatening viral sickness spreading throughout the world with high mortality rate of 10%–40%.The causative agents are ticks which show diversity in their strains and thus it is difficult to make vaccine,however some strains are conserved which is the positive point in vaccines development.From 2012 to 2015,a total of 161 cases were confirmed for Crimean-Congo hemorrhagic fever virus in Pakistan.And from 2012 to July 2014,45 deaths were reported in the country.It is spreading sporadically in Pakistan.Mapping of endemic areas and cross-border veterinary surveillance should be developed in high risk areas and workshops should be arranged to increase public awareness about the disease.Control measures must be taken to avoid spreading of the disease to new areas.展开更多
文摘Three mesoporous silica excipients （Syloid~ silicas AL-1 FR XDP 3050 and XDP 3150） were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although other forms of mesoporous silica have been investigated in previous studies, the effect of inclusion with these specific Syloid silica based excipients and more interestingly, with phenylbutazone, is unknown. This work reports a significant enhancement for both the extent and rate of drug release for all three forms of Syloid silica at a 1：1 drug：silica ratio over a period of 30 min. An explanation for this increase was determined to be conversion to the amorphous form and an enhanced drug loading ability within the pores. Differences between the release profiles of the three silicas were concluded to be a consequence of the physicochemical differences between the three forms. Overall, this study confirms that Syloid silica based excipients can be used to enhance dissolution, and potentially therefore bioavailability, for compounds with poor aqueous solubility such as phenylbutazone. In addition, it has been confirmed that drug release can be carefully tailored based on the choice of Syloid~ silica and desired release profile.
文摘This research aims to explore the intricate nature of the association between green attitudes and well-being in theworkplace. Based on the basic human value theory, this study attempted to unearth the moderating effects of itstwo main bipolar segments, namely self-transcendence-self-enhancement and openness to change-conservation.A quantitative approach with a sample of 1,532 hospitality employees from 35 European countries was used. Wefound that a green attitude contributes to deriving employee well-being. Further, we found empirical support forthe influence of human values, in the sense that this relationship is reinforced among the workers who are morealtruistic and receptive to changes. Moreover, this research suggests strategies oriented to reduce environmentaldegradation and achieve sustainable development in the hospitality sector. This article provides ideas to cope withthe challenges posed by COVID-19, particularly in the hospitality industry seriously damaged by the pandemicwhere the future of many jobs is in jeopardy.
文摘Hybrid cotton production through exploitation of heterosis is the only way for having vertical improvement and betterment in seed cotton yield which has been stagnated in the recent years. The current study was conducted to evaluate the performance of F2 population for studying mean performance, heterotic effects and inbreeding depression in upland cotton for polygenic traits. Parental genotypes and their F2s were sown at Khyber Pakhtunkhwa Agricultural University, Peshawar during 2010, manually. All the traits revealed highly significant (p ≤ 0.01) variations for both parents and their F2 hybrids. Mean performance for parents and their F2 hybrids is: (5.26 to 7.12 & 4.43 to 6.60) seeds locule-1, (21.10 to 28.03 & 20.40 to 28.50) seed boll-1, (32.20 to 34.80 & 32.22 to 35.05) lint% and (62.87 to 85.47 & 45.94 to 92.04) seed cotton yield plant-1, respectively. Heterotic effects found over mid parent and better parent were: 66.66% & 46.66% (seeds locule-1), 60% & 30% (seed boll-1), 43.33% & 30% (lint %) and 36.66% & 16.66% (seed cotton yield plant-1), respectively. For the parameters: seeds locule-1 (11 & 10), seeds boll-1 (2 & 1) and seed cotton yield plant-1 (3 & 1) showed positive highly significant heterosis for both mid and better parent, respectively while lint% did not reveal any positive significant heterosis. F2 populations i.e. CIM-499 × CIM-554 and CIM-554 × CIM-499 revealed highly significant heterotic effects over mid and better parent for all the traits except lint % while CIM-554 × CIM-707 showed highly significant heterotic effects for seeds locule-1 and seed cotton yield palnt-1. Positive economic heterotic effects were also exhibited by more than 50% of the F2 population i.e., 76.66% for seed locule-1, 50% for seeds boll-1, 3.33% for lint% and 20% for seed cotton yield plant-1, respectively. By comparing F2 mean values with F1s, only lint % showed (0.00% to 15.55%) maximum inbreeding depression while negligible amount of inbreeding depression was observed for the remaining traits. However, negative inbreeding depression was revealed by majority of the F2 population like 96.66% (seeds locule-1 & seeds boll-1), 60% (lint%) and 90% (seed cotton yield-1), respectively meant F2 population has shown more stability even after segregation and have exceeded the check cultivars and better parents in performance.
文摘Crimean-Congo hemorrhagic fever is a deadly and life-threatening viral sickness spreading throughout the world with high mortality rate of 10%–40%.The causative agents are ticks which show diversity in their strains and thus it is difficult to make vaccine,however some strains are conserved which is the positive point in vaccines development.From 2012 to 2015,a total of 161 cases were confirmed for Crimean-Congo hemorrhagic fever virus in Pakistan.And from 2012 to July 2014,45 deaths were reported in the country.It is spreading sporadically in Pakistan.Mapping of endemic areas and cross-border veterinary surveillance should be developed in high risk areas and workshops should be arranged to increase public awareness about the disease.Control measures must be taken to avoid spreading of the disease to new areas.
