Glucose-6-phosphate dehydrogenase(G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage prevention.Erythrocytes have a predisposition towards oxidized environments due to their lack of mito...Glucose-6-phosphate dehydrogenase(G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage prevention.Erythrocytes have a predisposition towards oxidized environments due to their lack of mitochondria,giving G6 PD a major role in its stability.G6 PD deficiency(G6PDd) is the most common enzyme deficiency in humans:it affects approximately 400 million individuals worldwide.The overall G6 PDd allele frequency across malaria endemic countries is estimated to be 8%.corresponding to approximately 220 million males and 133 million females.However,there are no reports on the prevalence of G6 PDd in Andean communities where bartonellosis is prevalent.展开更多
Objective:To characterize two Achromobaeter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program.Methods:Nasopharyngeal swabs from 2 children under 1 year ...Objective:To characterize two Achromobaeter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program.Methods:Nasopharyngeal swabs from 2 children under 1 year of age with clinical suspicion of pertussis were analyzed by culture and PCR.Results:Two Achromobaeter xylosoxidans A8,closely related to Bordetella spp.were recovered from 2 patients diagnosed of pertussis,both carrying the ptxA gene and IS418 the pertussis toxin encoding gene.Subsequently,antibiotic susceptibility was evaluated by disk-diffusion method and by PCR.Conclusions:Although more detailed studies are needed,the present data highlight the possibility that Achromobaeter xylosoxidans.closely related Bordetella pertussis microorganisms and not covered under the vaccine umbrella,might also result in cases of whooping cough.Thereby further surveillance is necessary to determine the extension and relevance of their pathogenic role in order to discriminate their real public health implication.展开更多
Carrion’s disease is a neglected tropical disease caused by Bartonella bacilliformis,a vector-borne pathogen restricted to the Andean valleys of Peru,Ecuador and Colombia.Carrion’s disease is a biphasic illness;in t...Carrion’s disease is a neglected tropical disease caused by Bartonella bacilliformis,a vector-borne pathogen restricted to the Andean valleys of Peru,Ecuador and Colombia.Carrion’s disease is a biphasic illness;in the acute phase the case-fatality rate can be as high as 88%,related to high parasitemia,arriving to almost all erythrocytes,and secondary bacterial infections close related with the development of transient immunosuppression in the earlier illness phases.In addition,there are an undefined number of asymptomatic carriers that are reservoirs of the etiological agent of Carrion’s disease in endemic areas,they make take into account due to they are the perpetuators of this disease.The actual scenario of Carrion’s disease,in which the illness is arriving to new areas,due to the expansion of the vector’s distribution,suggests that now may be a crucial time to design a strategy focusing on its elimination.展开更多
文摘Glucose-6-phosphate dehydrogenase(G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage prevention.Erythrocytes have a predisposition towards oxidized environments due to their lack of mitochondria,giving G6 PD a major role in its stability.G6 PD deficiency(G6PDd) is the most common enzyme deficiency in humans:it affects approximately 400 million individuals worldwide.The overall G6 PDd allele frequency across malaria endemic countries is estimated to be 8%.corresponding to approximately 220 million males and 133 million females.However,there are no reports on the prevalence of G6 PDd in Andean communities where bartonellosis is prevalent.
基金supported by Sanoti Aventis del Perua fellowship from the program 13.of the ISCIII(grant number:CES11/012)+1 种基金a PhD fellowship of the ISCIII(FI12/00561)a fellowship from CONCYTEC/FONDECYT
文摘Objective:To characterize two Achromobaeter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program.Methods:Nasopharyngeal swabs from 2 children under 1 year of age with clinical suspicion of pertussis were analyzed by culture and PCR.Results:Two Achromobaeter xylosoxidans A8,closely related to Bordetella spp.were recovered from 2 patients diagnosed of pertussis,both carrying the ptxA gene and IS418 the pertussis toxin encoding gene.Subsequently,antibiotic susceptibility was evaluated by disk-diffusion method and by PCR.Conclusions:Although more detailed studies are needed,the present data highlight the possibility that Achromobaeter xylosoxidans.closely related Bordetella pertussis microorganisms and not covered under the vaccine umbrella,might also result in cases of whooping cough.Thereby further surveillance is necessary to determine the extension and relevance of their pathogenic role in order to discriminate their real public health implication.
基金MJP has a postdoctoral fellowship from CONCYTEC/FONDECYT[grant number:CG05-2013-FONDECYT]and Programa Nacional de Innovación para la Competitividad y Productividad(Innóvate Perú),under the contract 117-PNICP-PIAP-2015 PerúCG has a PhD fellowship of the ISCIII[FI12/00561]JR has a fellowship from the program I3,of the ISCIII[grant number:CES11/012].
文摘Carrion’s disease is a neglected tropical disease caused by Bartonella bacilliformis,a vector-borne pathogen restricted to the Andean valleys of Peru,Ecuador and Colombia.Carrion’s disease is a biphasic illness;in the acute phase the case-fatality rate can be as high as 88%,related to high parasitemia,arriving to almost all erythrocytes,and secondary bacterial infections close related with the development of transient immunosuppression in the earlier illness phases.In addition,there are an undefined number of asymptomatic carriers that are reservoirs of the etiological agent of Carrion’s disease in endemic areas,they make take into account due to they are the perpetuators of this disease.The actual scenario of Carrion’s disease,in which the illness is arriving to new areas,due to the expansion of the vector’s distribution,suggests that now may be a crucial time to design a strategy focusing on its elimination.
