Elevation of serum transaminases is a frequent cause of consultation in hepatology departments.1 The most common causes of hypertransaminasemia are alcoholic and metabolic dysfunction–associated steatotic liver disea...Elevation of serum transaminases is a frequent cause of consultation in hepatology departments.1 The most common causes of hypertransaminasemia are alcoholic and metabolic dysfunction–associated steatotic liver disease,viral infections,autoimmune liver disease,celiac disease,iron overload,Wilson’s disease,and exposure to toxic compounds,including drugs.2 Although serum biochemistry,serological methods,functional approaches,imaging techniques,and liver biopsy can help to identify the etiology of liver damage,up to 15%of hypertransaminasemia cases in adults3 and 13%in children4 remain idiopathic.展开更多
Although only 10-15%of liver cancers are cholangiocarcinomas(CCAs),which derive from the epithelial cells of the biliary tree,these cancers constitute a serious and growing health problem worldwide.The rate of mortali...Although only 10-15%of liver cancers are cholangiocarcinomas(CCAs),which derive from the epithelial cells of the biliary tree,these cancers constitute a serious and growing health problem worldwide.The rate of mortality due to this tumor is very high because CCA usually appears in aged people and very often,in more than 70%of cases,are diagnosed late because of:(I)their anatomical localization in a big organ like the liver;(II)the lack of specific symptoms during most time of their development;and(III)the absence of available accurate,specific and sensitive biomarkers(1).These characteristics reduce the rate of success of surgical resection,which is the only curative option for CCA patients,because the response of this aggressive cancer to the available pharmacological armamentarium is extremely feeble(2).This justifies the interest of many groups to identify non-invasive markers to achieve early diagnosis that also permit to distinguish CCA from non-malignant biliary diseases and from hepatocellular carcinoma(HCC),the most frequent liver cancer,which derives from hepatocytes(3).展开更多
基金funded by Instituto de Salud Carlos Ⅲ(PI22/00526),co-funded by the European Unionthe Ministry of Science and Innovation through the grant PID2022-140210OB-I00+2 种基金CIBERehd(EHD15PI05/2016)CIBEResp(ESP23PI08)the“Junta de Castilla y León”(SA113P23),Spain.
文摘Elevation of serum transaminases is a frequent cause of consultation in hepatology departments.1 The most common causes of hypertransaminasemia are alcoholic and metabolic dysfunction–associated steatotic liver disease,viral infections,autoimmune liver disease,celiac disease,iron overload,Wilson’s disease,and exposure to toxic compounds,including drugs.2 Although serum biochemistry,serological methods,functional approaches,imaging techniques,and liver biopsy can help to identify the etiology of liver damage,up to 15%of hypertransaminasemia cases in adults3 and 13%in children4 remain idiopathic.
基金Carlos III Institute of Health,Spain(PI16/00598 and PI19/00819)co-financed by European Regional Development FundMinistry of Science and Innovation,Spain(SAF2016-75197-R)Asociación Espanola Contra el Cancer,Spain(AECC-Cancer raros 2017/2020)and Centro Internacional sobre el Envejecimiento,Spain(OLD-HEPAMARKER,0348_CIE_6_E)co-financed with European Union ERDF funds.
文摘Although only 10-15%of liver cancers are cholangiocarcinomas(CCAs),which derive from the epithelial cells of the biliary tree,these cancers constitute a serious and growing health problem worldwide.The rate of mortality due to this tumor is very high because CCA usually appears in aged people and very often,in more than 70%of cases,are diagnosed late because of:(I)their anatomical localization in a big organ like the liver;(II)the lack of specific symptoms during most time of their development;and(III)the absence of available accurate,specific and sensitive biomarkers(1).These characteristics reduce the rate of success of surgical resection,which is the only curative option for CCA patients,because the response of this aggressive cancer to the available pharmacological armamentarium is extremely feeble(2).This justifies the interest of many groups to identify non-invasive markers to achieve early diagnosis that also permit to distinguish CCA from non-malignant biliary diseases and from hepatocellular carcinoma(HCC),the most frequent liver cancer,which derives from hepatocytes(3).
