Biomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections.Innovations in smart biomaterials,especially those responding to light stimuli through photocatalytic mecha-nis...Biomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections.Innovations in smart biomaterials,especially those responding to light stimuli through photocatalytic mecha-nisms,are emerging as promising solutions for activating targeted antimicrobial responses.While extensive reviews have provided insight into photocatalysis and its medical and environmental applications,limited focus has been given to solutions specifically tailored for implant contexts.The recent introduction of photocatalysis in the implant field,particularly visible-light-triggered photocatalytic coatings,represents a versatile approach to managing infections.These coatings offer on-demand reactive oxygen species generation,delivering antibacte-rial effects against a range of pathogens.Hence,this comprehensive review aims to summarize the latest ad-vancements in design principles,physicochemical modifications,and surface optimizations,along with novel research concepts towards the achievement of visible-light-triggered photocatalytic antibacterial activity.Moreover,through a systematic search,this review discusses the current state-of-the-art regarding the antimi-crobial efficacy of these biomaterials and the key factors influencing their performance,including microorganism type,photocatalyst properties,light source and intensity,and exposure time.Finally,it provides an in-depth discussion of current challenges,future directions,and regulatory considerations targeting biofilm-related implant treatments,offering guidance for future clinical adoption of multifunctional photocatalytic coatings in implant therapy.展开更多
基金supported by the State of Sao Paulo Research Foundation(FAPESP)through grants 2019/17238-6,2020/05231-4,2022/16267-5,2024/15196-2,2024/02209-9supported by the Conselho Nacional de Desenvolvimento Científico Tecnol´ogico(CNPq)(BRICS grant number 440104/2022-0 and 307471/2021-7)the Coordenaç˜ao de Aperfeiçoamento de Pessoal de Nível Superior(CAPES)(Finance Code 001).
文摘Biomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections.Innovations in smart biomaterials,especially those responding to light stimuli through photocatalytic mecha-nisms,are emerging as promising solutions for activating targeted antimicrobial responses.While extensive reviews have provided insight into photocatalysis and its medical and environmental applications,limited focus has been given to solutions specifically tailored for implant contexts.The recent introduction of photocatalysis in the implant field,particularly visible-light-triggered photocatalytic coatings,represents a versatile approach to managing infections.These coatings offer on-demand reactive oxygen species generation,delivering antibacte-rial effects against a range of pathogens.Hence,this comprehensive review aims to summarize the latest ad-vancements in design principles,physicochemical modifications,and surface optimizations,along with novel research concepts towards the achievement of visible-light-triggered photocatalytic antibacterial activity.Moreover,through a systematic search,this review discusses the current state-of-the-art regarding the antimi-crobial efficacy of these biomaterials and the key factors influencing their performance,including microorganism type,photocatalyst properties,light source and intensity,and exposure time.Finally,it provides an in-depth discussion of current challenges,future directions,and regulatory considerations targeting biofilm-related implant treatments,offering guidance for future clinical adoption of multifunctional photocatalytic coatings in implant therapy.
