Biomolecules with metals can form supramolecular nanomaterials through coordination assembly,opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine.These biomaterials h...Biomolecules with metals can form supramolecular nanomaterials through coordination assembly,opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine.These biomaterials have been considered versatile and innovative nanoagents due to their structure‒function control,biological nature,and simple preparation methods.This review article summarized the recent developments in multicomponent nanomaterials formed from metal coordination interactions with amino acids,peptides,and proteins,together with anticancer drugs,for cancer theranostics.We discussed the role of functional groups anchored in building blocks for coordination interactions,and subsequently,the types of interactions were examined from a structure‒function perspective.Amino acids with different metals and anticancer drugs forming supramolecular nanomaterials and their anticancer mechanisms were highlighted.Peptides with different metals and anticancer drugs,proteins with metals and anticancer drugs used for material formations,and anticancer activity have been discussed.Ultimately,the conclusion and future outlook for multicomponent supramolecular nanomaterials offer fundamental insights into fabrication design and precision medicine.展开更多
Background:Fourier transform infrared(FTIR)spectroscopy technique has not been used as a diagnostic tool for diabetes in clinical practice.This study was linked to structural changes in hemoglobin(Hb)in type 2 diabete...Background:Fourier transform infrared(FTIR)spectroscopy technique has not been used as a diagnostic tool for diabetes in clinical practice.This study was linked to structural changes in hemoglobin(Hb)in type 2 diabetes patients at higher levels of HbA 1C using FTIR spectroscopy.Methods::Fifty-three diabetic patients from the Bahawal Victoria Hospital,Bahawalpur,Pakistan were categorized as group A(6%<HbA 1C<7%;n=25)and group B(HbA 1C≥9%;n=28).Another group(group N)of twenty blood samples was taken from healthy people from the Islamia University Bahawalpur,Pakistan.Data from all groups were collected from January 1,2018 to March 31,2019.The structure of Hb was studied by FTIR spectroscopy and impact of glucose on the fine structure of HbA 1C was estimated.Results::Hb secondary structure erythrocyte parameters were altered by changing glucose concentrations.From FTIR spectra of all three groups it was found that Hb structure was slightly altered in group A,but significantly changed in group B(P<0.05).There was an increase inβ-sheet structure and a reduction inα-helix structure at elevated levels of HbA 1C(group B)in type 2 diabetes.Conclusion::We suggest that higher level of glycation reflected by increased HbA 1C might be a contributing factor to structural changes in Hb in type 2 diabetic patients.FTIR spectroscopy can be a novel technique to find pathogenesis in type 2 diabetes.展开更多
基金support from the Khalifa University for the start-up project(No.8474000462)support for the Functional Biomaterials Group(No.8474000624)+1 种基金support from the National Natural Science Foundation of China(Nos.22072154 and 22377127)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.2021048).
文摘Biomolecules with metals can form supramolecular nanomaterials through coordination assembly,opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine.These biomaterials have been considered versatile and innovative nanoagents due to their structure‒function control,biological nature,and simple preparation methods.This review article summarized the recent developments in multicomponent nanomaterials formed from metal coordination interactions with amino acids,peptides,and proteins,together with anticancer drugs,for cancer theranostics.We discussed the role of functional groups anchored in building blocks for coordination interactions,and subsequently,the types of interactions were examined from a structure‒function perspective.Amino acids with different metals and anticancer drugs forming supramolecular nanomaterials and their anticancer mechanisms were highlighted.Peptides with different metals and anticancer drugs,proteins with metals and anticancer drugs used for material formations,and anticancer activity have been discussed.Ultimately,the conclusion and future outlook for multicomponent supramolecular nanomaterials offer fundamental insights into fabrication design and precision medicine.
文摘Background:Fourier transform infrared(FTIR)spectroscopy technique has not been used as a diagnostic tool for diabetes in clinical practice.This study was linked to structural changes in hemoglobin(Hb)in type 2 diabetes patients at higher levels of HbA 1C using FTIR spectroscopy.Methods::Fifty-three diabetic patients from the Bahawal Victoria Hospital,Bahawalpur,Pakistan were categorized as group A(6%<HbA 1C<7%;n=25)and group B(HbA 1C≥9%;n=28).Another group(group N)of twenty blood samples was taken from healthy people from the Islamia University Bahawalpur,Pakistan.Data from all groups were collected from January 1,2018 to March 31,2019.The structure of Hb was studied by FTIR spectroscopy and impact of glucose on the fine structure of HbA 1C was estimated.Results::Hb secondary structure erythrocyte parameters were altered by changing glucose concentrations.From FTIR spectra of all three groups it was found that Hb structure was slightly altered in group A,but significantly changed in group B(P<0.05).There was an increase inβ-sheet structure and a reduction inα-helix structure at elevated levels of HbA 1C(group B)in type 2 diabetes.Conclusion::We suggest that higher level of glycation reflected by increased HbA 1C might be a contributing factor to structural changes in Hb in type 2 diabetic patients.FTIR spectroscopy can be a novel technique to find pathogenesis in type 2 diabetes.
