AIMTo investigate serum omentin and vaspin levels in cirrhotic patients;and to assess the relationship of these levels with hemostatic parameters,metabolic abnormalities,cirrhosis severity and etiology.METHODSFifty-on...AIMTo investigate serum omentin and vaspin levels in cirrhotic patients;and to assess the relationship of these levels with hemostatic parameters,metabolic abnormalities,cirrhosis severity and etiology.METHODSFifty-one cirrhotic patients(17 with portal vein thrombosis)were analyzed.Serum omentin and vaspin levels were measured with commercially available direct enzyme-linked immunosorbent assays(ELISAs).To assess platelet activity,the following tests were performed using a MULTIPLATE<sup>®</sup>PLATELET FUNCTION ANALYZER:(1)an ADP-induced platelet activation test;(2)a cyclooxygenase dependent aggregation test(ASPI test);(3)a von Willebrand factor and glycoprotein Ib-dependent aggregation(using ristocetin)test(RISTO test);and(4)a test for thrombin receptor-activating peptide-6 induced activation of the thrombin receptor,which is sensitive to IIb/IIIa receptor antagonists.RESULTSOmentin,but not vaspin,serum concentrations were significantly decreased in patients with portal vein thrombosis(PVT)(P=0.01).Prothrombin levels were significantly increased in patients with PVT(P=0.01).The thrombin receptor activating peptide(TRAP)test results were significantly lower in the PVT group(P=0.03).No significant differences in adipokines serum levels were found regarding the etiology or severity of liver cirrhosis assessed according to the Child-Pugh or Model of End-Stage Liver Disease(MELD)scores.There was a significant increase in the TRAP(P=0.03),ASPI(P=0.001)and RISTO high-test(P=0.02)results in patients with lower MELD scores.Serum omentin and vaspin levels were significantly down-regulated in patients without insulin resistance(P=0.03,P=0.02,respectively).A positive relationship between omentin and vaspin levels were found both when all of the patients were analyzed(r=0.41,P=0.01)and among those with PVT(r=0.94,P<0.001).CONCLUSIONSerum omentin levels are increased in patients without PVT.Cirrhosis origin and grade do not affect omentin and vaspin levels.The analyzed adipokines do not influence platelet activity.展开更多
Many recent studies have examined the importance of Helicobacter pylori(H. pylori) infection in the pathogenesis of the diseases outside the stomach and explored the significance of this bacterium in the pathogenesis ...Many recent studies have examined the importance of Helicobacter pylori(H. pylori) infection in the pathogenesis of the diseases outside the stomach and explored the significance of this bacterium in the pathogenesis of some metabolic and cardiovascular diseases. Recent studies have provided evidence that H. pylori is also involved in the pathogenesis of some liver diseases. Many observations have proved that H. pylori infection is important in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis and cirrhosis. The worsening of liver inflammation of different origins also occurs during H. pylori infection. Some studies have indicated that H. pylori infection induces autoimmunological diseases in the liver and biliary tract. The potential significance of this bacterium in carcinogenesis is unclear, but it is within the scope of interest of many studies. The proposed mechanisms through which H. pylori impacts the development of hepatobiliary diseases are complex and ambiguous. The importance of other Helicobacter species in the development of hepatobiliary diseases is also considered because they could lead to the development of inflammatory, fibrotic and necrotic injuries of the liver and, consequently, to hepatocellular carcinoma. However, many contrary viewpoints indicate that some evidence is not convincing, and further studies of the subject are needed. This review presents the current knowledge about the importance of H. pylori in the pathogenesis of liver and in biliary diseases.展开更多
基金Supported by Medical University of Silesia-Contract,No.KNW1-090/N/6/0
文摘AIMTo investigate serum omentin and vaspin levels in cirrhotic patients;and to assess the relationship of these levels with hemostatic parameters,metabolic abnormalities,cirrhosis severity and etiology.METHODSFifty-one cirrhotic patients(17 with portal vein thrombosis)were analyzed.Serum omentin and vaspin levels were measured with commercially available direct enzyme-linked immunosorbent assays(ELISAs).To assess platelet activity,the following tests were performed using a MULTIPLATE<sup>®</sup>PLATELET FUNCTION ANALYZER:(1)an ADP-induced platelet activation test;(2)a cyclooxygenase dependent aggregation test(ASPI test);(3)a von Willebrand factor and glycoprotein Ib-dependent aggregation(using ristocetin)test(RISTO test);and(4)a test for thrombin receptor-activating peptide-6 induced activation of the thrombin receptor,which is sensitive to IIb/IIIa receptor antagonists.RESULTSOmentin,but not vaspin,serum concentrations were significantly decreased in patients with portal vein thrombosis(PVT)(P=0.01).Prothrombin levels were significantly increased in patients with PVT(P=0.01).The thrombin receptor activating peptide(TRAP)test results were significantly lower in the PVT group(P=0.03).No significant differences in adipokines serum levels were found regarding the etiology or severity of liver cirrhosis assessed according to the Child-Pugh or Model of End-Stage Liver Disease(MELD)scores.There was a significant increase in the TRAP(P=0.03),ASPI(P=0.001)and RISTO high-test(P=0.02)results in patients with lower MELD scores.Serum omentin and vaspin levels were significantly down-regulated in patients without insulin resistance(P=0.03,P=0.02,respectively).A positive relationship between omentin and vaspin levels were found both when all of the patients were analyzed(r=0.41,P=0.01)and among those with PVT(r=0.94,P<0.001).CONCLUSIONSerum omentin levels are increased in patients without PVT.Cirrhosis origin and grade do not affect omentin and vaspin levels.The analyzed adipokines do not influence platelet activity.
文摘Many recent studies have examined the importance of Helicobacter pylori(H. pylori) infection in the pathogenesis of the diseases outside the stomach and explored the significance of this bacterium in the pathogenesis of some metabolic and cardiovascular diseases. Recent studies have provided evidence that H. pylori is also involved in the pathogenesis of some liver diseases. Many observations have proved that H. pylori infection is important in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis and cirrhosis. The worsening of liver inflammation of different origins also occurs during H. pylori infection. Some studies have indicated that H. pylori infection induces autoimmunological diseases in the liver and biliary tract. The potential significance of this bacterium in carcinogenesis is unclear, but it is within the scope of interest of many studies. The proposed mechanisms through which H. pylori impacts the development of hepatobiliary diseases are complex and ambiguous. The importance of other Helicobacter species in the development of hepatobiliary diseases is also considered because they could lead to the development of inflammatory, fibrotic and necrotic injuries of the liver and, consequently, to hepatocellular carcinoma. However, many contrary viewpoints indicate that some evidence is not convincing, and further studies of the subject are needed. This review presents the current knowledge about the importance of H. pylori in the pathogenesis of liver and in biliary diseases.
