Microfluidic-NMR spectroscopy has been extended to study the kinetics in supramolecular chemistry and molecular assembly.Kinetics of a multicomponent host-vip supramolecular system containing viologen derivatives, ...Microfluidic-NMR spectroscopy has been extended to study the kinetics in supramolecular chemistry and molecular assembly.Kinetics of a multicomponent host-vip supramolecular system containing viologen derivatives, β-cyclodextrins and cucurbit[7]urils are studied by a PMMA based microfluidic chip combined with a dedicated transmission line probe for NMR detection.By combining microfluidic technology with NMR spectroscopy, the amount of material required for a full kinetic study could be minimized. This is crucial in supramolecular chemistry, which often involves highly sophisticated and synthetically costly building blocks. The small size of the microfluidic structure is crucial in bringing the time scale for kinetic monitoring down to seconds. At the same time, the transmission line NMR probe provides sufficient sensitivity to work at low(2 m M) concentrations.展开更多
It is challenging to investigate fast supramolecular processes due to the lack of appropriate characterization methods with high structural resolution.In this study,microfluidic nuclear magnetic resonance(μFNMR)spect...It is challenging to investigate fast supramolecular processes due to the lack of appropriate characterization methods with high structural resolution.In this study,microfluidic nuclear magnetic resonance(μFNMR)spectroscopy was employed to monitor the kinetics of threading and dethreading of a pseudo[6]rotaxane system.By employing high time resolutionμF-NMR,1 H and two-dimensional(2D)rotating frame nuclear Overhauser effect spectroscopy(ROESY)NMR spectra were recorded at any time point within 1.5 s after the onset of the process.This technique enabled the successful identification of kinetic intermediates and rate-determining steps,usually impossible to determine by other spectroscopic techniques.Thus,our study demonstrates the capability ofμF-NMR in investigating the mechanism of complex supramolecular systems.展开更多
基金supported by the National Basic Research Program of China (2015CB856500)the National Natural Science Foundation of China (21722304, 21573181, 91227111, 91427304)the Fundamental Research Funds for the Central Universities of China (20720160050)
文摘Microfluidic-NMR spectroscopy has been extended to study the kinetics in supramolecular chemistry and molecular assembly.Kinetics of a multicomponent host-vip supramolecular system containing viologen derivatives, β-cyclodextrins and cucurbit[7]urils are studied by a PMMA based microfluidic chip combined with a dedicated transmission line probe for NMR detection.By combining microfluidic technology with NMR spectroscopy, the amount of material required for a full kinetic study could be minimized. This is crucial in supramolecular chemistry, which often involves highly sophisticated and synthetically costly building blocks. The small size of the microfluidic structure is crucial in bringing the time scale for kinetic monitoring down to seconds. At the same time, the transmission line NMR probe provides sufficient sensitivity to work at low(2 m M) concentrations.
基金supported by the NSFC(grant nos.21991130,91427304,21573181,91227111,21971216,21722304,and 21971217)the Top-Notch Young Talents Program of China,and the Fundamental Research Funds for the Central Universities of China(grant no.20720160050)The development and construction of the NMR probe were supported in part by a Marie Curie Career Integration Grant to Marcel Utz(M.U.)by the European Commission(Projectμf-NMR)and by the European Union(EU)H2020 Project“TISuMR.”。
文摘It is challenging to investigate fast supramolecular processes due to the lack of appropriate characterization methods with high structural resolution.In this study,microfluidic nuclear magnetic resonance(μFNMR)spectroscopy was employed to monitor the kinetics of threading and dethreading of a pseudo[6]rotaxane system.By employing high time resolutionμF-NMR,1 H and two-dimensional(2D)rotating frame nuclear Overhauser effect spectroscopy(ROESY)NMR spectra were recorded at any time point within 1.5 s after the onset of the process.This technique enabled the successful identification of kinetic intermediates and rate-determining steps,usually impossible to determine by other spectroscopic techniques.Thus,our study demonstrates the capability ofμF-NMR in investigating the mechanism of complex supramolecular systems.
