Ischemic stroke is a devastating disease that affects millions of patients worldwide.Unfortunately,there are no effective medications for mitigating brain injury after ischemic stroke.TRP channels are evolutionally an...Ischemic stroke is a devastating disease that affects millions of patients worldwide.Unfortunately,there are no effective medications for mitigating brain injury after ischemic stroke.TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury.To date,many members of the TRP superfamily have been reported to contribute to ischemic brain injury,including the TRPC subfamily(1,3,4,5,6,7),TRPV subfamily(1,2,3,4)and TRPM subfamily(2,4,7).These TRP channels share structural similarities but have distinct channel functions and properties.Their activation during ischemic stroke can be beneficial,detrimental,or even both.In this review,we focus on discussing the interesting features of stroke-related TRP channels and summarizing the underlying cellular and molecular mechanisms responsible for their involvement in ischemic brain injury.展开更多
基金partially supported by the National Institute of Health(R01-HL143750 and R01NS131661)American Heart Association(19TPA34890022)to LYthe Connecticut Institute for the Brain and Cognitive Sciences Seed Grant(402194)to PZ.
文摘Ischemic stroke is a devastating disease that affects millions of patients worldwide.Unfortunately,there are no effective medications for mitigating brain injury after ischemic stroke.TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury.To date,many members of the TRP superfamily have been reported to contribute to ischemic brain injury,including the TRPC subfamily(1,3,4,5,6,7),TRPV subfamily(1,2,3,4)and TRPM subfamily(2,4,7).These TRP channels share structural similarities but have distinct channel functions and properties.Their activation during ischemic stroke can be beneficial,detrimental,or even both.In this review,we focus on discussing the interesting features of stroke-related TRP channels and summarizing the underlying cellular and molecular mechanisms responsible for their involvement in ischemic brain injury.
