Fe reducing bacteria(FRB),through extracellular electron transfer(EET)pathway,can reduce Fe(III)nanoparticles,thereby affecting the migration,transformation,and degradation of pollutants.However,the interaction of Fe(...Fe reducing bacteria(FRB),through extracellular electron transfer(EET)pathway,can reduce Fe(III)nanoparticles,thereby affecting the migration,transformation,and degradation of pollutants.However,the interaction of Fe(III)nanoparticles with the most commonly identified FRB,Geobacter sulfurreducens PCA,remains poorly understood.Herein,we demonstrated that the synergistic role of outer membrane proteins and periplasmic proteins in the EET process for-Fe_(2)O_(3),Fe3O4,and𝛽α-FeOOH nanoparticles by construction of multiple gene knockout strain.oxpG(involved in the type II secretion system)and omcST(outer membrane c-type cytochrome)medi-ated pathways accounted for approximately 67%of the total reduction of𝛼α-Fe_(2)O_(3) nanoparticles.The residual reduction of𝛼α-Fe_(2)O_(3) nanoparticles in∆oxpG-omcST strain was likely caused by redox-active substances in cell supernatant.Conversely,the reduction of dissolved Fe(III)was almost unaffected in∆oxpG-omcST strain at the same concentration.However,at high dissolved Fe(III)concentration,the reduction significantly decreased due to the formation of Fe(III)nanoparticles,suggesting that this EET process is specific to Fe(III)nanoparticles.Overall,our study provided a more comprehensive understanding for the EET pathways between G.sulfurreducens PCA and different Fe(III)species,enriching our knowledge on the role of microorganisms in iron biogeochemical cycles and remediation strategies of pollutants.展开更多
The removal and recovery of low-concentration phosphates from water have become crucial due to the dual challenges of eutrophication and the phosphorus crisis.Herein,we engineered a highly efficient and recyclable pho...The removal and recovery of low-concentration phosphates from water have become crucial due to the dual challenges of eutrophication and the phosphorus crisis.Herein,we engineered a highly efficient and recyclable phosphate trapping agent of La_(2-x)CexO_(2)CO_(3) solid solution.The incorporation of Ce enhances the surface area and surface potential of La_(2-x)CexO_(2)CO_(3),providing abundant adsorption sites for phosphate.Surprisingly,we found that adjusting the Ce proportion affects the carbonate content,thereby influencing the anion-exchange capacity between carbonate and phosphate.Specifically,at 3% Ce content(3%-CeL),the carbonate ratio is maximized,resulting in an optimal sorption capacity(196.4mg P/g)and a rapid removal rate(under 40min)for phosphate,unaffected by interfering ions.Remarkably,3%-CeL achieved nearly 100%phosphate removal efficiency in diverse water samples from sewage treatment plants,rivers,reservoirs,and groundwater.After five adsorption-desorption cycles,the phosphate removal and recovery efficiency of 3%-CeL remained above 90%.Mechanistic studies revealed that 3%Ce content yielded the highest proportion of Ce^(4+)/Ce^(3+),enabling greater carbonate binding for anion-exchange.This study proposes a high-performance phosphate trapping agentwith broad applicability for treating actual waters and provides a new perspective on enhancing low-concentration phosphate removal in La-based materials through manipulating Ce ratio and valence.展开更多
Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China a...Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China and investigated their association with obesity.MeP,BPP,PrP,BPA,EtP,BPE,and BPC were frequently detected in more than 50%of the adipose tissues.A positive correlation between bisphenol A and body mass index(BMI)was observed in both multivariate linear regression model(β=0.87,95%confidence interval:0.21-1.53,p=0.011)and multivariate logistic regression analysis(odds ratio=1.28,95%confidence interval:1.01-1.62,0.044).Restricted cubic spline regression analysis revealed a significant nonlinear association between bisphenol P and BMI.Weighted quantile sum regression and quantile-based g-computation revealed a slight positive trend between EDCs mixed exposure and BMI,with bisphenol A as the primary contributor to the positive correlation with BMI.Our findings suggest the extensive existence of environmental EDCs in the adipose tissue of the adult Chinese population and indicate that exposure to BPA in adipose tissue may be associated with the occurrence of obesity.展开更多
Biomimetic nanozymes opens up new opportunities for sensitive,rapid and field detection of organophosphorus pesticides(OPs).However,it still remains challenges in how to improve the sensitivity and stability of biomim...Biomimetic nanozymes opens up new opportunities for sensitive,rapid and field detection of organophosphorus pesticides(OPs).However,it still remains challenges in how to improve the sensitivity and stability of biomimetic nanozymes under harsh conditions.Herein,we synthesized a novel biomimetic nanozyme composed of hemin and bovine serum albumin(BSA)in the nanopores of poly-l-lysine methacryloyl(PLMA)inverse opal hydrogel(PLMA-Hemin-BSA).PLMA-Hemin-BSA achieves superior peroxidase-like activity and shows high stability due to the confinement effect.A multi-enzyme cascade reaction was constructed for the colorimetric detection of five widely used OPs by integrating PLMAHemin-BSA with natural choline oxidase and acetylcholinesterase.The detection limits for dichlorvos,chlorpyrifos,paraoxon,methamidophos,and parathion were as low as 0.024,0.073,0.12,0.56,and 1.4 ng/mL,respectively.More importantly,the average recovery rates and the relative standard deviations(RSD)of chlorpyrifos in paddy water,soil and wheat samples were 86.62%-100.13%and 2.08%-8.65%,which meet the standard of the International Union of Pure and Applied Chemistry(IUPAC,recoveries of 70%-120%with RSD<20%).This study represented advanced methods toward enhancing the activity and stability of biomimetic nanozymes via spatial nanopores-assisted strategy.展开更多
Endocrine disruptors such as bisphenol A(BPA)adversely affect the environment and human health.Laccases are used for the efficient biodegradation of various persistent organic pollutants in an environmentally safe man...Endocrine disruptors such as bisphenol A(BPA)adversely affect the environment and human health.Laccases are used for the efficient biodegradation of various persistent organic pollutants in an environmentally safe manner.However,the direct application of free laccases is generally hindered by short enzyme lifetimes,non-reusability,and the high cost of a single use.In this study,laccases were immobilized on a novel magnetic threedimensional poly(ethylene glycol)diacrylate(PEGDA)-chitosan(CS)inverse opal hydrogel(LAC@MPEGDA@CS@IOH).The immobilized laccase showed significant improvement in the BPA degradation performance and superior storage stability compared with the free laccase.91.1%of 100 mg/L BPA was removed by the LAC@MPEGDA@CS@IOH in 3 hr,whereas only 50.6%of BPA was removed by the same amount of the free laccase.Compared with the laccase,the outstanding BPA degradation efficiency of the LAC@MPEGDA@CS@IOH was maintained over a wider range of pH values and temperatures.Moreover,its relative activity of was maintained at 70.4%after 10 cycles,and the system performed well in actual water matrices.This efficientmethod for preparing immobilized laccases is simple and green,and it can be used to further develop ecofriendly biocatalysts to remove organic pollutants from wastewater.展开更多
Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal ag...Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal agents associated with this change.Chemical contaminants are widespread throughout our environment and human exposure is virtually unavoidable. The overall contribution of environmental exposure to infertility is unknown, but studies involving occupational exposure, together with results from animal experiments, suggest that environmental contaminants may adversely affect fertility. We reviewed the adverse effects of environmental exposure on fertility and related reproductive outcomes. Environmental contaminants covered in this review include heavy metals, organic solvents, pesticides and endocrine disrupting chemicals. It is hoped that this review will highlight the need for further research in this area.展开更多
This study aimed to determine the effect of exposure to heavy metals in pregnant women in Beijing, China. We also evaluated the association of these heavy metals with birth weight and length of newborns. We measured t...This study aimed to determine the effect of exposure to heavy metals in pregnant women in Beijing, China. We also evaluated the association of these heavy metals with birth weight and length of newborns. We measured the levels of 10 heavy metals,including lead(Pb), titanium(Ti), manganese(Mn), nickel(Ni), cadmium(Cd), chromium(Cr), antimony(Sb), stannum(Sn), vanadium(V), and arsenic(As), in 156 maternal and cord blood pairs. An inductively coupled plasma mass spectrometry method was used for measurement. Pb, As, Ti, Mn, and Sb showed high detection rates(> 50%) in both maternal and cord blood. Fourteen(9%) mothers had blood Pb levels greater than the United States Center for Disease Control allowable threshold limit for children(50 μg/L).In prenatal exposure to these heavy metals, there was no significant association between any heavy metal and birth weight/length. Moreover, we estimated the placental transfer efficiency of each heavy metal, and the median placental transfer efficiency ranged from 49.6%(Ni) to 194%(Mn)(except for Cd and Sn). The level and detection rate of Cd in maternal blood were much higher than that in cord blood, which suggested that Cd had difficulty in passing the placental barrier. Prospective research should focus on the source and risk of heavy metals in non-occupationally exposed pregnant women in Beijing.展开更多
Many per-and polyfluoralkyl substances(PFASs)may disrupt maternal thyroid hormone homeostasis in pregnancy.Concerns should be raised regarding the PFASs exposure in pregnant women because thyroid hormones are involved...Many per-and polyfluoralkyl substances(PFASs)may disrupt maternal thyroid hormone homeostasis in pregnancy.Concerns should be raised regarding the PFASs exposure in pregnant women because thyroid hormones are involved in the early development of the fetus.In this study,we measured the concentrations of 13 PFASs,including five novel shortchain PFASs,in serum from 123 pregnant women in Beijing,China.Linear regression models were used to investigate the association between thyroid-stimulating hormone(TSH)or free thyroxine(FT4)levels and PFASs concentrations under consideration of the impacts of pregnancy-induced physiological factors.We found that perfluorobutanoic acid(PFBA)(β=0.189,95%CI=-0.039,0.417,p=0.10)and perfluorodecanoic acid(PFDA)(β=-0.554,95%CI=-1.16,0.049,p=0.071)were suggestive of significant association with TSH in thyroid peroxidase antibody(TPOAb)negative women.No association was observed between all PFASs and FT4 levels after controlling for these confounding factors,such as BMI,gestational weight gain and maternal age.These findings suggest that it should pay more attention to the association between thyroid hormone levels and short-chain PFASs concentrations.Future studies could consider a greater sample and the inclusion of other clinical indicators of thyroid function,such as free T3 and total T3.展开更多
Dark formation of hydroxyl radical upon oxidation of reduced iron minerals plays an important role in the degradation and transformation of organic and inorganic pollutants.Herein,we compared the hydroxyl radical form...Dark formation of hydroxyl radical upon oxidation of reduced iron minerals plays an important role in the degradation and transformation of organic and inorganic pollutants.Herein,we compared the hydroxyl radical formation from various reduced iron minerals at different redox conditions.·OH production was generally observed from the oxidation of reduced iron minerals,following the order:mackinawite(FeS)>reduced nontronite(iron-bearing smectite clay)> pyrite(FeS2)> side rite(FeCO3).Structural Fe^2+ and dissolved O2 play critical roles in ·OH production from reduced iron minerals.·OH production increases with decreasing pH,and Cl^-has little effect on this process.More importantly,dissolved organic matter significantly enhances ·OH production,especially under O2 purging,highlighting the importance of this process in ambient environments.This sunlight-independent pathway in which ’OH forms during oxidation of reduced iron minerals is helpful for understanding the degradation and transformation of various inorganic and organic pollutants in the redox-fluctuation environments.展开更多
Bacterial infections have become a great threat to public health in recent years.A primary lysozyme is a natural antimicrobial protein;however,its widespread application is limited by its instability.Here,we present a...Bacterial infections have become a great threat to public health in recent years.A primary lysozyme is a natural antimicrobial protein;however,its widespread application is limited by its instability.Here,we present a poly(N-isopropylacrylamide)hydrogel inverse opal particle(PHIOP)as a microcarrier of lysozyme to prolong and enhance the efficiency against bacteria.This PHIOP-based lysozyme(PHIOP-Lys)formulation is temperature-responsive and exhibits long-term sustained release of lysozyme for up to 16 days.It shows a potent antibacterial effect toward both Escherichia coli and Staphylococcus aureus,which is even higher than that of free lysozyme in solution at the same concentration.PHIOPs-Lys were demonstrated to effectively inhibit bacterial infections and enhance wound healing in a full-thickness skin wound rat model.This study provides a novel pathway for prolonging the enzymatic activity and antibacterial effects of lysozyme.展开更多
The biogeochemical transformation of gold(Au),i.e.its dissolution and re-precipitation,is critical in supergene transport of Au and formation of Au granules.Besides biogenic reduction,the formation Au granules can als...The biogeochemical transformation of gold(Au),i.e.its dissolution and re-precipitation,is critical in supergene transport of Au and formation of Au granules.Besides biogenic reduction,the formation Au granules can also be driven by chemical processes.Previous studies have showed the fo rmation of Au nanoparticles(AuNPs)from ionic Au(Ⅲ)can be mediated by dissolved organic matter under sunlight.In this letter,we further demonstrated that these AuNPs can further slowly(in years)grow into visible Au granules.Different sized nano-flower and fractal dendrite-like branched gold structures(from tens of nanometres to over 100μm)were observed in the Au granule sample.This growth of AuNPs into visible Au granules may play a critical role in the supergene mineralization and enrichment of secondary Au and drive the biogeochemical cycle of Au.展开更多
The rapid deactivation of cost-effective MnO_(2)-based catalysts in humid air limits their application in practice,and the identification of the role of water in an oxidation process is significant for developing wate...The rapid deactivation of cost-effective MnO_(2)-based catalysts in humid air limits their application in practice,and the identification of the role of water in an oxidation process is significant for developing water-resistant MnO_(2)-based catalysts.Here,CuMnO_(2)showed a20.3%HCHO conversion in 10 hr at room temperature in humid air with relative humidity of 40%,but deactivated in 3 hr in dry air.The excellent activity and stability of HCHO oxidation in humid air were attributed to the positive effect of H_(2)O on HCHO oxidation to the H_(2)O-HOCH_(2)OH supermolecule assemblies via hydrogen bonds formed on CuMnO_(2).H_(2)O-HOCH_(2)OH supermolecule assemblies tend to be oxidized to carbonate,which is further oxidized to CO_(2).Furthermore,CuMnO_(2)exhibited a much poorer activity of CO oxidation in humid air,but the CO conversion was still 100%in 10 hr in dry air.H_(2)O showed a competitive adsorption effect to CO on CuMnO_(2).CuMnO_(2)could be applied in HCHO elimination in humid air and CO elimination in dry air.展开更多
Microplastics are ubiquitous in the global environment.As a typical emerging pollutant,its potential health hazards have been widely concerning.In this brief paper,we introduce the source,identification,toxicity,and h...Microplastics are ubiquitous in the global environment.As a typical emerging pollutant,its potential health hazards have been widely concerning.In this brief paper,we introduce the source,identification,toxicity,and health hazard of microplastics in the human.The literature review shows that microplastics are frequently detected in environmental and human samples.Humans are potentially exposed to microplastics through oral intake,inhalation,and skin contact.We summarize the toxic effects of microplastics in experimental models like cells,organoids,and animals.These effects consist of oxidative stress,DNA damage,organ dysfunction,metabolic disorder,immune response,neurotoxicity,as well as reproductive and developmental toxicity.In addition,the epidemiological evidence suggests that a variety of chronic diseases may be related to microplastics exposure.Finally,we put forward the gaps in toxicity research of microplastics and their future development directions.This review will be helpful to the understanding of the exposure risk and potential health hazards of microplastics.展开更多
Global attention on microplastics has increased because of their ubiquity in water,air,soil,and organisms.(1−4)Knowledge of the sources,occurrences,behaviors,and health risks of microplastics is quite limited.(5−7)Nev...Global attention on microplastics has increased because of their ubiquity in water,air,soil,and organisms.(1−4)Knowledge of the sources,occurrences,behaviors,and health risks of microplastics is quite limited.(5−7)Nevertheless,developing comprehensive health-based thresholds and regulatory guidelines for microplastics in water is impossible because of the limitations and complexity of determining their health effects.Writing in Environment&Health,Chowdhury et al.reported a“Threshold Microplastics Concentration”(TMC)concept and framework.(8)The TMC framework was used to identify microplastic concentrations that may result in the intake of regulated contaminants on/in microplastics at levels of human health concern and treatment targets for managing those potential risks.展开更多
Due to the relentless exploitation of non-renewable resources,humanity is faced with a resource depletion crisis in the coming decades and serious environmental issues.Achieving efficient removal and upcycling of poll...Due to the relentless exploitation of non-renewable resources,humanity is faced with a resource depletion crisis in the coming decades and serious environmental issues.Achieving efficient removal and upcycling of pollutants(ERUP)may become a potential strategy to address these issues.Wastewater,characterized by its large production volume and fluidity,can easily cause widespread environmental pollution through natural water networks.Due to solubility constraints,pollutants in wastewater typically exhibit low concentrations and complex compositions,thereby impeding effective recovery.Therefore,achieving ERUP in wastewater is both highly significant and extremely challenging.Unlike conventional wastewater treatment strategies that are focused on removing pollutants,ERUP strategies can not only realize the efficient removal of pollutants from water but also convert pollutants into valuable and functional products.Herein,we enumerated the latest research progress on ERUP in wastewater and highlighted studies that demonstrate the simultaneous achievement of pollutant removal and the direct conversion of these contaminants into high-efficiency catalysts,hydrogen energy,electrical energy,and other high-value chemicals.Finally,we identified the problems and challenges in the development of ERUP in wastewater and outlined potential research directions for future studies.展开更多
Microbial bioelectrochemical system(BES)is a promising sustainable technology for the electrical energy recovery and the treatment of recalcitrant and toxic pollutants.In microbial BESs,the conversion of harmful pollu...Microbial bioelectrochemical system(BES)is a promising sustainable technology for the electrical energy recovery and the treatment of recalcitrant and toxic pollutants.In microbial BESs,the conversion of harmful pollutants into harmless products can be catalyzed by microorganisms at the anode(Type I BES),chemical catalysts at the cathode(Type II BES)or microorganisms at the cathode(Type III BES).The application of synthetic biology in microbial BES can improve its pollutant removing capability.Synthetic biology techniques can promote EET kinetics,which is helpful for microbial anodic electro-respiration,expediting pollutant removing not only at the anode but also at the cathode.They offer tools to promote biofilm development on the electrode,enabling more microorganisms residing on the electrode for subsequent catalytic reactions,and to overexpress the pollutant removing-related genes directly in microorganisms,contributing to the pollutant decomposition.In this work,based on the summarized aspects mentioned above,we describe the major synthetic biology strategies in designing and improving the pollutant removing capabilities of microbial BES.Lastly,we discuss challenges and perspectives for future studies in the area.展开更多
Industrial expansion and population growth stimulates the utilization of natural resources and energy.It inevitably leads to environmental pollution with various pollutants like heavy metals,pesticide and xenobiotics....Industrial expansion and population growth stimulates the utilization of natural resources and energy.It inevitably leads to environmental pollution with various pollutants like heavy metals,pesticide and xenobiotics.Synthetic biology is an interdisciplinary field involving designation,construction,and manipulation of biological parts or devices in chassis and organisms for diverse purposes.It’s a promising alternative for synthetic biotechnology to overcome the global environmental issues by engineering microorganisms.展开更多
Introduction Microplastics(MPs)and nanoplastics(NPs)have become emerging particulate contaminants,(1−3)being detected worldwide from the Antarctic(4)to the Arctic,(5)and from the marine trenches(6)to the plateaus.(7)M...Introduction Microplastics(MPs)and nanoplastics(NPs)have become emerging particulate contaminants,(1−3)being detected worldwide from the Antarctic(4)to the Arctic,(5)and from the marine trenches(6)to the plateaus.(7)Most micro-and nanoplastics(MNPs)in the environment can be attributed to the large-scale manufacture,use,and improper management of plastic products.By 2050,the worldwide production of plastics will reach approximately 1 billion tons,(8)suggesting that MNP pollution will be one of the most serious global ecological hazards in the future.展开更多
In recent years,the environmental and health impacts ofnanoplastics have garnered significant attention,often portrayed as a novel and distinct threat.1−3 However,a groundbreaking study by Yan et al.challenges this na...In recent years,the environmental and health impacts ofnanoplastics have garnered significant attention,often portrayed as a novel and distinct threat.1−3 However,a groundbreaking study by Yan et al.challenges this narrative,arguing that the toxicity of nanoplastics is fundamentally a subset of the well-established field of nanotoxicology.4 Through extensive data mining,machine learning,and molecular dynamics simulations,the authors demonstrate that nanoplastics and engineered nanoparticles(ENPs)share striking similarities in their physicochemical properties,environmental behaviors,biological interactions,and toxicity profiles.This revelation calls for a paradigm shift in how nanoplastics research is conducted,advocating for the integration of this field into the broader nanotoxicology framework to avoid redundant efforts and accelerate the development of sustainable solutions.展开更多
基金supported by the National Key Research and Development Project(No.2020YFA0907500)the National Natural Science Foundation of China(No.22476206)+1 种基金the supports from the National Young Top-Notch Talents(No.W03070030)Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.Y202011).
文摘Fe reducing bacteria(FRB),through extracellular electron transfer(EET)pathway,can reduce Fe(III)nanoparticles,thereby affecting the migration,transformation,and degradation of pollutants.However,the interaction of Fe(III)nanoparticles with the most commonly identified FRB,Geobacter sulfurreducens PCA,remains poorly understood.Herein,we demonstrated that the synergistic role of outer membrane proteins and periplasmic proteins in the EET process for-Fe_(2)O_(3),Fe3O4,and𝛽α-FeOOH nanoparticles by construction of multiple gene knockout strain.oxpG(involved in the type II secretion system)and omcST(outer membrane c-type cytochrome)medi-ated pathways accounted for approximately 67%of the total reduction of𝛼α-Fe_(2)O_(3) nanoparticles.The residual reduction of𝛼α-Fe_(2)O_(3) nanoparticles in∆oxpG-omcST strain was likely caused by redox-active substances in cell supernatant.Conversely,the reduction of dissolved Fe(III)was almost unaffected in∆oxpG-omcST strain at the same concentration.However,at high dissolved Fe(III)concentration,the reduction significantly decreased due to the formation of Fe(III)nanoparticles,suggesting that this EET process is specific to Fe(III)nanoparticles.Overall,our study provided a more comprehensive understanding for the EET pathways between G.sulfurreducens PCA and different Fe(III)species,enriching our knowledge on the role of microorganisms in iron biogeochemical cycles and remediation strategies of pollutants.
基金supported by the National Key Research and Development Program of China(Nos.2022YFC3703700,2021YFA0910300,and 2021YFC3200902)the National Natural Science Foundation of China(No.22125606)+1 种基金the Special Project of Ecological Environmental Technology for Carbon Dioxide Emissions Peak and Carbon Neutrality(No.RCEESTDZ-2021-21)China South-to-North Water Diversion Corporation Limited Research Project(No.NSBDZX/SH/KY/2022-001).
文摘The removal and recovery of low-concentration phosphates from water have become crucial due to the dual challenges of eutrophication and the phosphorus crisis.Herein,we engineered a highly efficient and recyclable phosphate trapping agent of La_(2-x)CexO_(2)CO_(3) solid solution.The incorporation of Ce enhances the surface area and surface potential of La_(2-x)CexO_(2)CO_(3),providing abundant adsorption sites for phosphate.Surprisingly,we found that adjusting the Ce proportion affects the carbonate content,thereby influencing the anion-exchange capacity between carbonate and phosphate.Specifically,at 3% Ce content(3%-CeL),the carbonate ratio is maximized,resulting in an optimal sorption capacity(196.4mg P/g)and a rapid removal rate(under 40min)for phosphate,unaffected by interfering ions.Remarkably,3%-CeL achieved nearly 100%phosphate removal efficiency in diverse water samples from sewage treatment plants,rivers,reservoirs,and groundwater.After five adsorption-desorption cycles,the phosphate removal and recovery efficiency of 3%-CeL remained above 90%.Mechanistic studies revealed that 3%Ce content yielded the highest proportion of Ce^(4+)/Ce^(3+),enabling greater carbonate binding for anion-exchange.This study proposes a high-performance phosphate trapping agentwith broad applicability for treating actual waters and provides a new perspective on enhancing low-concentration phosphate removal in La-based materials through manipulating Ce ratio and valence.
基金supported by the National Natural Science Foundation of China(Nos.22125606 and 22241604)the Chinese Academy of Sciences Project of Young Scientists in Basic Research(No.YSBR-086).
文摘Bio-accumulation of endocrine-disrupting chemicals(EDCs)in human body may result in various adverse health effects.This study measured the levels of 16 EDCs in the visceral adipose tissue of 55 participants in China and investigated their association with obesity.MeP,BPP,PrP,BPA,EtP,BPE,and BPC were frequently detected in more than 50%of the adipose tissues.A positive correlation between bisphenol A and body mass index(BMI)was observed in both multivariate linear regression model(β=0.87,95%confidence interval:0.21-1.53,p=0.011)and multivariate logistic regression analysis(odds ratio=1.28,95%confidence interval:1.01-1.62,0.044).Restricted cubic spline regression analysis revealed a significant nonlinear association between bisphenol P and BMI.Weighted quantile sum regression and quantile-based g-computation revealed a slight positive trend between EDCs mixed exposure and BMI,with bisphenol A as the primary contributor to the positive correlation with BMI.Our findings suggest the extensive existence of environmental EDCs in the adipose tissue of the adult Chinese population and indicate that exposure to BPA in adipose tissue may be associated with the occurrence of obesity.
基金supported by the National Natural Science Foundation of China(Nos.22125606 and 22241604)Chinese Academy of Sciences Project for Young Scientists in Basic Research(No.YSBR-086)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(No.XBD0750000)the Research Start-up Funding Project of Kashi University(No.GCC2024ZK-014)。
文摘Biomimetic nanozymes opens up new opportunities for sensitive,rapid and field detection of organophosphorus pesticides(OPs).However,it still remains challenges in how to improve the sensitivity and stability of biomimetic nanozymes under harsh conditions.Herein,we synthesized a novel biomimetic nanozyme composed of hemin and bovine serum albumin(BSA)in the nanopores of poly-l-lysine methacryloyl(PLMA)inverse opal hydrogel(PLMA-Hemin-BSA).PLMA-Hemin-BSA achieves superior peroxidase-like activity and shows high stability due to the confinement effect.A multi-enzyme cascade reaction was constructed for the colorimetric detection of five widely used OPs by integrating PLMAHemin-BSA with natural choline oxidase and acetylcholinesterase.The detection limits for dichlorvos,chlorpyrifos,paraoxon,methamidophos,and parathion were as low as 0.024,0.073,0.12,0.56,and 1.4 ng/mL,respectively.More importantly,the average recovery rates and the relative standard deviations(RSD)of chlorpyrifos in paddy water,soil and wheat samples were 86.62%-100.13%and 2.08%-8.65%,which meet the standard of the International Union of Pure and Applied Chemistry(IUPAC,recoveries of 70%-120%with RSD<20%).This study represented advanced methods toward enhancing the activity and stability of biomimetic nanozymes via spatial nanopores-assisted strategy.
基金supported by the National Key Research and Development Program of China(Nos.2022YFC3703700 and 2021YFA0910300)the National Natural Science Foundation of China(No.22125606)the Special Project of Ecological Environmental Technology for Carbon Dioxide Emissions Peak and Carbon Neutrality(No.RCEES-TDZ-2021-21).
文摘Endocrine disruptors such as bisphenol A(BPA)adversely affect the environment and human health.Laccases are used for the efficient biodegradation of various persistent organic pollutants in an environmentally safe manner.However,the direct application of free laccases is generally hindered by short enzyme lifetimes,non-reusability,and the high cost of a single use.In this study,laccases were immobilized on a novel magnetic threedimensional poly(ethylene glycol)diacrylate(PEGDA)-chitosan(CS)inverse opal hydrogel(LAC@MPEGDA@CS@IOH).The immobilized laccase showed significant improvement in the BPA degradation performance and superior storage stability compared with the free laccase.91.1%of 100 mg/L BPA was removed by the LAC@MPEGDA@CS@IOH in 3 hr,whereas only 50.6%of BPA was removed by the same amount of the free laccase.Compared with the laccase,the outstanding BPA degradation efficiency of the LAC@MPEGDA@CS@IOH was maintained over a wider range of pH values and temperatures.Moreover,its relative activity of was maintained at 70.4%after 10 cycles,and the system performed well in actual water matrices.This efficientmethod for preparing immobilized laccases is simple and green,and it can be used to further develop ecofriendly biocatalysts to remove organic pollutants from wastewater.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14010300)the Beijing Municipal Science and Technology Commission(No.Z151100004015167)+1 种基金the Beijing Municipal Health Technology High-level Talent Project(No.2014-3-076)the Open fund of State Key Laboratory of Environmental Chemistry and Ecotoxicology(No.KF-2017-13)
文摘Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal agents associated with this change.Chemical contaminants are widespread throughout our environment and human exposure is virtually unavoidable. The overall contribution of environmental exposure to infertility is unknown, but studies involving occupational exposure, together with results from animal experiments, suggest that environmental contaminants may adversely affect fertility. We reviewed the adverse effects of environmental exposure on fertility and related reproductive outcomes. Environmental contaminants covered in this review include heavy metals, organic solvents, pesticides and endocrine disrupting chemicals. It is hoped that this review will highlight the need for further research in this area.
基金supported by the National Natural Science Foundation of China (No. 21677170)the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB14010300)
文摘This study aimed to determine the effect of exposure to heavy metals in pregnant women in Beijing, China. We also evaluated the association of these heavy metals with birth weight and length of newborns. We measured the levels of 10 heavy metals,including lead(Pb), titanium(Ti), manganese(Mn), nickel(Ni), cadmium(Cd), chromium(Cr), antimony(Sb), stannum(Sn), vanadium(V), and arsenic(As), in 156 maternal and cord blood pairs. An inductively coupled plasma mass spectrometry method was used for measurement. Pb, As, Ti, Mn, and Sb showed high detection rates(> 50%) in both maternal and cord blood. Fourteen(9%) mothers had blood Pb levels greater than the United States Center for Disease Control allowable threshold limit for children(50 μg/L).In prenatal exposure to these heavy metals, there was no significant association between any heavy metal and birth weight/length. Moreover, we estimated the placental transfer efficiency of each heavy metal, and the median placental transfer efficiency ranged from 49.6%(Ni) to 194%(Mn)(except for Cd and Sn). The level and detection rate of Cd in maternal blood were much higher than that in cord blood, which suggested that Cd had difficulty in passing the placental barrier. Prospective research should focus on the source and risk of heavy metals in non-occupationally exposed pregnant women in Beijing.
基金supported by the National Key R&D Program of China (No. 2018YFA0901200)the National Natural Science Foundation of China (Nos. 21876194 and 21677170)
文摘Many per-and polyfluoralkyl substances(PFASs)may disrupt maternal thyroid hormone homeostasis in pregnancy.Concerns should be raised regarding the PFASs exposure in pregnant women because thyroid hormones are involved in the early development of the fetus.In this study,we measured the concentrations of 13 PFASs,including five novel shortchain PFASs,in serum from 123 pregnant women in Beijing,China.Linear regression models were used to investigate the association between thyroid-stimulating hormone(TSH)or free thyroxine(FT4)levels and PFASs concentrations under consideration of the impacts of pregnancy-induced physiological factors.We found that perfluorobutanoic acid(PFBA)(β=0.189,95%CI=-0.039,0.417,p=0.10)and perfluorodecanoic acid(PFDA)(β=-0.554,95%CI=-1.16,0.049,p=0.071)were suggestive of significant association with TSH in thyroid peroxidase antibody(TPOAb)negative women.No association was observed between all PFASs and FT4 levels after controlling for these confounding factors,such as BMI,gestational weight gain and maternal age.These findings suggest that it should pay more attention to the association between thyroid hormone levels and short-chain PFASs concentrations.Future studies could consider a greater sample and the inclusion of other clinical indicators of thyroid function,such as free T3 and total T3.
基金financially supported by the National Natural Science Foundation of China (No.21777178)Key Projects for Frontier Sciences of the Chinese Academy of Sciences (No.QYZDBSSWDQC018)+2 种基金the CAS Interdisciplinary Innovation Team (No. JCTD-2018-04)supports from the National Young Top-Notch Talents (No.W03070030)Youth Innovation Promotion Association of the Chinese Academy of Sciences (No. 2016037)
文摘Dark formation of hydroxyl radical upon oxidation of reduced iron minerals plays an important role in the degradation and transformation of organic and inorganic pollutants.Herein,we compared the hydroxyl radical formation from various reduced iron minerals at different redox conditions.·OH production was generally observed from the oxidation of reduced iron minerals,following the order:mackinawite(FeS)>reduced nontronite(iron-bearing smectite clay)> pyrite(FeS2)> side rite(FeCO3).Structural Fe^2+ and dissolved O2 play critical roles in ·OH production from reduced iron minerals.·OH production increases with decreasing pH,and Cl^-has little effect on this process.More importantly,dissolved organic matter significantly enhances ·OH production,especially under O2 purging,highlighting the importance of this process in ambient environments.This sunlight-independent pathway in which ’OH forms during oxidation of reduced iron minerals is helpful for understanding the degradation and transformation of various inorganic and organic pollutants in the redox-fluctuation environments.
基金This work was supported by the National Key R&D Program of China(No.2021YFA0910300)the National Natural Science Foundation of China(Nos.22125606 and 21976198)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDPB2005).
文摘Bacterial infections have become a great threat to public health in recent years.A primary lysozyme is a natural antimicrobial protein;however,its widespread application is limited by its instability.Here,we present a poly(N-isopropylacrylamide)hydrogel inverse opal particle(PHIOP)as a microcarrier of lysozyme to prolong and enhance the efficiency against bacteria.This PHIOP-based lysozyme(PHIOP-Lys)formulation is temperature-responsive and exhibits long-term sustained release of lysozyme for up to 16 days.It shows a potent antibacterial effect toward both Escherichia coli and Staphylococcus aureus,which is even higher than that of free lysozyme in solution at the same concentration.PHIOPs-Lys were demonstrated to effectively inhibit bacterial infections and enhance wound healing in a full-thickness skin wound rat model.This study provides a novel pathway for prolonging the enzymatic activity and antibacterial effects of lysozyme.
基金the National Natural Science Foundation of China(No.21777178)Key Projects for Frontier Sciences ofthe Chinese Academy of Sciences(No.QYZDB-SSWDQC018)+2 种基金the CAS Interdisciplinary Innovation Team(No.JCTD-2018-04)supports from the National Young Top-Notch Talents(No.W03070030)Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.2016037)。
文摘The biogeochemical transformation of gold(Au),i.e.its dissolution and re-precipitation,is critical in supergene transport of Au and formation of Au granules.Besides biogenic reduction,the formation Au granules can also be driven by chemical processes.Previous studies have showed the fo rmation of Au nanoparticles(AuNPs)from ionic Au(Ⅲ)can be mediated by dissolved organic matter under sunlight.In this letter,we further demonstrated that these AuNPs can further slowly(in years)grow into visible Au granules.Different sized nano-flower and fractal dendrite-like branched gold structures(from tens of nanometres to over 100μm)were observed in the Au granule sample.This growth of AuNPs into visible Au granules may play a critical role in the supergene mineralization and enrichment of secondary Au and drive the biogeochemical cycle of Au.
基金supported by the National Natural Science Foundation of China (Nos. 21976198 and 21777175)the National Key Research and Development Program of China (No. 2018YFA0901200)。
文摘The rapid deactivation of cost-effective MnO_(2)-based catalysts in humid air limits their application in practice,and the identification of the role of water in an oxidation process is significant for developing water-resistant MnO_(2)-based catalysts.Here,CuMnO_(2)showed a20.3%HCHO conversion in 10 hr at room temperature in humid air with relative humidity of 40%,but deactivated in 3 hr in dry air.The excellent activity and stability of HCHO oxidation in humid air were attributed to the positive effect of H_(2)O on HCHO oxidation to the H_(2)O-HOCH_(2)OH supermolecule assemblies via hydrogen bonds formed on CuMnO_(2).H_(2)O-HOCH_(2)OH supermolecule assemblies tend to be oxidized to carbonate,which is further oxidized to CO_(2).Furthermore,CuMnO_(2)exhibited a much poorer activity of CO oxidation in humid air,but the CO conversion was still 100%in 10 hr in dry air.H_(2)O showed a competitive adsorption effect to CO on CuMnO_(2).CuMnO_(2)could be applied in HCHO elimination in humid air and CO elimination in dry air.
基金supported by the National Natural Science Foundation of China(Grant nos.22241604 and 22125606).
文摘Microplastics are ubiquitous in the global environment.As a typical emerging pollutant,its potential health hazards have been widely concerning.In this brief paper,we introduce the source,identification,toxicity,and health hazard of microplastics in the human.The literature review shows that microplastics are frequently detected in environmental and human samples.Humans are potentially exposed to microplastics through oral intake,inhalation,and skin contact.We summarize the toxic effects of microplastics in experimental models like cells,organoids,and animals.These effects consist of oxidative stress,DNA damage,organ dysfunction,metabolic disorder,immune response,neurotoxicity,as well as reproductive and developmental toxicity.In addition,the epidemiological evidence suggests that a variety of chronic diseases may be related to microplastics exposure.Finally,we put forward the gaps in toxicity research of microplastics and their future development directions.This review will be helpful to the understanding of the exposure risk and potential health hazards of microplastics.
基金Stretegic Priority Research Program of the Chinese Academy of Sciences(XDB0750300)National Natural Science Foundation of China(grants 22241604 and 22125606).
文摘Global attention on microplastics has increased because of their ubiquity in water,air,soil,and organisms.(1−4)Knowledge of the sources,occurrences,behaviors,and health risks of microplastics is quite limited.(5−7)Nevertheless,developing comprehensive health-based thresholds and regulatory guidelines for microplastics in water is impossible because of the limitations and complexity of determining their health effects.Writing in Environment&Health,Chowdhury et al.reported a“Threshold Microplastics Concentration”(TMC)concept and framework.(8)The TMC framework was used to identify microplastic concentrations that may result in the intake of regulated contaminants on/in microplastics at levels of human health concern and treatment targets for managing those potential risks.
基金National Key Research and Development Program of China(Grant No.2022YFC3703700)National Natural Science Foundation of China(Grant No.22125606)Special Project of Ecological Environmental Technology for Carbon Dioxide Emissions Peak and Carbon Neutrality(Grant No.RCEES-TDZ-2021-21).
文摘Due to the relentless exploitation of non-renewable resources,humanity is faced with a resource depletion crisis in the coming decades and serious environmental issues.Achieving efficient removal and upcycling of pollutants(ERUP)may become a potential strategy to address these issues.Wastewater,characterized by its large production volume and fluidity,can easily cause widespread environmental pollution through natural water networks.Due to solubility constraints,pollutants in wastewater typically exhibit low concentrations and complex compositions,thereby impeding effective recovery.Therefore,achieving ERUP in wastewater is both highly significant and extremely challenging.Unlike conventional wastewater treatment strategies that are focused on removing pollutants,ERUP strategies can not only realize the efficient removal of pollutants from water but also convert pollutants into valuable and functional products.Herein,we enumerated the latest research progress on ERUP in wastewater and highlighted studies that demonstrate the simultaneous achievement of pollutant removal and the direct conversion of these contaminants into high-efficiency catalysts,hydrogen energy,electrical energy,and other high-value chemicals.Finally,we identified the problems and challenges in the development of ERUP in wastewater and outlined potential research directions for future studies.
基金the National Key Research and Development Program of China(2021YFA0910300).
文摘Microbial bioelectrochemical system(BES)is a promising sustainable technology for the electrical energy recovery and the treatment of recalcitrant and toxic pollutants.In microbial BESs,the conversion of harmful pollutants into harmless products can be catalyzed by microorganisms at the anode(Type I BES),chemical catalysts at the cathode(Type II BES)or microorganisms at the cathode(Type III BES).The application of synthetic biology in microbial BES can improve its pollutant removing capability.Synthetic biology techniques can promote EET kinetics,which is helpful for microbial anodic electro-respiration,expediting pollutant removing not only at the anode but also at the cathode.They offer tools to promote biofilm development on the electrode,enabling more microorganisms residing on the electrode for subsequent catalytic reactions,and to overexpress the pollutant removing-related genes directly in microorganisms,contributing to the pollutant decomposition.In this work,based on the summarized aspects mentioned above,we describe the major synthetic biology strategies in designing and improving the pollutant removing capabilities of microbial BES.Lastly,we discuss challenges and perspectives for future studies in the area.
文摘Industrial expansion and population growth stimulates the utilization of natural resources and energy.It inevitably leads to environmental pollution with various pollutants like heavy metals,pesticide and xenobiotics.Synthetic biology is an interdisciplinary field involving designation,construction,and manipulation of biological parts or devices in chassis and organisms for diverse purposes.It’s a promising alternative for synthetic biotechnology to overcome the global environmental issues by engineering microorganisms.
基金Stretegic Priority Research Program of the Chinese Academy of Sciences(XDB0750300)National Natural Science Foundation of China(grants 22241604 and 22125606).
文摘Introduction Microplastics(MPs)and nanoplastics(NPs)have become emerging particulate contaminants,(1−3)being detected worldwide from the Antarctic(4)to the Arctic,(5)and from the marine trenches(6)to the plateaus.(7)Most micro-and nanoplastics(MNPs)in the environment can be attributed to the large-scale manufacture,use,and improper management of plastic products.By 2050,the worldwide production of plastics will reach approximately 1 billion tons,(8)suggesting that MNP pollution will be one of the most serious global ecological hazards in the future.
基金supported by the National Natural Science Foundation of China(Grants 22241604 and 22125606).
文摘In recent years,the environmental and health impacts ofnanoplastics have garnered significant attention,often portrayed as a novel and distinct threat.1−3 However,a groundbreaking study by Yan et al.challenges this narrative,arguing that the toxicity of nanoplastics is fundamentally a subset of the well-established field of nanotoxicology.4 Through extensive data mining,machine learning,and molecular dynamics simulations,the authors demonstrate that nanoplastics and engineered nanoparticles(ENPs)share striking similarities in their physicochemical properties,environmental behaviors,biological interactions,and toxicity profiles.This revelation calls for a paradigm shift in how nanoplastics research is conducted,advocating for the integration of this field into the broader nanotoxicology framework to avoid redundant efforts and accelerate the development of sustainable solutions.
