目的总结肺移植受者居家自我管理的证据,为其制订居家自我管理方案提供参考。方法系统检索BMJ、UpToDate、全球指南协作网、英国国家卫生与临床优化研究所、苏格兰院级指南网、美国国立指南库、国际心肺移植学会、美国胸科学会、美国移...目的总结肺移植受者居家自我管理的证据,为其制订居家自我管理方案提供参考。方法系统检索BMJ、UpToDate、全球指南协作网、英国国家卫生与临床优化研究所、苏格兰院级指南网、美国国立指南库、国际心肺移植学会、美国胸科学会、美国移植学会、英国胸科学会、Web of Science核心合集数据库、CINAHL、PubMed、Cochrane Library、Embase、中国知网、中国生物医学数据库、万方数据知识服务平台和维普网中有关肺移植受者居家自我管理的临床决策、指南、专家共识、证据总结、系统评价及原始研究等,检索时限为建库到2024年6月30日。两名研究人员进行文献筛选、评价和证据提取。结果纳入19篇文献,包括4篇临床决策、3篇指南、2篇证据总结、6篇专家共识、3篇系统评价,1篇随机对照试验。围绕肺移植受者居家自我管理的目标和原则、康复训练、心理调节、营养管理、药物管理、感染预防、自我监测和规范随访8个方面汇总了32条证据。结论本研究科学全面地提炼和分析了肺移植受者居家自我管理的最佳证据,建议医护人员结合临床情景和患者意愿应用证据。展开更多
The purpose of this experiment was to investigate the effect and mechanism of quercetin on reproductive performance in perinatal sows.According to the similar principle of parity and body weight,24 perinatal sows were...The purpose of this experiment was to investigate the effect and mechanism of quercetin on reproductive performance in perinatal sows.According to the similar principle of parity and body weight,24 perinatal sows were randomly divided into four treatments with six replicates,including normal control and three treatments fed by a basal diet supplemented with 0,0.025%,0.050%,and 0.075%quercetin,respectively.The feeding trial was conducted from 100 days of gestation to 28 days post-partum.Reproductive performance,colostrum composition,serum indexes of antioxidation,inflammation,hormones,and the diversity and relative abundance of fecal microflora were determined in perinatal sows.Compared with the control,quercetin significantly reduced the rate of constipation,serum content of malondialdehyde(MDA),prolactin(PRL),and progesterone(PROG),and significantly increased the content of serum estradiol(E2)and insulin-like growth factor-1(IGF-1)in colostrum of perinatal sows(P<0.05).Meanwhile,0.025%quercetin significantly increased glutathione(GSH)content in serum(P<0.05),0.050%quercetin significantly reduced the rate of backfat loss(P<0.05),and 0.075%quercetin significantly increased immunoglobulin M(IgM)content in colostrum of perinatal sows(P<0.05).In addition,0.050%and 0.075%quercetin significantly shortened estrus interval(P<0.05)and significantly increased the content of IgA and IgG in colostrum(P<0.05)and dopamine(DA)content in serum of perinatal sows(P<0.05).Quercetin significantly decreased the content of nitric oxide(NO),IL-1β,IL-6,TNF-α,and MCP-1 in serum(P<0.05)and significantly improved microflora abundance and diversity in feces of perinatal sows(P<0.05).In conclusion,dietary supplementation of quercetin reduced oxidative stress and inflammatory responses and regulated intestinal microflora in perinatal sows,thus improved reproductive performance in perinatal sows.Under this experimental condition,the optimal supplementation with dietary quercetin was 0.075%in perinatal sows.展开更多
文摘目的总结肺移植受者居家自我管理的证据,为其制订居家自我管理方案提供参考。方法系统检索BMJ、UpToDate、全球指南协作网、英国国家卫生与临床优化研究所、苏格兰院级指南网、美国国立指南库、国际心肺移植学会、美国胸科学会、美国移植学会、英国胸科学会、Web of Science核心合集数据库、CINAHL、PubMed、Cochrane Library、Embase、中国知网、中国生物医学数据库、万方数据知识服务平台和维普网中有关肺移植受者居家自我管理的临床决策、指南、专家共识、证据总结、系统评价及原始研究等,检索时限为建库到2024年6月30日。两名研究人员进行文献筛选、评价和证据提取。结果纳入19篇文献,包括4篇临床决策、3篇指南、2篇证据总结、6篇专家共识、3篇系统评价,1篇随机对照试验。围绕肺移植受者居家自我管理的目标和原则、康复训练、心理调节、营养管理、药物管理、感染预防、自我监测和规范随访8个方面汇总了32条证据。结论本研究科学全面地提炼和分析了肺移植受者居家自我管理的最佳证据,建议医护人员结合临床情景和患者意愿应用证据。
基金Supported by the National Natural Science Foundation of China(32072749)。
文摘The purpose of this experiment was to investigate the effect and mechanism of quercetin on reproductive performance in perinatal sows.According to the similar principle of parity and body weight,24 perinatal sows were randomly divided into four treatments with six replicates,including normal control and three treatments fed by a basal diet supplemented with 0,0.025%,0.050%,and 0.075%quercetin,respectively.The feeding trial was conducted from 100 days of gestation to 28 days post-partum.Reproductive performance,colostrum composition,serum indexes of antioxidation,inflammation,hormones,and the diversity and relative abundance of fecal microflora were determined in perinatal sows.Compared with the control,quercetin significantly reduced the rate of constipation,serum content of malondialdehyde(MDA),prolactin(PRL),and progesterone(PROG),and significantly increased the content of serum estradiol(E2)and insulin-like growth factor-1(IGF-1)in colostrum of perinatal sows(P<0.05).Meanwhile,0.025%quercetin significantly increased glutathione(GSH)content in serum(P<0.05),0.050%quercetin significantly reduced the rate of backfat loss(P<0.05),and 0.075%quercetin significantly increased immunoglobulin M(IgM)content in colostrum of perinatal sows(P<0.05).In addition,0.050%and 0.075%quercetin significantly shortened estrus interval(P<0.05)and significantly increased the content of IgA and IgG in colostrum(P<0.05)and dopamine(DA)content in serum of perinatal sows(P<0.05).Quercetin significantly decreased the content of nitric oxide(NO),IL-1β,IL-6,TNF-α,and MCP-1 in serum(P<0.05)and significantly improved microflora abundance and diversity in feces of perinatal sows(P<0.05).In conclusion,dietary supplementation of quercetin reduced oxidative stress and inflammatory responses and regulated intestinal microflora in perinatal sows,thus improved reproductive performance in perinatal sows.Under this experimental condition,the optimal supplementation with dietary quercetin was 0.075%in perinatal sows.
