针对维间耦合会影响六维腕力传感器测量精度的问题,提出了基于多输出支持向量回归机(Multi-output support vector regression,MSVR)的解耦算法。以实验室研制的六维腕力传感器为例进行静态标定实验,使用基于MSVR的解耦算法以及传统的...针对维间耦合会影响六维腕力传感器测量精度的问题,提出了基于多输出支持向量回归机(Multi-output support vector regression,MSVR)的解耦算法。以实验室研制的六维腕力传感器为例进行静态标定实验,使用基于MSVR的解耦算法以及传统的基于最小二乘求解标定矩阵的解耦算法对标定数据进行处理分析。实验结果表明,本文提出的解耦算法稳定可靠,能有效抑制维间耦合的干扰,具有较高的解耦精度。展开更多
Background Hypertension is associated with an increased risk of calcific aortic valve stenosis(CAVS).However,the directionality of causation between blood pressure traits and aortic stenosis is unclear,as is the benef...Background Hypertension is associated with an increased risk of calcific aortic valve stenosis(CAVS).However,the directionality of causation between blood pressure traits and aortic stenosis is unclear,as is the benefit of antihypertensive drugs for CAVS.Methods Using genome-wide association studies(GWAS)summary statistics,we performed bidirectional two-sample univariable mendelian randomization(UVMR)to assess the causal associations of systolic blood pressure(SBP),diastolic blood pressure(DBP),and pulse pressure(PP)with CAVS.Multivariable mendelian randomization(MVMR)was conducted to evaluate the direct effect of hypertension on CAVS,adjusting for confounders.Drug target mendelian randomization(MR)and summary-level MR(SMR)were used to estimate the effects of 12 classes of antihypertensive drugs and their target genes on CAVS risk.Inverse variance weighting was the primary MR method,with sensitivity analyses to validate results.Results UVMR showed SBP,DBP,and PP have causal effects on CAVS,with no significant reverse causality.MVMR confirmed the causality between hypertension and CAVS after adjusting for confounders.Drug-target MR analyses indicated that calcium channel blockers(CCBs),loop diuretics,and thiazide diuretics via SBP lowering exerted protective effects on CAVS risk.SMR analysis showed that the CCBs target gene CACNA2D2 and ARBs target gene AGTR1 were positively associated with CAVS risk,while diuretics target genes SLC12A5 and SLC12A1 were negatively associated with aortic stenosis risk.Conclusions Hypertension has a causal relationship with CAVS.Managing SBP in hypertensive patients with CCBs may prevent CAVS.ARBs might exert protective effects on CAVS independent of blood pressure reduction.The relationship between diuretics and CAVS is complex,with opposite effects through different mechanisms.展开更多
Mitral regurgitation (MR) is a highly prevalent valvular heart disease globally,with untreated severe cases demonstrating associations with elevated morbidity,mortality,and adverse cardiovascular outcomes.[1,2]While t...Mitral regurgitation (MR) is a highly prevalent valvular heart disease globally,with untreated severe cases demonstrating associations with elevated morbidity,mortality,and adverse cardiovascular outcomes.[1,2]While transcatheter edge-toedge repair (TEER) has emerged as an alternative option for high surgical risk patients with severe MR,[3,4]severe MR of Carpentier class IIIa (characterized by restricted leaflet motion during both systole and diastole) has been considered a relative contraindication for TEER interventions due to stenosis risk and procedural complexity.[5,6]展开更多
This study analyzes the influence of TiO_(2) and Al_(2)O_(3) contents on the microstructure of CaO-SiO_(2)-MgO-xwt%Al_(2)O_(3)-ywt%TiO_(2)(14≤x≤22,0≤y≤10)blast furnace slag systems based on the change of slag visc...This study analyzes the influence of TiO_(2) and Al_(2)O_(3) contents on the microstructure of CaO-SiO_(2)-MgO-xwt%Al_(2)O_(3)-ywt%TiO_(2)(14≤x≤22,0≤y≤10)blast furnace slag systems based on the change of slag viscosity,Raman spectroscopy,and molecular dynamics.The Raman spectroscopy results indicate that an increase in TiO_(2) content leads to the gradual depolymerization of complex Q_(Si)^(3) Q_(Si)^(2) Q_(Si)^(0) Q_(Si)^(1)silicate structures(and)into simpler structures(and)in the slag.At the same time,the Al-O-Al bonds in the aluminate structures of the slag also depolymerize into simpler Al-O-forms,resulting in a decrease in the degree of polymerization of both silicates and aluminates.In contrast,an increase in Al_(2)O_(3) content generally results in an increased degree of polymerization for the silicates and aluminates.Molecular dynamics simulations of the polymerization and depolymerization processes in the microstructure of the blast fur-nace slag reveal that Si and Al mainly exist in tetrahedral[SiO_(4)]^(4-)and[AlO_(4)]^(4-),while Ti mainly exists in the form of simple pentaco-ordinate[TiO_(5)]^(6-)and hexacoordinate[TiO_(6)]^(8-).TiO_(2) exhibits basic properties in this system,whereas Al_(2)O_(3) demonstrates acidic behavior.The addition of TiO_(2) introduces free oxide ions into the system,causing the bridging oxygens to break into non-bridging oxygens,lead-Q_(Si)^(4) Q_(Si)^(3)ing to the depolymerization of complex structures and,which simplifies the slag structure.On the other hand,an increase in Al_(2)O_(3) content tends to capture or share the oxide ions within the system to form[AlO_(4)]^(4-),resulting in the polymerization of free oxygens into Q_(Si)^(0) Q_(Si)^(1)non-bridging oxygens,which further polymerize into bridging oxygens and lead to the consolidation of simple structures and,resulting in a more complex slag structure.Both Raman spectroscopy analysis and molecular dynamics simulation results indicate that the degree of polymerization of[SiO_(4)]^(4-) and[AlO_(4)]^(4-) in the slag network structure is a crucial factor determining the fluidity of the slag.展开更多
The angiogenic response is essential for the repair of ischemic brain tissue.Integrin α6(Itga6)expression has been shown to increase under hypoxic conditions and is expressed exclusively in vascular structures;howeve...The angiogenic response is essential for the repair of ischemic brain tissue.Integrin α6(Itga6)expression has been shown to increase under hypoxic conditions and is expressed exclusively in vascular structures;however,its role in post-ischemic angiogenesis remains poorly understood.In this study,we demonstrate that mice with endothelial cell-specific knockout of Itga6 exhibit reduced neovascularization,reduced pericyte coverage on microvessels,and accelerated breakdown of microvascular integrity in the peri-infarct area.In vitro,endothelial cells with ITGA6 knockdown display reduced proliferation,migration,and tube-formation.Mechanistically,we demonstrated that ITGA6 regulates post-stroke angiogenesis through the PI3K/Akt-eNOS-VEGFA axis.Importantly,the specific overexpression of Itga6 in endothelial cells significantly enhanced neovascularization and enhanced the integrity of microvessels,leading to improved functional recovery.Our results suggest that endothelial cell Itga6 plays a crucial role in key steps of post-stroke angiogenesis,and may represent a promising therapeutic target for promoting recovery after stroke.展开更多
文摘针对维间耦合会影响六维腕力传感器测量精度的问题,提出了基于多输出支持向量回归机(Multi-output support vector regression,MSVR)的解耦算法。以实验室研制的六维腕力传感器为例进行静态标定实验,使用基于MSVR的解耦算法以及传统的基于最小二乘求解标定矩阵的解耦算法对标定数据进行处理分析。实验结果表明,本文提出的解耦算法稳定可靠,能有效抑制维间耦合的干扰,具有较高的解耦精度。
基金supported by the National Natural Science Foundation of China(82170375,U23A20395)1.3.5 project for disciplines of excellence from West China Hospital of Sichuan University(ZYGD23021,23HXF-H009)Sichuan Science and Technology Program 2023NSFSC1645。
文摘Background Hypertension is associated with an increased risk of calcific aortic valve stenosis(CAVS).However,the directionality of causation between blood pressure traits and aortic stenosis is unclear,as is the benefit of antihypertensive drugs for CAVS.Methods Using genome-wide association studies(GWAS)summary statistics,we performed bidirectional two-sample univariable mendelian randomization(UVMR)to assess the causal associations of systolic blood pressure(SBP),diastolic blood pressure(DBP),and pulse pressure(PP)with CAVS.Multivariable mendelian randomization(MVMR)was conducted to evaluate the direct effect of hypertension on CAVS,adjusting for confounders.Drug target mendelian randomization(MR)and summary-level MR(SMR)were used to estimate the effects of 12 classes of antihypertensive drugs and their target genes on CAVS risk.Inverse variance weighting was the primary MR method,with sensitivity analyses to validate results.Results UVMR showed SBP,DBP,and PP have causal effects on CAVS,with no significant reverse causality.MVMR confirmed the causality between hypertension and CAVS after adjusting for confounders.Drug-target MR analyses indicated that calcium channel blockers(CCBs),loop diuretics,and thiazide diuretics via SBP lowering exerted protective effects on CAVS risk.SMR analysis showed that the CCBs target gene CACNA2D2 and ARBs target gene AGTR1 were positively associated with CAVS risk,while diuretics target genes SLC12A5 and SLC12A1 were negatively associated with aortic stenosis risk.Conclusions Hypertension has a causal relationship with CAVS.Managing SBP in hypertensive patients with CCBs may prevent CAVS.ARBs might exert protective effects on CAVS independent of blood pressure reduction.The relationship between diuretics and CAVS is complex,with opposite effects through different mechanisms.
基金supported by the 1·3·5 Project for Disciplines of Excellence from West China Hospital of Sichuan University(ZYGD23021&23HXFH009)Sichuan Science and Technology Program(No.2025ZNSFSC1698)the Sichuan Provincial Cadre Health Research Program(ZH2024-103).
文摘Mitral regurgitation (MR) is a highly prevalent valvular heart disease globally,with untreated severe cases demonstrating associations with elevated morbidity,mortality,and adverse cardiovascular outcomes.[1,2]While transcatheter edge-toedge repair (TEER) has emerged as an alternative option for high surgical risk patients with severe MR,[3,4]severe MR of Carpentier class IIIa (characterized by restricted leaflet motion during both systole and diastole) has been considered a relative contraindication for TEER interventions due to stenosis risk and procedural complexity.[5,6]
基金financially supported by the National Natural Science Foundation of China(No.52174299)the State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization,China(No.2024P4FZG10).
文摘This study analyzes the influence of TiO_(2) and Al_(2)O_(3) contents on the microstructure of CaO-SiO_(2)-MgO-xwt%Al_(2)O_(3)-ywt%TiO_(2)(14≤x≤22,0≤y≤10)blast furnace slag systems based on the change of slag viscosity,Raman spectroscopy,and molecular dynamics.The Raman spectroscopy results indicate that an increase in TiO_(2) content leads to the gradual depolymerization of complex Q_(Si)^(3) Q_(Si)^(2) Q_(Si)^(0) Q_(Si)^(1)silicate structures(and)into simpler structures(and)in the slag.At the same time,the Al-O-Al bonds in the aluminate structures of the slag also depolymerize into simpler Al-O-forms,resulting in a decrease in the degree of polymerization of both silicates and aluminates.In contrast,an increase in Al_(2)O_(3) content generally results in an increased degree of polymerization for the silicates and aluminates.Molecular dynamics simulations of the polymerization and depolymerization processes in the microstructure of the blast fur-nace slag reveal that Si and Al mainly exist in tetrahedral[SiO_(4)]^(4-)and[AlO_(4)]^(4-),while Ti mainly exists in the form of simple pentaco-ordinate[TiO_(5)]^(6-)and hexacoordinate[TiO_(6)]^(8-).TiO_(2) exhibits basic properties in this system,whereas Al_(2)O_(3) demonstrates acidic behavior.The addition of TiO_(2) introduces free oxide ions into the system,causing the bridging oxygens to break into non-bridging oxygens,lead-Q_(Si)^(4) Q_(Si)^(3)ing to the depolymerization of complex structures and,which simplifies the slag structure.On the other hand,an increase in Al_(2)O_(3) content tends to capture or share the oxide ions within the system to form[AlO_(4)]^(4-),resulting in the polymerization of free oxygens into Q_(Si)^(0) Q_(Si)^(1)non-bridging oxygens,which further polymerize into bridging oxygens and lead to the consolidation of simple structures and,resulting in a more complex slag structure.Both Raman spectroscopy analysis and molecular dynamics simulation results indicate that the degree of polymerization of[SiO_(4)]^(4-) and[AlO_(4)]^(4-) in the slag network structure is a crucial factor determining the fluidity of the slag.
基金supported by grants from the Scientific Research Foundation for Young Doctors of the Second Affiliated Hospital,Army Medical University(2022YQB041)the Chongqing Natural Science Foundation(CSTB2024NSCQ-MSX0924 and CSTB2024NSCQ-MSX0909).
文摘The angiogenic response is essential for the repair of ischemic brain tissue.Integrin α6(Itga6)expression has been shown to increase under hypoxic conditions and is expressed exclusively in vascular structures;however,its role in post-ischemic angiogenesis remains poorly understood.In this study,we demonstrate that mice with endothelial cell-specific knockout of Itga6 exhibit reduced neovascularization,reduced pericyte coverage on microvessels,and accelerated breakdown of microvascular integrity in the peri-infarct area.In vitro,endothelial cells with ITGA6 knockdown display reduced proliferation,migration,and tube-formation.Mechanistically,we demonstrated that ITGA6 regulates post-stroke angiogenesis through the PI3K/Akt-eNOS-VEGFA axis.Importantly,the specific overexpression of Itga6 in endothelial cells significantly enhanced neovascularization and enhanced the integrity of microvessels,leading to improved functional recovery.Our results suggest that endothelial cell Itga6 plays a crucial role in key steps of post-stroke angiogenesis,and may represent a promising therapeutic target for promoting recovery after stroke.
