Ulcerative colitis(UC)is a chronic,non-specific inflammatory disorder of the intestines whose etiology is influenced by various factors.Intestinal barrier impairment due to disturbances in the intestinal microenvironm...Ulcerative colitis(UC)is a chronic,non-specific inflammatory disorder of the intestines whose etiology is influenced by various factors.Intestinal barrier impairment due to disturbances in the intestinal microenvironment is a key feature of UC.Current therapeutic strategies are constrained in their capacity to fully restore the intestinal barrier and achieve comprehensive resolution of inflammation in a coordinated manner.In this study,we constructed a pterostilbene(PSB)-loaded prebiotic microcapsule(PSB@MC)using a microfluidic electrospray method and characterized it using various means.Its safety,biodistribution,protective,and therapeutic effects on colitis were evaluated in various animal models.The potential mechanisms by which PSB@MC exerts its therapeutic effects were subsequently explored.The results indicated that PSB@MC exhibited favorable biocompatibility and facilitated targeted delivery of PSB to the colon.Moreover,the wrinkled morphology of PSB@MC contributed to prolonged drug retention in the colon.Oral PSB@MC administration restored intestinal microenvironment homeostasis by scavenging reactive oxygen species(ROS),decreasing pro-inflammatory cytokines,modulating gut microbiota and metabolism,and providing protective and therapeutic benefits against dextran sulfate sodium-induced colitis.Additionally,our research demonstrated that PSB@MC could activate the aryl hydrocarbon receptor/interleukin-22(AHR/IL-22)pathway to enhance the integrity of the intestinal barrier.These results suggest that PSB@MC could be a new,secure,and efficient UC therapy option.展开更多
Nanomedicine is an interdisciplinary area that utilizes nanoscience and technology in the realm of medicine.Rapid advances in science and technology have propelled the medical sector into a new era.The most commonly u...Nanomedicine is an interdisciplinary area that utilizes nanoscience and technology in the realm of medicine.Rapid advances in science and technology have propelled the medical sector into a new era.The most commonly used nanotechnology in the field of medicine is nanoparticles.Due to their unique physicochemical properties,nanoparticles offer significant benefits of precision medicine for diseases such as inflammatory bowel disease that cannot be effectively treated by existing approaches.Nanomedicine has emerged as a highly active research field,with extensive scientific and technological studies being carried out,as well as growing international competition in the commercialization of this field.The accumulation of expertise in the key technologies relating to nanomedicine would provide strategic advantages in the development of cutting-edge medical techniques.This review presented a comprehensive analysis of the primary uses of nanoparticles in medicine,including recent advances in their application for the diagnosis and treatment of inflammatory bowel disease.Furthermore,we discussed the challenges and possibilities associated with the application of nanoparticles in clinical settings.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC2406600)the Program for Innovation Team of Shaanxi Province(2021TD-23)+3 种基金the Fundamental Research Funds for the Central Universities(xtr052023008)the Young Talent Support Plan of Xi’an Jiaotong University(YX6J001)the Shaanxi Province Key Research and Development Program(2023-YBSF-072 and 2024JC-YBMS-664)the Xi’an Science and Technology Plan Project(24YXYJ0143)。
文摘Ulcerative colitis(UC)is a chronic,non-specific inflammatory disorder of the intestines whose etiology is influenced by various factors.Intestinal barrier impairment due to disturbances in the intestinal microenvironment is a key feature of UC.Current therapeutic strategies are constrained in their capacity to fully restore the intestinal barrier and achieve comprehensive resolution of inflammation in a coordinated manner.In this study,we constructed a pterostilbene(PSB)-loaded prebiotic microcapsule(PSB@MC)using a microfluidic electrospray method and characterized it using various means.Its safety,biodistribution,protective,and therapeutic effects on colitis were evaluated in various animal models.The potential mechanisms by which PSB@MC exerts its therapeutic effects were subsequently explored.The results indicated that PSB@MC exhibited favorable biocompatibility and facilitated targeted delivery of PSB to the colon.Moreover,the wrinkled morphology of PSB@MC contributed to prolonged drug retention in the colon.Oral PSB@MC administration restored intestinal microenvironment homeostasis by scavenging reactive oxygen species(ROS),decreasing pro-inflammatory cytokines,modulating gut microbiota and metabolism,and providing protective and therapeutic benefits against dextran sulfate sodium-induced colitis.Additionally,our research demonstrated that PSB@MC could activate the aryl hydrocarbon receptor/interleukin-22(AHR/IL-22)pathway to enhance the integrity of the intestinal barrier.These results suggest that PSB@MC could be a new,secure,and efficient UC therapy option.
基金This work was supported by grants from the National Natural Science Foundation of China(No.82472127)Shaanxi Province Key Research and Development Program(Nos.2023-YBSF-072 and 2024JC-YBMS-664)+2 种基金The Innovation Team of Xi’an Medical University(No.2021TD15)Xi’an Science and Technology Plan Project(No.24YXYJ0143)2024 Shaanxi Provincial Health Commission High level Talent Cultivation Project.
文摘Nanomedicine is an interdisciplinary area that utilizes nanoscience and technology in the realm of medicine.Rapid advances in science and technology have propelled the medical sector into a new era.The most commonly used nanotechnology in the field of medicine is nanoparticles.Due to their unique physicochemical properties,nanoparticles offer significant benefits of precision medicine for diseases such as inflammatory bowel disease that cannot be effectively treated by existing approaches.Nanomedicine has emerged as a highly active research field,with extensive scientific and technological studies being carried out,as well as growing international competition in the commercialization of this field.The accumulation of expertise in the key technologies relating to nanomedicine would provide strategic advantages in the development of cutting-edge medical techniques.This review presented a comprehensive analysis of the primary uses of nanoparticles in medicine,including recent advances in their application for the diagnosis and treatment of inflammatory bowel disease.Furthermore,we discussed the challenges and possibilities associated with the application of nanoparticles in clinical settings.
