Background:Hypertensive nephropathy remains a leading cause of end-stage renal disease with limited targeted therapies.Methods:We conducted a bibliometric analysis(1992-2024)of 440 basic studies from 7 databases,using...Background:Hypertensive nephropathy remains a leading cause of end-stage renal disease with limited targeted therapies.Methods:We conducted a bibliometric analysis(1992-2024)of 440 basic studies from 7 databases,using VOSviewer and R to quantify research evolution.Intervention modalities,signaling pathways,and mechanisms were innovatively extracted.Results:Quantified analysis revealed a distinct temporal evolution:early research was dominated by TGF-βsignaling,while starting from 2015,the focus of the research turned to podocyte-targeted studies.Traditional Chinese medicine compounds emerged as the predominant intervention,yet standardization deficits persisted across 73 formulas.Despite limited human pathological concordance,Spontaneously hypertensive rats models were utilized in most studies.Critically,only a few podocyte-focused therapeutics advanced to clinical trials,primarily hindered by species-specific Transient receptor potential channel expression divergence and mesenchymal stem cells renal delivery.Conclusion:Podocyte protection and standardized traditional Chinese medicine are potential translational targets,but there is a lack of reliable clinical trials for clinical verification.展开更多
基金funded by National Natural Science Foundation of China,No.811734071The Fundamental Research Funds for the Central Universities(2023-JYB-XJSJJ043)The fifth batch of National TCM Clinical Outstanding Talents Training Program(National TCM Personnel Education Letter[2022]No.1)。
文摘Background:Hypertensive nephropathy remains a leading cause of end-stage renal disease with limited targeted therapies.Methods:We conducted a bibliometric analysis(1992-2024)of 440 basic studies from 7 databases,using VOSviewer and R to quantify research evolution.Intervention modalities,signaling pathways,and mechanisms were innovatively extracted.Results:Quantified analysis revealed a distinct temporal evolution:early research was dominated by TGF-βsignaling,while starting from 2015,the focus of the research turned to podocyte-targeted studies.Traditional Chinese medicine compounds emerged as the predominant intervention,yet standardization deficits persisted across 73 formulas.Despite limited human pathological concordance,Spontaneously hypertensive rats models were utilized in most studies.Critically,only a few podocyte-focused therapeutics advanced to clinical trials,primarily hindered by species-specific Transient receptor potential channel expression divergence and mesenchymal stem cells renal delivery.Conclusion:Podocyte protection and standardized traditional Chinese medicine are potential translational targets,but there is a lack of reliable clinical trials for clinical verification.
