The study aimed to examine the applicability of carbon nanoparticles as a tracer for lymph node mapping and the related factors of lymph node and No.8p subgroup metastasis in patients with gastric cancer.Clinical data...The study aimed to examine the applicability of carbon nanoparticles as a tracer for lymph node mapping and the related factors of lymph node and No.8p subgroup metastasis in patients with gastric cancer.Clinical data of 50 patients with gastric cancer,who had not received treatment preoperatively and underwent gastrectomy in Department of Gastrointestinal Surgery,Wuhan Union Hospital,between October 2014 and August 2015,were retrospectively analyzed.These patients were found to have no distant metastasis preoperatively.Thirty-five out of 50 patients were subjected to lymphatic mapping technique using carbon nanoparticles as the tracer,and the rest 15 cases did not experience the lymphatic mapping and served as controls.The sensitivity,specificity,false positive rate and false negative rate were calculated according to the number of lymph nodes,and the staining and metastasis condition of lymph nodes.The diagnostic value of carbon nanoparticles on metastatic lymph nodes was evaluated.The relationship between the metastasis of lymph nodes or subgroup No.8p lymph nodes and clinicopathologic features was analyzed by χ^2-test or Fisher＇s exact test.All patients underwent D2 surgery（lymph node dissection including all the group 1 and group 2 nodes） plus the dissection of the subgroup No.8p lymph nodes.It was found that the average number of harvested lymph nodes in lymphatic mapping technique group（45.7±14.5） was greater than that in control group（39.2±11.7）,but the difference was not significantly different（P=0.138〉0.05）.The success rate,the accuracy,sensitivity,specificity and false negative rate was 97%,57%,28%,62% and 72% respectively.The metastasis of lymph nodes was correlated to the depth of cancer invasion（T stage）（P=0.004〈0.05）,and the metastasis of No.8p lymph nodes was correlated to the extent of lymph node involvement（N stage）（P=0.007〈0.05）.Six cases had lymph node metastasis in subgroup No.8p,and their TNM stages and clinical stages were as follows：T1N2M0 ⅡA,T3N3M0 ⅢB,T4 a N3M0 ⅢC,T4 a N3M0 ⅢC,T4 a N3M0 ⅢC,and T4 b N3M0 ⅢC.In conclusion,our study indicated that carbon nanoparticles failed to show good selectivity for metastatic lymph nodes;the result of lymphatic mapping does not achieve a satisfactory performance;the incidence of lymph node metastasis may increase,accompanying with the increase of the depth of cancer invasion;No.8p lymph node metastasis tends to occur for gastric carcinoma patients with the extent of lymph node metastasis over N2 stage.展开更多
Exploring inorganic materials with two or more different physical properties has become an important and emerging topic in solid-state chemistry.Despite the considerable progress achieved recently,however,multifunctio...Exploring inorganic materials with two or more different physical properties has become an important and emerging topic in solid-state chemistry.Despite the considerable progress achieved recently,however,multifunctional infrared nonlinear-optical(IR-NLO)chalcogenides are still rarely reported.This paper is the first report of quaternary manganese thioantimonates,A_(3)Mn_(2)Sb_(3)S_(8)(A=K and Rb),developed using a facile surfactant–thermal method.Both compounds are isostructural and belong to the tetragonal space group I4¯2m(no.121).Their structures are composed of unique three-dimensional non-centrosymmetric[Mn_(2)Sb_(3)S_(8)]^(3−)frameworks and intervening alkali A+cations.Significantly,A_(3)Mn_(2)Sb_(3)S_(8)(A=K and Rb)not only show type-I phase-matching features with moderate second-harmonic generation(SHG)effects and strong laser-induced damage thresholds but also display temperature-dependent paramagnetism and photocurrent responses.In addition,the highly polarizable[Sb_(3)S_(7)]^(5−)group in this type of structure is a beneficial NLO-active motif,which can be instrumental in designing new IR-NLO materials with suitable birefringence and strong SHG efficiency based on the experimental and theoretical research results.This study will contribute to enrich the diversity of lone-pair cation-based NLO-active units and open a new avenue for discovering other multifunctional IR-NLO materials.展开更多
文摘The study aimed to examine the applicability of carbon nanoparticles as a tracer for lymph node mapping and the related factors of lymph node and No.8p subgroup metastasis in patients with gastric cancer.Clinical data of 50 patients with gastric cancer,who had not received treatment preoperatively and underwent gastrectomy in Department of Gastrointestinal Surgery,Wuhan Union Hospital,between October 2014 and August 2015,were retrospectively analyzed.These patients were found to have no distant metastasis preoperatively.Thirty-five out of 50 patients were subjected to lymphatic mapping technique using carbon nanoparticles as the tracer,and the rest 15 cases did not experience the lymphatic mapping and served as controls.The sensitivity,specificity,false positive rate and false negative rate were calculated according to the number of lymph nodes,and the staining and metastasis condition of lymph nodes.The diagnostic value of carbon nanoparticles on metastatic lymph nodes was evaluated.The relationship between the metastasis of lymph nodes or subgroup No.8p lymph nodes and clinicopathologic features was analyzed by χ^2-test or Fisher＇s exact test.All patients underwent D2 surgery（lymph node dissection including all the group 1 and group 2 nodes） plus the dissection of the subgroup No.8p lymph nodes.It was found that the average number of harvested lymph nodes in lymphatic mapping technique group（45.7±14.5） was greater than that in control group（39.2±11.7）,but the difference was not significantly different（P=0.138〉0.05）.The success rate,the accuracy,sensitivity,specificity and false negative rate was 97%,57%,28%,62% and 72% respectively.The metastasis of lymph nodes was correlated to the depth of cancer invasion（T stage）（P=0.004〈0.05）,and the metastasis of No.8p lymph nodes was correlated to the extent of lymph node involvement（N stage）（P=0.007〈0.05）.Six cases had lymph node metastasis in subgroup No.8p,and their TNM stages and clinical stages were as follows：T1N2M0 ⅡA,T3N3M0 ⅢB,T4 a N3M0 ⅢC,T4 a N3M0 ⅢC,T4 a N3M0 ⅢC,and T4 b N3M0 ⅢC.In conclusion,our study indicated that carbon nanoparticles failed to show good selectivity for metastatic lymph nodes;the result of lymphatic mapping does not achieve a satisfactory performance;the incidence of lymph node metastasis may increase,accompanying with the increase of the depth of cancer invasion;No.8p lymph node metastasis tends to occur for gastric carcinoma patients with the extent of lymph node metastasis over N2 stage.
基金supported by the National Key R&D Program of China(2018YFB0605700)the National Natural Science Foundation of China(Nos.51778570,51879230,and 21771179)+1 种基金the Natural Science Foundation of Fujian Province(No.2019J01133)the Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China(2021ZR118).
文摘Exploring inorganic materials with two or more different physical properties has become an important and emerging topic in solid-state chemistry.Despite the considerable progress achieved recently,however,multifunctional infrared nonlinear-optical(IR-NLO)chalcogenides are still rarely reported.This paper is the first report of quaternary manganese thioantimonates,A_(3)Mn_(2)Sb_(3)S_(8)(A=K and Rb),developed using a facile surfactant–thermal method.Both compounds are isostructural and belong to the tetragonal space group I4¯2m(no.121).Their structures are composed of unique three-dimensional non-centrosymmetric[Mn_(2)Sb_(3)S_(8)]^(3−)frameworks and intervening alkali A+cations.Significantly,A_(3)Mn_(2)Sb_(3)S_(8)(A=K and Rb)not only show type-I phase-matching features with moderate second-harmonic generation(SHG)effects and strong laser-induced damage thresholds but also display temperature-dependent paramagnetism and photocurrent responses.In addition,the highly polarizable[Sb_(3)S_(7)]^(5−)group in this type of structure is a beneficial NLO-active motif,which can be instrumental in designing new IR-NLO materials with suitable birefringence and strong SHG efficiency based on the experimental and theoretical research results.This study will contribute to enrich the diversity of lone-pair cation-based NLO-active units and open a new avenue for discovering other multifunctional IR-NLO materials.
