Liposomes(LPs)are capable of transporting a wide range of bioactive compounds(BACs)that have significant applications in the pharmaceutical,food,and cosmetic industries.These BACs can be administered through various r...Liposomes(LPs)are capable of transporting a wide range of bioactive compounds(BACs)that have significant applications in the pharmaceutical,food,and cosmetic industries.These BACs can be administered through various routes,including parenteral(injection),oral ingestion,or transdermal absorption.In addition,there have been limited studies conducted on the toxicological and safety aspects of LPs.This highlights the need for more research to be conducted on the potential risks of oral exposure before considering their use in food applications.Therefore,the purpose of this review is to present the latest information on the composition of LP,the materials used to coat LPs for applications in the pharmaceutical and food industries to enhance the stability of LPs containing delicate BACs,and the absorption of LPs and commercially available liposomal products produced using different technologies in the market.In addition,this paper revisits various advanced technologies used in the field of food and nutraceutical processing.These technologies include the supercritical fluid method,supercritical antisolvent method,supercritical reverse phase evaporation method,micro-fluidization,and ultrasonication.The article also discusses the applications of these technologies.展开更多
Costus pictus D.,a medicinal herb renowned for its antidiabetic and antioxidant potential,remains underutilized due to its high perishability and the lack of effective post-harvest preservation technologies.This study...Costus pictus D.,a medicinal herb renowned for its antidiabetic and antioxidant potential,remains underutilized due to its high perishability and the lack of effective post-harvest preservation technologies.This study used ultraviolet-C(UV-C)radiation(254 nm,10 min,8 W;228.6 mJ/cm^(2))as a novel,non-thermal pretreatment to enhance drying efficiency and bioactive compound retention in C.pictus leaves.Post UV-C exposure,the leaves were subjected to three conventional drying techniques,such as hot air drying(HD),vacuum drying(VD),and freeze drying(FD),at temperatures of 40◦C,50◦C,and 60◦C.Drying behavior was analyzed through empirical kinetic modelling using six thin-layer models,with the Page model demonstrating superior predictive accuracy(R2=0.998).UV-C pre-treatment significantly enhanced effective moisture diffusivity,reduced activation energy requirements,and improved mass transfer coefficients,accelerating the drying process.Drying durations were notably shortened across all methods,for example,in HD,from 120-300 min to 90-120 min,and in VD,from 360-540 min to 300-360 min.Regarding phytochemical preservation,vacuum-dried UV-C pretreated samples exhibited the highest retention of total phenolics and flavonoids,while freeze-dried counterparts demonstrated superior antioxidant capacity and microstructural integrity.Scanning electron microscopy(SEM)revealed microstructural modifications induced by UV-C treatment that facilitated enhanced moisture migration.FTIR spectroscopy confirmed the preservation of key functional groups associated with antioxidant bioactivity.These findings support the potential of UV-C-assisted drying as a scalable,energy-efficient technique for valorizing C.pictus in functional food and nutraceutical applications targeting chronic disease prevention and management.展开更多
The present research aims to establish its scientific basis by proposing and validating the hypothesis that bioactive phytochemicals of Carica papaya can be an ideal functional food and drug compound for the managemen...The present research aims to establish its scientific basis by proposing and validating the hypothesis that bioactive phytochemicals of Carica papaya can be an ideal functional food and drug compound for the management of diabetes mellitus.The in silico molecular docking and pharmacokinetic analysis of phytochemicals of C.papaya revealed that the phytochemicals have a high potential to inhibitα-amylase andα-glucosidase enzymes(9.3 to7.7 kcal/mol),responsible for post-prandial high blood glucose level and low to moderate level of absorption,distribution,metabolism and excretion(ADME)and toxicity.The experimental design was set up for industrial application for high-yield recovery of bioactive components from C.papaya leaf.The microwave-assisted extraction optimized response variables from 17 experimental runs,like total phenol content,total flavonoid content,total tannin content,and antioxidant activities(1,1-diphenyl-2-picrylhydrazyl and ferric-reducing antioxidant power)were obtained at a temperature of 61℃ at a microwave power level of 807 W and 45 min of processing.The phytochemical screening,thin-layer chromatography,Ultraviolet-visible spectroscopy,Fourier transform infrared spectroscopy,and liquid chromatography-mass spectrometry spectral analysis revealed the presence of 18 out of 21 reported major phytochemicals of C.papaya.The in vitro enzymatic activity indicated high inhibition for α-amylase(IC_(50)40.03±2.61μg/mL)andα-glucosidase(IC_(50)66.52±1.52μg/mL)enzymes.The hemolytic activity was found to be less than 5%compatible with ISO standards for the intervention of biomaterials.Furthermore,the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide and chorioallantoic membrane assay assays suggested low toxicity at the concentration of up to 62.5μg/mL.This study will help food and pharmaceutical researchers,scientists,and industrialists produce antidiabetic food compositions and medications to help diabetics manage their diabetes and enhance their health.展开更多
基金supported by Ministry of Education(formerly the Ministry of Human Resource Development),Government of India for an Institute Research Assistantship and the authors。
文摘Liposomes(LPs)are capable of transporting a wide range of bioactive compounds(BACs)that have significant applications in the pharmaceutical,food,and cosmetic industries.These BACs can be administered through various routes,including parenteral(injection),oral ingestion,or transdermal absorption.In addition,there have been limited studies conducted on the toxicological and safety aspects of LPs.This highlights the need for more research to be conducted on the potential risks of oral exposure before considering their use in food applications.Therefore,the purpose of this review is to present the latest information on the composition of LP,the materials used to coat LPs for applications in the pharmaceutical and food industries to enhance the stability of LPs containing delicate BACs,and the absorption of LPs and commercially available liposomal products produced using different technologies in the market.In addition,this paper revisits various advanced technologies used in the field of food and nutraceutical processing.These technologies include the supercritical fluid method,supercritical antisolvent method,supercritical reverse phase evaporation method,micro-fluidization,and ultrasonication.The article also discusses the applications of these technologies.
文摘Costus pictus D.,a medicinal herb renowned for its antidiabetic and antioxidant potential,remains underutilized due to its high perishability and the lack of effective post-harvest preservation technologies.This study used ultraviolet-C(UV-C)radiation(254 nm,10 min,8 W;228.6 mJ/cm^(2))as a novel,non-thermal pretreatment to enhance drying efficiency and bioactive compound retention in C.pictus leaves.Post UV-C exposure,the leaves were subjected to three conventional drying techniques,such as hot air drying(HD),vacuum drying(VD),and freeze drying(FD),at temperatures of 40◦C,50◦C,and 60◦C.Drying behavior was analyzed through empirical kinetic modelling using six thin-layer models,with the Page model demonstrating superior predictive accuracy(R2=0.998).UV-C pre-treatment significantly enhanced effective moisture diffusivity,reduced activation energy requirements,and improved mass transfer coefficients,accelerating the drying process.Drying durations were notably shortened across all methods,for example,in HD,from 120-300 min to 90-120 min,and in VD,from 360-540 min to 300-360 min.Regarding phytochemical preservation,vacuum-dried UV-C pretreated samples exhibited the highest retention of total phenolics and flavonoids,while freeze-dried counterparts demonstrated superior antioxidant capacity and microstructural integrity.Scanning electron microscopy(SEM)revealed microstructural modifications induced by UV-C treatment that facilitated enhanced moisture migration.FTIR spectroscopy confirmed the preservation of key functional groups associated with antioxidant bioactivity.These findings support the potential of UV-C-assisted drying as a scalable,energy-efficient technique for valorizing C.pictus in functional food and nutraceutical applications targeting chronic disease prevention and management.
文摘The present research aims to establish its scientific basis by proposing and validating the hypothesis that bioactive phytochemicals of Carica papaya can be an ideal functional food and drug compound for the management of diabetes mellitus.The in silico molecular docking and pharmacokinetic analysis of phytochemicals of C.papaya revealed that the phytochemicals have a high potential to inhibitα-amylase andα-glucosidase enzymes(9.3 to7.7 kcal/mol),responsible for post-prandial high blood glucose level and low to moderate level of absorption,distribution,metabolism and excretion(ADME)and toxicity.The experimental design was set up for industrial application for high-yield recovery of bioactive components from C.papaya leaf.The microwave-assisted extraction optimized response variables from 17 experimental runs,like total phenol content,total flavonoid content,total tannin content,and antioxidant activities(1,1-diphenyl-2-picrylhydrazyl and ferric-reducing antioxidant power)were obtained at a temperature of 61℃ at a microwave power level of 807 W and 45 min of processing.The phytochemical screening,thin-layer chromatography,Ultraviolet-visible spectroscopy,Fourier transform infrared spectroscopy,and liquid chromatography-mass spectrometry spectral analysis revealed the presence of 18 out of 21 reported major phytochemicals of C.papaya.The in vitro enzymatic activity indicated high inhibition for α-amylase(IC_(50)40.03±2.61μg/mL)andα-glucosidase(IC_(50)66.52±1.52μg/mL)enzymes.The hemolytic activity was found to be less than 5%compatible with ISO standards for the intervention of biomaterials.Furthermore,the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide and chorioallantoic membrane assay assays suggested low toxicity at the concentration of up to 62.5μg/mL.This study will help food and pharmaceutical researchers,scientists,and industrialists produce antidiabetic food compositions and medications to help diabetics manage their diabetes and enhance their health.
