BACKGROUND Chronic gastritis(CG) is an inflammatory disease of the gastric mucosa. Shenling-bai-zhu san(SLBZS), a traditional Chinese medicine formula, is widely used for treating CG. Nevertheless, its effects are cur...BACKGROUND Chronic gastritis(CG) is an inflammatory disease of the gastric mucosa. Shenling-bai-zhu san(SLBZS), a traditional Chinese medicine formula, is widely used for treating CG. Nevertheless, its effects are currently unclear.AIM To determine the clinical evidence and potential mechanisms of SLBZS for the treatment of CG.METHODS We systematically searched 3 English(PubMed, Embase, Medline) and 4 Chinese databases(Cochrane Library Central Register of Controlled Trials, China National Knowledge Infrastructure database, Wanfang Data Knowledge Service Platform,and the VIP information resource integration service platform) without language or publication bias restriction. Qualified studies were selected according to pre-set inclusion and exclusion criteria. RevMan 5.3 software was used for meta-analysis and literature quality assessment, Stata 14.0 software was used for sensitivity analysis, GRADE profiler 3.6 was used to evaluate the quality of evidence. And then, network pharmacology analysis was applied to primary research the mechanisms of action of SLBZS on CG.RESULTS Fourteen studies were finally included, covering 1335 participants. Meta-analysis indicated that:(1) SLBZS was superior to conventional therapies [risk ratio(RR):1.29, 95% confidence interval(CI): 1.21 to 1.37, P < 0.00001];(2) SLBZS was better than conventional therapies [RR: 0.24, 95% confidence interval(95%CI): 0.11 to 0.55, P = 0.0007] in terms of recurrence rate and reversal of Helicobacter pylori positivity(RR: 1.20, 95%CI: 1.11 to 1.30,P < 0.00001);and(3) The safety of SLBZS for CG remains unclear. According to the GRADE method, the quality of evidence was not high. Besides, SNZJS might treat CG by acting on related targets and pathways such as EGFR tyrosine kinase inhibitor resistance, the PI3K-Akt signaling pathway, and others.CONCLUSION SLBZS might be useful in treating CG, but long-term effects and specific clinical mechanisms of it maintain unclear. More samples and high-quality clinical experiments should be assessed and verified in the next step.展开更多
BACKGROUND: This study aims to investigate whether small balloon aortic valvuloplasty(BAV) reduces the need for permanent pacemaker implantation (PPMI) after transcatheter aortic valveimplantation (TAVI).METHODS: This...BACKGROUND: This study aims to investigate whether small balloon aortic valvuloplasty(BAV) reduces the need for permanent pacemaker implantation (PPMI) after transcatheter aortic valveimplantation (TAVI).METHODS: This was a retrospective analysis using data from our local TAVI database. SmallBAV was defined as a small balloon size (=18 mm) pre-dilatation. Normal BAV was defined as aballoon size >18 mm. The primary endpoint was the incidence of new PPMI.RESULTS: Of 99 consecutive TAVI patients, five patients were excluded due to pre-existingpermanent pacemaker. Patients in the small BAV group (n=57) had a signifi cantly lower PPMI ratecompared with the normal BAV group (n=37) (3.5% vs. 18.9%, P=0.026). Moderate or severe aorticvalve regurgitation post-procedure was similar between the small BAV and normal BAV groups (5.3%vs. 8.1%, P=0.480);likewise, the mean aortic gradient post-procedure did not differ significantly(11.5±5.2 mmHg vs. 12.2±7.3 mmHg, 1 mmHg=0.133 kPa, P=0.580) between the groups. Devicesuccess rates were also similar (94.7% vs. 91.8%, P=0.680). In multivariable analysis, small BAV(P=0.027), the ratio of prosthesis diameter to annulus diameter (P=0.048), and mean aortic gradientby echo in the basement (P=0.021) were independent predictors of PPMI.CONCLUSIONS: The small BAV strategy is associated with a low rate of permanentpacemaker implantation after transcatheter self-expanding valve implantation in this single-centerobservational study.展开更多
In a single-pixel fast imaging setup,the data collected by the single-pixel detector needs to be processed by a computer,but the speed of the latter will affect the image reconstruction time.Here we propose two kinds ...In a single-pixel fast imaging setup,the data collected by the single-pixel detector needs to be processed by a computer,but the speed of the latter will affect the image reconstruction time.Here we propose two kinds of setups which are able to transform non-visible into visible light imaging,wherein their computing process is replaced by a camera integration mode.The image captured by the camera has a low contrast,so here we present an algorithm that can realize a high quality image in near-infrared to visible cross-waveband imaging.The scheme is verified both by simulation and in actual experiments.The setups demonstrate the great potential for single-pixel imaging and high-speed cross-waveband imaging for future practical applications.展开更多
We present a proof-of-principle demonstration of energy-resolved resonant neutron ghost imaging.Based on the resonant absorption dips of different elements,we simultaneously image and distinguish the composition of th...We present a proof-of-principle demonstration of energy-resolved resonant neutron ghost imaging.Based on the resonant absorption dips of different elements,we simultaneously image and distinguish the composition of three differently shaped components of an object.The initial neutron beam is spatially and energy selectively modulated by a series of Hadamard matrix masks of pixel width 100μm.The spectral intensity transmitted through an object is measured by a^(6)Li glass single-pixel detector.Through integration of the total counts within resonant dips and correlating them with the corresponding Hadamard patterns,isotopespecific images of In,Ag and W objects are obtained at an effective spatial resolution of~200μm.Reconstruction algorithms based on compressed sensing or convolutional neural networks can greatly reduce the data acquisition time by~70%with respect to the full set of 1024 patterns,as well as enhance the image quality.Incorporating ghost imaging into energy-resolved neutron imaging thus has great potential for the simultaneous realization of fine spatial and spectral resolution,which has important value for the noninvasive analysis of material composition and distribution not only in basic research but also in industrial applications.展开更多
For practical applications of X-ray ghost imaging(XGI),the imaging time is a major challenge.In this paper,we propose a fast XGI scheme based on a continuous translation mask with etched aggregate patterns.High contra...For practical applications of X-ray ghost imaging(XGI),the imaging time is a major challenge.In this paper,we propose a fast XGI scheme based on a continuous translation mask with etched aggregate patterns.High contrastto-noise ratio images are obtained with an exposure time of only 4 s and 24 s for a 3.4 mm×3.8 mm and 5.9 mm×6.1 mm field-of-view,respectively.The spatial resolution can reach∼150μm.The influences of the sampling frequency,the mask scanning speed,and the detector integration time on image quality are examined,from which we demonstrate that the imaging time can be further reduced by increasing the mask translation speed.By applying a compressed sensing reconstruction algorithm,the exposure time is greatly reduced while maintaining image quality.Our method indicates a path for the development of future XGI applications.展开更多
Neutron imaging is an invaluable tool for noninvasive analysis in many fields.However,neutron facilities are expensive and inconvenient to access,while portable sources are not strong enough to form even a static imag...Neutron imaging is an invaluable tool for noninvasive analysis in many fields.However,neutron facilities are expensive and inconvenient to access,while portable sources are not strong enough to form even a static image within an acceptable time frame using traditional neutron imaging.Here we demonstrate a new scheme for single-pixel neutron imaging of real objects,with spatial and spectral resolutions of 100 lm and 0.4%at 1A,respectively.Low illumination down to 1000 neutron counts per frame pattern was achieved.The experimental setup is simple,inexpensive,and especially suitable for low intensity portable sources,which should greatly benefit applications in biology,material science,and industry.展开更多
文摘BACKGROUND Chronic gastritis(CG) is an inflammatory disease of the gastric mucosa. Shenling-bai-zhu san(SLBZS), a traditional Chinese medicine formula, is widely used for treating CG. Nevertheless, its effects are currently unclear.AIM To determine the clinical evidence and potential mechanisms of SLBZS for the treatment of CG.METHODS We systematically searched 3 English(PubMed, Embase, Medline) and 4 Chinese databases(Cochrane Library Central Register of Controlled Trials, China National Knowledge Infrastructure database, Wanfang Data Knowledge Service Platform,and the VIP information resource integration service platform) without language or publication bias restriction. Qualified studies were selected according to pre-set inclusion and exclusion criteria. RevMan 5.3 software was used for meta-analysis and literature quality assessment, Stata 14.0 software was used for sensitivity analysis, GRADE profiler 3.6 was used to evaluate the quality of evidence. And then, network pharmacology analysis was applied to primary research the mechanisms of action of SLBZS on CG.RESULTS Fourteen studies were finally included, covering 1335 participants. Meta-analysis indicated that:(1) SLBZS was superior to conventional therapies [risk ratio(RR):1.29, 95% confidence interval(CI): 1.21 to 1.37, P < 0.00001];(2) SLBZS was better than conventional therapies [RR: 0.24, 95% confidence interval(95%CI): 0.11 to 0.55, P = 0.0007] in terms of recurrence rate and reversal of Helicobacter pylori positivity(RR: 1.20, 95%CI: 1.11 to 1.30,P < 0.00001);and(3) The safety of SLBZS for CG remains unclear. According to the GRADE method, the quality of evidence was not high. Besides, SNZJS might treat CG by acting on related targets and pathways such as EGFR tyrosine kinase inhibitor resistance, the PI3K-Akt signaling pathway, and others.CONCLUSION SLBZS might be useful in treating CG, but long-term effects and specific clinical mechanisms of it maintain unclear. More samples and high-quality clinical experiments should be assessed and verified in the next step.
基金supported by National Key R & D Plan(2017YFC1104202).
文摘BACKGROUND: This study aims to investigate whether small balloon aortic valvuloplasty(BAV) reduces the need for permanent pacemaker implantation (PPMI) after transcatheter aortic valveimplantation (TAVI).METHODS: This was a retrospective analysis using data from our local TAVI database. SmallBAV was defined as a small balloon size (=18 mm) pre-dilatation. Normal BAV was defined as aballoon size >18 mm. The primary endpoint was the incidence of new PPMI.RESULTS: Of 99 consecutive TAVI patients, five patients were excluded due to pre-existingpermanent pacemaker. Patients in the small BAV group (n=57) had a signifi cantly lower PPMI ratecompared with the normal BAV group (n=37) (3.5% vs. 18.9%, P=0.026). Moderate or severe aorticvalve regurgitation post-procedure was similar between the small BAV and normal BAV groups (5.3%vs. 8.1%, P=0.480);likewise, the mean aortic gradient post-procedure did not differ significantly(11.5±5.2 mmHg vs. 12.2±7.3 mmHg, 1 mmHg=0.133 kPa, P=0.580) between the groups. Devicesuccess rates were also similar (94.7% vs. 91.8%, P=0.680). In multivariable analysis, small BAV(P=0.027), the ratio of prosthesis diameter to annulus diameter (P=0.048), and mean aortic gradientby echo in the basement (P=0.021) were independent predictors of PPMI.CONCLUSIONS: The small BAV strategy is associated with a low rate of permanentpacemaker implantation after transcatheter self-expanding valve implantation in this single-centerobservational study.
文摘In a single-pixel fast imaging setup,the data collected by the single-pixel detector needs to be processed by a computer,but the speed of the latter will affect the image reconstruction time.Here we propose two kinds of setups which are able to transform non-visible into visible light imaging,wherein their computing process is replaced by a camera integration mode.The image captured by the camera has a low contrast,so here we present an algorithm that can realize a high quality image in near-infrared to visible cross-waveband imaging.The scheme is verified both by simulation and in actual experiments.The setups demonstrate the great potential for single-pixel imaging and high-speed cross-waveband imaging for future practical applications.
基金supported by the National Natural Science Foundation of China(Nos.61975229,12335016,11991073,and W2412039)the Strategic Priority Research Program of the CAS(Nos.XDA25030400 and XDA25010100).
文摘We present a proof-of-principle demonstration of energy-resolved resonant neutron ghost imaging.Based on the resonant absorption dips of different elements,we simultaneously image and distinguish the composition of three differently shaped components of an object.The initial neutron beam is spatially and energy selectively modulated by a series of Hadamard matrix masks of pixel width 100μm.The spectral intensity transmitted through an object is measured by a^(6)Li glass single-pixel detector.Through integration of the total counts within resonant dips and correlating them with the corresponding Hadamard patterns,isotopespecific images of In,Ag and W objects are obtained at an effective spatial resolution of~200μm.Reconstruction algorithms based on compressed sensing or convolutional neural networks can greatly reduce the data acquisition time by~70%with respect to the full set of 1024 patterns,as well as enhance the image quality.Incorporating ghost imaging into energy-resolved neutron imaging thus has great potential for the simultaneous realization of fine spatial and spectral resolution,which has important value for the noninvasive analysis of material composition and distribution not only in basic research but also in industrial applications.
基金National Natural Science Foundation of China(61975229,12335016,11991073,W2412039,61805006)National Key R&D Program of China(2018YFB0504302)Strategic Priority Research Program of the CAS(XDA25030400,XDA25010100).
文摘For practical applications of X-ray ghost imaging(XGI),the imaging time is a major challenge.In this paper,we propose a fast XGI scheme based on a continuous translation mask with etched aggregate patterns.High contrastto-noise ratio images are obtained with an exposure time of only 4 s and 24 s for a 3.4 mm×3.8 mm and 5.9 mm×6.1 mm field-of-view,respectively.The spatial resolution can reach∼150μm.The influences of the sampling frequency,the mask scanning speed,and the detector integration time on image quality are examined,from which we demonstrate that the imaging time can be further reduced by increasing the mask translation speed.By applying a compressed sensing reconstruction algorithm,the exposure time is greatly reduced while maintaining image quality.Our method indicates a path for the development of future XGI applications.
基金supported by the National Key R&D Program of China(2016YFA0401504,2017YFA0403301,2017YFB0503301,and 2018YFB0504302)the National Natural Science Foundation of China(11991073,61975229,61805006,and U1932219)+2 种基金the Key Program of Chinese Academy of Sciences(XDA25030400,and XDB17030500)the Civil Space Project(D040301)the Science Challenge Project(TZ2018005)。
文摘Neutron imaging is an invaluable tool for noninvasive analysis in many fields.However,neutron facilities are expensive and inconvenient to access,while portable sources are not strong enough to form even a static image within an acceptable time frame using traditional neutron imaging.Here we demonstrate a new scheme for single-pixel neutron imaging of real objects,with spatial and spectral resolutions of 100 lm and 0.4%at 1A,respectively.Low illumination down to 1000 neutron counts per frame pattern was achieved.The experimental setup is simple,inexpensive,and especially suitable for low intensity portable sources,which should greatly benefit applications in biology,material science,and industry.
