Background:Aging is a key risk factor for human health,causing damage to the brain and liver tissues.Accumulating evidence indicates that oxidative stress is a critical driver of the aging process.Shuangshen tablet(SS...Background:Aging is a key risk factor for human health,causing damage to the brain and liver tissues.Accumulating evidence indicates that oxidative stress is a critical driver of the aging process.Shuangshen tablet(SST),a functional food formulated with Ginseng Radix et Rhizoma and Apostichopus japonicus as main ingredients,possesses potential antioxidant and anti-aging properties.Thus,this study aimed to evaluate the anti-aging effects of SST using a D-galactose-induced aging model.Methods:The formula of SST was optimized via single-factor experiments and response surface methodology.Chemical components of SST were identified by UHPLC-Q-Exactive Orbitrap HRMS,and their in vitro antioxidant activity was determined.D-galactose-induced aging mice were intervened with SST,followed by detection of serum oxidative stress and pro-inflammatory factor levels,as well as the activities of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)content in brain and liver tissues.Hematoxylin and eosin(HE)staining was used to observe brain and liver histopathological changes.Mechanistic studies were conducted to analyze the protein expression levels of Nrf2-HO-1 pathway-related proteins,phosphorylated PI3K(p-PI3K),and phosphorylated AKT(p-AKT).Acute and subacute toxicity tests were performed to evaluate the safety of SST.Results:A total of 46 active components were identified from SST,including ketones,terpenes,phenylpropanoids,and organic acids.SST intervention significantly regulated serum oxidative stress and pro-inflammatory factor levels in aging mice:it reduced MDA content in brain and liver tissues,increased SOD,CAT,and GSH-Px activities,and decreased serum tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β)levels.HE staining showed that SST alleviated D-galactose-induced brain and liver damage.Mechanistically,SST mitigated oxidative damage by activating the Nrf2-HO-1 pathway and upregulating the protein expression of p-PI3K and p-AKT.Acute and subacute toxicity tests confirmed the safety of SST.Conclusion:SST can effectively delay the D-galactose-induced aging process by improving the oxidative stress signaling pathway,providing a theoretical basis for the development of antioxidant functional foods.展开更多
对燃气轮机进行掺氢运行可以提升可再生能源的储存消纳和有效实现降碳,但掺氢会带来燃气轮机动态特性变化,需开展相关仿真及控制策略研究。本研究构建了包含涡轮特性修正的天然气/氢混合燃料燃气轮机的变工况特性预测混合模型,使用了国...对燃气轮机进行掺氢运行可以提升可再生能源的储存消纳和有效实现降碳,但掺氢会带来燃气轮机动态特性变化,需开展相关仿真及控制策略研究。本研究构建了包含涡轮特性修正的天然气/氢混合燃料燃气轮机的变工况特性预测混合模型,使用了国家管网提供的实机数据进行模型校准,针对掺氢带来的燃气轮机动力涡轮转速、高压轴转速、燃料质量流量及燃气初温的动态特性变化,提出了基于线性自抗扰控制(Linear Active Disturbance Rejection Control,简称LADRC)的控制策略。结果表明:负载波动工况下,增加掺氢比可以提高动力涡轮转速、高压轴转速、燃料质量流量、燃气初温的响应速度及压气机喘振裕度;但定负载下氢含量瞬时突增时,燃气初温会瞬时升高,同时使得动力涡轮转速及高压轴转速升高,燃料流量降低。所提出的基于LADRC的控制策略可以改善负载突变及掺氢比波动时燃气轮机动态特性,其中对动力涡轮转速影响最显著;相较于传统PID控制器,动力涡轮转速超调量和恢复时间可分别降低至50%和20%,同时LADRC器控制能够有效改善氢含量波动时燃气初温的峰值变化,提高系统的可靠性。展开更多
The microstructure evolution and strengthening mechanism of WE54 alloy with different hard-plate rolling(HPR)processes were systematically investigated.The results suggest that the mechanical properties of the as-roll...The microstructure evolution and strengthening mechanism of WE54 alloy with different hard-plate rolling(HPR)processes were systematically investigated.The results suggest that the mechanical properties of the as-rolled alloys are significantly enhanced compared to those of the as-cast alloy.When subjected to three rolling passes at 450℃ and 490℃,grain refinement occurs due to dynamic recrystallization.A mixed-grain structure is formed after a single pass rolling with a substantial reduction(65%)at 490℃.The dynamic recrystallization(DRX)mechanism of the alloy during the HPR includes continuous dynamic recrystallization(CDRX),discontinuous dynamic recrystallization(DDRX),and twin-induced recrystallization(TDRX).The WE54 alloy exhibits the highest strength after three passes of HPR at 450℃,with tensile strength and yield strength of 374 and 323 MPa,respectively.The significant improvement in the mechanical properties of the alloy is primarily attributed to fine-grain strengthening,solid solution strengthening,and dislocation strengthening.展开更多
基金funded by Jilin Provincial Science and Technology Development Plan Project-Research and Development of Shuangshen Tablets(20210401123YY)Jilin Provincial Science and Technology Development Plan Project-Jilin Province High-quality and Authentic Medicinal Materials(Ginseng)Science and Technology Demonstration Base+(Ji'an Dadi Ginseng Industry Co.,Ltd.Ginseng Planting Base)(20220401114YY)Scientific Research Fund of Hebei Normal University of Science&Technology(2024YB019).
文摘Background:Aging is a key risk factor for human health,causing damage to the brain and liver tissues.Accumulating evidence indicates that oxidative stress is a critical driver of the aging process.Shuangshen tablet(SST),a functional food formulated with Ginseng Radix et Rhizoma and Apostichopus japonicus as main ingredients,possesses potential antioxidant and anti-aging properties.Thus,this study aimed to evaluate the anti-aging effects of SST using a D-galactose-induced aging model.Methods:The formula of SST was optimized via single-factor experiments and response surface methodology.Chemical components of SST were identified by UHPLC-Q-Exactive Orbitrap HRMS,and their in vitro antioxidant activity was determined.D-galactose-induced aging mice were intervened with SST,followed by detection of serum oxidative stress and pro-inflammatory factor levels,as well as the activities of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)content in brain and liver tissues.Hematoxylin and eosin(HE)staining was used to observe brain and liver histopathological changes.Mechanistic studies were conducted to analyze the protein expression levels of Nrf2-HO-1 pathway-related proteins,phosphorylated PI3K(p-PI3K),and phosphorylated AKT(p-AKT).Acute and subacute toxicity tests were performed to evaluate the safety of SST.Results:A total of 46 active components were identified from SST,including ketones,terpenes,phenylpropanoids,and organic acids.SST intervention significantly regulated serum oxidative stress and pro-inflammatory factor levels in aging mice:it reduced MDA content in brain and liver tissues,increased SOD,CAT,and GSH-Px activities,and decreased serum tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β)levels.HE staining showed that SST alleviated D-galactose-induced brain and liver damage.Mechanistically,SST mitigated oxidative damage by activating the Nrf2-HO-1 pathway and upregulating the protein expression of p-PI3K and p-AKT.Acute and subacute toxicity tests confirmed the safety of SST.Conclusion:SST can effectively delay the D-galactose-induced aging process by improving the oxidative stress signaling pathway,providing a theoretical basis for the development of antioxidant functional foods.
文摘对燃气轮机进行掺氢运行可以提升可再生能源的储存消纳和有效实现降碳,但掺氢会带来燃气轮机动态特性变化,需开展相关仿真及控制策略研究。本研究构建了包含涡轮特性修正的天然气/氢混合燃料燃气轮机的变工况特性预测混合模型,使用了国家管网提供的实机数据进行模型校准,针对掺氢带来的燃气轮机动力涡轮转速、高压轴转速、燃料质量流量及燃气初温的动态特性变化,提出了基于线性自抗扰控制(Linear Active Disturbance Rejection Control,简称LADRC)的控制策略。结果表明:负载波动工况下,增加掺氢比可以提高动力涡轮转速、高压轴转速、燃料质量流量、燃气初温的响应速度及压气机喘振裕度;但定负载下氢含量瞬时突增时,燃气初温会瞬时升高,同时使得动力涡轮转速及高压轴转速升高,燃料流量降低。所提出的基于LADRC的控制策略可以改善负载突变及掺氢比波动时燃气轮机动态特性,其中对动力涡轮转速影响最显著;相较于传统PID控制器,动力涡轮转速超调量和恢复时间可分别降低至50%和20%,同时LADRC器控制能够有效改善氢含量波动时燃气初温的峰值变化,提高系统的可靠性。
基金financially supported by the Natural Science Basic Research Program of Shaanxi Province,China(No.2023-JC-QN-0581)Advanced Power Specialty,China(No.YK22C-9)。
文摘The microstructure evolution and strengthening mechanism of WE54 alloy with different hard-plate rolling(HPR)processes were systematically investigated.The results suggest that the mechanical properties of the as-rolled alloys are significantly enhanced compared to those of the as-cast alloy.When subjected to three rolling passes at 450℃ and 490℃,grain refinement occurs due to dynamic recrystallization.A mixed-grain structure is formed after a single pass rolling with a substantial reduction(65%)at 490℃.The dynamic recrystallization(DRX)mechanism of the alloy during the HPR includes continuous dynamic recrystallization(CDRX),discontinuous dynamic recrystallization(DDRX),and twin-induced recrystallization(TDRX).The WE54 alloy exhibits the highest strength after three passes of HPR at 450℃,with tensile strength and yield strength of 374 and 323 MPa,respectively.The significant improvement in the mechanical properties of the alloy is primarily attributed to fine-grain strengthening,solid solution strengthening,and dislocation strengthening.
