Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzhei...Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease development.To do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of age.Twelve-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 mice.Notably,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 mice.These findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.展开更多
Microstructure topology evolution during severe plastic deformation(SPD)is crucial for understanding and optimising the mechanical properties of metallic materials,though its prediction remains challenging.Herein,we c...Microstructure topology evolution during severe plastic deformation(SPD)is crucial for understanding and optimising the mechanical properties of metallic materials,though its prediction remains challenging.Herein,we combine discrete cell complexes(DCC),a fully discrete algebraic topology model-with finite element analysis(FEA)to simulate and analyse the microstructure topology of pure copper under SPD.Using DCC,we model the evolution of microstructure topology characterised by Betti numbers(β_(0),β_(1),β_(2))and Euler characteristic(χ).This captures key changes in GBNs and topological features within representative volume elements(RVEs)containing several hundred grains during SPD-induced recrystallisation.As SPD cycles increase,high-angle grain boundaries(HAGBs)progressively form.Topological analysis reveals an overall decrease in β_(0)values,indicating fewer isolated HAGB substructures,while β_(2) values show a steady upward trend,highlighting new grain formation.Leveraging DCC-derived RVE topology and FEA-generated plastic strain data,we directly simulate the evolution and spatial distribution of microstructure topology and HAGB fraction in a copper tube undergoing cyclic parallel tube channel angular pressing(PTCAP),a representative SPD technique.Within the tube,the HAGB fraction continuously increases with PTCAP cycles,reflecting the microstructure’s gradual transition from subgrains to fully-formed grains.Analysis of Betti number distribution and evolution reveals the microstructural reconstruction mechanism underpinning this subgrain to grain transition during PTCAP.We further demonstrate the significant influence of spatially non-uniform plastic strain distribution on microstructure reconstruction kinetics.This study demonstrates a feasible approach for simulating microstructure topology evolution of metals processed by cyclic SPD via the integration of DCC and FEA.展开更多
To extract the valuable elements from the steel slag, a novel approach has been proposed by modification treatment to provide the stronger driving forces and accelerate the reduction. Three types of dephosphorization ...To extract the valuable elements from the steel slag, a novel approach has been proposed by modification treatment to provide the stronger driving forces and accelerate the reduction. Three types of dephosphorization steel slags were reduced using carbon-saturated iron bath to extract iron and phosphorus simultaneously. During the process of reduction, slag composition, temperature, and original P2O5 content were investigated respectively. Slag modification treatment, adding either silica or alumina to vary the slag composition, was proven to accelerate the reduction of dephosphorization slag. The equilibrium time can be shortened from 60 to 30 min. Slag modification also allowed the reduction reaction to occur at lower temperature. After slag modification, the original P2O5 content in slag presents a slight difference on reduction process. Almost half of the reduced phosphorus was vaporized within 5 and 20 min. As more and more FeO was reduced, CO gas generation decreased, and evaporation amount of phosphorus therefore decreases.展开更多
基金financially supported by the National Natural Science Foundation of China,No.823 74552 (to WP)the Science and Technology Innovation Program of Hunan Province,No.2022RC1220 (to WP)+1 种基金the Natural Science Foundation of Hunan Province of China,Nos.2020JJ4803 (to WP),2022JJ40723 (to MY)the Scientific Research Launch Project for New Employees of the Second Xiangya Hospital of Central South University (to MY)
文摘Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease development.To do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of age.Twelve-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 mice.Notably,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 mice.These findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.
基金support from Outstanding Youth Fund of Jiangsu Province(BK20240077)Key Project(Provincial-Municipal Joint)of Jiangsu Province(BK20243044)+2 种基金Fundamental Research Funds for the Central Universities(NE2024001)National Youth Talents Programof Chinaa project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘Microstructure topology evolution during severe plastic deformation(SPD)is crucial for understanding and optimising the mechanical properties of metallic materials,though its prediction remains challenging.Herein,we combine discrete cell complexes(DCC),a fully discrete algebraic topology model-with finite element analysis(FEA)to simulate and analyse the microstructure topology of pure copper under SPD.Using DCC,we model the evolution of microstructure topology characterised by Betti numbers(β_(0),β_(1),β_(2))and Euler characteristic(χ).This captures key changes in GBNs and topological features within representative volume elements(RVEs)containing several hundred grains during SPD-induced recrystallisation.As SPD cycles increase,high-angle grain boundaries(HAGBs)progressively form.Topological analysis reveals an overall decrease in β_(0)values,indicating fewer isolated HAGB substructures,while β_(2) values show a steady upward trend,highlighting new grain formation.Leveraging DCC-derived RVE topology and FEA-generated plastic strain data,we directly simulate the evolution and spatial distribution of microstructure topology and HAGB fraction in a copper tube undergoing cyclic parallel tube channel angular pressing(PTCAP),a representative SPD technique.Within the tube,the HAGB fraction continuously increases with PTCAP cycles,reflecting the microstructure’s gradual transition from subgrains to fully-formed grains.Analysis of Betti number distribution and evolution reveals the microstructural reconstruction mechanism underpinning this subgrain to grain transition during PTCAP.We further demonstrate the significant influence of spatially non-uniform plastic strain distribution on microstructure reconstruction kinetics.This study demonstrates a feasible approach for simulating microstructure topology evolution of metals processed by cyclic SPD via the integration of DCC and FEA.
基金Item Sponsored by National Natural Science Foundation of China(50904017)Fundamental Research Funds for Central Universities of China(100402016)Postdoctoral Science Foundation of China(2011M500823)
文摘To extract the valuable elements from the steel slag, a novel approach has been proposed by modification treatment to provide the stronger driving forces and accelerate the reduction. Three types of dephosphorization steel slags were reduced using carbon-saturated iron bath to extract iron and phosphorus simultaneously. During the process of reduction, slag composition, temperature, and original P2O5 content were investigated respectively. Slag modification treatment, adding either silica or alumina to vary the slag composition, was proven to accelerate the reduction of dephosphorization slag. The equilibrium time can be shortened from 60 to 30 min. Slag modification also allowed the reduction reaction to occur at lower temperature. After slag modification, the original P2O5 content in slag presents a slight difference on reduction process. Almost half of the reduced phosphorus was vaporized within 5 and 20 min. As more and more FeO was reduced, CO gas generation decreased, and evaporation amount of phosphorus therefore decreases.
