Elevated atmospheric carbon dioxide concentration([CO_(2)])can stimulate crop growth and increase yield,but the effect may be constrained by soil contamination with heavy metals.In a free-air carbon dioxide enrichment...Elevated atmospheric carbon dioxide concentration([CO_(2)])can stimulate crop growth and increase yield,but the effect may be constrained by soil contamination with heavy metals.In a free-air carbon dioxide enrichment experiment over three seasons,we found that soil heavy metal contamination can constrain or even reverse the projected CO_(2)fertilization effect on rice yield.Elevated[CO_(2)]produced opposing effects on the accumulation of arsenic and cadmium in rice grain.Breeding crops for heavy-metal resistance and low arsenic accumulation may become necessary with continuing climate change.展开更多
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by elimi...Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by eliminating activated hepatic stellate cells(HSCs).However,the underlying mechanism remains unclear despite these findings.Notably,endocytic adaptor protein(NUMB)has significant implications for treating hepatic diseases,but current research primarily focuses on liver regeneration and hepatocellular carcinoma.The precise function of NUMB in liver fibrosis,particularly its ability to regulate HSCs,requires further investigation.This study aims to elucidate the role of NUMB in the anti-hepatic fibrosis action of ART in HSCs.We observed that the expression level of NUMB significantly decreased in activated HSCs compared to quiescent HSCs,exhibiting a negative correlation with the progression of liver fibrosis.Additionally,ART induced senescence in activated HSCs through the NUMB/P53 tumor suppressor(P53)axis.We identified NUMB as a crucial regulator of senescence in activated HSCs and as a mediator of ART in determining cell fate.This research examines the specific target of ART in eliminating activated HSCs,providing both theoretical and experimental evidence for the treatment of liver fibrosis.展开更多
Alzheimer’s disease(AD)is regarded as a neurodegenerative disease,and it has been proposed that AD may be a systemic disease.Studies have reported associations between non-neurological diseases and AD.The correlation...Alzheimer’s disease(AD)is regarded as a neurodegenerative disease,and it has been proposed that AD may be a systemic disease.Studies have reported associations between non-neurological diseases and AD.The correlations between AD pathology and systemic(non-neurological)pathological changes are intricate,and the mechanisms underlying these correlations and their causality are unclear.In this article,we review the association between AD and disorders of other systems.In addition,we summarize the possible mechanisms associated with AD and disorders of other systems,mainly from the perspective of AD pathology.Regarding the relationship between AD and systemic pathological changes,we aim to provide a new outlook on the early warning signs and treatment of AD,such as establishing a diagnostic and screening system based on more accessible peripheral samples.展开更多
Objective:Circular RNAs(circRNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including autophagy.This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in I...Objective:Circular RNAs(circRNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including autophagy.This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms.Methods:Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected.Hippocampal neurons were treated with oxygen and glucose deprivation(OGD)to establish IS in vitro model.The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope.Cell apoptosis rate and the expression of cleaved caspase-3,Bax,and Bcl-2 were assessed byflow cytometry and western blotting.The binding relationships among circR-ZC3HC1,miR-384-5p,and SIRT1 were predicted and verified.Results:Low expression of circR-ZC3HC1 was found in blood samples of IS patients and OGD-treated neurons.Overexpressed circR-ZC3HC1 or inhibited miR-384-5p expression promoted autophagy and inhibited apoptosis of OGD-treated neurons,which could be reversed by further 3-MA treatment.Mechanistically,circR-ZC3HC1 targeted miR-384-5p to mediate SIRT1 expression.miR-384-5p overexpression or SIRT1 knockdown in the presence of circR-ZC3HC1 overexpression in OGD-treated neurons lead to reduced autophagy and enhanced apoptosis.Conclusion:Collectively,circR-ZC3HC1 promoted neuronal autophagy to attenuate IS via miR-384-5p/SIRT1 axis.展开更多
Objective:To explore the effectiveness of a chest compression device combined with extended self-care for scar prevention in patients following keloid excision surgery.Methods:Forty patients(36 lesions)who underwent k...Objective:To explore the effectiveness of a chest compression device combined with extended self-care for scar prevention in patients following keloid excision surgery.Methods:Forty patients(36 lesions)who underwent keloid excision surgery at the Department of Plastic and Reconstructive Surgery,First Medical Center,PLA General Hospital from June 2022 to June 2024 were selected.They were randomly divided into an experimental group and a control group,with 20 patients in each group.The control group received traditional elastic garment compression therapy,while the experimental group used a chest compression device designed for scar prevention.Scar width,hypertrophy,and Vancouver Scar Scale(VSS)scores were compared between the two groups at 6 months post-operation.Results:There were no statistically significant differences between the two groups in terms of gender,age,disease duration,lesion area,or location(P>0.05).However,VSS scores(except for pliability)in the experimental group were significantly lower than those in the control group(P<0.05).Conclusion:The chest compression device for scar prevention is more effective than traditional elastic garments in preventing scar hypertrophy after chest wall keloid excision surgery,and it has high clinical value,making it worthy of promotion.展开更多
Objective:To investigate the effect of a chest compression device for scar prevention combined with a nurse-patient WeChat group on scar formation after keloid excision.Methods:Forty patients with chest wall keloids w...Objective:To investigate the effect of a chest compression device for scar prevention combined with a nurse-patient WeChat group on scar formation after keloid excision.Methods:Forty patients with chest wall keloids who underwent keloid excision surgery at the Department of Plastic and Reconstructive Surgery,First Medical Center of PLA General Hospital from June 2022 to June 2024 were selected.They were randomly divided into two groups:the observation group(20 cases)and the control group(20 cases).Both groups underwent routine keloid excision,followed by compression therapy for 6 months.The observation group used a chest compression device,while the control group used a compression garment.Scar width,hypertrophy,and Vancouver Scar Scale(VSS)scores were compared between the two groups.Results:There were no significant differences between the two groups in terms of gender,age,disease course,lesion area,and lesion site(P>0.05).The overall effective rate in the observation group was 95.00%,significantly higher than the 65.00%in the control group,with a statistically significant difference(P<0.05).After a 6-month follow-up,all VSS indicators(except for pliability)in the observation group(using the chest compression device)were significantly lower than those in the control group(P<0.05).Conclusion:Compared to the traditional compression garment,the chest compression device for scar prevention is more effective in preventing scar hypertrophy after chest wall keloid excision and improving the appearance of scars.It is worth promoting for clinical application.展开更多
AIM:To examine the clinical features and analyze prognostic factors in a prospective study of primary biliary cirrhosis(PBC) patients.METHODS:From 1995 to 2010,PBC patients without hepatic decompensation seen at the P...AIM:To examine the clinical features and analyze prognostic factors in a prospective study of primary biliary cirrhosis(PBC) patients.METHODS:From 1995 to 2010,PBC patients without hepatic decompensation seen at the Peking Union Medical College Hospital were enrolled.Clinical signs and manifestations(pruritus,persistent fatigue,jaundice and pain in the right hypochondrium),laboratory parameters(auto-antibodies for autoimmune hepatic disease,biliary and hepatic enzymes,immunoglobulin,bilirubin,and albumin) and imaging findings were recorded at entry and at specific time points during follow-up.Cox regression and Kaplan-Meier analyses,respectively,assessed the risk factors for hepatic decompensation and survival.RESULTS:Two hundred and sixty-two PBC patients were enrolled with a median follow-up of 75.2 mo(range,21-201 mo).The 240 patients were aged 51.5 ± 10.2 years at diagnosis and 91.6% were female.Two hundred and forty-five(93.5%) were seropositive for anti-mitochondrial antibodies.At presentation,170 patients(64.9%) were symptomatic,while 96 patients(36.6%) had extra-hepatic autoimmune disease.During the follow-up period,62(23.7%) patients developed hepatic decompensation of whom four underwent liver transplantation and 17 died.The cumulative survival rate and median survival time were 83.9% and 181.7 mo,respectively.Cox regression analysis revealed that an incomplete ursodeoxycholic acid(UDCA) response or inconsistent treatment [P < 0.001;hazard risk(HR) 95%CI = 2.423-7.541],anti-centromere antibodies(ACA) positivity(P < 0.001;HR 95%CI = 2.516-7.137),alanine aminotransferase ratio(AAR) elevations(P < 0.001;HR 95%CI = 1.357-2.678),and histological advanced liver disease(P = 0.006;HR 95%CI = 1.481-10.847) were predictors of hepatic decompensation.The clinical features and survival of PBC in China are consistent with those described in Western countries.CONCLUSION:Incomplete UDCA response or inconsistent treatment,ACA positivity,AAR elevations,and advanced histological stage are predictors of decompensation.展开更多
Three global datasets, the History Database of the Global Environment （HYDE）, Kaplan and Krurnhardt （KK） and Pongratz of reconstructed anthropogenic land cover change （ALCC） were introduced and compared in this ...Three global datasets, the History Database of the Global Environment （HYDE）, Kaplan and Krurnhardt （KK） and Pongratz of reconstructed anthropogenic land cover change （ALCC） were introduced and compared in this paper. The HYDE dataset was recon- structed by Goldewijk and his colleagues at the National institute of Public ttealth and the Environment in Netherland, covering the past 12 000 years. The KK dataset was reconstructed by Kaplan and his colleagues, the Soil-Vegetation-Atmosphere Research Group at the Institute of Environmental Engineering in Switzerland, covering the past 8000 years. The Pongratz dataset was reconstructed by Pon- gratz and her colleagues at the Max Planck Institute for Meteorology in Germany, coveting AD 800-1992. The results show that the reconstructed datasets are quite different from each other due to the different methods used. The three datasets all allocated the historical ALCC according to human population density. The main reason causing the differences among the three datasets lies on the different relationships between population density and land use used in each reconstructed dataset. The KK dataset is better than the other two datasets for two important reasons. First, it used the nonlinear relationship between population density and land use, while the other two used the linear relationship. Second, Kaplan and his colleagues adopted the technological development and intensification parameters and considered the wood harvesting and the long-term fallow area resulted from shifting cultivation, which were neglected in the recon- structions of the other two datasets. Therefore, the KK dataset is more suitable as one of the anthropogenic forcing fields for climate simulation over the past two millennia that is recently concerned by two projects, the National Basic Research Program and the Strategic and Special Frontier Project of Science and Technology of the Chinese Academy of Sciences.展开更多
1.Introduction Cemented carbides are composites of WC ceramic phases and metallic Co binders that endow them with superior hardness and excellent toughness.Hard metals are widely used as metal cutting and rock drillin...1.Introduction Cemented carbides are composites of WC ceramic phases and metallic Co binders that endow them with superior hardness and excellent toughness.Hard metals are widely used as metal cutting and rock drilling tools[1,2].Their hardness is believed to be inversely proportional to the sizes of WC grains^([3]).Grain growth inhibitors are widely employed to achieve smaller grain sizes.展开更多
BACKGROUND Understanding a virus shedding patterns in body fluids/secretions is importantto determine the samples to be used for diagnosis and to formulate infectioncontrol measures.AIM To investigate the severe acute...BACKGROUND Understanding a virus shedding patterns in body fluids/secretions is importantto determine the samples to be used for diagnosis and to formulate infectioncontrol measures.AIM To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)shedding patterns and its risk factors.METHODS All laboratory-confirmed coronavirus disease 2019 patients with completemedical records admitted to the Shenzhen Third People’s Hospital from January28, 2020 to March 8, 2020 were included. Among 145 patients (54.5% males;median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid(BALF) had the highest virus load compared with the other samples. The viralload peaked at admission (3.3 × 108 copies) and sharply decreased 10 d afteradmission.RESULTS The viral load was associated with prolonged intensive care unit (ICU) duration.Patients in the ICU had significantly longer shedding time compared to those inthe wards (P < 0.0001). Age > 60 years [hazard ratio (HR) = 0.6;95% confidenceinterval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2 shedding,while chloroquine (HR = 22.8;95%CI: 2.3-224.6) was a protective factor.CONCLUSION BALF had the highest SARS-CoV-2 load. Elderly patients had higher virus loads,which was associated with a prolonged ICU stay. Chloroquine was associatedwith shorter shedding duration and increased the chance of viral negativity.展开更多
A novel iron-hydrogen battery system, whose Fe^(3+)/Fe^(2+)cathode circumvents slowly dynamic oxygen reduction reaction and anode is fed with clean and cordial hydrogen, is systematically investigated. The maximum dis...A novel iron-hydrogen battery system, whose Fe^(3+)/Fe^(2+)cathode circumvents slowly dynamic oxygen reduction reaction and anode is fed with clean and cordial hydrogen, is systematically investigated. The maximum discharge power density of the iron-hydrogen battery reaches to 96.0 m W/cm^(2) under the room temperature. The capacity reaches to 17.2 Ah/L and the coulombic and energy efficiency are achieved to99% and 86%, respectively, during the galvanostatic charge-discharge test. Moreover, stable cycling test is observed for more than 240 h and 100 cycles with the iron sulfate in the sulfuric acid solutions. It is found that air plasma treatment onto the cathode carbon paper can generate the oxygen-containing groups and increase the hydrophilic pores proportion to ca. 40%, enlarging nearly 6-fold effective diffusion coefficient and improving the mass transfer in the battery performance. The simple iron-hydrogen energy storage battery design offers us a new strategy for the large-scale energy storage and hydrogen involved economy.展开更多
On the basis of the analysis of main problems existing in current agricultural meteorological service in China,for the purpose of exploring a solution to the "last kilometer" problem in rural meteorological ...On the basis of the analysis of main problems existing in current agricultural meteorological service in China,for the purpose of exploring a solution to the "last kilometer" problem in rural meteorological service,this article designed four short message service products with the business brand name "meteorology for agricultural condition",including "weather prediction for farming season","weather forecast for farming","weather alert",and "meteorological hazards of agriculture".By taking advantage of telecom operators' market,these products have been spread to more than 1 million rural mobile phone users and widely welcomed.They also contributed enormously to disaster prevention and peasants' income growth,and achieved good social and economic benefits.展开更多
A 22-year-old Chinese man presented with fever, cough, hoarseness, neck pain, acute heart failure and hemoptysis. Pulmonary tuberculosis was proved by sputum culture. Chest imaging showed an aortic arch pseudoaneurysm...A 22-year-old Chinese man presented with fever, cough, hoarseness, neck pain, acute heart failure and hemoptysis. Pulmonary tuberculosis was proved by sputum culture. Chest imaging showed an aortic arch pseudoaneurysm and bilateral ground glass opacities. Echocardiography confirmed cardiomyopathy. With anti-TB drugs, high-dose prednisone and surgery, the life of this patient was successfully prolonged for more than four months. The concomitant disorders of aortic pseudoaneurysm, alveolar hemorrhage and cardiomyopathy in pulmonary tuberculosis are intriguing. We postulate that immune-mediated small vessel vasculitis triggered by pathogens plays an important role in the pathogenesis of this disease, rather than a direct TB infection.展开更多
Vaccinium bracteatum Thunb.,an important native Chinese wild blueberry species,is widely used as a rootstock and in blueberry cultivar breeding,as well as in traditional medicine and local food.We report here the geno...Vaccinium bracteatum Thunb.,an important native Chinese wild blueberry species,is widely used as a rootstock and in blueberry cultivar breeding,as well as in traditional medicine and local food.We report here the genome sequence of V.bracteatum using a combination of Oxford Nanopore Technologies long-read and Illumina HiSeq short-read sequencing technologies to obtain 65.30 Gb of clean data,achieving 114.60-fold genome coverage.The assembled genome has a total sequence length of 569.81 Mb and consists of 36,756 predicted genes.Repetitive DNA sequences represent 57.78%of the genome sequence.Comparative genomic analysis revealed that a total of 336 gene families had expanded and that 298 candidate genes had undergone positive selection during evolution in V.bracteatum.The divergence of V.bracteatum from the related Rhododendron williamsianum and Rhododendron delavayi occurred~13−85 million years ago.The genome sequence of V.bracteatum allowed us to identify some important genes associated with traits involved in fruit development,such as flavonoid biosynthesis,sugar and acid metabolism,MYB transcription factor gene expression,and hormone regulation.The differential expression patterns of genes encoding flavonoid biosynthesis enzymes and MYB transcription factors might explain the high flavonoid content of V.bracteatum.This chromosome-level genome assembly provides reference sequences for the identification and characterization of genes important in the improvement of blueberry and related research.展开更多
Somatic stem cells （SSCs）, being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are i...Somatic stem cells （SSCs）, being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells （CSCs） which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated （1）.展开更多
基金supported by KeyArea Research and Development Program of Guangdong ProvinceChina(2020B020201006)to Chunwu Zhu+5 种基金National Natural Science Foundation of China(31870423)to Chunwu ZhuNational Natural Science Foundation of China(41930758)to Fang-Jie ZhaoJiangsu Science and Technology Department(BM20222002)to Chunwu ZhuCarbon Peaking and Carbon Neutrality Special Fund for Science and Technology from Nanjing Science and Technology Bureau(20221103)to Chunwu ZhuKey Research and Development Program of Jiangsu Province(BE2022308)to Chunwu ZhuErdos City Science and Technology Major Project(2022EEDSKJZDZX010)to Chunwu Zhu。
文摘Elevated atmospheric carbon dioxide concentration([CO_(2)])can stimulate crop growth and increase yield,but the effect may be constrained by soil contamination with heavy metals.In a free-air carbon dioxide enrichment experiment over three seasons,we found that soil heavy metal contamination can constrain or even reverse the projected CO_(2)fertilization effect on rice yield.Elevated[CO_(2)]produced opposing effects on the accumulation of arsenic and cadmium in rice grain.Breeding crops for heavy-metal resistance and low arsenic accumulation may become necessary with continuing climate change.
基金supported by the National Natural Science Foundation of China(Nos.82474164,82374124,82073914,82173874,82274185,82305046 and 82304902)the Natural Science Foundation of Jiangsu Province(Nos.BK20230458 and BK20220467)+1 种基金the General Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.23KJB310017)Young Elite Scientists Sponsorship Program by CACM(No.2022-QNRC2-B15).
文摘Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by eliminating activated hepatic stellate cells(HSCs).However,the underlying mechanism remains unclear despite these findings.Notably,endocytic adaptor protein(NUMB)has significant implications for treating hepatic diseases,but current research primarily focuses on liver regeneration and hepatocellular carcinoma.The precise function of NUMB in liver fibrosis,particularly its ability to regulate HSCs,requires further investigation.This study aims to elucidate the role of NUMB in the anti-hepatic fibrosis action of ART in HSCs.We observed that the expression level of NUMB significantly decreased in activated HSCs compared to quiescent HSCs,exhibiting a negative correlation with the progression of liver fibrosis.Additionally,ART induced senescence in activated HSCs through the NUMB/P53 tumor suppressor(P53)axis.We identified NUMB as a crucial regulator of senescence in activated HSCs and as a mediator of ART in determining cell fate.This research examines the specific target of ART in eliminating activated HSCs,providing both theoretical and experimental evidence for the treatment of liver fibrosis.
基金supported by the Zhejiang Key Research and Development Project(2024C03101)the National Natural Science Foundation of China(32171035)+2 种基金the Graduate Student Scientific Research and Innovation Project of Ningbo University(IF2023055)the National 111 Project of China(D16013)the One Health Interdisciplinary Research Project,Ningbo University(HY202411).
文摘Alzheimer’s disease(AD)is regarded as a neurodegenerative disease,and it has been proposed that AD may be a systemic disease.Studies have reported associations between non-neurological diseases and AD.The correlations between AD pathology and systemic(non-neurological)pathological changes are intricate,and the mechanisms underlying these correlations and their causality are unclear.In this article,we review the association between AD and disorders of other systems.In addition,we summarize the possible mechanisms associated with AD and disorders of other systems,mainly from the perspective of AD pathology.Regarding the relationship between AD and systemic pathological changes,we aim to provide a new outlook on the early warning signs and treatment of AD,such as establishing a diagnostic and screening system based on more accessible peripheral samples.
基金Supported by Ningbo Health Technology Project,Nos.2020Y12 and 2022Y12.
文摘Objective:Circular RNAs(circRNAs)have been shown to involve in pathological processes of ischemic stroke(IS),including autophagy.This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms.Methods:Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected.Hippocampal neurons were treated with oxygen and glucose deprivation(OGD)to establish IS in vitro model.The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope.Cell apoptosis rate and the expression of cleaved caspase-3,Bax,and Bcl-2 were assessed byflow cytometry and western blotting.The binding relationships among circR-ZC3HC1,miR-384-5p,and SIRT1 were predicted and verified.Results:Low expression of circR-ZC3HC1 was found in blood samples of IS patients and OGD-treated neurons.Overexpressed circR-ZC3HC1 or inhibited miR-384-5p expression promoted autophagy and inhibited apoptosis of OGD-treated neurons,which could be reversed by further 3-MA treatment.Mechanistically,circR-ZC3HC1 targeted miR-384-5p to mediate SIRT1 expression.miR-384-5p overexpression or SIRT1 knockdown in the presence of circR-ZC3HC1 overexpression in OGD-treated neurons lead to reduced autophagy and enhanced apoptosis.Conclusion:Collectively,circR-ZC3HC1 promoted neuronal autophagy to attenuate IS via miR-384-5p/SIRT1 axis.
文摘Objective:To explore the effectiveness of a chest compression device combined with extended self-care for scar prevention in patients following keloid excision surgery.Methods:Forty patients(36 lesions)who underwent keloid excision surgery at the Department of Plastic and Reconstructive Surgery,First Medical Center,PLA General Hospital from June 2022 to June 2024 were selected.They were randomly divided into an experimental group and a control group,with 20 patients in each group.The control group received traditional elastic garment compression therapy,while the experimental group used a chest compression device designed for scar prevention.Scar width,hypertrophy,and Vancouver Scar Scale(VSS)scores were compared between the two groups at 6 months post-operation.Results:There were no statistically significant differences between the two groups in terms of gender,age,disease duration,lesion area,or location(P>0.05).However,VSS scores(except for pliability)in the experimental group were significantly lower than those in the control group(P<0.05).Conclusion:The chest compression device for scar prevention is more effective than traditional elastic garments in preventing scar hypertrophy after chest wall keloid excision surgery,and it has high clinical value,making it worthy of promotion.
文摘Objective:To investigate the effect of a chest compression device for scar prevention combined with a nurse-patient WeChat group on scar formation after keloid excision.Methods:Forty patients with chest wall keloids who underwent keloid excision surgery at the Department of Plastic and Reconstructive Surgery,First Medical Center of PLA General Hospital from June 2022 to June 2024 were selected.They were randomly divided into two groups:the observation group(20 cases)and the control group(20 cases).Both groups underwent routine keloid excision,followed by compression therapy for 6 months.The observation group used a chest compression device,while the control group used a compression garment.Scar width,hypertrophy,and Vancouver Scar Scale(VSS)scores were compared between the two groups.Results:There were no significant differences between the two groups in terms of gender,age,disease course,lesion area,and lesion site(P>0.05).The overall effective rate in the observation group was 95.00%,significantly higher than the 65.00%in the control group,with a statistically significant difference(P<0.05).After a 6-month follow-up,all VSS indicators(except for pliability)in the observation group(using the chest compression device)were significantly lower than those in the control group(P<0.05).Conclusion:Compared to the traditional compression garment,the chest compression device for scar prevention is more effective in preventing scar hypertrophy after chest wall keloid excision and improving the appearance of scars.It is worth promoting for clinical application.
基金Supported by National Science Technology Pillar Program in the 11th Five-Year Plan,No. 2008BAI59B03Research Special Fund for the Public Welfare Industry of Health,No.201202004
文摘AIM:To examine the clinical features and analyze prognostic factors in a prospective study of primary biliary cirrhosis(PBC) patients.METHODS:From 1995 to 2010,PBC patients without hepatic decompensation seen at the Peking Union Medical College Hospital were enrolled.Clinical signs and manifestations(pruritus,persistent fatigue,jaundice and pain in the right hypochondrium),laboratory parameters(auto-antibodies for autoimmune hepatic disease,biliary and hepatic enzymes,immunoglobulin,bilirubin,and albumin) and imaging findings were recorded at entry and at specific time points during follow-up.Cox regression and Kaplan-Meier analyses,respectively,assessed the risk factors for hepatic decompensation and survival.RESULTS:Two hundred and sixty-two PBC patients were enrolled with a median follow-up of 75.2 mo(range,21-201 mo).The 240 patients were aged 51.5 ± 10.2 years at diagnosis and 91.6% were female.Two hundred and forty-five(93.5%) were seropositive for anti-mitochondrial antibodies.At presentation,170 patients(64.9%) were symptomatic,while 96 patients(36.6%) had extra-hepatic autoimmune disease.During the follow-up period,62(23.7%) patients developed hepatic decompensation of whom four underwent liver transplantation and 17 died.The cumulative survival rate and median survival time were 83.9% and 181.7 mo,respectively.Cox regression analysis revealed that an incomplete ursodeoxycholic acid(UDCA) response or inconsistent treatment [P < 0.001;hazard risk(HR) 95%CI = 2.423-7.541],anti-centromere antibodies(ACA) positivity(P < 0.001;HR 95%CI = 2.516-7.137),alanine aminotransferase ratio(AAR) elevations(P < 0.001;HR 95%CI = 1.357-2.678),and histological advanced liver disease(P = 0.006;HR 95%CI = 1.481-10.847) were predictors of hepatic decompensation.The clinical features and survival of PBC in China are consistent with those described in Western countries.CONCLUSION:Incomplete UDCA response or inconsistent treatment,ACA positivity,AAR elevations,and advanced histological stage are predictors of decompensation.
基金Under the auspices of Strategic and Special Frontier Project of Science and Technology of Chinese Academy of Sciences (No. XDA05080800)National Basic Research Program of China (No. 2010CB950102)National Natural Science Foundation of China (No. 40871007)
文摘Three global datasets, the History Database of the Global Environment （HYDE）, Kaplan and Krurnhardt （KK） and Pongratz of reconstructed anthropogenic land cover change （ALCC） were introduced and compared in this paper. The HYDE dataset was recon- structed by Goldewijk and his colleagues at the National institute of Public ttealth and the Environment in Netherland, covering the past 12 000 years. The KK dataset was reconstructed by Kaplan and his colleagues, the Soil-Vegetation-Atmosphere Research Group at the Institute of Environmental Engineering in Switzerland, covering the past 8000 years. The Pongratz dataset was reconstructed by Pon- gratz and her colleagues at the Max Planck Institute for Meteorology in Germany, coveting AD 800-1992. The results show that the reconstructed datasets are quite different from each other due to the different methods used. The three datasets all allocated the historical ALCC according to human population density. The main reason causing the differences among the three datasets lies on the different relationships between population density and land use used in each reconstructed dataset. The KK dataset is better than the other two datasets for two important reasons. First, it used the nonlinear relationship between population density and land use, while the other two used the linear relationship. Second, Kaplan and his colleagues adopted the technological development and intensification parameters and considered the wood harvesting and the long-term fallow area resulted from shifting cultivation, which were neglected in the recon- structions of the other two datasets. Therefore, the KK dataset is more suitable as one of the anthropogenic forcing fields for climate simulation over the past two millennia that is recently concerned by two projects, the National Basic Research Program and the Strategic and Special Frontier Project of Science and Technology of the Chinese Academy of Sciences.
基金the support from the National Natural Science Foundation of China(Nos.51871058 and 51701170)Financial support from the Project of Science and Technology Plan of Fujian Province(No.2018J01520)the Talented Youth Scientist Support Program of the Eyas Program of Fujian Province。
文摘1.Introduction Cemented carbides are composites of WC ceramic phases and metallic Co binders that endow them with superior hardness and excellent toughness.Hard metals are widely used as metal cutting and rock drilling tools[1,2].Their hardness is believed to be inversely proportional to the sizes of WC grains^([3]).Grain growth inhibitors are widely employed to achieve smaller grain sizes.
基金Supported by Startup Fund forYouth Faculty of ShenzhenUniversity, No. 2018009.
文摘BACKGROUND Understanding a virus shedding patterns in body fluids/secretions is importantto determine the samples to be used for diagnosis and to formulate infectioncontrol measures.AIM To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)shedding patterns and its risk factors.METHODS All laboratory-confirmed coronavirus disease 2019 patients with completemedical records admitted to the Shenzhen Third People’s Hospital from January28, 2020 to March 8, 2020 were included. Among 145 patients (54.5% males;median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid(BALF) had the highest virus load compared with the other samples. The viralload peaked at admission (3.3 × 108 copies) and sharply decreased 10 d afteradmission.RESULTS The viral load was associated with prolonged intensive care unit (ICU) duration.Patients in the ICU had significantly longer shedding time compared to those inthe wards (P < 0.0001). Age > 60 years [hazard ratio (HR) = 0.6;95% confidenceinterval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2 shedding,while chloroquine (HR = 22.8;95%CI: 2.3-224.6) was a protective factor.CONCLUSION BALF had the highest SARS-CoV-2 load. Elderly patients had higher virus loads,which was associated with a prolonged ICU stay. Chloroquine was associatedwith shorter shedding duration and increased the chance of viral negativity.
基金financial support granted by National Key R&D Program of China (No.2020YFB1505704)Dongyue Polymer Material Company of Dongyue Federation+2 种基金State Key Laboratory of Fluorinated Functional Membrane Materials (Dongyue Group institute)Dongyue Future Hydrogen Energy Materials Companysponsored by the Collaborative Innovation Center of Suzhou Nano Science and Technology。
文摘A novel iron-hydrogen battery system, whose Fe^(3+)/Fe^(2+)cathode circumvents slowly dynamic oxygen reduction reaction and anode is fed with clean and cordial hydrogen, is systematically investigated. The maximum discharge power density of the iron-hydrogen battery reaches to 96.0 m W/cm^(2) under the room temperature. The capacity reaches to 17.2 Ah/L and the coulombic and energy efficiency are achieved to99% and 86%, respectively, during the galvanostatic charge-discharge test. Moreover, stable cycling test is observed for more than 240 h and 100 cycles with the iron sulfate in the sulfuric acid solutions. It is found that air plasma treatment onto the cathode carbon paper can generate the oxygen-containing groups and increase the hydrophilic pores proportion to ca. 40%, enlarging nearly 6-fold effective diffusion coefficient and improving the mass transfer in the battery performance. The simple iron-hydrogen energy storage battery design offers us a new strategy for the large-scale energy storage and hydrogen involved economy.
文摘On the basis of the analysis of main problems existing in current agricultural meteorological service in China,for the purpose of exploring a solution to the "last kilometer" problem in rural meteorological service,this article designed four short message service products with the business brand name "meteorology for agricultural condition",including "weather prediction for farming season","weather forecast for farming","weather alert",and "meteorological hazards of agriculture".By taking advantage of telecom operators' market,these products have been spread to more than 1 million rural mobile phone users and widely welcomed.They also contributed enormously to disaster prevention and peasants' income growth,and achieved good social and economic benefits.
文摘A 22-year-old Chinese man presented with fever, cough, hoarseness, neck pain, acute heart failure and hemoptysis. Pulmonary tuberculosis was proved by sputum culture. Chest imaging showed an aortic arch pseudoaneurysm and bilateral ground glass opacities. Echocardiography confirmed cardiomyopathy. With anti-TB drugs, high-dose prednisone and surgery, the life of this patient was successfully prolonged for more than four months. The concomitant disorders of aortic pseudoaneurysm, alveolar hemorrhage and cardiomyopathy in pulmonary tuberculosis are intriguing. We postulate that immune-mediated small vessel vasculitis triggered by pathogens plays an important role in the pathogenesis of this disease, rather than a direct TB infection.
基金supported by Anhui Provincial Natural Science Foundation(2008085QC129 and 2008085MC77)the 17th Huo Yingdong Education Fund Project(171022)Key Research and Development Program in Anhui Province(202204c06020029).
文摘Vaccinium bracteatum Thunb.,an important native Chinese wild blueberry species,is widely used as a rootstock and in blueberry cultivar breeding,as well as in traditional medicine and local food.We report here the genome sequence of V.bracteatum using a combination of Oxford Nanopore Technologies long-read and Illumina HiSeq short-read sequencing technologies to obtain 65.30 Gb of clean data,achieving 114.60-fold genome coverage.The assembled genome has a total sequence length of 569.81 Mb and consists of 36,756 predicted genes.Repetitive DNA sequences represent 57.78%of the genome sequence.Comparative genomic analysis revealed that a total of 336 gene families had expanded and that 298 candidate genes had undergone positive selection during evolution in V.bracteatum.The divergence of V.bracteatum from the related Rhododendron williamsianum and Rhododendron delavayi occurred~13−85 million years ago.The genome sequence of V.bracteatum allowed us to identify some important genes associated with traits involved in fruit development,such as flavonoid biosynthesis,sugar and acid metabolism,MYB transcription factor gene expression,and hormone regulation.The differential expression patterns of genes encoding flavonoid biosynthesis enzymes and MYB transcription factors might explain the high flavonoid content of V.bracteatum.This chromosome-level genome assembly provides reference sequences for the identification and characterization of genes important in the improvement of blueberry and related research.
文摘Somatic stem cells （SSCs）, being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells （CSCs） which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated （1）.
