The continuously available satellites of European Galileo currently reach more than 25.To explore the rationality and reliability of the L-band and satellite laser ranging(SLR)data processing strategies,we design the ...The continuously available satellites of European Galileo currently reach more than 25.To explore the rationality and reliability of the L-band and satellite laser ranging(SLR)data processing strategies,we design the Galileo L-band,the SLR-only,and the combined L-band/SLR dynamic precise orbit determination(POD)strategies by using the normal equations(NEQs)stacking,and investigate their continuity and stability by employing the Galileo L-band data and SLR observations for the time span of the whole year of 2023,based on the Bei Dou/GNSS analysis center platform of Shandong University by using the modified Bernese GNSS Software Version 5.4.The orbital consistency of the L-band 1-day solution is the best with the Three-dimensional Root-Mean-Square(3D-RMS)values of 3.6 cm compared with the Center for Orbit Determination in Europe Multi-GNSS Experiment(COM)orbits,the corresponding values is 1.4 cm,2.5 cm,and 2.3 cm in Radial,the Tangential,and the Normal(RTN)direction,respectively.While the SLR-only 9-day arc length is optimal with the RTN values of 5.3 cm,30 cm,and 38.2 cm,as well as the 3D-RMS values of 48.9 cm.Encouragingly,the difference of the orbital accuracy between the combined L-band/SLR multi-day solution and the COM orbits is reduced by 0.5 cm and 0.9 cm,0.6 cm and 1.2 cm in T-,and N-direction for the 3-and 5-day solution respectively.The corresponding values improve 0.7 cm and 0.9 cm,1.4 cm and 1.8 cm for the 3-and 5-day orbital overlaps difference between the combined L-band/SLR and the L-band solution.Take the E09 satellite as a case study,the SLR-only orbital accuracy is regularly optimized as the multi-day arc lengthens and with the sites increase.Furthermore,the SLR residuals of its three types of orbits further demonstrate the positive contribution of SLR to the combination of the GNSS and SLR techniques.展开更多
Our goal was to establish two new predictive models of prostate cancer to determine whether to require a prostate biopsy when the prostate-specific antigen level is in the diagnostic gray zone.A retrospective analysis...Our goal was to establish two new predictive models of prostate cancer to determine whether to require a prostate biopsy when the prostate-specific antigen level is in the diagnostic gray zone.A retrospective analysis of 197 patients undergoing prostate biopsy with prostate-specific antigens between 4 and 10 ng ml^?1 was conducted.Of these,47 patients were confirmed to have cancer,while the remaining 150 patients were diagnosed with benign prostate disease after examining biopsy pathology.Two multivariate logistic regression models were established including age,prostate volumes,free/total prostate-specific antigen ratio,and prostate-specific antigen density using SPSS 19.0 to obtain the predicted probability and Logit P,and then,two receiver operating characteristic(ROC)curves were drawn to obtain the best cutoff value for prostate biopsy:one for the group of all the prostate cancers and one for the group of clinically significant prostate cancers.The best cutoff value for prostate biopsy was 0.25 from the multivariate logistic regression ROC curve model of all the prostate cancers,which gave a sensitivity of 75.4%and a specificity of 75.8%.The best cutoff value for prostate biopsy was 0.20 from the multivariate logistic regression model of clinically significant prostate cancers,which gave a sensitivity of 76.7%and a specificity of 80.1%.We identified the best cutoff values for prostate biopsy(0.25 for all prostate cancers and 0.20 for clinically significant prostate cancers)to determine whether to require prostate biopsy when the PSA level is in the diagnostic gray zone.展开更多
Objective:To observe the clinical therapeutic effect on refractory peripheral facial paralysis treated with the combination of warming-needle moxibustion and stuck-needle-pulling therapy.Methods:A total of 33 patients...Objective:To observe the clinical therapeutic effect on refractory peripheral facial paralysis treated with the combination of warming-needle moxibustion and stuck-needle-pulling therapy.Methods:A total of 33 patients with refractory peripheral facial paralysis were treated with the combination of warming-needle moxibustion and stuck-needle-pulling technique.The treatment was given once daily and there were 2 days at interval after consecutive 5 treatments.A total of 10 treatments made one course and consecutive 2 courses of treatment were required.Before and after treatment,HouseBrackmann(H-B)facial nerve grading scale score was adopted to evaluate the degree of facial paralysis in the patients and the clinical effect was assessed.Results:After treatment,the mean H-B score was higher than that before treatment in the patients,indicating a statistical significance(P<0.05).After treatment,of 33 cases,12 cases were cured,9 cases effective remarkably,8 cases effective and 4 cases no effect.The total effective rate was 87.88%.Conclusion:The combination treatment of warming-needle moxibustion and stuck-needle-pulling technique achieves a definite effect on refractory peripheral facial paralysis.展开更多
Near infrared(NIR) fluorescent probes are highly attractive in the field of fluorescent imaging of living organisms for their outstanding signal-to-noise ratio, strong tissue penetration and low biotoxicity.Herein, we...Near infrared(NIR) fluorescent probes are highly attractive in the field of fluorescent imaging of living organisms for their outstanding signal-to-noise ratio, strong tissue penetration and low biotoxicity.Herein, we summarized some recent progress in the synthesis and application of NIR rhodamines by replacing the bridging oxygen atom with main group elements such as silicon and phosphorus.展开更多
Amine elimination of Ln[N(SiMe3)2]3(μ-Cl)Li(THF)3 with aminophenol H[ON]{H[ON]=2-(CH2 NC5 H10)-4,6-tBu2-C6 H3OH}in 1:2 molar ratio in THF gave the monometallic rare-earth metal amide complexes[ON]2 LnN(SiMe3)2(Ln=Yb(...Amine elimination of Ln[N(SiMe3)2]3(μ-Cl)Li(THF)3 with aminophenol H[ON]{H[ON]=2-(CH2 NC5 H10)-4,6-tBu2-C6 H3OH}in 1:2 molar ratio in THF gave the monometallic rare-earth metal amide complexes[ON]2 LnN(SiMe3)2(Ln=Yb(1),Y(2),Gd(3),Sm(4),Nd(5))in 57%-73%isolated yields.All these complexes were characterized by elemental analysis.The molecular structures of complexes 1-4 were determined by single crystal X-ray diffraction.These complexes are highly active for L-Iactide polymerization to give high molecular weight polymers with unimodal molecular weight distributions.In addition,these complexes can also initiate rac-lactide polymerization with high activity to afford heterotactic-rich polylactides.展开更多
Selective reductive amination of carbonyl compounds with high activity is very essential for the chemical and pharmaceutical industry,but scarcely successful paradigm was reported via efficient photocatalytic reaction...Selective reductive amination of carbonyl compounds with high activity is very essential for the chemical and pharmaceutical industry,but scarcely successful paradigm was reported via efficient photocatalytic reactions.Herein,the ultrasmall Ru nanoclusters(~0.9 nm)were successfully fabricated over P25 support with positive charged Ru^(δ+)species at the interface.A new route was developed to achieve the furfural(FAL)to furfurylamine(FAM)by coupling the light-driven reductive amination and hydrogen transfer of ethanol over this type catalyst.Strikingly,the photocatalytic activity and selectivity are strongly dependent on the particle size and electronic structure of Ruthenium.The Ru^(δ+)species at the interface promote the formation of active imine intermediates;moreover,the Ru nanoclusters facilitate the separation efficiency of electrons and holes as well as accelerate the further hydrogenation of imine intermediates to product primary amines.In contrast Ru particles in larger nanometer size facilitate the formation of the furfuryl alcohol and excessive hydrogenation products.In addition,the coupling byproducts can be effectively inhibited via the construction of sub-nanocluster.This study offers a new path to produce the primary amines from biomass-derived carbonyl compounds over hybrid semiconductor/metal-clusters photocatalyst via light-driven tandem catalytic process.展开更多
Different types of lightning air terminals have been designed over the years.Concern regarding the effect of different types of air terminals,especially the early streamer emission(ESE)-type,remains controversial.This...Different types of lightning air terminals have been designed over the years.Concern regarding the effect of different types of air terminals,especially the early streamer emission(ESE)-type,remains controversial.This paper describes the discharge characteristics of different types of air terminals,two of which are quite similar to the ESE-type dynasphere,and concludes that the tested non-standard air terminals have discharge characteristics similar to those of Franklin rods and that their lightning protection performance should be similar.展开更多
Four mono-and bi-nuclear lanthanide complexes [LnL1(No3)(H2O)DMF](Ln=Nd(1) and Yb(2)) and[Ln2(L2)2(OAc)2](Ln=Nd(3) and Yb(4)) were synthesized by using two new Schiff base ligands with long(CH2)2 NH(CH2)2 backbone.The...Four mono-and bi-nuclear lanthanide complexes [LnL1(No3)(H2O)DMF](Ln=Nd(1) and Yb(2)) and[Ln2(L2)2(OAc)2](Ln=Nd(3) and Yb(4)) were synthesized by using two new Schiff base ligands with long(CH2)2 NH(CH2)2 backbone.The lengths of the Schiff base ligands are about 1.8 nm.The bi-nuclear lanthanide complexes 3 and 4 have nanoscale structures with sizes of approximately 0.7 nm×1.1 nm×1.6 nm.For 3,the molar ratio of Nd:Br:O obtained by the energy dispersive X-ray spectroscopy analysis is in agreement with the crystal structure.The chromogenic Schiff base ligands in1-4 can efficiently transfer energy to lanthanide ions,thus,these complexes exhibit the typical NIR luminescence of lanthanide ions.Interestingly,3 and 4 have higher NIR emission quantum yields(Φem)than 1 and 2,respectively.展开更多
AIM: To assess the diagnostic value of computed tomography (CT) imaging in screening for abdominal nonhematogenous disseminated tuberculous lymphadenopathy (TL). METHODS: The CT scans of 12 patients with abdominal non...AIM: To assess the diagnostic value of computed tomography (CT) imaging in screening for abdominal nonhematogenous disseminated tuberculous lymphadenopathy (TL). METHODS: The CT scans of 12 patients with abdominal nonhematogenous disseminated TL suggestive of neoplasm were retrospectively analyzed in this review. The final diagnoses were confirmed by lymph node pathology for seven patients and by laparoscopic surgery for five patients. All of the patients were treated at our institution between April 1995 and August 2009. RESULTS: The sites of involvement were the periportal (n = 6), peripancreatic (n = 3), periaortic (n = 3), and mesenteric (n = 2) regions. On the plain CT scan, the lymphadenopathy showed a heterogeneous isodensity or hypodensity in 11 patients and a low density in one patient. Peripheral enhancement was observed on the dynamic contrast-enhanced CT scans for all patients. In two cases, scans were more revealing during the portal venous and delayed phases. CONCLUSION: Abdominal lymphadenopathy with predominant peripheral rim-like enhancement on the dynamic contrast-enhanced CT scan may suggest a diagnosis of TL.展开更多
[Objective] The paper was to clarify the bioactivity of trans-2-hexenal,oregano oil and thyme oil against Semiaphis heraclei and the synergistic effect of orange peel essential oil and organosilicon on the aphidicidal...[Objective] The paper was to clarify the bioactivity of trans-2-hexenal,oregano oil and thyme oil against Semiaphis heraclei and the synergistic effect of orange peel essential oil and organosilicon on the aphidicidal activity of the three agents.[Method] With S.heraclei,the dominant species of aphids in Lonicera japonica thunb.,as the test insect,the bioactivity and control effect were evaluated by the method of leaf dipping and foliar spraying.[Result] The indoor toxicity of thyme oil was the highest,with the LC_(50) of 1.793 mg/L.Adding additives significantly increased the toxicity of the agents to S.heraclei.Among them,trans-2-hexenal+OSi,oregano oil+OSi and thyme oil+OSi had obvious synergistic effects,with the toxicity coefficients of 1.80,1.48 and 1.45,respectively.Field test showed that the corrected control effect of thyme oil was the highest after con-ventional spraying,and the toxicities of the three agents were higher than that of the control group at 7 d post spraying.Under the condition of 20%reduction of three agents and adding organosilicon,the control effect was increased by about 10% at 1 d post spraying,which was higher than that of the control group at 4 d post spraying,and reached over 98% at 14 d post spraying.[Conclusion] Thyme oil has the highest toxicity and control effect on S.heraclei.Three agents combined with organosilicon have the obvious effect of reducing the quantity and increasing the efficiency,which has the potential for further development.展开更多
With the rapid development of artificial intelligence,the Internet of Things(IoT)can deploy various machine learning algorithms for network and application management.In the IoT environment,many sensors and devices ge...With the rapid development of artificial intelligence,the Internet of Things(IoT)can deploy various machine learning algorithms for network and application management.In the IoT environment,many sensors and devices generatemassive data,but data security and privacy protection have become a serious challenge.Federated learning(FL)can achieve many intelligent IoT applications by training models on local devices and allowing AI training on distributed IoT devices without data sharing.This review aims to deeply explore the combination of FL and the IoT,and analyze the application of federated learning in the IoT from the aspects of security and privacy protection.In this paper,we first describe the potential advantages of FL and the challenges faced by current IoT systems in the fields of network burden and privacy security.Next,we focus on exploring and analyzing the advantages of the combination of FL on the Internet,including privacy security,attack detection,efficient communication of the IoT,and enhanced learning quality.We also list various application scenarios of FL on the IoT.Finally,we propose several open research challenges and possible solutions.展开更多
Objective:The aim of the study was to compare the effects of photodynamic therapy(PDT) with δ-aminolevulinic acid(ALA) for patients with different kinds of skin cancers and pre-cancers.Methods:The present study enrol...Objective:The aim of the study was to compare the effects of photodynamic therapy(PDT) with δ-aminolevulinic acid(ALA) for patients with different kinds of skin cancers and pre-cancers.Methods:The present study enrolled seventyfive cases,which included 17 cases of actinic keratosis(AK),9 cases of Bowen's disease,11 cases of superficial basal cell carcinomas(BCC),23 cases of nodule basal cell carcinomas and 15 cases of squamous cell carcinomas(SCC),and every patient had single lesion.All patients were treated with 20% ALA topically and He-Ne laser weekly for three times,and followed up 1-3 years.Results:After therapy,the rates of complete reaction(CR) were 100% in AK lesions,77.8% in Bowen's diseases,90.9% in superficial BCCs,47.8% in nodule BCCs,and 50.3% in SCCs,which had significant differences among these five kinds of lesions(H = 18.27,P < 0.05).The therapeutic effectiveness of ALA-PDT for AK was superior to that of Bowen's disease(Q = 4.364,P < 0.05),superficial BCC(Q = 5.55,P < 0.01),SCC(Q = 8.94,P < 0.01) and nodule BCC(Q = 17.91,P < 0.01);the effect of Bowen's disease was better than that of SCC(Q = 7.8,P < 0.01),nodule BCC(Q = 13.44,P < 0.01);the effect of superficial BCC was better than that of SCC(Q = 9.73,P < 0.01),nodule BCC(Q = 16.28,P < 0.01),but similar with Bowen's disease(Q = 0.96,P > 0.05);the effect of SCC was better than that of nodule BCC(Q = 17.74,P < 0.01).Conclusion:Our study shows that therapeutic effectiveness of ALA-PDT for AK is best in five diseases,and Bowen's disease and superficial BCC are secondary,while nodule BCC and SCC are at the bottom.展开更多
Objective:To explore the mechanism of Kangguan decoction in the treatment of coronavirus disease 2019(COVID-19)and then perform preliminary verification.Methods:The effective compounds and target genes of Kangguan dec...Objective:To explore the mechanism of Kangguan decoction in the treatment of coronavirus disease 2019(COVID-19)and then perform preliminary verification.Methods:The effective compounds and target genes of Kangguan decoction were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.COVID-19 related target genes were searched in the GeneCards database.The active target genes of Kangguan decoction acting on COVID-19 were identified to perform GO function enrichment and KEGG pathway enrichment analysis.The compound-target network and protein-protein interaction were constructed;Molecular docking simulations of macromolecular protein target receptors and their corresponding compounds were performed.The clinical data of COVID-19 patients were retrieved from their electronic medical records of Nantong Third People's Hospital.Results:We screened out 137 effective compounds and 274 effective target genes of Kangguan decoction from TCMSP.The active target genes of Kangguan decoction were compared with the COVID-19 related target genes,and 63 active target genes for Kangguan decoction acting on COVID-19 were identified.GO function enrichment and KEGG pathway enrichment analysis were performed.The compound-target network and PPI network were constructed and the key compounds and key targets were selected to construct a key compound-target network.Finally,the binding of the target and its corresponding components was verified by molecular docking and two clinical cases with obvious clinical efficacy after Kangguan decoction application were demonstrated.Conclusion:The pharmacological mechanism of Kangguan decoction acting on COVID-19 has been explored,and the active compounds and targets of Kangguan decoction acting on COVID-19 and clinical efficacy for Kangguan decoction treating COVID-19 patients have been preliminarily verified.展开更多
Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu...Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.展开更多
The coastal ocean west of Guangdong Province(refers to Yuexi)is characterized as wide and shallow continental shelf,and connected to the Beibu Gulf through the Qiongzhou Strait(as shown in Fig.1).The circulation patte...The coastal ocean west of Guangdong Province(refers to Yuexi)is characterized as wide and shallow continental shelf,and connected to the Beibu Gulf through the Qiongzhou Strait(as shown in Fig.1).The circulation pattern is complicated,controlled by the East Asian monsoon,tides,buoyancy forcing,and topography.In general,the mean cur-rent on the shelf flows southwestward in winter and northeastward in summer,while the coastal current flows always southwestward in summer(Yang et al.,2003;Shu et al.,2018).展开更多
BACKGROUND The dexmedetomidine(DEX)plus ropivacaine treatment enables a transversus abdominis plane block(TAPB)of the peripheral nerves in patients undergoing radical resection for colorectal cancer(CRC)that can provi...BACKGROUND The dexmedetomidine(DEX)plus ropivacaine treatment enables a transversus abdominis plane block(TAPB)of the peripheral nerves in patients undergoing radical resection for colorectal cancer(CRC)that can provide clinical data for improving the postoperative analgesic effect,reducing the risk of cognitive impairment,and decreasing the circulating levels of serum inflammatory factors and stress hormones.AIM To assess the impact of DEX plus ropivacaine-enabled TAPB on pain,postoperative cognitive dysfunction(POCD),and inflammatory/stress factors.METHODS Our patient cohort was randomly divided into control and observation groups(60/group).The observation group used a DEX plus ropivacaine-enabled TAPB,while the control group employed a ropivacaine-enabled TAPB.The pain score[Visual Analogy Scale(VAS),Montreal Cognitive Assessment(MoCA)],serum inflammatory factor level(C-reactive protein,interleukin-6 and tumor necrosis factor-α),serum stress hormone levels(cortisol and adrenaline)and postoperative adverse reactions were compared between the two groups.RESULTS The observation group VAS scores were lower than those of the control group(better analgesic effect,P<0.05).The MoCA and POCD scores decreased post-surgery in the observation group(P<0.05).In the elderly,the overall VAS and MoCA scores were significantly reduced compared with the young group.The C-reactive protein,interleukin-6,tumor necrosis factor-α,cortisol and adrenaline levels were lower in the observation group compared with the control group post-surgery(P<0.05).There was no significant difference in adverse reactions between the two groups post-surgery,but the incidence of adverse reactions in the observation group was still lower.DEX continuously inhibited p65-phosphorylation levels in the nuclear factorκB pathway at multiple time points,and its inhibitory effect became more significant over time.CONCLUSION DEX plus ropivacaine-enabled TAPB reduces POCD and inflammatory/stress hormone levels,and significantly improves the postoperative analgesic effect of patients undergoing radical resection for colorectal cancer.展开更多
Post-translational modifications(PTMs)regulate the activity and functionality of RELA,but their role in the pathogenesis of liver fibrosis is unclear.This study was performed to understand the regulation mechanism of ...Post-translational modifications(PTMs)regulate the activity and functionality of RELA,but their role in the pathogenesis of liver fibrosis is unclear.This study was performed to understand the regulation mechanism of acetylation of RELA on liver inflammation and fibrosis in a model animal of innate glucose intolerance,largemouth bass,and to provide a potential target and biomarker for liver fibrosis therapy.We found that the acetylation of total proteins and RELA was significantly reduced in fibrotic livers of largemouth bass induced by a high-carbohydrate and high-fat diet(HCHFD)and CCL4 challenge.Furthermore,quantitative acetylome data showed that the K119 site of RELA was deacetylated in fibrotic livers compared to healthy controls.Subsequently,we reveal a new mechanism that SIRT7 deacetylates RELA at the K119 site in largemouth bass.RELA K119 deacetylation enhances RELA transcriptional activity by increasing its DNA-binding activity,and facilitates nuclear translocation of RELA,resulting in the overwhelming release of proinflammatory factors,and subsequently enhancing liver inflammation and fibrosis.Pharmacological inhibition of SIRT7 using a specific inhibitor restores the decreased acetylation of RELA in vivo and in vitro,and reduces the transcriptional activity,nuclear localization of RELA and the expression of its target genes,which ultimately attenuates liver inflammation and fibrosis.These findings uncover a novel mechanism underlying liver fibrosis involving SIRT7-mediated deacetylation of RELA to activate the proinflammatory gene program,and thus provide important insights and biomarkers into the effective strategies for limiting liver inflammation and fibrosis.展开更多
BACKGROUND Kushenol I(KSCI)exhibits potential anti-inflammatory and antioxidant activities.However,its therapeutic effects and mechanisms in ulcerative colitis(UC)remain unclear.AIM To investigate the therapeutic effe...BACKGROUND Kushenol I(KSCI)exhibits potential anti-inflammatory and antioxidant activities.However,its therapeutic effects and mechanisms in ulcerative colitis(UC)remain unclear.AIM To investigate the therapeutic effects and mechanisms of KSCI in alleviating UC.METHODS Therapeutic targets for KSCI in treating UC were identified using network pharmacology.Molecular docking and dynamics simulations confirmed the interactions between KSCI and these targets.In a murine UC model induced by dextran sodium sulfate(DSS),the anti-inflammatory and antioxidant effects of KSCI were evaluated following oral administration,as well as its impact on intestinal barrier function and immune response modulation.Finally,changes in gut microbiota composition were analyzed using 16S ribosomal RNA sequencing.RESULTS A total of 192 potential targets of KSCI in treating UC were identified using network pharmacology.KSCI bound stably to core targets including protein kinase B(AKT),p38 mitogen-activated protein kinase(p38 MAPK),NOD-like receptor thermal protein domain associated protein 3(NLRP3),phosphoinositide 3-kinase(PI3K),forkhead box O1(FOXO1),and Toll-like receptor 4(TLR4).The oral administration of KSCI improved colon length and body weight,and reduced disease activity in a mouse model of DSS-induced UC.KSCI suppressed pro-inflammatory cytokines(interleukin[IL-1β],IL-6,IL-17,and tumor necrosis factor alpha)and promoted the expression of the anti-inflammatory cytokine IL-10.It also inhibited key signaling molecules and modulated the expression of IL-1β,AKT,p38 MAPK,NLRP3,PI3K,AKT,FOXO1,and TLR4.KSCI exhibited potent antioxidant effects,ameliorating colonic inflammation and tissue damage.It improved intestinal barrier function,influenced gut microbiota composition,and increased splenic T-cell percentages.CONCLUSION KSCI alleviated DSS-induced UC by modulating gut microbiota,enhancing the intestinal barrier,reducing inflam-mation and oxidative stress,and regulating the immune response.展开更多
In this paper,the N-soliton solutions for the massive Thirring model(MTM)in laboratory coordinates are analyzed via the Riemann-Hilbert(RH)approach.The direct scattering including the analyticity,symmetries,and asympt...In this paper,the N-soliton solutions for the massive Thirring model(MTM)in laboratory coordinates are analyzed via the Riemann-Hilbert(RH)approach.The direct scattering including the analyticity,symmetries,and asymptotic behaviors of the Jost solutions as|λ|→∞andλ→0 are given.Considering that the scattering coefficients have simple zeros,the matrix RH problem,reconstruction formulas and corresponding trace formulas are also derived.Further,the N-soliton solutions in the reflectionless case are obtained explicitly in the form of determinants.The propagation characteristics of one-soliton solutions and interaction properties of two-soliton solutions are discussed.In particular,the asymptotic expressions of two-soliton solutions as|t|→∞are obtained,which show that the velocities and amplitudes of the asymptotic solitons do not change before and after interaction except the position shifts.In addition,three types of bounded states for two-soliton solutions are presented with certain parametric conditions.展开更多
基金under the support of the National Natural Science Foundation of China(Grant No.42388102),ChinaYouth Fund of the Natural Science Foundation of Hebei Province(Grant No.D2023523003),China。
文摘The continuously available satellites of European Galileo currently reach more than 25.To explore the rationality and reliability of the L-band and satellite laser ranging(SLR)data processing strategies,we design the Galileo L-band,the SLR-only,and the combined L-band/SLR dynamic precise orbit determination(POD)strategies by using the normal equations(NEQs)stacking,and investigate their continuity and stability by employing the Galileo L-band data and SLR observations for the time span of the whole year of 2023,based on the Bei Dou/GNSS analysis center platform of Shandong University by using the modified Bernese GNSS Software Version 5.4.The orbital consistency of the L-band 1-day solution is the best with the Three-dimensional Root-Mean-Square(3D-RMS)values of 3.6 cm compared with the Center for Orbit Determination in Europe Multi-GNSS Experiment(COM)orbits,the corresponding values is 1.4 cm,2.5 cm,and 2.3 cm in Radial,the Tangential,and the Normal(RTN)direction,respectively.While the SLR-only 9-day arc length is optimal with the RTN values of 5.3 cm,30 cm,and 38.2 cm,as well as the 3D-RMS values of 48.9 cm.Encouragingly,the difference of the orbital accuracy between the combined L-band/SLR multi-day solution and the COM orbits is reduced by 0.5 cm and 0.9 cm,0.6 cm and 1.2 cm in T-,and N-direction for the 3-and 5-day solution respectively.The corresponding values improve 0.7 cm and 0.9 cm,1.4 cm and 1.8 cm for the 3-and 5-day orbital overlaps difference between the combined L-band/SLR and the L-band solution.Take the E09 satellite as a case study,the SLR-only orbital accuracy is regularly optimized as the multi-day arc lengthens and with the sites increase.Furthermore,the SLR residuals of its three types of orbits further demonstrate the positive contribution of SLR to the combination of the GNSS and SLR techniques.
文摘Our goal was to establish two new predictive models of prostate cancer to determine whether to require a prostate biopsy when the prostate-specific antigen level is in the diagnostic gray zone.A retrospective analysis of 197 patients undergoing prostate biopsy with prostate-specific antigens between 4 and 10 ng ml^?1 was conducted.Of these,47 patients were confirmed to have cancer,while the remaining 150 patients were diagnosed with benign prostate disease after examining biopsy pathology.Two multivariate logistic regression models were established including age,prostate volumes,free/total prostate-specific antigen ratio,and prostate-specific antigen density using SPSS 19.0 to obtain the predicted probability and Logit P,and then,two receiver operating characteristic(ROC)curves were drawn to obtain the best cutoff value for prostate biopsy:one for the group of all the prostate cancers and one for the group of clinically significant prostate cancers.The best cutoff value for prostate biopsy was 0.25 from the multivariate logistic regression ROC curve model of all the prostate cancers,which gave a sensitivity of 75.4%and a specificity of 75.8%.The best cutoff value for prostate biopsy was 0.20 from the multivariate logistic regression model of clinically significant prostate cancers,which gave a sensitivity of 76.7%and a specificity of 80.1%.We identified the best cutoff values for prostate biopsy(0.25 for all prostate cancers and 0.20 for clinically significant prostate cancers)to determine whether to require prostate biopsy when the PSA level is in the diagnostic gray zone.
基金Supported by Guangdong Graduate Innovation Program Project:2017SFKC13。
文摘Objective:To observe the clinical therapeutic effect on refractory peripheral facial paralysis treated with the combination of warming-needle moxibustion and stuck-needle-pulling therapy.Methods:A total of 33 patients with refractory peripheral facial paralysis were treated with the combination of warming-needle moxibustion and stuck-needle-pulling technique.The treatment was given once daily and there were 2 days at interval after consecutive 5 treatments.A total of 10 treatments made one course and consecutive 2 courses of treatment were required.Before and after treatment,HouseBrackmann(H-B)facial nerve grading scale score was adopted to evaluate the degree of facial paralysis in the patients and the clinical effect was assessed.Results:After treatment,the mean H-B score was higher than that before treatment in the patients,indicating a statistical significance(P<0.05).After treatment,of 33 cases,12 cases were cured,9 cases effective remarkably,8 cases effective and 4 cases no effect.The total effective rate was 87.88%.Conclusion:The combination treatment of warming-needle moxibustion and stuck-needle-pulling technique achieves a definite effect on refractory peripheral facial paralysis.
基金financial support from the National Natural Science Foundation of China (Nos. 21705049, 21827814)the Thousand Talent Program for Young Scholar, Shanghai Pujiang Program (No. 17PJ1402000)+1 种基金the Innovation Program of Shanghai Municipal Education Commission (No. 20170107005E00020)the Program for Professor of Special Appointment (Eastern Scholar No. TP2017039)
文摘Near infrared(NIR) fluorescent probes are highly attractive in the field of fluorescent imaging of living organisms for their outstanding signal-to-noise ratio, strong tissue penetration and low biotoxicity.Herein, we summarized some recent progress in the synthesis and application of NIR rhodamines by replacing the bridging oxygen atom with main group elements such as silicon and phosphorus.
基金Project supported by the National Natural Science Foundation of China(21572205,21971130,21871198,21674070)the Natural Science Foundation of Zhejiang Province(LY19B040002)+2 种基金the State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciencesthe Natural Science Foundation of Ningbo Municipal(2019A610030,2019A610129)K.C.Wong Magna Fund in Ningbo University。
文摘Amine elimination of Ln[N(SiMe3)2]3(μ-Cl)Li(THF)3 with aminophenol H[ON]{H[ON]=2-(CH2 NC5 H10)-4,6-tBu2-C6 H3OH}in 1:2 molar ratio in THF gave the monometallic rare-earth metal amide complexes[ON]2 LnN(SiMe3)2(Ln=Yb(1),Y(2),Gd(3),Sm(4),Nd(5))in 57%-73%isolated yields.All these complexes were characterized by elemental analysis.The molecular structures of complexes 1-4 were determined by single crystal X-ray diffraction.These complexes are highly active for L-Iactide polymerization to give high molecular weight polymers with unimodal molecular weight distributions.In addition,these complexes can also initiate rac-lactide polymerization with high activity to afford heterotactic-rich polylactides.
基金financially supported by the National Natural Science Foundation of China(202102007,21978147 and 21935001)the Fundamental Research Funds for the Central Universities(buctrc202112)。
文摘Selective reductive amination of carbonyl compounds with high activity is very essential for the chemical and pharmaceutical industry,but scarcely successful paradigm was reported via efficient photocatalytic reactions.Herein,the ultrasmall Ru nanoclusters(~0.9 nm)were successfully fabricated over P25 support with positive charged Ru^(δ+)species at the interface.A new route was developed to achieve the furfural(FAL)to furfurylamine(FAM)by coupling the light-driven reductive amination and hydrogen transfer of ethanol over this type catalyst.Strikingly,the photocatalytic activity and selectivity are strongly dependent on the particle size and electronic structure of Ruthenium.The Ru^(δ+)species at the interface promote the formation of active imine intermediates;moreover,the Ru nanoclusters facilitate the separation efficiency of electrons and holes as well as accelerate the further hydrogenation of imine intermediates to product primary amines.In contrast Ru particles in larger nanometer size facilitate the formation of the furfuryl alcohol and excessive hydrogenation products.In addition,the coupling byproducts can be effectively inhibited via the construction of sub-nanocluster.This study offers a new path to produce the primary amines from biomass-derived carbonyl compounds over hybrid semiconductor/metal-clusters photocatalyst via light-driven tandem catalytic process.
基金partly supported by National Natural Science Foundation of China(No.51577098)the State Grid Corporation of China,and China Southern Power Grid
文摘Different types of lightning air terminals have been designed over the years.Concern regarding the effect of different types of air terminals,especially the early streamer emission(ESE)-type,remains controversial.This paper describes the discharge characteristics of different types of air terminals,two of which are quite similar to the ESE-type dynasphere,and concludes that the tested non-standard air terminals have discharge characteristics similar to those of Franklin rods and that their lightning protection performance should be similar.
基金supported by the National Natural Science Foundation of China(21771141).
文摘Four mono-and bi-nuclear lanthanide complexes [LnL1(No3)(H2O)DMF](Ln=Nd(1) and Yb(2)) and[Ln2(L2)2(OAc)2](Ln=Nd(3) and Yb(4)) were synthesized by using two new Schiff base ligands with long(CH2)2 NH(CH2)2 backbone.The lengths of the Schiff base ligands are about 1.8 nm.The bi-nuclear lanthanide complexes 3 and 4 have nanoscale structures with sizes of approximately 0.7 nm×1.1 nm×1.6 nm.For 3,the molar ratio of Nd:Br:O obtained by the energy dispersive X-ray spectroscopy analysis is in agreement with the crystal structure.The chromogenic Schiff base ligands in1-4 can efficiently transfer energy to lanthanide ions,thus,these complexes exhibit the typical NIR luminescence of lanthanide ions.Interestingly,3 and 4 have higher NIR emission quantum yields(Φem)than 1 and 2,respectively.
文摘AIM: To assess the diagnostic value of computed tomography (CT) imaging in screening for abdominal nonhematogenous disseminated tuberculous lymphadenopathy (TL). METHODS: The CT scans of 12 patients with abdominal nonhematogenous disseminated TL suggestive of neoplasm were retrospectively analyzed in this review. The final diagnoses were confirmed by lymph node pathology for seven patients and by laparoscopic surgery for five patients. All of the patients were treated at our institution between April 1995 and August 2009. RESULTS: The sites of involvement were the periportal (n = 6), peripancreatic (n = 3), periaortic (n = 3), and mesenteric (n = 2) regions. On the plain CT scan, the lymphadenopathy showed a heterogeneous isodensity or hypodensity in 11 patients and a low density in one patient. Peripheral enhancement was observed on the dynamic contrast-enhanced CT scans for all patients. In two cases, scans were more revealing during the portal venous and delayed phases. CONCLUSION: Abdominal lymphadenopathy with predominant peripheral rim-like enhancement on the dynamic contrast-enhanced CT scan may suggest a diagnosis of TL.
基金Supported by National Key R&D Program of China (2017YFC1701503)Major Science and Technology Innovation Project of Shandong Province (2018CXGC0309)。
文摘[Objective] The paper was to clarify the bioactivity of trans-2-hexenal,oregano oil and thyme oil against Semiaphis heraclei and the synergistic effect of orange peel essential oil and organosilicon on the aphidicidal activity of the three agents.[Method] With S.heraclei,the dominant species of aphids in Lonicera japonica thunb.,as the test insect,the bioactivity and control effect were evaluated by the method of leaf dipping and foliar spraying.[Result] The indoor toxicity of thyme oil was the highest,with the LC_(50) of 1.793 mg/L.Adding additives significantly increased the toxicity of the agents to S.heraclei.Among them,trans-2-hexenal+OSi,oregano oil+OSi and thyme oil+OSi had obvious synergistic effects,with the toxicity coefficients of 1.80,1.48 and 1.45,respectively.Field test showed that the corrected control effect of thyme oil was the highest after con-ventional spraying,and the toxicities of the three agents were higher than that of the control group at 7 d post spraying.Under the condition of 20%reduction of three agents and adding organosilicon,the control effect was increased by about 10% at 1 d post spraying,which was higher than that of the control group at 4 d post spraying,and reached over 98% at 14 d post spraying.[Conclusion] Thyme oil has the highest toxicity and control effect on S.heraclei.Three agents combined with organosilicon have the obvious effect of reducing the quantity and increasing the efficiency,which has the potential for further development.
基金supported by the Shandong Province Science and Technology Project(2023TSGC0509,2022TSGC2234)Qingdao Science and Technology Plan Project(23-1-5-yqpy-2-qy)Open Topic Grants of Anhui Province Key Laboratory of Intelligent Building&Building Energy Saving,Anhui Jianzhu University(IBES2024KF08).
文摘With the rapid development of artificial intelligence,the Internet of Things(IoT)can deploy various machine learning algorithms for network and application management.In the IoT environment,many sensors and devices generatemassive data,but data security and privacy protection have become a serious challenge.Federated learning(FL)can achieve many intelligent IoT applications by training models on local devices and allowing AI training on distributed IoT devices without data sharing.This review aims to deeply explore the combination of FL and the IoT,and analyze the application of federated learning in the IoT from the aspects of security and privacy protection.In this paper,we first describe the potential advantages of FL and the challenges faced by current IoT systems in the fields of network burden and privacy security.Next,we focus on exploring and analyzing the advantages of the combination of FL on the Internet,including privacy security,attack detection,efficient communication of the IoT,and enhanced learning quality.We also list various application scenarios of FL on the IoT.Finally,we propose several open research challenges and possible solutions.
文摘Objective:The aim of the study was to compare the effects of photodynamic therapy(PDT) with δ-aminolevulinic acid(ALA) for patients with different kinds of skin cancers and pre-cancers.Methods:The present study enrolled seventyfive cases,which included 17 cases of actinic keratosis(AK),9 cases of Bowen's disease,11 cases of superficial basal cell carcinomas(BCC),23 cases of nodule basal cell carcinomas and 15 cases of squamous cell carcinomas(SCC),and every patient had single lesion.All patients were treated with 20% ALA topically and He-Ne laser weekly for three times,and followed up 1-3 years.Results:After therapy,the rates of complete reaction(CR) were 100% in AK lesions,77.8% in Bowen's diseases,90.9% in superficial BCCs,47.8% in nodule BCCs,and 50.3% in SCCs,which had significant differences among these five kinds of lesions(H = 18.27,P < 0.05).The therapeutic effectiveness of ALA-PDT for AK was superior to that of Bowen's disease(Q = 4.364,P < 0.05),superficial BCC(Q = 5.55,P < 0.01),SCC(Q = 8.94,P < 0.01) and nodule BCC(Q = 17.91,P < 0.01);the effect of Bowen's disease was better than that of SCC(Q = 7.8,P < 0.01),nodule BCC(Q = 13.44,P < 0.01);the effect of superficial BCC was better than that of SCC(Q = 9.73,P < 0.01),nodule BCC(Q = 16.28,P < 0.01),but similar with Bowen's disease(Q = 0.96,P > 0.05);the effect of SCC was better than that of nodule BCC(Q = 17.74,P < 0.01).Conclusion:Our study shows that therapeutic effectiveness of ALA-PDT for AK is best in five diseases,and Bowen's disease and superficial BCC are secondary,while nodule BCC and SCC are at the bottom.
基金the Research Grant of Jiangyin Hospital of Traditional Chinese Medicine(202013 to Jiang and 202014 to Zhang)the Nantong Science and Technology Bureau Plan Project(grant XG202003-4 to Li,grant XG202003-3 to Han).
文摘Objective:To explore the mechanism of Kangguan decoction in the treatment of coronavirus disease 2019(COVID-19)and then perform preliminary verification.Methods:The effective compounds and target genes of Kangguan decoction were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.COVID-19 related target genes were searched in the GeneCards database.The active target genes of Kangguan decoction acting on COVID-19 were identified to perform GO function enrichment and KEGG pathway enrichment analysis.The compound-target network and protein-protein interaction were constructed;Molecular docking simulations of macromolecular protein target receptors and their corresponding compounds were performed.The clinical data of COVID-19 patients were retrieved from their electronic medical records of Nantong Third People's Hospital.Results:We screened out 137 effective compounds and 274 effective target genes of Kangguan decoction from TCMSP.The active target genes of Kangguan decoction were compared with the COVID-19 related target genes,and 63 active target genes for Kangguan decoction acting on COVID-19 were identified.GO function enrichment and KEGG pathway enrichment analysis were performed.The compound-target network and PPI network were constructed and the key compounds and key targets were selected to construct a key compound-target network.Finally,the binding of the target and its corresponding components was verified by molecular docking and two clinical cases with obvious clinical efficacy after Kangguan decoction application were demonstrated.Conclusion:The pharmacological mechanism of Kangguan decoction acting on COVID-19 has been explored,and the active compounds and targets of Kangguan decoction acting on COVID-19 and clinical efficacy for Kangguan decoction treating COVID-19 patients have been preliminarily verified.
基金supported by the National Natural Science Foundation of China,No.82071254(to WZ).
文摘Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.
基金The National Key Research and Development Program of China under contract No.2022YFC3104805the National Natural Science Foundation of China under contract Nos 42276019,42176184,and 42476027+3 种基金the Guangdong Basic and Applied Basic Research Foundation under contract Nos 2024A1515012572 and 2025A1515010741the Innovation Team Plan for Universities in Guangdong Province under contract No.2023KCXTD015the Tropical Ocean Environment in Western Coastal Waters Observation and Research Station of Guangdong Province under contract No.2024B1212040008the Undergraduate Innovation Team Project under contract No.CXTD2019001.
文摘The coastal ocean west of Guangdong Province(refers to Yuexi)is characterized as wide and shallow continental shelf,and connected to the Beibu Gulf through the Qiongzhou Strait(as shown in Fig.1).The circulation pattern is complicated,controlled by the East Asian monsoon,tides,buoyancy forcing,and topography.In general,the mean cur-rent on the shelf flows southwestward in winter and northeastward in summer,while the coastal current flows always southwestward in summer(Yang et al.,2003;Shu et al.,2018).
文摘BACKGROUND The dexmedetomidine(DEX)plus ropivacaine treatment enables a transversus abdominis plane block(TAPB)of the peripheral nerves in patients undergoing radical resection for colorectal cancer(CRC)that can provide clinical data for improving the postoperative analgesic effect,reducing the risk of cognitive impairment,and decreasing the circulating levels of serum inflammatory factors and stress hormones.AIM To assess the impact of DEX plus ropivacaine-enabled TAPB on pain,postoperative cognitive dysfunction(POCD),and inflammatory/stress factors.METHODS Our patient cohort was randomly divided into control and observation groups(60/group).The observation group used a DEX plus ropivacaine-enabled TAPB,while the control group employed a ropivacaine-enabled TAPB.The pain score[Visual Analogy Scale(VAS),Montreal Cognitive Assessment(MoCA)],serum inflammatory factor level(C-reactive protein,interleukin-6 and tumor necrosis factor-α),serum stress hormone levels(cortisol and adrenaline)and postoperative adverse reactions were compared between the two groups.RESULTS The observation group VAS scores were lower than those of the control group(better analgesic effect,P<0.05).The MoCA and POCD scores decreased post-surgery in the observation group(P<0.05).In the elderly,the overall VAS and MoCA scores were significantly reduced compared with the young group.The C-reactive protein,interleukin-6,tumor necrosis factor-α,cortisol and adrenaline levels were lower in the observation group compared with the control group post-surgery(P<0.05).There was no significant difference in adverse reactions between the two groups post-surgery,but the incidence of adverse reactions in the observation group was still lower.DEX continuously inhibited p65-phosphorylation levels in the nuclear factorκB pathway at multiple time points,and its inhibitory effect became more significant over time.CONCLUSION DEX plus ropivacaine-enabled TAPB reduces POCD and inflammatory/stress hormone levels,and significantly improves the postoperative analgesic effect of patients undergoing radical resection for colorectal cancer.
基金supported by National Natural Sci-ence Foundation of China(32273141,32202954,32172981)Beijing Natural Science Foundation(6232038).
文摘Post-translational modifications(PTMs)regulate the activity and functionality of RELA,but their role in the pathogenesis of liver fibrosis is unclear.This study was performed to understand the regulation mechanism of acetylation of RELA on liver inflammation and fibrosis in a model animal of innate glucose intolerance,largemouth bass,and to provide a potential target and biomarker for liver fibrosis therapy.We found that the acetylation of total proteins and RELA was significantly reduced in fibrotic livers of largemouth bass induced by a high-carbohydrate and high-fat diet(HCHFD)and CCL4 challenge.Furthermore,quantitative acetylome data showed that the K119 site of RELA was deacetylated in fibrotic livers compared to healthy controls.Subsequently,we reveal a new mechanism that SIRT7 deacetylates RELA at the K119 site in largemouth bass.RELA K119 deacetylation enhances RELA transcriptional activity by increasing its DNA-binding activity,and facilitates nuclear translocation of RELA,resulting in the overwhelming release of proinflammatory factors,and subsequently enhancing liver inflammation and fibrosis.Pharmacological inhibition of SIRT7 using a specific inhibitor restores the decreased acetylation of RELA in vivo and in vitro,and reduces the transcriptional activity,nuclear localization of RELA and the expression of its target genes,which ultimately attenuates liver inflammation and fibrosis.These findings uncover a novel mechanism underlying liver fibrosis involving SIRT7-mediated deacetylation of RELA to activate the proinflammatory gene program,and thus provide important insights and biomarkers into the effective strategies for limiting liver inflammation and fibrosis.
基金Supported by the National Natural Science Foundation of China,No.82060707 and No.82104381Application and Basis Research Project of Yunnan China,No.202201AW070016+2 种基金Central Special Fund for Guiding Local Science and Technology Development,No.202407AB110018Engineering Research Center of Yunnan Education Department,No.2022YGG03Open Research Fund Program of Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment,No.2019DG016.
文摘BACKGROUND Kushenol I(KSCI)exhibits potential anti-inflammatory and antioxidant activities.However,its therapeutic effects and mechanisms in ulcerative colitis(UC)remain unclear.AIM To investigate the therapeutic effects and mechanisms of KSCI in alleviating UC.METHODS Therapeutic targets for KSCI in treating UC were identified using network pharmacology.Molecular docking and dynamics simulations confirmed the interactions between KSCI and these targets.In a murine UC model induced by dextran sodium sulfate(DSS),the anti-inflammatory and antioxidant effects of KSCI were evaluated following oral administration,as well as its impact on intestinal barrier function and immune response modulation.Finally,changes in gut microbiota composition were analyzed using 16S ribosomal RNA sequencing.RESULTS A total of 192 potential targets of KSCI in treating UC were identified using network pharmacology.KSCI bound stably to core targets including protein kinase B(AKT),p38 mitogen-activated protein kinase(p38 MAPK),NOD-like receptor thermal protein domain associated protein 3(NLRP3),phosphoinositide 3-kinase(PI3K),forkhead box O1(FOXO1),and Toll-like receptor 4(TLR4).The oral administration of KSCI improved colon length and body weight,and reduced disease activity in a mouse model of DSS-induced UC.KSCI suppressed pro-inflammatory cytokines(interleukin[IL-1β],IL-6,IL-17,and tumor necrosis factor alpha)and promoted the expression of the anti-inflammatory cytokine IL-10.It also inhibited key signaling molecules and modulated the expression of IL-1β,AKT,p38 MAPK,NLRP3,PI3K,AKT,FOXO1,and TLR4.KSCI exhibited potent antioxidant effects,ameliorating colonic inflammation and tissue damage.It improved intestinal barrier function,influenced gut microbiota composition,and increased splenic T-cell percentages.CONCLUSION KSCI alleviated DSS-induced UC by modulating gut microbiota,enhancing the intestinal barrier,reducing inflam-mation and oxidative stress,and regulating the immune response.
基金supported by the National Natural Science Foundation of China(Grant Nos.12475003 and11705284)by the Natural Science Foundation of Beijing Municipality(Grant Nos.1232022 and 1212007)。
文摘In this paper,the N-soliton solutions for the massive Thirring model(MTM)in laboratory coordinates are analyzed via the Riemann-Hilbert(RH)approach.The direct scattering including the analyticity,symmetries,and asymptotic behaviors of the Jost solutions as|λ|→∞andλ→0 are given.Considering that the scattering coefficients have simple zeros,the matrix RH problem,reconstruction formulas and corresponding trace formulas are also derived.Further,the N-soliton solutions in the reflectionless case are obtained explicitly in the form of determinants.The propagation characteristics of one-soliton solutions and interaction properties of two-soliton solutions are discussed.In particular,the asymptotic expressions of two-soliton solutions as|t|→∞are obtained,which show that the velocities and amplitudes of the asymptotic solitons do not change before and after interaction except the position shifts.In addition,three types of bounded states for two-soliton solutions are presented with certain parametric conditions.
