Organic electrochemical transistors have emerged as a solution for artificial synapses that mimic the neural functions of the brain structure,holding great potentials to break the bottleneck of von Neumann architectur...Organic electrochemical transistors have emerged as a solution for artificial synapses that mimic the neural functions of the brain structure,holding great potentials to break the bottleneck of von Neumann architectures.However,current artificial synapses rely primarily on electrical signals,and little attention has been paid to the vital role of neurotransmitter-mediated artificial synapses.Dopamine is a key neurotransmitter associated with emotion regulation and cognitive processes that needs to be monitored in real time to advance the development of disease diagnostics and neuroscience.To provide insights into the development of artificial synapses with neurotransmitter involvement,this review proposes three steps towards future biomimic and bioinspired neuromorphic systems.We first summarize OECT-based dopamine detection devices,and then review advances in neurotransmitter-mediated artificial synapses and resultant advanced neuromorphic systems.Finally,by exploring the challenges and opportunities related to such neuromorphic systems,we provide a perspective on the future development of biomimetic and bioinspired neuromorphic systems.展开更多
Exploiting high-performance electrolyte holds the key for realization practical application of rechargeable magnesium batteries(RMBs).Herein,a new non-nucleophilic mononuclear electrolyte was developed and its electro...Exploiting high-performance electrolyte holds the key for realization practical application of rechargeable magnesium batteries(RMBs).Herein,a new non-nucleophilic mononuclear electrolyte was developed and its electrochemical active species was identified as[Mg(DME)_(3)][GaCl_(4)]_(2) through single-crystal X-ray diffraction analysis.The as-synthesized Mg(GaCl_(4))_(2)-IL-DME electrolyte could achieve a high ionic conductivity(9.85 m S cm^(-1)),good anodic stability(2.9 V vs.Mg/Mg^(2+)),and highly reversible Mg plating/stripping.The remarkable electrochemical performance should be attributed to the in-situ formation of Mg^(2+)-conducting Ga_(5)Mg_(2)alloy layer at the Mg/electrolyte interface during electrochemical cycling,which not only efficiently protects the Mg anode from passivation,but also allows for rapid Mg-ion transport.Significantly,the Mg(GaCl_(4))_(2)-IL-DME electrolyte showed excellent compatibility with both conversion and intercalation cathodes.The Mg/S batteries with Mg(Ga Cl_(4))_(2)-IL-DME electrolyte and KB/S cathode showed a high specific capacity of 839 m Ah g^(-1)after 50 cycles at 0.1 C with the Coulombic efficiency of~100%.Moreover,the assembled Mg|Mo_6 S_8 batteries delivered a reversible discharge capacity of 85 m Ah g^(-1)after 120 cycles at 0.2 C.This work provides a universal electrolyte for the realization of high-performance and practical RMBs,especially Mg/S batteries.展开更多
Split Hopkinson pressure bar(SHPB)was utilized to explore the effects of loading strain rate on the dynamic compressing strength of the titanium alloy lattice material.Results reveal that the yield strength of alloy l...Split Hopkinson pressure bar(SHPB)was utilized to explore the effects of loading strain rate on the dynamic compressing strength of the titanium alloy lattice material.Results reveal that the yield strength of alloy lattice material reaches 342 MPa initially and then drops to 200 MPa before it rebounds to 252 MPa while the loading strain rate correspondingly increases from the static value 1401/s to 2084/s.Numerical simulations were then carried out to explore the possible reason underlying.Results show that the lattice structure changed the stress distribution and caused significate stress concentration at finite strain with high strain rate.It is believed that the strain rate strengthening effect and layer-wise failure mode are the main reasons of the above mechanical properties change.展开更多
Inflammation and lung function decline are the main pathophysiological features of chronic obstructive pulmonary disease （COPD）. Acupuncture can improve lung function in patients with COPD, but the underlying mechan...Inflammation and lung function decline are the main pathophysiological features of chronic obstructive pulmonary disease （COPD）. Acupuncture can improve lung function in patients with COPD, but the underlying mechanisms are not well understood. Orexins （OXs）, which are found in peripheral plasma, are neuropeptides that regulate respiration and their levels are related to COPD. Therefore, we hypothesized that acupuncture might alter OXs, reduce lung inflammation and improve lung function in COPD. METHODS： COPD was induced in rats by exposure to cigarette smoke for 8 weeks and injecting with lipopolysaccharide twice. Electroacupuncture （EA） was performed at Feishu （BL13） and Zusanli （ST36） for 30 min/d for 2 weeks. Rat lung function and morphology were assessed after EA. The levels of tumor necrosis factor-α （TNF-a） and intedeukin-1β （IL-16） in bronchoalveolar lavage fluid （BALF） and orexin A and B levels in the lung tissue were detected by enzyme-linked immunosorbent assay. OX receptor mRNA levels and immunopositive cells were assessed with real-time polymerase chain reaction and immunohistochemical methods, respectively. The relationships among lung function, cell factors, and OX levels were analyzed by Pearson correlation analyses. RESULTS： Compared with the control group, lung function was significantly decreased in the rats with COPD （P〈0.05）. There were obvious increases in TNF-α and IL-1β levels in BALF （P〈0.05 and P〈0.01, respectively）, orexin A level in lung tissue （P〈0.01; but not orexin B） and mRNA expressions of OX 1 type receptor （OXR1） and OX 2 type receptor （OXR2） in lung tissue （P〈0.05 and P〈0.01, respectively）; the integrative optical densities （IODs） of both receptors were greater in the COPD group （P〈0.05）. For rats with COPD subjected to EA, lung function was improved （P〈0.05）. There were notable decreases in TNF-a and IL-1β levels （P〈0.05 and 〈0.01, respectively） in BALF. Orexin A, but not orexin B, levels in lung tissue also decreased （P〈0.01）, as did mRNA expression of OXlR and OX2R in lung tissue （P〈0.05 and P〈0.01, respectively）. Receptor IODs were also reduced after EA treatment （P〈0.05）. Furthermore, orexin A levels and ratio of forced expiratory volume in 0.3 s to forced vital capacity were strongly negatively correlated （P〈0.01）, and orexin A was positively correlated with TNF-α and IL-1β （P〈0.001 and P〈0.05, respectively）.CONCLUSION： EA at Zusanli and Feishu improved lung function of rats with COPD and had an anti-inflammatory effect, which may be related to down-regulation of OXA and its receptors.展开更多
农业自然灾害可接受风险水平的确定是实现农业灾害风险管理和区域农业可持续发展的有效途径。基于2010—2020年中国农业和农业自然灾害(包括干旱、洪涝、地质灾害、台风、风雹、低温冷冻和雪灾等)损失数据(不含港澳台地区数据),分析农...农业自然灾害可接受风险水平的确定是实现农业灾害风险管理和区域农业可持续发展的有效途径。基于2010—2020年中国农业和农业自然灾害(包括干旱、洪涝、地质灾害、台风、风雹、低温冷冻和雪灾等)损失数据(不含港澳台地区数据),分析农业自然灾害的时空分布特征,并在最低合理可行原则(As Low As Reasonably Practicable,即ALARP原则)下,应用F-N曲线法,构建不同风险厌恶程度的全国及其7大地理分区的农业自然灾害可接受风险曲线。结果表明:(1)2010—2020年中国农作物受灾率总体呈下降趋势,农作物成灾率为先波动上升至2015年达最高值后又波动下降,农作物绝收率总体呈上升趋势;华北和西北地区是我国农作物年均受灾率和成灾率最大的地区,而华南地区是农作物年均成灾率和绝收率最小的地区;(2)风险厌恶程度分别为1、1.5和2时,农业自然灾害致1万hm^(2)农作物年绝收的累计频率分别不超过0.12、0.07和0.02为可接受风险,超过0.50、0.15和0.07为不可接受风险。不区分风险厌恶程度,农业自然灾害导致农作物年绝收面积超过300万hm2,其年绝收的累计频率为任意值均是不可接受的。同理,7大地理分区的农业自然灾害可接受风险水平也被依次确定。该研究结果可为中国农业自然灾害风险管理提供决策建议。展开更多
基金supported by the National Natural Science Foundation of China(Grant No.62074163)Beijing Natural Science Foundation(Grant No.JQ24030).
文摘Organic electrochemical transistors have emerged as a solution for artificial synapses that mimic the neural functions of the brain structure,holding great potentials to break the bottleneck of von Neumann architectures.However,current artificial synapses rely primarily on electrical signals,and little attention has been paid to the vital role of neurotransmitter-mediated artificial synapses.Dopamine is a key neurotransmitter associated with emotion regulation and cognitive processes that needs to be monitored in real time to advance the development of disease diagnostics and neuroscience.To provide insights into the development of artificial synapses with neurotransmitter involvement,this review proposes three steps towards future biomimic and bioinspired neuromorphic systems.We first summarize OECT-based dopamine detection devices,and then review advances in neurotransmitter-mediated artificial synapses and resultant advanced neuromorphic systems.Finally,by exploring the challenges and opportunities related to such neuromorphic systems,we provide a perspective on the future development of biomimetic and bioinspired neuromorphic systems.
基金financially supported by National Natural Science Foundation of China(21773291,52303130,62205231,61904118,22002102)Natural Science Foundation of the Jiangsu Higher Education Institutions of China(19KJA210005)+1 种基金Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX23_1710)Postgraduate Research&Practice Innovation Program of Suzhou University of Science and Technology(CLKYCX23_06)。
文摘Exploiting high-performance electrolyte holds the key for realization practical application of rechargeable magnesium batteries(RMBs).Herein,a new non-nucleophilic mononuclear electrolyte was developed and its electrochemical active species was identified as[Mg(DME)_(3)][GaCl_(4)]_(2) through single-crystal X-ray diffraction analysis.The as-synthesized Mg(GaCl_(4))_(2)-IL-DME electrolyte could achieve a high ionic conductivity(9.85 m S cm^(-1)),good anodic stability(2.9 V vs.Mg/Mg^(2+)),and highly reversible Mg plating/stripping.The remarkable electrochemical performance should be attributed to the in-situ formation of Mg^(2+)-conducting Ga_(5)Mg_(2)alloy layer at the Mg/electrolyte interface during electrochemical cycling,which not only efficiently protects the Mg anode from passivation,but also allows for rapid Mg-ion transport.Significantly,the Mg(GaCl_(4))_(2)-IL-DME electrolyte showed excellent compatibility with both conversion and intercalation cathodes.The Mg/S batteries with Mg(Ga Cl_(4))_(2)-IL-DME electrolyte and KB/S cathode showed a high specific capacity of 839 m Ah g^(-1)after 50 cycles at 0.1 C with the Coulombic efficiency of~100%.Moreover,the assembled Mg|Mo_6 S_8 batteries delivered a reversible discharge capacity of 85 m Ah g^(-1)after 120 cycles at 0.2 C.This work provides a universal electrolyte for the realization of high-performance and practical RMBs,especially Mg/S batteries.
文摘Split Hopkinson pressure bar(SHPB)was utilized to explore the effects of loading strain rate on the dynamic compressing strength of the titanium alloy lattice material.Results reveal that the yield strength of alloy lattice material reaches 342 MPa initially and then drops to 200 MPa before it rebounds to 252 MPa while the loading strain rate correspondingly increases from the static value 1401/s to 2084/s.Numerical simulations were then carried out to explore the possible reason underlying.Results show that the lattice structure changed the stress distribution and caused significate stress concentration at finite strain with high strain rate.It is believed that the strain rate strengthening effect and layer-wise failure mode are the main reasons of the above mechanical properties change.
基金supported by grants from the National Natural Science Foundation of China(No.81072870No.81102660+1 种基金No.81373743)Open Research Fund of Zhejiang First-foremost Key Subject-Acupuncture&Moxibustion(No.ZTK2010B06)
文摘Inflammation and lung function decline are the main pathophysiological features of chronic obstructive pulmonary disease （COPD）. Acupuncture can improve lung function in patients with COPD, but the underlying mechanisms are not well understood. Orexins （OXs）, which are found in peripheral plasma, are neuropeptides that regulate respiration and their levels are related to COPD. Therefore, we hypothesized that acupuncture might alter OXs, reduce lung inflammation and improve lung function in COPD. METHODS： COPD was induced in rats by exposure to cigarette smoke for 8 weeks and injecting with lipopolysaccharide twice. Electroacupuncture （EA） was performed at Feishu （BL13） and Zusanli （ST36） for 30 min/d for 2 weeks. Rat lung function and morphology were assessed after EA. The levels of tumor necrosis factor-α （TNF-a） and intedeukin-1β （IL-16） in bronchoalveolar lavage fluid （BALF） and orexin A and B levels in the lung tissue were detected by enzyme-linked immunosorbent assay. OX receptor mRNA levels and immunopositive cells were assessed with real-time polymerase chain reaction and immunohistochemical methods, respectively. The relationships among lung function, cell factors, and OX levels were analyzed by Pearson correlation analyses. RESULTS： Compared with the control group, lung function was significantly decreased in the rats with COPD （P〈0.05）. There were obvious increases in TNF-α and IL-1β levels in BALF （P〈0.05 and P〈0.01, respectively）, orexin A level in lung tissue （P〈0.01; but not orexin B） and mRNA expressions of OX 1 type receptor （OXR1） and OX 2 type receptor （OXR2） in lung tissue （P〈0.05 and P〈0.01, respectively）; the integrative optical densities （IODs） of both receptors were greater in the COPD group （P〈0.05）. For rats with COPD subjected to EA, lung function was improved （P〈0.05）. There were notable decreases in TNF-a and IL-1β levels （P〈0.05 and 〈0.01, respectively） in BALF. Orexin A, but not orexin B, levels in lung tissue also decreased （P〈0.01）, as did mRNA expression of OXlR and OX2R in lung tissue （P〈0.05 and P〈0.01, respectively）. Receptor IODs were also reduced after EA treatment （P〈0.05）. Furthermore, orexin A levels and ratio of forced expiratory volume in 0.3 s to forced vital capacity were strongly negatively correlated （P〈0.01）, and orexin A was positively correlated with TNF-α and IL-1β （P〈0.001 and P〈0.05, respectively）.CONCLUSION： EA at Zusanli and Feishu improved lung function of rats with COPD and had an anti-inflammatory effect, which may be related to down-regulation of OXA and its receptors.
文摘农业自然灾害可接受风险水平的确定是实现农业灾害风险管理和区域农业可持续发展的有效途径。基于2010—2020年中国农业和农业自然灾害(包括干旱、洪涝、地质灾害、台风、风雹、低温冷冻和雪灾等)损失数据(不含港澳台地区数据),分析农业自然灾害的时空分布特征,并在最低合理可行原则(As Low As Reasonably Practicable,即ALARP原则)下,应用F-N曲线法,构建不同风险厌恶程度的全国及其7大地理分区的农业自然灾害可接受风险曲线。结果表明:(1)2010—2020年中国农作物受灾率总体呈下降趋势,农作物成灾率为先波动上升至2015年达最高值后又波动下降,农作物绝收率总体呈上升趋势;华北和西北地区是我国农作物年均受灾率和成灾率最大的地区,而华南地区是农作物年均成灾率和绝收率最小的地区;(2)风险厌恶程度分别为1、1.5和2时,农业自然灾害致1万hm^(2)农作物年绝收的累计频率分别不超过0.12、0.07和0.02为可接受风险,超过0.50、0.15和0.07为不可接受风险。不区分风险厌恶程度,农业自然灾害导致农作物年绝收面积超过300万hm2,其年绝收的累计频率为任意值均是不可接受的。同理,7大地理分区的农业自然灾害可接受风险水平也被依次确定。该研究结果可为中国农业自然灾害风险管理提供决策建议。
