Background and Objective:LTB4 has been shown to be involved in rheumatoid arthritis(RA)pathogenesis.The effect of Dioscin(Dio)on the LTB4 pathway of RA have not been reported yet.This study aimed at further exploring ...Background and Objective:LTB4 has been shown to be involved in rheumatoid arthritis(RA)pathogenesis.The effect of Dioscin(Dio)on the LTB4 pathway of RA have not been reported yet.This study aimed at further exploring whether Dioscin’s effects on TNF-αinduced collagen-induced arthritis(CIA)rat fibroblast-like synoviocytes(FLS)connected with the LTB4 and its receptor pathway.Materials&Methods:In this experiment,control group,TNF-αgroup,and different concentrations of Dioscin groups were established.Cell viability was evaluated using MTT assay.The levels of LTB4 in the samples of above groups were measured using ELISA.The mRNA expression levels of LTA4H,BLT1,and BLT2 were detected by quantitative real time PCR,while the expression level of LTA4H proteins were detected using western blot.The distribution of LTA4H was assessed by immunofluorescence assay.Results:the LTB4 level of TNF-αgroup in sample supernatant was higher than both control group and Dioscin groups with decreased LTB4 levels(p<0.05).Compared with the control group,the expression of LTA4H was significantly increased in TNF-αgroup(p<0.05),whereas LTA4H expressions were significantly decreased in all Dioscin groups when compared to TNF-αgroup(p<0.05).The mRNA expressions of BLT1 and BLT2 were markedly higher in TNF-αgroup than those in control group while Dioscin treatment significantly inhibited the increased expressions of BLT1 and BLT2 induced by TNF-α(p<0.05).Conclusions:These results firstly demonstrate that the protective effect of Dioscin on TNF-αinduced FLS may involve in its reducing LTB4 production by down-regulating LTA4H expression,and may inhibit its downstream pathway by decreasing LTB4 receptors levels.This findings suggest that dioscin produces a potential therapeutic effects for RA via its influencing LTA4H/LTB4/BLT pathway.展开更多
The scorpionfly fauna of the genus Panorpa Linnaeus,1758 in the Nanling Mountains,southern China is reviewed,including three new species:Panorpa filititilana sp.nov.from Mangshan,Panorpa muricata sp.nov.from Jintongsh...The scorpionfly fauna of the genus Panorpa Linnaeus,1758 in the Nanling Mountains,southern China is reviewed,including three new species:Panorpa filititilana sp.nov.from Mangshan,Panorpa muricata sp.nov.from Jintongshan and Mao’ershan,and Panorpa yuechenglingensis sp.nov.from Mao’ershan.The species number of Panorpa is raised to 13 in the Nanling Mountains region.A key to species of Panorpa in the Nanling Mountains is provided.展开更多
Genome duplication events,comprising whole-genome duplication and single-gene duplication,produce a complex genomic context leading to multiple levels of genetic changes.However,the characteristics of m^(6)A modificat...Genome duplication events,comprising whole-genome duplication and single-gene duplication,produce a complex genomic context leading to multiple levels of genetic changes.However,the characteristics of m^(6)A modification,the most widespread internal eukaryotic mRNA modification,in polyploid species are still poorly understood.This study revealed the characteristics of m^(6)A methylomes within the early formation and following the evolution of allopolyploid Brassica napus.We found a complex relationship between m^(6)A modification abundance and gene expression level depending on the degree of enrichment or presence/absence of m^(6)A modification.Overall,the m^(6)A genes had lower gene expression levels than the non-m^(6)A genes.Allopolyploidization may change the expression divergence of duplicated gene pairs with identical m^(6)A patterns and diverged m^(6)A patterns.Compared with duplicated genes,singletons with a higher evolutionary rate exhibited higher m^(6)A modification.Five kinds of duplicated genes exhibited distinct distributions of m^(6)A modifications in transcripts and gene expression level.In particular,tandem duplication-derived genes showed unique m^(6)A modification enrichment around the transcript start site.Active histone modifications(H3K27ac and H3K4me3)but not DNA methylation were enriched around genes of m^(6)A peaks.These findings provide a new understanding of the features of m 6A modification and gene expression regulation in allopolyploid plants with sophisticated genomic architecture.展开更多
The laws and regulations in human history can be revealed by computational models.From 221 before Christ(BC)to 1912 Anno Domini(AD),the unification pattern has dominated the main part of Chinese history for 2132 years...The laws and regulations in human history can be revealed by computational models.From 221 before Christ(BC)to 1912 Anno Domini(AD),the unification pattern has dominated the main part of Chinese history for 2132 years.Before the emergence of the first unified empire,the Qin Empire in 221 BC,there existed the Eastern Zhou dynasty(770 BC to 221 BC).This long dynasty has two stages,and here we focus on the first stage.This Spring-Autumn stage was from 770 BC(with 148 states)to 476 BC(with 32 states).The whole country(China)is modelled as a multi‐agent system,which contains multiple local states.They behave autonomously under certain action rules(wars and conflicts),which forms the main reason for the annexations and disappearance of most states.Key factors(power,loyalty,bellicosity and alliance)have been considered in our model settings,and simulation outcomes will be monitored and collected.Eventually,an optimal solution is obtained,which well unveils the internal mechanism and statistical features of real big history.Furthermore,counterfactuals are used to explore the non‐linear effects of the key factors,which deepens the authors’understanding of civilisa-tion evolutions in human history.展开更多
Mesenchymal stromal cell-derived extracellular vesicles(MSC-EVs)are recognized as a promising strategy for cell-free therapy,however,their therapeutic role in pulmonary fibrosis remains unrevealed.Here,we report the s...Mesenchymal stromal cell-derived extracellular vesicles(MSC-EVs)are recognized as a promising strategy for cell-free therapy,however,their therapeutic role in pulmonary fibrosis remains unrevealed.Here,we report the safety and efficacy of MSC-EVs from human umbilical cord(hUCMSC-EVs)evaluated in mouse models and pulmonary fibrosis patients.We established a rigorous system to produce high-quality of hUCMSC-EVs,characterized by miRNA,protein,and metabolite profiles.When administered via nebulization,hUCMSC-EVs predominantly accumulated in murine lungs and ameliorated bleomycin-induced pulmonary fibrosis,with increased survival rate(from 20%to 80%),restored lung volume,and attenuated injury severity accompanied by elevated oxyhemoglobin saturation and improved pulmonary function evaluations.We performed a phase l clinical trial involving twentyfour patients in a randomized,single-blind,and placebo-controlled study to treat pulmonary fibrosis(MR-46-22-004531,ChiCTR2300075466).All participants tolerated the nebulized hUCMSC-EVs well,with no serious adverse events.Patients receiving the combined therapy of nebulized hUCMSC-EVs and routine treatment demonstrated significant improvements in both lung function indices(forced vital capacity and maximal voluntary ventilation)and respiratory health status(as measured by the Saint George’s Respiratory Questionnaire and Leicester Cough Questionnaire.Overall,patients upon the additional therapy with nebulized hUCMSC-EVs gained significant benefits compared with those accepted only routine treatment.Remarkably,two patients with advanced post-inflammatory pulmonary fibrosis exhibited clinically significant regression on serial CT scans after hUCMSC-EVs therapy.These findings suggest that nebulized hUCMSC-EVs could be used as a promising therapeutic strategy for treating pulmonary fibrosis diseases.展开更多
It is difficult for the traditional PI controller to meet high-performance control requirements under the demagnetization fault of a permanent magnet synchronous motor(PMSM).To address this problem,this study proposes...It is difficult for the traditional PI controller to meet high-performance control requirements under the demagnetization fault of a permanent magnet synchronous motor(PMSM).To address this problem,this study proposes a novel sliding mode fault-tolerant control method for PMSM demagnetization faults.First,the mathematical model of PMSM under demagnetization fault state is established,and the reasons for poor fault tolerance of the conventional PI controller are analyzed.A new convergence law is used to design the speed loop sliding mode feedback controller,and its stability is demonstrated.Meanwhile,an adaptive forgetting factor recursive least squares(AFRLS)flux linkage observer is designed to keep the controller parameter values in line with the actual motor parameter values,to reduce the impact of demagnetization faults on motor control performance and achieve fault-tolerant control of demagnetization faults.Finally,simulation and experimental comparison with conventional PI control demonstrate that the proposed method is more robust and resistant to interference.展开更多
Fruit taste quality is greatly influenced by the content of soluble sugars,which are predominantly stored in the vacuolar lumen.However,the accumulation and regulation mechanisms of sugars in most fruits remain unclea...Fruit taste quality is greatly influenced by the content of soluble sugars,which are predominantly stored in the vacuolar lumen.However,the accumulation and regulation mechanisms of sugars in most fruits remain unclear.Recently,we established the citrus fruit vacuole proteome and discovered the major transporters localized in the vacuole membrane.Here,we demonstrated that the expression of tonoplast sugar transporter 2(CsTST2)is closely associated with sugar accumulation during sweet orange(Citrus sinensis)ripening.It was further demonstrated that CsTST2 had the function of transporting hexose and sucrose into the vacuole.Overexpression of CsTST2 resulted in an elevation of sugar content in citrus juice sac,calli,and tomato fruit,whereas the downregulation of its expression led to the reduction in sugar levels.CsTST2 was identified as interacting with CsCIPK23,which binds to the upstream calcium signal sensor protein CsCBL1.The phosphorylation of the three serine residues(Ser277,Ser337,and Ser354)in the loop region of CsTST2 by CsCIPK23 is crucial for maintaining the sugar transport activity of CsTST2.Additionally,the expression of CsCIPK23 is positively correlated with sugar content.Genetic evidence further confirmed that calcium and CsCIPK23-mediated increase in sugar accumulation depends on CsTST2 and its phosphorylation level.These findings not only unveil the functional mechanism of CsTST2 in sugar accumulation,but also explore a vital calcium signal regulation module of CsCBL1/CIPK23 for citrus sweetness quality.展开更多
Dear Editor,The rapid development of barley genomics research in recent years has greatly enhanced our understanding of the molecular regulatory mechanisms underlying the complex characters(Jiang et al.,2025).However,...Dear Editor,The rapid development of barley genomics research in recent years has greatly enhanced our understanding of the molecular regulatory mechanisms underlying the complex characters(Jiang et al.,2025).However,a huge challenge has also been posed for researchers to deal with the dramatically increasing amount of multi-omics data.展开更多
Barley is the fourth largest cereal crop in the world.It is mainly used for feeding,beer production and food.Barley is receiving more attention from both agricultural and food scientists because of its special chemica...Barley is the fourth largest cereal crop in the world.It is mainly used for feeding,beer production and food.Barley is receiving more attention from both agricultural and food scientists because of its special chemical composition and health benefits.In comparison with other cereal crops,including wheat,rice and maize,barley grains are rich in dietary fiber(such asβ-glucan)and tocols,which are beneficial to human health.It is well proved that diets rich in those chemicals can provide protection against hypertension,cardiovascular disease,and diabetes.Barley has been widely recognized to have great potential as a healthy or functional food.In this review,we present information about studies on the phys-ical structure of the barley grain and the distribution of its main chemical components,nutrient and functional composition of barley grain and their health benefits,and the approaches of improving and utilizing the nutrient and functional chemicals in barley grain.With the development of processing technologies,functional components in barley grains,especiallyβ-glucan,can be efficiently extracted and concentrated.Moreover,nutrient and functional components in barley grains can be efficiently improved by precise breeding and agronomic approaches.The review high-lights the great potential of barley used as healthy and functional foods,and may be instructive for better utilization of barley in food processing.展开更多
It remains an urgent task to develop alternative hole-transporting layer(HTL)materials beyond commonly used PEDOT:PSS to increase the shelf-life of organic solar cells(OSCs).Inorganic metal oxide type materials,such a...It remains an urgent task to develop alternative hole-transporting layer(HTL)materials beyond commonly used PEDOT:PSS to increase the shelf-life of organic solar cells(OSCs).Inorganic metal oxide type materials,such as NiO_(x),CoO_(x)and VO_(x),with suitable work functions have attracted numerous research attention recently.In this work,more abundant and easily accessible oxygenated salt,vanadyl sulfate(VOSO_(4))has been demonstrated to be excellent choice as HTL for OSCs.The VOSO_(4)-based HTL can be readily processed by spin-coating from the precursor solution with subsequent thermal annealing and UVO treatment.As a consequence,a high power conversion efficiency(PCE)of 18.72%can be achieved for PM8:L8-BO based OSCs with the VOSO_(4)-based HTL.High transmittance,smooth film surface,suitable energy level and high conductivity were revealed to contribute to the high OSC performance.More importantly,compared to device with PEDOT:PSS,VOSO_(4)-based OSCs exhibit improved stability when stored in the N_(2)filled glove box.After being stored for 600 h,VOSO_(4)-based device can retain 89%of its initial efficiency.Notably,VOSO_(4)can be used as general HTL in PM6:BTP-BO-4Cl and PM6:IT-4F based OSCs,yielding high PCEs of 17.87%and 13.85%,respectively.展开更多
基金supported by the National Natural Science Foundation of China(Nos.82060661,81660751,81660151)Jiangxi Provincial Natural Science Foundation of China(No.20171BAB205085).
文摘Background and Objective:LTB4 has been shown to be involved in rheumatoid arthritis(RA)pathogenesis.The effect of Dioscin(Dio)on the LTB4 pathway of RA have not been reported yet.This study aimed at further exploring whether Dioscin’s effects on TNF-αinduced collagen-induced arthritis(CIA)rat fibroblast-like synoviocytes(FLS)connected with the LTB4 and its receptor pathway.Materials&Methods:In this experiment,control group,TNF-αgroup,and different concentrations of Dioscin groups were established.Cell viability was evaluated using MTT assay.The levels of LTB4 in the samples of above groups were measured using ELISA.The mRNA expression levels of LTA4H,BLT1,and BLT2 were detected by quantitative real time PCR,while the expression level of LTA4H proteins were detected using western blot.The distribution of LTA4H was assessed by immunofluorescence assay.Results:the LTB4 level of TNF-αgroup in sample supernatant was higher than both control group and Dioscin groups with decreased LTB4 levels(p<0.05).Compared with the control group,the expression of LTA4H was significantly increased in TNF-αgroup(p<0.05),whereas LTA4H expressions were significantly decreased in all Dioscin groups when compared to TNF-αgroup(p<0.05).The mRNA expressions of BLT1 and BLT2 were markedly higher in TNF-αgroup than those in control group while Dioscin treatment significantly inhibited the increased expressions of BLT1 and BLT2 induced by TNF-α(p<0.05).Conclusions:These results firstly demonstrate that the protective effect of Dioscin on TNF-αinduced FLS may involve in its reducing LTB4 production by down-regulating LTA4H expression,and may inhibit its downstream pathway by decreasing LTB4 receptors levels.This findings suggest that dioscin produces a potential therapeutic effects for RA via its influencing LTA4H/LTB4/BLT pathway.
基金funded by the GDAS’(Guangdong Academy of Sciences)Special Project of Science and Technology Development(2020GDASYL-20200102021)。
文摘The scorpionfly fauna of the genus Panorpa Linnaeus,1758 in the Nanling Mountains,southern China is reviewed,including three new species:Panorpa filititilana sp.nov.from Mangshan,Panorpa muricata sp.nov.from Jintongshan and Mao’ershan,and Panorpa yuechenglingensis sp.nov.from Mao’ershan.The species number of Panorpa is raised to 13 in the Nanling Mountains region.A key to species of Panorpa in the Nanling Mountains is provided.
基金This work was supported by the National Natural Science Foundation of China(31970241).
文摘Genome duplication events,comprising whole-genome duplication and single-gene duplication,produce a complex genomic context leading to multiple levels of genetic changes.However,the characteristics of m^(6)A modification,the most widespread internal eukaryotic mRNA modification,in polyploid species are still poorly understood.This study revealed the characteristics of m^(6)A methylomes within the early formation and following the evolution of allopolyploid Brassica napus.We found a complex relationship between m^(6)A modification abundance and gene expression level depending on the degree of enrichment or presence/absence of m^(6)A modification.Overall,the m^(6)A genes had lower gene expression levels than the non-m^(6)A genes.Allopolyploidization may change the expression divergence of duplicated gene pairs with identical m^(6)A patterns and diverged m^(6)A patterns.Compared with duplicated genes,singletons with a higher evolutionary rate exhibited higher m^(6)A modification.Five kinds of duplicated genes exhibited distinct distributions of m^(6)A modifications in transcripts and gene expression level.In particular,tandem duplication-derived genes showed unique m^(6)A modification enrichment around the transcript start site.Active histone modifications(H3K27ac and H3K4me3)but not DNA methylation were enriched around genes of m^(6)A peaks.These findings provide a new understanding of the features of m 6A modification and gene expression regulation in allopolyploid plants with sophisticated genomic architecture.
基金supported by the National Social Science Foundation of China(Grant No.17ZDA117).
文摘The laws and regulations in human history can be revealed by computational models.From 221 before Christ(BC)to 1912 Anno Domini(AD),the unification pattern has dominated the main part of Chinese history for 2132 years.Before the emergence of the first unified empire,the Qin Empire in 221 BC,there existed the Eastern Zhou dynasty(770 BC to 221 BC).This long dynasty has two stages,and here we focus on the first stage.This Spring-Autumn stage was from 770 BC(with 148 states)to 476 BC(with 32 states).The whole country(China)is modelled as a multi‐agent system,which contains multiple local states.They behave autonomously under certain action rules(wars and conflicts),which forms the main reason for the annexations and disappearance of most states.Key factors(power,loyalty,bellicosity and alliance)have been considered in our model settings,and simulation outcomes will be monitored and collected.Eventually,an optimal solution is obtained,which well unveils the internal mechanism and statistical features of real big history.Furthermore,counterfactuals are used to explore the non‐linear effects of the key factors,which deepens the authors’understanding of civilisa-tion evolutions in human history.
基金supported by the Tsinghua University Spring Breeze Fund(20201080606)Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University(2022Z82WKJ008)+4 种基金the joint fund between Shanghai Jinwei Cell and Tissue Storage Service Co.,Ltd and Tsinghua University(20232000265)a grant from Jinfeng Laboratory,Chongqing(JFLKYXM202303AZ-203)fundings of Hainan Province Clinical Medical Center Construction Project,China([2022]276)Science and Technology Special Fund of Hainan Province,China(ZDYF2024SHFZ114)Health Science and Technology Innovation Joint Project of Hainan Province,China(WSJK2024MS231)。
文摘Mesenchymal stromal cell-derived extracellular vesicles(MSC-EVs)are recognized as a promising strategy for cell-free therapy,however,their therapeutic role in pulmonary fibrosis remains unrevealed.Here,we report the safety and efficacy of MSC-EVs from human umbilical cord(hUCMSC-EVs)evaluated in mouse models and pulmonary fibrosis patients.We established a rigorous system to produce high-quality of hUCMSC-EVs,characterized by miRNA,protein,and metabolite profiles.When administered via nebulization,hUCMSC-EVs predominantly accumulated in murine lungs and ameliorated bleomycin-induced pulmonary fibrosis,with increased survival rate(from 20%to 80%),restored lung volume,and attenuated injury severity accompanied by elevated oxyhemoglobin saturation and improved pulmonary function evaluations.We performed a phase l clinical trial involving twentyfour patients in a randomized,single-blind,and placebo-controlled study to treat pulmonary fibrosis(MR-46-22-004531,ChiCTR2300075466).All participants tolerated the nebulized hUCMSC-EVs well,with no serious adverse events.Patients receiving the combined therapy of nebulized hUCMSC-EVs and routine treatment demonstrated significant improvements in both lung function indices(forced vital capacity and maximal voluntary ventilation)and respiratory health status(as measured by the Saint George’s Respiratory Questionnaire and Leicester Cough Questionnaire.Overall,patients upon the additional therapy with nebulized hUCMSC-EVs gained significant benefits compared with those accepted only routine treatment.Remarkably,two patients with advanced post-inflammatory pulmonary fibrosis exhibited clinically significant regression on serial CT scans after hUCMSC-EVs therapy.These findings suggest that nebulized hUCMSC-EVs could be used as a promising therapeutic strategy for treating pulmonary fibrosis diseases.
基金Supported by the National Natural Science Foundation of China under Grant 52077011Hunan Provincial Natural Science Foundation 2024JJ7614,2024JJ7615 and 2024JJ6089+1 种基金Hunan Education Department Science Research Project under Grant 23B0785 and 23B0793Major Special Projects of Changsha under Grant kq2105001.
文摘It is difficult for the traditional PI controller to meet high-performance control requirements under the demagnetization fault of a permanent magnet synchronous motor(PMSM).To address this problem,this study proposes a novel sliding mode fault-tolerant control method for PMSM demagnetization faults.First,the mathematical model of PMSM under demagnetization fault state is established,and the reasons for poor fault tolerance of the conventional PI controller are analyzed.A new convergence law is used to design the speed loop sliding mode feedback controller,and its stability is demonstrated.Meanwhile,an adaptive forgetting factor recursive least squares(AFRLS)flux linkage observer is designed to keep the controller parameter values in line with the actual motor parameter values,to reduce the impact of demagnetization faults on motor control performance and achieve fault-tolerant control of demagnetization faults.Finally,simulation and experimental comparison with conventional PI control demonstrate that the proposed method is more robust and resistant to interference.
基金supported by National Key Research and Development Program of China(2023YFD2300603,2022YFF1003100)the National Natural Science Foundation of China(32322073)+2 种基金Foundation of Hubei Hongshan Laboratory(2021hszd016)Fundamental Research Funds for the Central Universities(2662023PY011)the Huazhong Agricultural University(start-up funding to C.L.)。
文摘Fruit taste quality is greatly influenced by the content of soluble sugars,which are predominantly stored in the vacuolar lumen.However,the accumulation and regulation mechanisms of sugars in most fruits remain unclear.Recently,we established the citrus fruit vacuole proteome and discovered the major transporters localized in the vacuole membrane.Here,we demonstrated that the expression of tonoplast sugar transporter 2(CsTST2)is closely associated with sugar accumulation during sweet orange(Citrus sinensis)ripening.It was further demonstrated that CsTST2 had the function of transporting hexose and sucrose into the vacuole.Overexpression of CsTST2 resulted in an elevation of sugar content in citrus juice sac,calli,and tomato fruit,whereas the downregulation of its expression led to the reduction in sugar levels.CsTST2 was identified as interacting with CsCIPK23,which binds to the upstream calcium signal sensor protein CsCBL1.The phosphorylation of the three serine residues(Ser277,Ser337,and Ser354)in the loop region of CsTST2 by CsCIPK23 is crucial for maintaining the sugar transport activity of CsTST2.Additionally,the expression of CsCIPK23 is positively correlated with sugar content.Genetic evidence further confirmed that calcium and CsCIPK23-mediated increase in sugar accumulation depends on CsTST2 and its phosphorylation level.These findings not only unveil the functional mechanism of CsTST2 in sugar accumulation,but also explore a vital calcium signal regulation module of CsCBL1/CIPK23 for citrus sweetness quality.
基金supported by the National Natural Science Foundation of China(32171917)the Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(2021C02064-3)+1 种基金the Shenzhen Science and Technology Program(KQTD20230301092839007)the China Agricultural Research System(CARS-05).
文摘Dear Editor,The rapid development of barley genomics research in recent years has greatly enhanced our understanding of the molecular regulatory mechanisms underlying the complex characters(Jiang et al.,2025).However,a huge challenge has also been posed for researchers to deal with the dramatically increasing amount of multi-omics data.
基金the Science and Technology Program of Zhejiang Province of China(LGN20C130007,2021 C02064-3,2020C02002)the National Natural Science Foundation of China(No.32171917)the earmarked fund for China Agriculture Research System(CARS-05).
文摘Barley is the fourth largest cereal crop in the world.It is mainly used for feeding,beer production and food.Barley is receiving more attention from both agricultural and food scientists because of its special chemical composition and health benefits.In comparison with other cereal crops,including wheat,rice and maize,barley grains are rich in dietary fiber(such asβ-glucan)and tocols,which are beneficial to human health.It is well proved that diets rich in those chemicals can provide protection against hypertension,cardiovascular disease,and diabetes.Barley has been widely recognized to have great potential as a healthy or functional food.In this review,we present information about studies on the phys-ical structure of the barley grain and the distribution of its main chemical components,nutrient and functional composition of barley grain and their health benefits,and the approaches of improving and utilizing the nutrient and functional chemicals in barley grain.With the development of processing technologies,functional components in barley grains,especiallyβ-glucan,can be efficiently extracted and concentrated.Moreover,nutrient and functional components in barley grains can be efficiently improved by precise breeding and agronomic approaches.The review high-lights the great potential of barley used as healthy and functional foods,and may be instructive for better utilization of barley in food processing.
基金supported by NSFC(52163018,52073016,92163128)Jiangxi Provincial Department of Science and Technology(No.20212BCJ23035)+1 种基金Jiangxi Academy of Sciences(2023YJC1001,2023YSBG22025,2022YRCS002)the Hong Kong scholar program(XJ2022019)。
文摘It remains an urgent task to develop alternative hole-transporting layer(HTL)materials beyond commonly used PEDOT:PSS to increase the shelf-life of organic solar cells(OSCs).Inorganic metal oxide type materials,such as NiO_(x),CoO_(x)and VO_(x),with suitable work functions have attracted numerous research attention recently.In this work,more abundant and easily accessible oxygenated salt,vanadyl sulfate(VOSO_(4))has been demonstrated to be excellent choice as HTL for OSCs.The VOSO_(4)-based HTL can be readily processed by spin-coating from the precursor solution with subsequent thermal annealing and UVO treatment.As a consequence,a high power conversion efficiency(PCE)of 18.72%can be achieved for PM8:L8-BO based OSCs with the VOSO_(4)-based HTL.High transmittance,smooth film surface,suitable energy level and high conductivity were revealed to contribute to the high OSC performance.More importantly,compared to device with PEDOT:PSS,VOSO_(4)-based OSCs exhibit improved stability when stored in the N_(2)filled glove box.After being stored for 600 h,VOSO_(4)-based device can retain 89%of its initial efficiency.Notably,VOSO_(4)can be used as general HTL in PM6:BTP-BO-4Cl and PM6:IT-4F based OSCs,yielding high PCEs of 17.87%and 13.85%,respectively.
