以多功能全回转起重船为研究对象,针对起重机起吊重物并做大角度回转作业工况,建立多目标优化数学模型,以各个压载舱调载量最大值最小、起重机起吊重物回转过程中船舶纵倾角最小和横倾角最小作为三个优化目标,利用多目标遗传算法,求解...以多功能全回转起重船为研究对象,针对起重机起吊重物并做大角度回转作业工况,建立多目标优化数学模型,以各个压载舱调载量最大值最小、起重机起吊重物回转过程中船舶纵倾角最小和横倾角最小作为三个优化目标,利用多目标遗传算法,求解获得配载方案最优集,同时利用基于熵权的TOPSIS(Technique for Order Preference by Similarity to an Ideal Solution)方法,客观准确地得到压载调拨与吊机作业配合的最终配载方案。结果表明利用AQWA(Advanced Quantitative Wave Analysis)静水力分析可较为准确地获得船舶重心与倾角的关系,且多目标优化方法可输出多个最优配载方案,多准则决策方法可结合工程经验和客观性输出最终配载方案,该优化决策方法可高效得到简单有效的起重船配载方案,为工程中的压载优化提供参考。展开更多
基于多学科交叉技术,本文提出了一种考虑运动和动力耦合的复杂多体系统优化设计分析方法。基于ADAMS(Automatic Dynamic Analysis of Mechanical Systems)平台建立全回转重吊船刚柔耦合虚拟样机,以AQWA(Advanced Quantitative Wave Anal...基于多学科交叉技术,本文提出了一种考虑运动和动力耦合的复杂多体系统优化设计分析方法。基于ADAMS(Automatic Dynamic Analysis of Mechanical Systems)平台建立全回转重吊船刚柔耦合虚拟样机,以AQWA(Advanced Quantitative Wave Analysis)软件计算的船体水动力时域响应作为运动驱动,完成典型服役海况下系统关键区域应力耦合响应特征分析。依托ANSYS有限元软件优化模块,结合客观熵权TOPSIS(Technique for Order Preference by Similarity to an Ideal Solution)决策方法得到该区域最优设计方案。分析表明:船体横摇及垂荡对支撑区域动力响应影响较大;相较船体静止,横摇、垂荡耦合运动使吊装绳索张力与支撑区域关键节点应力增幅均超过20%;对比初始方案支撑结构的钢材用量,最优方案可节省12.30%。将虚拟样机技术与有限元力学分析结合并融入管理科学的多目标优化和多准则决策,可提高复杂多体系统的分析效率,得到科学合理的设计方案。展开更多
To identify sociodemographic characteristics and risk factor of Demodex infestation,756 students aged 13-22 years in Xi'an,China were sampled for the school-based cross-sectional study.Demodex was examined using t...To identify sociodemographic characteristics and risk factor of Demodex infestation,756 students aged 13-22 years in Xi'an,China were sampled for the school-based cross-sectional study.Demodex was examined using the cellophane tape method(CTP).The results showed that the total detection rate of Demodex was 67.6%.Logistic regression analysis revealed that five variables(gender,residence,sharing sanitary ware,frequency of face-wash per day,and use of facial cleanser) were found to be uncorrelated with Demodex infestation,whereas three variables(age,skin type,and skin disease) were found to be independent correlates.Students aged over 18 years had 22.1 times higher odds of Demodex infestation compared to those under 16 years and students aged 16-18 years also had 2.1 times higher odds compared to those aged 13-15 years.Odds of having a Demodex infestation for oily or mixed skin were 2.1 times those for dry or neutral skin.Students with a facial skin disease had 3.0 times higher odds of being infested with Demodex compared to those without.The inception rate of students with facial dermatoses increased in parallel with increasing mite count.The inception rates were 21.3%,40.7%,59.2%,and 67.7% in the negative,mild,moderate,and severe infestation groups,respectively(χ2=60.6,P<0.001).Specifically,the amount of infested mites and inception rate of acne vulgaris were positively correlated(R2=0.57,moderate infestation odds ratio(OR)=7.1,severe infestation OR=10.3).It was concluded that Demodex prevalence increases with age,and Demodex presents in nearly all adult human.Sebaceous hyperplasia with oily or mixed skin seems to favour Demodex proliferation.Demodex infestation could be associated with acne vulgaris.The CTP is a good sampling method for studies of Demodex prevalence.展开更多
AIM:To investigate cytokeratin 8(CK8)overexpression during hepatitis C virus(HCV)infection and its pathogenesis,and the effect of ectopic CK8 expression on hepatoma cell lines.METHODS:We successfully established an in...AIM:To investigate cytokeratin 8(CK8)overexpression during hepatitis C virus(HCV)infection and its pathogenesis,and the effect of ectopic CK8 expression on hepatoma cell lines.METHODS:We successfully established an in vitro HCV cell culture system(HCVcc)to investigate the different expression profiles of CK8 in Huh-7-HCV and Huh-7.5-HCV cells.The expression of CK8 at the mRNA level was determined by real-time polymerase chain reaction(RT-PCR).The expression of CK8 at the protein level was evaluated by Western blotting.We then constructed a eukaryotic expression combination vector containing the coding sequence of human full length CK8 gene.CK8cDNA was amplified by reverse transcription-PCR and inserted into pEGFP-C1 and the positive clone pEGFPCK8 was obtained.After confirming the sequence,the recombinant plasmid was transfected into SMMC7721cells with lipofectamine2000 and CK8 expression was detected using inverted fluorescence microscopy,RTPCR and Western blotting.Besides,we identified biological function of CK8 on SMMC7721 cells,including cell proliferation,cell cycle and apoptosis detection.RESULTS:RT-PCR showed that the expression level of CK8 in Huh-7-HCV and Huh-7.5-HCV cells was 2.88and 2.95 times higher than in control cells.Western blot showed that CK8 expression in Huh-7-HCV and Huh-7.5-HCV cells was 2.53 and 3.26 times higher than that in control cells,respectively.We found that CK8at mRNA and protein levels were both significantly increased in HCVcc.CK8 was up-regulated in SMMC7721cells.CK8 expression at the mRNA level was significantly upregulated in SMMC7721/pEGFP-CK8 cells.CK8expression in SMMC7721/pEGFP-CK8 cells was 2.69times higher than in SMMC7721 cells,and was 2.64times higher than in SMMC7721/pEGFP-C1 cells.CK8expression at the protein level in SMMC7721/pEGFPCK8 cells was 2.46 times higher than in SMMC7721cells,and was 2.29 times higher than in SMMC7721/pEGFP-C1 cells.Further analysis demonstrated that forced expression of CK8 slowed cell growth and induced apoptosis of SMMC7721 cells.CONCLUSION:CK8 up-regulation might have a functional role in HCV infection and pathogenesis,and could be a promising target for the treatment of HCV infection.展开更多
On the basis of a potential theory and Euler-Bernoulli beam theory, an analytical solution for oblique wave scattering by a semi-infinite elastic plate with finite draft floating on a step topography is developed usin...On the basis of a potential theory and Euler-Bernoulli beam theory, an analytical solution for oblique wave scattering by a semi-infinite elastic plate with finite draft floating on a step topography is developed using matched eigenfunction expansions. Different from previous studies, the effects of a wave incident angle, a plate draft, three different plate edge conditions （free, simply supported and built-in） and a sea-bottom topography are all taken into account. Moreover, the plate edge conditions are directly incorporated into linear algebraic equations for determining unknown expansion coefficients in velocity potentials, which leads to a simple and efficient solving procedure. Numerical results show that the convergence of the present solution is good, and an energy conservation relation is well satisfied. Also, the present predictions are in good agreement with known results for special cases. The effects of the wave incident angle, the plate draft, the plate edge conditions and the sea-bottom topography on various hydrodynamic quantities are analyzed. Some useful results are presented for engineering designs.展开更多
An analytical procedure is presented to evaluate the fluid sloshing characteristics in a two-dimensional(2D)rectangular container with a bottom-mounted T-shaped baffle.The fluid region is divided into several sub-doma...An analytical procedure is presented to evaluate the fluid sloshing characteristics in a two-dimensional(2D)rectangular container with a bottom-mounted T-shaped baffle.The fluid region is divided into several sub-domains with hypothetical interfaces and the velocities and pressures of the fluid on adjacent interfaces should be identical.The separation of variables in conjunction with the superposition principle is employed to formulate the velocity potential of each sub-domain.The Fourier series expansion is used to derive the eigenvalue equation by substituting the velocity potential solutions into the free surface conditions and the continuity conditions on adjacent interfaces.Under the horizontal base excitation,the total velocity potential of fluid is decomposed of the impulsive and perturbed velocity potentials.The orthogonality of the sloshing modes is demonstrated by implementing Gauss formula.The dynamic response equation is established by incorporating the total velocity potential solution into the surface wave equation.Excellent agreements are achieved between the present results and those from the reported literature and finite element code.Numerical results are exhibited to reveal the effect of the baffle parameters and excitation frequency on sloshing characteristics and responses of liquid.展开更多
The recent COVID-19 pandemic poses a global health emergency.Cellular entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor-human angiotensin converting enzyme 2(A...The recent COVID-19 pandemic poses a global health emergency.Cellular entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor-human angiotensin converting enzyme 2(ACE2).Here,by using lentivirus based pseudotypes bearing spike protein,we demonstrated that entry of SARS-CoV-2 into host cells was dependent on clathrin-mediated endocytosis,and phosphoinositides played essential roles during this process.In addition,we showed that the intracellular domain and the catalytic activity of ACE2 were not required for efficient virus entry.Finally,we showed that the current predominant Delta variant,although with high infectivity and high syncytium formation,also entered cells through clathrin-mediated endocytosis.These results provide new insights into SARS-CoV-2 cellular entry and present proof of principle that targeting viral entry could be an effective way to treat different variant infections.展开更多
Coxsackievirus belongs to the Picornaviridae family and is one of the major pathogens that cause hand,foot and mouth disease(HFMD)in infants and children with potential serious complications and even deaths.The pathog...Coxsackievirus belongs to the Picornaviridae family and is one of the major pathogens that cause hand,foot and mouth disease(HFMD)in infants and children with potential serious complications and even deaths.The pathogenesis of this virus is not fully elucidated and no vaccine or antiviral drug has been approved.In this study,a full-length infectious cDNA clone of coxsackievirus B5 virus was assembled and the recombinant virus displayed similar growth kinetics and ability to cause cytopathic effects as the parental virus.Luciferase reporter was then incorporated to generate both full-length and subgenomic replicon(SGR)reporter viruses.The full-length reporter virus is suitable for high-throughput antiviral screening,while the SGR is a useful tool to study viral-host interactions.More importantly,the full-length reporter virus has also been shown to infect the suckling mouse model and the reporter gene could be detected using an in vivo imaging system,thus providing a powerful tool to track viruses in vivo.In summary,we have generated coxsackievirus B5 reporter viruses and provided unique tools for studying virus-host interactions in vitro and in vivo as well as for high-throughput screenings(HTS)to identify novel antivirals.展开更多
The 808-nm vertical cavity surface emitting laser(VCSEL) with strained In_(0.13)Ga_(0.75)Al_(0.12)As/Al_(0.3)Ga_(0.7)As quantum wells is designed and fabricated. Compared with the VCSELs with Al_(0.05)Ga_(0.95)As/Al_(...The 808-nm vertical cavity surface emitting laser(VCSEL) with strained In_(0.13)Ga_(0.75)Al_(0.12)As/Al_(0.3)Ga_(0.7)As quantum wells is designed and fabricated. Compared with the VCSELs with Al_(0.05)Ga_(0.95)As/Al_(0.3)Ga_(0.7)As quantum wells, the VCSEL with strained In_(0.13)Ga_(0.75)Al_(0.12)As/Al_(0.3)Ga_(0.7)As quantum wells is demonstrated to possess higher power conversion efficiency(PCE) and better temperature stability. The maximum PCE of 43.8% for 10-μm VCSEL is achieved at an ambient temperature of 30°C. The size-dependent thermal characteristics are also analyzed by characterizing the spectral power and output power. It demonstrates that small oxide-aperture VCSELs are advantageous for temperature-stable performance.展开更多
Vertical cavity surface emitting lasers(VCSELs)have emerged as a versatile and promising platform for developing advanced integrated photonic devices and systems due to their low power consumption,high modulation band...Vertical cavity surface emitting lasers(VCSELs)have emerged as a versatile and promising platform for developing advanced integrated photonic devices and systems due to their low power consumption,high modulation bandwidth,small footprint,excellent scalability,and compatibility with monolithic integration.By combining these unique capabilities of VCSELs with the functionalities offered by micro/nano optical structures(e.g.metasurfaces),it enables various versatile energy-efficient integrated photonic devices and systems with compact size,enhanced performance,and improved reliability and functionality.This review provides a comprehensive overview of the stateof-the-art versatile integrated photonic devices/systems based on VCSELs,including photonic neural networks,vortex beam emitters,holographic devices,beam deflectors,atomic sensors,and biosensors.By leveraging the capabilities of VCSELs,these integrated photonic devices/systems open up new opportunities in various fields,including artificial intelligence,large-capacity optical communication,imaging,biosensing,and so on.Through this comprehensive review,we aim to provide a detailed understanding of the pivotal role played by VCSELs in integrated photonics and highlight their significance in advancing the feld towards effcient,compact,and versatile photonic solutions.展开更多
文摘以多功能全回转起重船为研究对象,针对起重机起吊重物并做大角度回转作业工况,建立多目标优化数学模型,以各个压载舱调载量最大值最小、起重机起吊重物回转过程中船舶纵倾角最小和横倾角最小作为三个优化目标,利用多目标遗传算法,求解获得配载方案最优集,同时利用基于熵权的TOPSIS(Technique for Order Preference by Similarity to an Ideal Solution)方法,客观准确地得到压载调拨与吊机作业配合的最终配载方案。结果表明利用AQWA(Advanced Quantitative Wave Analysis)静水力分析可较为准确地获得船舶重心与倾角的关系,且多目标优化方法可输出多个最优配载方案,多准则决策方法可结合工程经验和客观性输出最终配载方案,该优化决策方法可高效得到简单有效的起重船配载方案,为工程中的压载优化提供参考。
文摘基于多学科交叉技术,本文提出了一种考虑运动和动力耦合的复杂多体系统优化设计分析方法。基于ADAMS(Automatic Dynamic Analysis of Mechanical Systems)平台建立全回转重吊船刚柔耦合虚拟样机,以AQWA(Advanced Quantitative Wave Analysis)软件计算的船体水动力时域响应作为运动驱动,完成典型服役海况下系统关键区域应力耦合响应特征分析。依托ANSYS有限元软件优化模块,结合客观熵权TOPSIS(Technique for Order Preference by Similarity to an Ideal Solution)决策方法得到该区域最优设计方案。分析表明:船体横摇及垂荡对支撑区域动力响应影响较大;相较船体静止,横摇、垂荡耦合运动使吊装绳索张力与支撑区域关键节点应力增幅均超过20%;对比初始方案支撑结构的钢材用量,最优方案可节省12.30%。将虚拟样机技术与有限元力学分析结合并融入管理科学的多目标优化和多准则决策,可提高复杂多体系统的分析效率,得到科学合理的设计方案。
基金Project supported by the National Natural Science Foundation of China (No. 30872199)the Natural Science Foundation of Shaanxi Province (No. 2006C247),China
文摘To identify sociodemographic characteristics and risk factor of Demodex infestation,756 students aged 13-22 years in Xi'an,China were sampled for the school-based cross-sectional study.Demodex was examined using the cellophane tape method(CTP).The results showed that the total detection rate of Demodex was 67.6%.Logistic regression analysis revealed that five variables(gender,residence,sharing sanitary ware,frequency of face-wash per day,and use of facial cleanser) were found to be uncorrelated with Demodex infestation,whereas three variables(age,skin type,and skin disease) were found to be independent correlates.Students aged over 18 years had 22.1 times higher odds of Demodex infestation compared to those under 16 years and students aged 16-18 years also had 2.1 times higher odds compared to those aged 13-15 years.Odds of having a Demodex infestation for oily or mixed skin were 2.1 times those for dry or neutral skin.Students with a facial skin disease had 3.0 times higher odds of being infested with Demodex compared to those without.The inception rate of students with facial dermatoses increased in parallel with increasing mite count.The inception rates were 21.3%,40.7%,59.2%,and 67.7% in the negative,mild,moderate,and severe infestation groups,respectively(χ2=60.6,P<0.001).Specifically,the amount of infested mites and inception rate of acne vulgaris were positively correlated(R2=0.57,moderate infestation odds ratio(OR)=7.1,severe infestation OR=10.3).It was concluded that Demodex prevalence increases with age,and Demodex presents in nearly all adult human.Sebaceous hyperplasia with oily or mixed skin seems to favour Demodex proliferation.Demodex infestation could be associated with acne vulgaris.The CTP is a good sampling method for studies of Demodex prevalence.
基金Supported by National Natural Science Foundation of China,No.81170393
文摘AIM:To investigate cytokeratin 8(CK8)overexpression during hepatitis C virus(HCV)infection and its pathogenesis,and the effect of ectopic CK8 expression on hepatoma cell lines.METHODS:We successfully established an in vitro HCV cell culture system(HCVcc)to investigate the different expression profiles of CK8 in Huh-7-HCV and Huh-7.5-HCV cells.The expression of CK8 at the mRNA level was determined by real-time polymerase chain reaction(RT-PCR).The expression of CK8 at the protein level was evaluated by Western blotting.We then constructed a eukaryotic expression combination vector containing the coding sequence of human full length CK8 gene.CK8cDNA was amplified by reverse transcription-PCR and inserted into pEGFP-C1 and the positive clone pEGFPCK8 was obtained.After confirming the sequence,the recombinant plasmid was transfected into SMMC7721cells with lipofectamine2000 and CK8 expression was detected using inverted fluorescence microscopy,RTPCR and Western blotting.Besides,we identified biological function of CK8 on SMMC7721 cells,including cell proliferation,cell cycle and apoptosis detection.RESULTS:RT-PCR showed that the expression level of CK8 in Huh-7-HCV and Huh-7.5-HCV cells was 2.88and 2.95 times higher than in control cells.Western blot showed that CK8 expression in Huh-7-HCV and Huh-7.5-HCV cells was 2.53 and 3.26 times higher than that in control cells,respectively.We found that CK8at mRNA and protein levels were both significantly increased in HCVcc.CK8 was up-regulated in SMMC7721cells.CK8 expression at the mRNA level was significantly upregulated in SMMC7721/pEGFP-CK8 cells.CK8expression in SMMC7721/pEGFP-CK8 cells was 2.69times higher than in SMMC7721 cells,and was 2.64times higher than in SMMC7721/pEGFP-C1 cells.CK8expression at the protein level in SMMC7721/pEGFPCK8 cells was 2.46 times higher than in SMMC7721cells,and was 2.29 times higher than in SMMC7721/pEGFP-C1 cells.Further analysis demonstrated that forced expression of CK8 slowed cell growth and induced apoptosis of SMMC7721 cells.CONCLUSION:CK8 up-regulation might have a functional role in HCV infection and pathogenesis,and could be a promising target for the treatment of HCV infection.
基金The National Natural Science Foundation of China under contract Nos 51490675,51322903 and 51279224
文摘On the basis of a potential theory and Euler-Bernoulli beam theory, an analytical solution for oblique wave scattering by a semi-infinite elastic plate with finite draft floating on a step topography is developed using matched eigenfunction expansions. Different from previous studies, the effects of a wave incident angle, a plate draft, three different plate edge conditions （free, simply supported and built-in） and a sea-bottom topography are all taken into account. Moreover, the plate edge conditions are directly incorporated into linear algebraic equations for determining unknown expansion coefficients in velocity potentials, which leads to a simple and efficient solving procedure. Numerical results show that the convergence of the present solution is good, and an energy conservation relation is well satisfied. Also, the present predictions are in good agreement with known results for special cases. The effects of the wave incident angle, the plate draft, the plate edge conditions and the sea-bottom topography on various hydrodynamic quantities are analyzed. Some useful results are presented for engineering designs.
基金The study was financially supported by the National Natural Science Foundation of China(Grant No.51978336)the Science and Technology Project of Water Resources Department of Jiangsu Province(Grant No.2021022).
文摘An analytical procedure is presented to evaluate the fluid sloshing characteristics in a two-dimensional(2D)rectangular container with a bottom-mounted T-shaped baffle.The fluid region is divided into several sub-domains with hypothetical interfaces and the velocities and pressures of the fluid on adjacent interfaces should be identical.The separation of variables in conjunction with the superposition principle is employed to formulate the velocity potential of each sub-domain.The Fourier series expansion is used to derive the eigenvalue equation by substituting the velocity potential solutions into the free surface conditions and the continuity conditions on adjacent interfaces.Under the horizontal base excitation,the total velocity potential of fluid is decomposed of the impulsive and perturbed velocity potentials.The orthogonality of the sloshing modes is demonstrated by implementing Gauss formula.The dynamic response equation is established by incorporating the total velocity potential solution into the surface wave equation.Excellent agreements are achieved between the present results and those from the reported literature and finite element code.Numerical results are exhibited to reveal the effect of the baffle parameters and excitation frequency on sloshing characteristics and responses of liquid.
基金supported by the National Natural Science Foundation of China(81871662,82150201)Xi’an Jiaotong University Fund(xzy012019066 and xzy032020037)Xi’an Jiaotong University Health Science Center-Qinnong Bank Fund(QNXJTU-04&QNXJTU-07)。
文摘The recent COVID-19 pandemic poses a global health emergency.Cellular entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor-human angiotensin converting enzyme 2(ACE2).Here,by using lentivirus based pseudotypes bearing spike protein,we demonstrated that entry of SARS-CoV-2 into host cells was dependent on clathrin-mediated endocytosis,and phosphoinositides played essential roles during this process.In addition,we showed that the intracellular domain and the catalytic activity of ACE2 were not required for efficient virus entry.Finally,we showed that the current predominant Delta variant,although with high infectivity and high syncytium formation,also entered cells through clathrin-mediated endocytosis.These results provide new insights into SARS-CoV-2 cellular entry and present proof of principle that targeting viral entry could be an effective way to treat different variant infections.
基金supported by the National Natural Science Foundation of China (82272309).
文摘Coxsackievirus belongs to the Picornaviridae family and is one of the major pathogens that cause hand,foot and mouth disease(HFMD)in infants and children with potential serious complications and even deaths.The pathogenesis of this virus is not fully elucidated and no vaccine or antiviral drug has been approved.In this study,a full-length infectious cDNA clone of coxsackievirus B5 virus was assembled and the recombinant virus displayed similar growth kinetics and ability to cause cytopathic effects as the parental virus.Luciferase reporter was then incorporated to generate both full-length and subgenomic replicon(SGR)reporter viruses.The full-length reporter virus is suitable for high-throughput antiviral screening,while the SGR is a useful tool to study viral-host interactions.More importantly,the full-length reporter virus has also been shown to infect the suckling mouse model and the reporter gene could be detected using an in vivo imaging system,thus providing a powerful tool to track viruses in vivo.In summary,we have generated coxsackievirus B5 reporter viruses and provided unique tools for studying virus-host interactions in vitro and in vivo as well as for high-throughput screenings(HTS)to identify novel antivirals.
基金Project supported by the National Natural Science Foundation of China (Grant No. 61804175)the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (Grant No. ZDBS-LY-JSC031)the China Postdoctoral Science Foundation (Grant No. BX20200358)。
文摘The 808-nm vertical cavity surface emitting laser(VCSEL) with strained In_(0.13)Ga_(0.75)Al_(0.12)As/Al_(0.3)Ga_(0.7)As quantum wells is designed and fabricated. Compared with the VCSELs with Al_(0.05)Ga_(0.95)As/Al_(0.3)Ga_(0.7)As quantum wells, the VCSEL with strained In_(0.13)Ga_(0.75)Al_(0.12)As/Al_(0.3)Ga_(0.7)As quantum wells is demonstrated to possess higher power conversion efficiency(PCE) and better temperature stability. The maximum PCE of 43.8% for 10-μm VCSEL is achieved at an ambient temperature of 30°C. The size-dependent thermal characteristics are also analyzed by characterizing the spectral power and output power. It demonstrates that small oxide-aperture VCSELs are advantageous for temperature-stable performance.
基金support from the National Natural Science Foundation of China(Nos.62374179,62104251,and 62174178.)the Key Research Program of Frontier Sciences,CAS(ZDBS-LY-JSCo31)+3 种基金the Youth Innovation Promotion Association CAS(2022115),the Beijing Nova Program(2022032)the National Key Basic Research Program(2022YFB2803000),the Shanghai Sailing Program(23YF1429500)the Science and Technology Commission of Shanghai Municipality(Grant No.21DZ1100500)the Shanghai Municipal Science and Technology Major Project,and the Shanghai Frontiers Science Center Program(2021-2025 No.20).
文摘Vertical cavity surface emitting lasers(VCSELs)have emerged as a versatile and promising platform for developing advanced integrated photonic devices and systems due to their low power consumption,high modulation bandwidth,small footprint,excellent scalability,and compatibility with monolithic integration.By combining these unique capabilities of VCSELs with the functionalities offered by micro/nano optical structures(e.g.metasurfaces),it enables various versatile energy-efficient integrated photonic devices and systems with compact size,enhanced performance,and improved reliability and functionality.This review provides a comprehensive overview of the stateof-the-art versatile integrated photonic devices/systems based on VCSELs,including photonic neural networks,vortex beam emitters,holographic devices,beam deflectors,atomic sensors,and biosensors.By leveraging the capabilities of VCSELs,these integrated photonic devices/systems open up new opportunities in various fields,including artificial intelligence,large-capacity optical communication,imaging,biosensing,and so on.Through this comprehensive review,we aim to provide a detailed understanding of the pivotal role played by VCSELs in integrated photonics and highlight their significance in advancing the feld towards effcient,compact,and versatile photonic solutions.
