实现临床治愈是目前慢性乙型肝炎(乙肝)患者的理想治疗目标,主要通过干扰素治疗实现。但目前仍存在乙型肝炎表面抗原(hepatitis B surface antigen, HBsAg)阴转率偏低,部分患者还面临HBsAg复发的问题。促进HBsAg清除、减少HBsAg清除后复...实现临床治愈是目前慢性乙型肝炎(乙肝)患者的理想治疗目标,主要通过干扰素治疗实现。但目前仍存在乙型肝炎表面抗原(hepatitis B surface antigen, HBsAg)阴转率偏低,部分患者还面临HBsAg复发的问题。促进HBsAg清除、减少HBsAg清除后复发,为当前研究的热点之一。预防性乙肝疫苗在乙肝临床治愈中的作用值得关注和研究。本研究系统综述乙肝疫苗在乙肝治疗中的应用,重点总结了其在HBsAg清除患者诱导产生抗-HBs的初步临床证据,并基于免疫学机制探讨了其在增强临床治愈中的潜在价值。展开更多
Cu/ZnO-based catalysts are widely employed for methanol synthesis via CO_(2) hydrogenation.The preparation procedure is sensitive to the particle size and interfacial structure,which are considered as potential active...Cu/ZnO-based catalysts are widely employed for methanol synthesis via CO_(2) hydrogenation.The preparation procedure is sensitive to the particle size and interfacial structure,which are considered as potential active centers influencing the rate of both methanol and CO formation.The particle size and the interaction between Cu and the support materials are influenced by the coprecipitation conditions,let alone that the mechanistic divergence remains unclear.In this work,a series of Cu/ZnO/ZrO_(2) catalysts were prepared via co-precipitation at different pH value and systematically characterized.The structure has been correlated with kinetic results to establish the structure-performance relationship.Kinetic analysis demonstrates that methanol synthesis follows a single-site Langmuir-Hinshelwood(L-H)mechanism,i.e.,Cu serves as the active site where CO_(2) and H_(2) competitively adsorb and react to form methanol.In contrast,CO formation proceeds via a dual-site L-H mechanism,where CO_(2) adsorbs onto ZnO and H_(2) onto Cu,with the reaction occurring at the Cu/ZnO interface.Therefore,for the direct formation of methanol,solely reducing the particle size of Cu would not be beneficial.展开更多
文摘实现临床治愈是目前慢性乙型肝炎(乙肝)患者的理想治疗目标,主要通过干扰素治疗实现。但目前仍存在乙型肝炎表面抗原(hepatitis B surface antigen, HBsAg)阴转率偏低,部分患者还面临HBsAg复发的问题。促进HBsAg清除、减少HBsAg清除后复发,为当前研究的热点之一。预防性乙肝疫苗在乙肝临床治愈中的作用值得关注和研究。本研究系统综述乙肝疫苗在乙肝治疗中的应用,重点总结了其在HBsAg清除患者诱导产生抗-HBs的初步临床证据,并基于免疫学机制探讨了其在增强临床治愈中的潜在价值。
基金supported by Research Grant from China Petroleum and Chemical Corp。
文摘Cu/ZnO-based catalysts are widely employed for methanol synthesis via CO_(2) hydrogenation.The preparation procedure is sensitive to the particle size and interfacial structure,which are considered as potential active centers influencing the rate of both methanol and CO formation.The particle size and the interaction between Cu and the support materials are influenced by the coprecipitation conditions,let alone that the mechanistic divergence remains unclear.In this work,a series of Cu/ZnO/ZrO_(2) catalysts were prepared via co-precipitation at different pH value and systematically characterized.The structure has been correlated with kinetic results to establish the structure-performance relationship.Kinetic analysis demonstrates that methanol synthesis follows a single-site Langmuir-Hinshelwood(L-H)mechanism,i.e.,Cu serves as the active site where CO_(2) and H_(2) competitively adsorb and react to form methanol.In contrast,CO formation proceeds via a dual-site L-H mechanism,where CO_(2) adsorbs onto ZnO and H_(2) onto Cu,with the reaction occurring at the Cu/ZnO interface.Therefore,for the direct formation of methanol,solely reducing the particle size of Cu would not be beneficial.
