Since the discovery of graphene and the rise of MoS_2,atomically thin two-dimensional(2D)crystals have grown into a huge family of materials ranging from semimetal,semiconductors to insulators.Monolayer transition-met...Since the discovery of graphene and the rise of MoS_2,atomically thin two-dimensional(2D)crystals have grown into a huge family of materials ranging from semimetal,semiconductors to insulators.Monolayer transition-metal dichalcogenides denoted as MX_2(e.g.,M=Mo,W,and X=S,Se,Te)have been prepared by physical exfoliation and展开更多
GENTING Highlands,one of Malaysia's bestdeveloped hilI resorts,lies just 58 kilometers from the national capitalof Kuala Lumpur.Embraced by beautiful hills,the resort attracts tourists from around the world who co...GENTING Highlands,one of Malaysia's bestdeveloped hilI resorts,lies just 58 kilometers from the national capitalof Kuala Lumpur.Embraced by beautiful hills,the resort attracts tourists from around the world who come for top line entertainment and a broad choice of recreational facilities.Its pleasant climate,enchanting scenery and wide range of services make the 20 million tourists who visit the resort annually reluctant to go home.展开更多
Hyaluronic acid (HA) and chitosan (CS) were immobilized on the surface of poly-L-lactide (PLLA) by the following procedure: Firstly, PLLA was aminolyzed with 1, 6-hexanediamine, and part of the PLLA surface ester grou...Hyaluronic acid (HA) and chitosan (CS) were immobilized on the surface of poly-L-lactide (PLLA) by the following procedure: Firstly, PLLA was aminolyzed with 1, 6-hexanediamine, and part of the PLLA surface ester groups were converted to free amino groups. Then negatively charged hyaluronic acid and positively charged chitosan were deposited onto the surface of aminolyzed PLLA film in a layer-by-layer assembly manner. The effect of the layer-by- layer deposition was evaluated by ATR-FTIR spectroscopy, Raman spectroscopy and static contact angle measurements. The cytocompatibility of PLLA sample to bone marrow stromal cells (BMSCs) was improved after modification with chitosan and HA. The cell attachment, activity, and prolif- eration on CS/HA modified PLLA films were enhanced comparing with the control. The cells cultured on the modi- fied PLLA samples excreted abundant cytoplasm and can differentiate to vascular smooth muscle (SM)-like (SM-like) cells. A macroporous three-dimensional PLLA scaffold was prepared by integrating both the technique of freeze-drying and particle leaching. Layer-by-layer modification by HA/CS and cell culture was also applied on this scaffold. The scaf- fold cultured with BMSCs for 2 weeks has been tested suc- cessfully in vivo as a patch for repairing the artificial incision on canine pulmonary artery.展开更多
基金supported by the National Natural Science Foundation of China and the Ministry of Science and Technology of China
文摘Since the discovery of graphene and the rise of MoS_2,atomically thin two-dimensional(2D)crystals have grown into a huge family of materials ranging from semimetal,semiconductors to insulators.Monolayer transition-metal dichalcogenides denoted as MX_2(e.g.,M=Mo,W,and X=S,Se,Te)have been prepared by physical exfoliation and
文摘GENTING Highlands,one of Malaysia's bestdeveloped hilI resorts,lies just 58 kilometers from the national capitalof Kuala Lumpur.Embraced by beautiful hills,the resort attracts tourists from around the world who come for top line entertainment and a broad choice of recreational facilities.Its pleasant climate,enchanting scenery and wide range of services make the 20 million tourists who visit the resort annually reluctant to go home.
基金was supported by the National Natural Science Foundation of China(Grant No.201 44001)the Shanghai Municipal Foundation of Science and Technology(Grant No.014119025).
文摘Hyaluronic acid (HA) and chitosan (CS) were immobilized on the surface of poly-L-lactide (PLLA) by the following procedure: Firstly, PLLA was aminolyzed with 1, 6-hexanediamine, and part of the PLLA surface ester groups were converted to free amino groups. Then negatively charged hyaluronic acid and positively charged chitosan were deposited onto the surface of aminolyzed PLLA film in a layer-by-layer assembly manner. The effect of the layer-by- layer deposition was evaluated by ATR-FTIR spectroscopy, Raman spectroscopy and static contact angle measurements. The cytocompatibility of PLLA sample to bone marrow stromal cells (BMSCs) was improved after modification with chitosan and HA. The cell attachment, activity, and prolif- eration on CS/HA modified PLLA films were enhanced comparing with the control. The cells cultured on the modi- fied PLLA samples excreted abundant cytoplasm and can differentiate to vascular smooth muscle (SM)-like (SM-like) cells. A macroporous three-dimensional PLLA scaffold was prepared by integrating both the technique of freeze-drying and particle leaching. Layer-by-layer modification by HA/CS and cell culture was also applied on this scaffold. The scaf- fold cultured with BMSCs for 2 weeks has been tested suc- cessfully in vivo as a patch for repairing the artificial incision on canine pulmonary artery.
