The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia areata.The primary bioactive constituents,sesquiterpene coumar...The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia areata.The primary bioactive constituents,sesquiterpene coumarins,have demonstrated notable therapeutic potential against neuroinflammation.In this study,a structure-guided fractionation method was used to isolate nine novel sesquiterpene coumarins from the resin of F.sinkiangensis.These compounds were characterized and structurally elucidated using comprehensive physicochemical and spectroscopic techniques,including calculated electronic circular dichroism(ECD).Anti-neuroinflammatory assays revealed that compounds 2,3,and 6 significantly inhibited nitric oxide(NO)production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells,with IC_(50)values ranging from 1.63 to 12.25μmol·L^(−1).展开更多
目的分析微创内固定支架经皮微创内固定技术治疗对C型老年桡骨远端骨折患者腕关节功能的影响。方法随机选取2012年5月至2016年5月期间在我们医院骨科就诊的C型老年桡骨远端骨折患者136例,分为微创内固定支架经皮微创内固定技术组(试验组...目的分析微创内固定支架经皮微创内固定技术治疗对C型老年桡骨远端骨折患者腕关节功能的影响。方法随机选取2012年5月至2016年5月期间在我们医院骨科就诊的C型老年桡骨远端骨折患者136例,分为微创内固定支架经皮微创内固定技术组(试验组)和外固定组(对照组),各68例,利用腕关节Gartland-Werley评分标准评价患者手术后的临床效果,最后通过SPSS 20.0统计学软件对本次研究所得数据进行分析。结果试验组的背甚度高于对照组(75.4±12.72 vs. 66.5±9.04),试验组的掌屈度高于对照组(61.27±9.43 vs. 53.51±5.82),试验组的旋前度高于对照组(77.01±7.34 vs. 69.24±4.61),试验组的旋后度高于对照组(73.76±8.22 vs. 62.36±5.46),试验组的Gartland-Werley评分低于对照组(2.36±1.24 vs. 8.61±6.69),两组之间比较差异有统计学意义(P<0.05)。结论微创内固定支架经皮微创内固定技术治疗C型老年桡骨远端骨折患者过程中,骨内固定效果更好,腕关节功能恢复更快,术后并发症发生概率更小,值得推广应用。展开更多
基金supported by the National Natural Science Foundation of China(No.U1903122)the Scientific Research Fund of Liaoning Province Education Department(No.LJKZ0945)the Natural Science Foundation of Liaoning Province(No.2022-MS-242).
文摘The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia areata.The primary bioactive constituents,sesquiterpene coumarins,have demonstrated notable therapeutic potential against neuroinflammation.In this study,a structure-guided fractionation method was used to isolate nine novel sesquiterpene coumarins from the resin of F.sinkiangensis.These compounds were characterized and structurally elucidated using comprehensive physicochemical and spectroscopic techniques,including calculated electronic circular dichroism(ECD).Anti-neuroinflammatory assays revealed that compounds 2,3,and 6 significantly inhibited nitric oxide(NO)production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells,with IC_(50)values ranging from 1.63 to 12.25μmol·L^(−1).
文摘目的分析微创内固定支架经皮微创内固定技术治疗对C型老年桡骨远端骨折患者腕关节功能的影响。方法随机选取2012年5月至2016年5月期间在我们医院骨科就诊的C型老年桡骨远端骨折患者136例,分为微创内固定支架经皮微创内固定技术组(试验组)和外固定组(对照组),各68例,利用腕关节Gartland-Werley评分标准评价患者手术后的临床效果,最后通过SPSS 20.0统计学软件对本次研究所得数据进行分析。结果试验组的背甚度高于对照组(75.4±12.72 vs. 66.5±9.04),试验组的掌屈度高于对照组(61.27±9.43 vs. 53.51±5.82),试验组的旋前度高于对照组(77.01±7.34 vs. 69.24±4.61),试验组的旋后度高于对照组(73.76±8.22 vs. 62.36±5.46),试验组的Gartland-Werley评分低于对照组(2.36±1.24 vs. 8.61±6.69),两组之间比较差异有统计学意义(P<0.05)。结论微创内固定支架经皮微创内固定技术治疗C型老年桡骨远端骨折患者过程中,骨内固定效果更好,腕关节功能恢复更快,术后并发症发生概率更小,值得推广应用。
